2xqn - Revision history

OCA at 08:02, 23 August 2023

2023-08-23T08:02:34Z

←Older revision		Revision as of 08:02, 23 August 2023
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	<StructureSection load='2xqn' size='340' side='right'caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2xqn' size='340' side='right'caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.62Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2iyb\|2iyb]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [https://pdbe.org/2xqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [https://www.ebi.ac.uk/pdbsum/2xqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [https://pdbe.org/2xqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [https://www.ebi.ac.uk/pdbsum/2xqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TES_HUMAN TES_HUMAN~~]] Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.<ref>PMID:11420696</ref> <ref>PMID:12695497</ref> <ref>PMID:12571287</ref> [[https://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>	+	[https://www.uniprot.org/uniprot/ACL7A_HUMAN ACL7A_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2xqn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xqn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Actin-related protein 3D structures\|Actin-related protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briggs~~, D C~~]]	+	[[Category: Briggs DC]]
-	[[Category: Knowles~~, P P~~]]	+	[[Category: Knowles PP]]
-	[[Category: McDonald~~, N Q~~]]	+	[[Category: McDonald NQ]]
-	[[Category: Murray-Rust, J]]	+	[[Category: Murray-Rust J]]
-	~~[[Category: Acrosome]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Focal adhesion]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metal-binding protein~~]]	+

OCA at 14:52, 17 November 2021

2021-11-17T14:52:56Z

←Older revision		Revision as of 14:52, 17 November 2021
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	<StructureSection load='2xqn' size='340' side='right'caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2xqn' size='340' side='right'caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iyb\|2iyb]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [~~http~~://pdbe.org/2xqn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xqn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [https://pdbe.org/2xqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [https://www.ebi.ac.uk/pdbsum/2xqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TES_HUMAN TES_HUMAN]] Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.<ref>PMID:11420696</ref> <ref>PMID:12695497</ref> <ref>PMID:12571287</ref> [[~~http~~://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>	+	[[https://www.uniprot.org/uniprot/TES_HUMAN TES_HUMAN]] Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.<ref>PMID:11420696</ref> <ref>PMID:12695497</ref> <ref>PMID:12571287</ref> [[https://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:25, 10 May 2019

2019-05-10T12:25:05Z

←Older revision		Revision as of 12:25, 10 May 2019
Line 1:		Line 1:

	==Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal domain of actin-like protein Arp7A==		==Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal domain of actin-like protein Arp7A==
-	<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>	+	<StructureSection load='2xqn' size='340' side='right'caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Briggs, D C]]		[[Category: Briggs, D C]]
	[[Category: Knowles, P P]]		[[Category: Knowles, P P]]

OCA at 07:01, 28 February 2018

2018-02-28T07:01:12Z

←Older revision		Revision as of 07:01, 28 February 2018
Line 3:		Line 3:
	<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Briggs, D C]]		[[Category: Briggs, D C]]
	[[Category: Knowles, P P]]		[[Category: Knowles, P P]]
-	[[Category: ~~Mcdonald~~, N Q]]	+	[[Category: McDonald, N Q]]
	[[Category: Murray-Rust, J]]		[[Category: Murray-Rust, J]]
	[[Category: Acrosome]]		[[Category: Acrosome]]

OCA at 11:42, 3 August 2017

2017-08-03T11:42:53Z

←Older revision		Revision as of 11:42, 3 August 2017
Line 1:		Line 1:

-	==~~COMPLEX OF THE 2ND AND 3RD~~ LIM ~~DOMAINS OF~~ TES ~~WITH THE~~ EVH1 DOMAIN OF MENA ~~AND THE~~ N-~~TERMINAL DOMAIN OF ACTIN~~-~~LIKE PROTEIN ARP7A~~==	+	==Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal domain of actin-like protein Arp7A==
	<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Briggs, D C]]		[[Category: Briggs, D C]]
	[[Category: Knowles, P P]]		[[Category: Knowles, P P]]
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	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Focal adhesion]]		[[Category: Focal adhesion]]
		+	[[Category: Metal binding protein]]
	[[Category: Metal-binding protein]]		[[Category: Metal-binding protein]]

OCA at 17:59, 5 August 2016

2016-08-05T17:59:34Z

←Older revision		Revision as of 17:59, 5 August 2016
Line 1:		Line 1:
		+
	==COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A==		==COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A==
	<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [http://www.ebi.ac.uk/pdbsum/2xqn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [http://pdbe.org/2xqn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [http://www.ebi.ac.uk/pdbsum/2xqn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xqn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Briggs, D C]]		[[Category: Briggs, D C]]
	[[Category: Knowles, P P]]		[[Category: Knowles, P P]]

