2xru - Revision history

OCA at 10:29, 9 May 2024

2024-05-09T10:29:12Z

←Older revision		Revision as of 10:29, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2xru' size='340' side='right'caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xru' size='340' side='right'caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=400:3~~-({[~~4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-~~[~~(1R)-1-PHENYLPROPYL~~]~~-1H-THIENO[3,~~2~~-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1muo\|1muo]], [[2x6d\|2x6d]], [[2j50\|2j50]], [[2w1d\|2w1d]], [[1ol6\|1ol6]], [[2xne\|2xne]], [[2bmc\|2bmc]], [[2c6e\|2c6e]], [[2j4z\|2j4z]], [[1ol5\|1ol5]], [[2x81\|2x81]], [[2xng\|2xng]], [[2c6d\|2c6d]], [[2wtw\|2wtw]], [[2wqe\|2wqe]], [[2w1c\|2w1c]], [[2w1g\|2w1g]], [[2wtv\|2wtv]], [[1ol7\|1ol7]], [[2w1e\|2w1e]], [[2w1f\|2w1f]], [[2x6e\|2x6e]], [[1mq4\|1mq4]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=400:3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Non~~-~~specific_serine/threonine_protein_kinase Non~~-~~specific serine/threonine protein kinase~~]~~, with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.7.11.~~1 2~~.7.11.1~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [https://pdbe.org/2xru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [https://www.ebi.ac.uk/pdbsum/2xru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xru ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [https://pdbe.org/2xru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [https://www.ebi.ac.uk/pdbsum/2xru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xru ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>	+	[https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Alli C]]
-	[[Category: Alli, C]]	+	[[Category: Berta D]]
-	~~[[Category: Anello, M D~~]]	+	[[Category: Bertrand JA]]
-	[[Category: Berta, D]]	+	[[Category: Bindi S]]
-	[[Category: Bertrand~~, J A~~]]	+	[[Category: Cameron AD]]
-	[[Category: Bindi, S]]	+	[[Category: Cappella P]]
-	[[Category: Cameron~~, A D~~]]	+	[[Category: Carpinelli P]]
-	[[Category: Cappella, P]]	+	[[Category: Cervi G]]
-	[[Category: Carpinelli, P]]	+	[[Category: Croci W]]
-	[[Category: Cervi, G]]	+	[[Category: D'Anello M]]
-	[[Category: Croci, W]]	+	[[Category: Fancelli D]]
-	[[Category: Fancelli, D]]	+	[[Category: Forte B]]
-	[[Category: Forte, B]]	+	[[Category: LauraGiorgini M]]
-	[[Category: LauraGiorgini, M]]	+	[[Category: Marsiglio A]]
-	[[Category: Marsiglio, A]]	+	[[Category: Moll J]]
-	[[Category: Moll, J]]	+	[[Category: Pesenti E]]
-	[[Category: Pesenti, E]]	+	[[Category: Pittala V]]
-	[[Category: Pittala, V]]	+	[[Category: Pulici M]]
-	[[Category: Pulici, M]]	+	[[Category: Riccardi-Sirtori F]]
-	[[Category: Riccardi-Sirtori, F]]	+	[[Category: Roletto F]]
-	[[Category: Roletto, F]]	+	[[Category: Soncini C]]
-	[[Category: Soncini, C]]	+	[[Category: Storici P]]
-	[[Category: Storici, P]]	+	[[Category: Varasi M]]
-	[[Category: Varasi, M]]	+	[[Category: Vianello P]]
-	[[Category: Vianello, P]]	+	[[Category: Volpi D]]
-	[[Category: Volpi, D]]	+	[[Category: Zugnoni P]]
-	[[Category: Zugnoni, P]]	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:53, 17 November 2021

2021-11-17T14:53:41Z

←Older revision		Revision as of 14:53, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2xru' size='340' side='right'caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xru' size='340' side='right'caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=400:3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=400:3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1muo\|1muo]], [[2x6d\|2x6d]], [[2j50\|2j50]], [[2w1d\|2w1d]], [[1ol6\|1ol6]], [[2xne\|2xne]], [[2bmc\|2bmc]], [[2c6e\|2c6e]], [[2j4z\|2j4z]], [[1ol5\|1ol5]], [[2x81\|2x81]], [[2xng\|2xng]], [[2c6d\|2c6d]], [[2wtw\|2wtw]], [[2wqe\|2wqe]], [[2w1c\|2w1c]], [[2w1g\|2w1g]], [[2wtv\|2wtv]], [[1ol7\|1ol7]], [[2w1e\|2w1e]], [[2w1f\|2w1f]], [[2x6e\|2x6e]], [[1mq4\|1mq4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1muo\|1muo]], [[2x6d\|2x6d]], [[2j50\|2j50]], [[2w1d\|2w1d]], [[1ol6\|1ol6]], [[2xne\|2xne]], [[2bmc\|2bmc]], [[2c6e\|2c6e]], [[2j4z\|2j4z]], [[1ol5\|1ol5]], [[2x81\|2x81]], [[2xng\|2xng]], [[2c6d\|2c6d]], [[2wtw\|2wtw]], [[2wqe\|2wqe]], [[2w1c\|2w1c]], [[2w1g\|2w1g]], [[2wtv\|2wtv]], [[1ol7\|1ol7]], [[2w1e\|2w1e]], [[2w1f\|2w1f]], [[2x6e\|2x6e]], [[1mq4\|1mq4]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [~~http~~://pdbe.org/2xru PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xru PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xru ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [https://pdbe.org/2xru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [https://www.ebi.ac.uk/pdbsum/2xru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xru ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>	+	[[https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:35, 3 April 2019

