2xna - Revision history

OCA at 10:35, 20 December 2023

2023-12-20T10:35:07Z

←Older revision		Revision as of 10:35, 20 December 2023
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	<StructureSection load='2xna' size='340' side='right'caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xna' size='340' side='right'caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XNA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1enf\|1enf]]~~, [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [https://pdbe.org/2xna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [https://www.ebi.ac.uk/pdbsum/2xna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [https://pdbe.org/2xna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [https://www.ebi.ac.uk/pdbsum/2xna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] TCR-alpha-beta-positive T-cell deficiency. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~ETXH_STAAU ETXH_STAAU~~]~~] Staphylococcal enterotoxins cause~~ the ~~intoxication staphylococcal food poisoning syndrome~~. ~~The illness characterized~~ by ~~high fever~~, ~~hypotension~~, ~~diarrhea~~, ~~shock~~, and in ~~some cases death~~.	+	[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).<ref>PMID:15040585</ref> <ref>PMID:23524462</ref> <ref>PMID:24600447</ref> <ref>PMID:25493333</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fischer, G]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Karlsson~~, B G~~]]	+	[[Category: Fischer G]]
-	[[Category: Lindkvist-Petersson, K]]	+	[[Category: Karlsson BG]]
-	[[Category: Orekhov~~, V Y~~]]	+	[[Category: Lindkvist-Petersson K]]
-	[[Category: Rodstrom~~, K E.J~~]]	+	[[Category: Orekhov VY]]
-	[[Category: Saline, M]]	+	[[Category: Rodstrom KEJ]]
-	~~[[Category: Immune system]]~~	+	[[Category: Saline M]]
-	~~[[Category: Superantigen~~]]	+

OCA at 12:14, 27 April 2022

2022-04-27T12:14:08Z

←Older revision		Revision as of 12:14, 27 April 2022
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	<StructureSection load='2xna' size='340' side='right'caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xna' size='340' side='right'caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XNA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [~~http~~://pdbe.org/2xna PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xna PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [https://pdbe.org/2xna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [https://www.ebi.ac.uk/pdbsum/2xna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ETXH_STAAU ETXH_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.	+	[[https://www.uniprot.org/uniprot/ETXH_STAAU ETXH_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:13, 22 July 2020

2020-07-22T12:13:20Z

←Older revision		Revision as of 12:13, 22 July 2020
Line 1:		Line 1:

	==Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin==		==Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin==
-	<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2xna' size='340' side='right'caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XNA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://pdbe.org/2xna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://pdbe.org/2xna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[T-cell receptor\|T-cell receptor]]		*[[T-cell receptor\|T-cell receptor]]
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fischer, G]]		[[Category: Fischer, G]]
	[[Category: Karlsson, B G]]		[[Category: Karlsson, B G]]

OCA at 09:13, 10 October 2018

2018-10-10T09:13:43Z

←Older revision		Revision as of 09:13, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN~~ T ~~CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN~~==	+	==Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin==
	<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 17:22, 4 August 2016

2016-08-04T17:22:18Z

←Older revision		Revision as of 17:22, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN==		==CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN==
	<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://pdbe.org/2xna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xna" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens]]~~	+	[[Category: Human]]
-	~~[[Category: Staphylococcus aureus~~]]	+
	[[Category: Fischer, G]]		[[Category: Fischer, G]]
	[[Category: Karlsson, B G]]		[[Category: Karlsson, B G]]

OCA at 17:31, 24 December 2014

2014-12-24T17:31:11Z

←Older revision		Revision as of 17:31, 24 December 2014
Line 2:		Line 2:
	<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. <br>	+	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ETXH_STAAU ETXH_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 15:
	The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.,Saline M, Rodstrom KE, Fischer G, Orekhov VY, Karlsson BG, Lindkvist-Petersson K Nat Commun. 2010 Nov 16;1:119. PMID:21081917<ref>PMID:21081917</ref>		The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.,Saline M, Rodstrom KE, Fischer G, Orekhov VY, Karlsson BG, Lindkvist-Petersson K Nat Commun. 2010 Nov 16;1:119. PMID:21081917<ref>PMID:21081917</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[T-cell receptor\|T-cell receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 26:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Fischer, G.]]	+	[[Category: Fischer, G]]
-	[[Category: Karlsson, B G.]]	+	[[Category: Karlsson, B G]]
-	[[Category: Lindkvist-Petersson, K.]]	+	[[Category: Lindkvist-Petersson, K]]
-	[[Category: Orekhov, V Y.]]	+	[[Category: Orekhov, V Y]]
-	[[Category: Rodstrom, K E.J.]]	+	[[Category: Rodstrom, K E.J]]
-	[[Category: Saline, M.]]	+	[[Category: Saline, M]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Superantigen]]		[[Category: Superantigen]]