OCA at 20:48, 25 December 2014

2014-12-25T20:48:37Z

←Older revision		Revision as of 20:48, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. <br>	+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [http://www.ebi.ac.uk/pdbsum/2xqn PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [http://www.ebi.ac.uk/pdbsum/2xqn PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TES_HUMAN TES_HUMAN]] Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.<ref>PMID:11420696</ref> <ref>PMID:12695497</ref> <ref>PMID:12571287</ref> [[http://www.uniprot.org/uniprot/ENAH_HUMAN ENAH_HUMAN]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).<ref>PMID:11696321</ref> <ref>PMID:18158903</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 15:
	Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.,Boeda B, Knowles PP, Briggs D, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M J Biol Chem. 2011 Jan 29. PMID:21278383<ref>PMID:21278383</ref>		Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.,Boeda B, Knowles PP, Briggs D, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M J Biol Chem. 2011 Jan 29. PMID:21278383<ref>PMID:21278383</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Briggs, D C.]]	+	[[Category: Briggs, D C]]
-	[[Category: Knowles, P P.]]	+	[[Category: Knowles, P P]]
-	[[Category: Mcdonald, N Q.]]	+	[[Category: Mcdonald, N Q]]
-	[[Category: Murray-Rust, J.]]	+	[[Category: Murray-Rust, J]]
	[[Category: Acrosome]]		[[Category: Acrosome]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Focal adhesion]]		[[Category: Focal adhesion]]
	[[Category: Metal-binding protein]]		[[Category: Metal-binding protein]]

OCA at 07:49, 14 May 2014

2014-05-14T07:49:30Z

←Older revision		Revision as of 07:49, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xqn.~~png~~\|~~left~~\|~~200px~~]]	+	==COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A==
		+	<StructureSection load='2xqn' size='340' side='right' caption='[[2xqn]], [[Resolution\|resolution]] 2.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xqn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iyb\|2iyb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqn RCSB], [http://www.ebi.ac.uk/pdbsum/2xqn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Actin related proteins (Arps) are a highly conserved family of proteins that have extensive sequence and structural similarity to actin. All characterized Arps are components of large multimeric complexes associated with chromatin or the cytoskeleton. In addition, the human genome encodes five conserved but largely uncharacterized ''orphan'' Arps, which appear to be mostly testis specific. Here we show that Arp7A, which has 43% sequence identity with beta-actin, forms a complex with the cytoskeletal proteins Tes and Mena in the subacrosomal layer of round spermatids. The N-terminal 65 residue extension to the actin-like fold of Arp7A interacts directly with Tes. The crystal structure of the 1-65Arp7A:LIM2-3Tes:EVH1Mena complex reveals that residues 28 - 49 of Arp7A contact the LIM2-3 domains of Tes. Two alanine residues from Arp7A that occupy equivalent apolar pockets in both LIM domains as well as an intervening GPAK linker that binds the LIM2-3 junction, are critical for the Arp7A:Tes interaction. Equivalent occupied apolar pockets are also seen in the tandem LIM domain structures of LMO4 and Lhx3 bound to unrelated ligands. Our results indicate that apolar pocket interactions are a common feature of tandem LIM domain interactions, but ligand specificity is principally determined by the linker sequence.

-	<!--	+	Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.,Boeda B, Knowles PP, Briggs D, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M J Biol Chem. 2011 Jan 29. PMID:21278383<ref>PMID:21278383</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xqn"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xqn\| PDB=2xqn \| SCENE= }}~~	+

-	~~===COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21278383}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21278383 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21278383}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xqn]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021278383<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Briggs, D C.]]		[[Category: Briggs, D C.]]

OCA at 06:36, 24 August 2011

2011-08-24T06:36:23Z

←Older revision		Revision as of 06:36, 24 August 2011
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21278383~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021278383</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Briggs, D C.]]		[[Category: Briggs, D C.]]
Line 28:		Line 28:
	[[Category: Mcdonald, N Q.]]		[[Category: Mcdonald, N Q.]]
	[[Category: Murray-Rust, J.]]		[[Category: Murray-Rust, J.]]
		+	[[Category: Acrosome]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Focal adhesion]]
		+	[[Category: Metal-binding protein]]

OCA at 08:10, 6 April 2011

2011-04-06T08:10:44Z

←Older revision		Revision as of 08:10, 6 April 2011
Line 9:		Line 9:
	{{STRUCTURE_2xqn\| PDB=2xqn \| SCENE= }}		{{STRUCTURE_2xqn\| PDB=2xqn \| SCENE= }}

-	===COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF ~~TESTIN~~ WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A===	+	===COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A===