2xrw - Revision history

OCA at 10:38, 20 December 2023

2023-12-20T10:38:04Z

←Older revision		Revision as of 10:38, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xrw' size='340' side='right'caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>		<StructureSection load='2xrw' size='340' side='right'caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~ADENYLATE+ESTER'>ANP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.33Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2xs0\|2xs0]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [https://pdbe.org/2xrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [https://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [https://pdbe.org/2xrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [https://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NFAC3_HUMAN NFAC3_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Mitogen-activated protein kinase]]~~	+	[[Category: Barkai T]]
-	[[Category: Barkai, T]]	+	[[Category: Garai A]]
-	[[Category: Garai, A]]	+	[[Category: Remenyi A]]
-	[[Category: Remenyi, A]]	+	[[Category: Toeoroe I]]
-	[[Category: Toeoroe, I]]	+
-	~~[[Category: Linear binding motif]]~~	+
-	~~[[Category: Mapk signaling pathway]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 12:16, 27 April 2022

2022-04-27T12:16:05Z

←Older revision		Revision as of 12:16, 27 April 2022
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	<StructureSection load='2xrw' size='340' side='right'caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>		<StructureSection load='2xrw' size='340' side='right'caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs0\|2xs0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xs0\|2xs0]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [~~http~~://pdbe.org/2xrw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [https://pdbe.org/2xrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [https://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:18, 22 July 2020

2020-07-22T12:18:00Z

←Older revision		Revision as of 12:18, 22 July 2020
Line 1:		Line 1:

	==Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4==		==Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4==
-	<StructureSection load='2xrw' size='340' side='right' caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>	+	<StructureSection load='2xrw' size='340' side='right'caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XRW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs0\|2xs0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs0\|2xs0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [http://pdbe.org/2xrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [http://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [http://pdbe.org/2xrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [http://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]	+	*[[Mitogen-activated protein kinase 3D structures\|Mitogen-activated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
	[[Category: Barkai, T]]		[[Category: Barkai, T]]

OCA at 10:10, 5 August 2016

2016-08-05T10:10:18Z

←Older revision		Revision as of 10:10, 5 August 2016
Line 1:		Line 1:
		+
	==Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4==		==Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4==
	<StructureSection load='2xrw' size='340' side='right' caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>		<StructureSection load='2xrw' size='340' side='right' caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs0\|2xs0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs0\|2xs0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [http://www.ebi.ac.uk/pdbsum/2xrw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [http://pdbe.org/2xrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [http://www.ebi.ac.uk/pdbsum/2xrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xrw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
	[[Category: Barkai, T]]		[[Category: Barkai, T]]

OCA at 01:28, 25 December 2014

2014-12-25T01:28:43Z

←Older revision		Revision as of 01:28, 25 December 2014
Line 25:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]
-	[[Category: Barkai, T.]]	+	[[Category: Barkai, T]]
-	[[Category: Garai, A.]]	+	[[Category: Garai, A]]
-	[[Category: Remenyi, A.]]	+	[[Category: Remenyi, A]]
-	[[Category: Toeoroe, I.]]	+	[[Category: Toeoroe, I]]
	[[Category: Linear binding motif]]		[[Category: Linear binding motif]]
	[[Category: Mapk signaling pathway]]		[[Category: Mapk signaling pathway]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 13:11, 22 October 2014

2014-10-22T13:11:19Z

←Older revision		Revision as of 13:11, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xrw.~~png~~\|~~left~~\|~~200px~~]]	+	==Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4==
		+	<StructureSection load='2xrw' size='340' side='right' caption='[[2xrw]], [[Resolution\|resolution]] 1.33Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs0\|2xs0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrw RCSB], [http://www.ebi.ac.uk/pdbsum/2xrw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitogen-activated protein kinases (MAPKs) have a docking groove that interacts with linear "docking" motifs in binding partners. To determine the structural basis of binding specificity between MAPKs and docking motifs, we quantitatively analyzed the ability of 15 docking motifs from diverse MAPK partners to bind to c-Jun amino-terminal kinase 1 (JNK1), p38alpha, and extracellular signal-regulated kinase 2 (ERK2). Classical docking motifs mediated highly specific binding only to JNK1, and only those motifs with a sequence pattern distinct from the classical MAPK binding docking motif consensus differentiated between the topographically similar docking grooves of ERK and p38alpha. Crystal structures of four complexes of MAPKs with docking peptides, representing JNK-specific, ERK-specific, or ERK- and p38-selective binding modes, revealed that the regions located between consensus positions in the docking motifs showed conformational diversity. Although the consensus positions in the docking motifs served as anchor points that bound to common MAPK surface features and mostly contributed to docking in a nondiscriminatory fashion, the conformation of the intervening region between the anchor points mostly determined specificity. We designed peptides with tailored MAPK binding profiles by rationally changing the length and amino acid composition of intervening regions located between anchor points. These results suggest a coherent structural model for MAPK docking specificity that reveals how short linear motifs binding to a common kinase docking groove can mediate diverse interaction patterns and contribute to correct MAPK partner selection in signaling networks.

-	~~{{STRUCTURE_2xrw\| PDB=2xrw \| SCENE= }}~~	+	Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.,Garai A, Zeke A, Gogl G, Toro I, Fordos F, Blankenburg H, Barkai T, Varga J, Alexa A, Emig D, Albrecht M, Remenyi A Sci Signal. 2012 Oct 9;5(245):ra74. doi: 10.1126/scisignal.2003004. PMID:23047924<ref>PMID:23047924</ref>

-	~~===Linear binding motifs for JNK and for calcineurin antagonistically control~~ the ~~nuclear shuttling of NFAT4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_23047924}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xrw]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA].~~	+

	==See Also==		==See Also==
	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]		*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]

OCA at 06:17, 24 October 2012

2012-10-24T06:17:44Z

←Older revision		Revision as of 06:17, 24 October 2012
Line 3:		Line 3:
	{{STRUCTURE_2xrw\| PDB=2xrw \| SCENE= }}		{{STRUCTURE_2xrw\| PDB=2xrw \| SCENE= }}

-	===~~LINEAR BINDING MOTIFS FOR~~ JNK ~~AND FOR CALCINEURIN ANTAGONISTICALLY CONTROL THE NUCLEAR SHUTTLING OF~~ NFAT4===	+	===Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4===

		+	{{ABSTRACT_PUBMED_23047924}}

	==About this Structure==		==About this Structure==

OCA at 11:08, 20 October 2012

2012-10-20T11:08:52Z

←Older revision		Revision as of 11:08, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2xrw]] is a 2 chain structure ~~of [[Mitogen-activated protein kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA].	+	[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA].

	==See Also==		==See Also==

OCA at 04:23, 26 July 2012

2012-07-26T04:23:26Z

←Older revision		Revision as of 04:23, 26 July 2012
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-	[[Image:2xrw.~~jpg~~\|left\|200px]]	+	[[Image:2xrw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xrw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xrw\| PDB=2xrw \| SCENE= }}		{{STRUCTURE_2xrw\| PDB=2xrw \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	[[2xrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA].	+	[[2xrw]] is a 2 chain structure of [[Mitogen-activated protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRW OCA].
		+
		+	==See Also==
		+	*[[Mitogen-activated protein kinase\|Mitogen-activated protein kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mitogen-activated protein kinase]]		[[Category: Mitogen-activated protein kinase]]

OCA: Protected "2xrw" [edit=sysop:move=sysop]

2011-09-28T05:42:01Z

Protected "2xrw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 28 September 2011