2019-04-03T07:35:34Z

←Older revision		Revision as of 07:35, 3 April 2019
Line 1:		Line 1:

	==AURORA-A T288E COMPLEXED WITH PHA-828300==		==AURORA-A T288E COMPLEXED WITH PHA-828300==
-	<StructureSection load='2xru' size='340' side='right' caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2xru' size='340' side='right'caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRU FirstGlance]. <br>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Alli, C]]		[[Category: Alli, C]]

OCA at 09:03, 10 October 2018

2018-10-10T09:03:49Z

←Older revision		Revision as of 09:03, 10 October 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/2xru_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/2xru_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 51:		Line 51:
	[[Category: Fancelli, D]]		[[Category: Fancelli, D]]
	[[Category: Forte, B]]		[[Category: Forte, B]]
-	[[Category: ~~Lauragiorgini~~, M]]	+	[[Category: LauraGiorgini, M]]
	[[Category: Marsiglio, A]]		[[Category: Marsiglio, A]]
	[[Category: Moll, J]]		[[Category: Moll, J]]

OCA at 13:17, 5 August 2016

2016-08-05T13:17:51Z

←Older revision		Revision as of 13:17, 5 August 2016
Line 1:		Line 1:
		+
	==AURORA-A T288E COMPLEXED WITH PHA-828300==		==AURORA-A T288E COMPLEXED WITH PHA-828300==
	<StructureSection load='2xru' size='340' side='right' caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xru' size='340' side='right' caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=400:3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=400:3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1muo\|1muo]], [[2x6d\|2x6d]], [[2j50\|2j50]], [[2w1d\|2w1d]], [[1ol6\|1ol6]], [[2xne\|2xne]], [[2bmc\|2bmc]], [[2c6e\|2c6e]], [[2j4z\|2j4z]], [[1ol5\|1ol5]], [[2x81\|2x81]], [[2xng\|2xng]], [[2c6d\|2c6d]], [[2wtw\|2wtw]], [[2wqe\|2wqe]], [[2w1c\|2w1c]], [[2w1g\|2w1g]], [[2wtv\|2wtv]], [[1ol7\|1ol7]], [[2w1e\|2w1e]], [[2w1f\|2w1f]], [[2x6e\|2x6e]], [[1mq4\|1mq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1muo\|1muo]], [[2x6d\|2x6d]], [[2j50\|2j50]], [[2w1d\|2w1d]], [[1ol6\|1ol6]], [[2xne\|2xne]], [[2bmc\|2bmc]], [[2c6e\|2c6e]], [[2j4z\|2j4z]], [[1ol5\|1ol5]], [[2x81\|2x81]], [[2xng\|2xng]], [[2c6d\|2c6d]], [[2wtw\|2wtw]], [[2wqe\|2wqe]], [[2w1c\|2w1c]], [[2w1g\|2w1g]], [[2wtv\|2wtv]], [[1ol7\|1ol7]], [[2w1e\|2w1e]], [[2w1f\|2w1f]], [[2x6e\|2x6e]], [[1mq4\|1mq4]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://pdbe.org/2xru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xru ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~STK6_HUMAN STK6_HUMAN~~]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>	+	[[http://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xru ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xru" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Alli, C]]		[[Category: Alli, C]]