OCA at 07:52, 14 May 2014

2014-05-14T07:52:17Z

←Older revision		Revision as of 07:52, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xna.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN==
		+	<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1enf\|1enf]], [[2esv\|2esv]], [[1f77\|1f77]], [[1qrn\|1qrn]], [[1kgc\|1kgc]], [[2bnr\|2bnr]], [[2ak4\|2ak4]], [[2gj6\|2gj6]], [[2cdg\|2cdg]], [[2bnu\|2bnu]], [[2eys\|2eys]], [[1mi5\|1mi5]], [[2cdf\|2cdf]], [[1fyt\|1fyt]], [[1ymm\|1ymm]], [[1ewc\|1ewc]], [[1j8h\|1j8h]], [[1zgl\|1zgl]], [[2axh\|2axh]], [[1ktk\|1ktk]], [[2eyt\|2eyt]], [[2bnq\|2bnq]], [[1oga\|1oga]], [[2eyr\|2eyr]], [[2cde\|2cde]], [[2xn9\|2xn9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Superantigens (SAgs) are bacterial toxins that interact with immunoreceptors, T cell receptor (TCR) and major histocompatibility complex (MHC) class II, conventionally through the variable beta-domain of TCR (TCRVbeta). They induce a massive release of cytokines, which can lead to diseases such as food poisoning and toxic shock syndrome. In this study, we report the X-ray structure of the ternary complex between staphylococcal enterotoxin H (SEH) and its human receptors, MHC class II and TCR. The structure demonstrates that SEH predominantly interacts with the variable alpha-domain of TCR (TCRValpha), which is supported by nuclear magnetic resonance (NMR) analyses. Furthermore, there is no contact between MHC and TCR upon complex formation. Structural analyses suggest that the major contact points to TCRValpha are conserved among other bacterial SAgs. Consequently, a new dimension of SAg biology emerges, suggesting that in addition to the conventional interactions with the TCRVbeta domain, SAgs can also activate T cells through the TCRValpha domain.

-	~~<!--~~	+	The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.,Saline M, Rodstrom KE, Fischer G, Orekhov VY, Karlsson BG, Lindkvist-Petersson K Nat Commun. 2010 Nov 16;1:119. PMID:21081917<ref>PMID:21081917</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_2xna"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2xna\| PDB=2xna \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21081917}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21081917 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21081917}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xna]] is a 3 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021081917<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA: Protected "2xna" [edit=sysop:move=sysop]

2011-08-24T05:49:31Z

Protected "2xna" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:49, 24 August 2011

OCA at 05:49, 24 August 2011

2011-08-24T05:49:29Z

←Older revision		Revision as of 05:49, 24 August 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2xna.png\|left\|200px]]
-	[[Image:2xna.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN===		===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21081917}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21081917 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21081917}}

	==About this Structure==		==About this Structure==
-	~~2XNA~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA].	+	[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021081917</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
Line 25:		Line 33:
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Superantigen]]		[[Category: Superantigen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:11:24 2010''

OCA at 11:00, 24 November 2010

2010-11-24T11:00:03Z

←Older revision		Revision as of 11:00, 24 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2xna.jpg\|left\|200px]]

-	The ~~entry 2xna~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xna", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xna\| PDB=2xna \| SCENE= }}

-	~~Authors: Saline, M., Rodstrom, K.E.J., Fischer, G., Orekhov, V.Y., Karlsson, B.G., Lindkvist-Petersson, K.~~	+	===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN T CELL RECEPTOR AND STAPHYLOCOCCAL ENTEROTOXIN===

-	Description: Crystal structure of the ternary complex between human T cell receptor and staphylococcal enterotoxin H

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 25 08~~:30:48 2010''	+	==About this Structure==
		+	2XNA is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Fischer, G.]]
		+	[[Category: Karlsson, B G.]]
		+	[[Category: Lindkvist-Petersson, K.]]
		+	[[Category: Orekhov, V Y.]]
		+	[[Category: Rodstrom, K E.J.]]
		+	[[Category: Saline, M.]]
		+	[[Category: Immune system]]
		+	[[Category: Superantigen]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:11:24 2010''