OCA at 02:47, 25 December 2014

2014-12-25T02:47:56Z

←Older revision		Revision as of 02:47, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STK6_HUMAN STK6_HUMAN]] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Alli, C.]]	+	[[Category: Alli, C]]
-	[[Category: Anello, M D.]]	+	[[Category: Anello, M D]]
-	[[Category: Berta, D.]]	+	[[Category: Berta, D]]
-	[[Category: Bertrand, J A.]]	+	[[Category: Bertrand, J A]]
-	[[Category: Bindi, S.]]	+	[[Category: Bindi, S]]
-	[[Category: Cameron, A D.]]	+	[[Category: Cameron, A D]]
-	[[Category: Cappella, P.]]	+	[[Category: Cappella, P]]
-	[[Category: Carpinelli, P.]]	+	[[Category: Carpinelli, P]]
-	[[Category: Cervi, G.]]	+	[[Category: Cervi, G]]
-	[[Category: Croci, W.]]	+	[[Category: Croci, W]]
-	[[Category: Fancelli, D.]]	+	[[Category: Fancelli, D]]
-	[[Category: Forte, B.]]	+	[[Category: Forte, B]]
-	[[Category: Lauragiorgini, M.]]	+	[[Category: Lauragiorgini, M]]
-	[[Category: Marsiglio, A.]]	+	[[Category: Marsiglio, A]]
-	[[Category: Moll, J.]]	+	[[Category: Moll, J]]
-	[[Category: Pesenti, E.]]	+	[[Category: Pesenti, E]]
-	[[Category: Pittala, V.]]	+	[[Category: Pittala, V]]
-	[[Category: Pulici, M.]]	+	[[Category: Pulici, M]]
-	[[Category: Riccardi-Sirtori, F.]]	+	[[Category: Riccardi-Sirtori, F]]
-	[[Category: Roletto, F.]]	+	[[Category: Roletto, F]]
-	[[Category: Soncini, C.]]	+	[[Category: Soncini, C]]
-	[[Category: Storici, P.]]	+	[[Category: Storici, P]]
-	[[Category: Varasi, M.]]	+	[[Category: Varasi, M]]
-	[[Category: Vianello, P.]]	+	[[Category: Vianello, P]]
-	[[Category: Volpi, D.]]	+	[[Category: Volpi, D]]
-	[[Category: Zugnoni, P.]]	+	[[Category: Zugnoni, P]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 13:12, 22 October 2014

2014-10-22T13:12:27Z

←Older revision		Revision as of 13:12, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xru.~~png~~\|~~left~~\|200px]]	+	==AURORA-A T288E COMPLEXED WITH PHA-828300==
		+	<StructureSection load='2xru' size='340' side='right' caption='[[2xru]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=400:3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE'>400</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1muo\|1muo]], [[2x6d\|2x6d]], [[2j50\|2j50]], [[2w1d\|2w1d]], [[1ol6\|1ol6]], [[2xne\|2xne]], [[2bmc\|2bmc]], [[2c6e\|2c6e]], [[2j4z\|2j4z]], [[1ol5\|1ol5]], [[2x81\|2x81]], [[2xng\|2xng]], [[2c6d\|2c6d]], [[2wtw\|2wtw]], [[2wqe\|2wqe]], [[2w1c\|2w1c]], [[2w1g\|2w1g]], [[2wtv\|2wtv]], [[1ol7\|1ol7]], [[2w1e\|2w1e]], [[2w1f\|2w1f]], [[2x6e\|2x6e]], [[1mq4\|1mq4]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xru RCSB], [http://www.ebi.ac.uk/pdbsum/2xru PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/2xru_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel series of 3-amino-1H-thieno[3,2-c]pyrazole derivatives demonstrating high potency in inhibiting Aurora kinases was developed. Here we describe the synthesis and a preliminary structure-activity relationship, which led to the discovery of a representative compound (38), which showed low nanomolar inhibitory activity in the anti-proliferation assay and was able to block the cell cycle in HCT-116 cell line. This compound demonstrated favorable pharmacokinetic properties and good efficacy in the HL-60 xenograft tumor model.

-	~~{{STRUCTURE_2xru\| PDB=2xru \| SCENE= }}~~	+	Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.,Bindi S, Fancelli D, Alli C, Berta D, Bertrand JA, Cameron AD, Cappella P, Carpinelli P, Cervi G, Croci V, D'Anello M, Forte B, Giorgini ML, Marsiglio A, Moll J, Pesenti E, Pittala V, Pulici M, Riccardi-Sirtori F, Roletto F, Soncini C, Storici P, Varasi M, Volpi D, Zugnoni P, Vianello P Bioorg Med Chem. 2010 Oct 1;18(19):7113-20. Epub 2010 Jul 25. PMID:20817473<ref>PMID:20817473</ref>

-	~~===AURORA-A T288E COMPLEXED WITH PHA-828300===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_20817473}}~~	+	==See Also==
-		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2xru]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA~~].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:020817473<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA: Protected "2xru" [edit=sysop:move=sysop]

2013-01-07T17:55:04Z

Protected "2xru" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:55, 7 January 2013

OCA at 17:54, 7 January 2013

2013-01-07T17:54:57Z

←Older revision		Revision as of 17:54, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2xru.png\|left\|200px]]
-	[[Image:2xru.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xru", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xru\| PDB=2xru \| SCENE= }}		{{STRUCTURE_2xru\| PDB=2xru \| SCENE= }}

	===AURORA-A T288E COMPLEXED WITH PHA-828300===		===AURORA-A T288E COMPLEXED WITH PHA-828300===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20817473}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20817473 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20817473}}		{{ABSTRACT_PUBMED_20817473}}

	==About this Structure==		==About this Structure==
-	~~2XRU~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA].	+	[[2xru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20817473~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020817473</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
Line 56:		Line 44:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Transferase]]		[[Category: Transferase]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:11:24 2010''

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