2xsf - Revision history

OCA at 10:38, 20 December 2023

2023-12-20T10:38:24Z

←Older revision		Revision as of 10:38, 20 December 2023
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	<StructureSection load='2xsf' size='340' side='right'caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xsf' size='340' side='right'caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2xs5\|2xs5]]~~, ~~[[2xs2\|2xs2]], [[2xs7\|2xs7]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [https://pdbe.org/2xsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [https://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [https://pdbe.org/2xsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [https://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DAZL_MOUSE DAZL_MOUSE]] RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.<ref>PMID:22021443</ref> <ref>PMID:9288969</ref>	+	[https://www.uniprot.org/uniprot/DAZL_MOUSE DAZL_MOUSE] RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.<ref>PMID:22021443</ref> <ref>PMID:9288969</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Edwards~~, T A~~]]	+	[[Category: Edwards TA]]
-	[[Category: Jenkins~~, H T]]~~	+	[[Category: Jenkins HT]]
-	~~[[Category: Rna binding protein~~]]	+

OCA at 12:16, 27 April 2022

2022-04-27T12:16:31Z

←Older revision		Revision as of 12:16, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xsf' size='340' side='right'caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xsf' size='340' side='right'caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [~~http~~://pdbe.org/2xsf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [https://pdbe.org/2xsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [https://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DAZL_MOUSE DAZL_MOUSE]] RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.<ref>PMID:22021443</ref> <ref>PMID:9288969</ref>	+	[[https://www.uniprot.org/uniprot/DAZL_MOUSE DAZL_MOUSE]] RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.<ref>PMID:22021443</ref> <ref>PMID:9288969</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:19, 22 July 2020

2020-07-22T12:19:07Z

←Older revision		Revision as of 12:19, 22 July 2020
Line 1:		Line 1:

	==Crystal structure of the RRM domain of mouse Deleted in azoospermia- like==		==Crystal structure of the RRM domain of mouse Deleted in azoospermia- like==
-	<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2xsf' size='340' side='right'caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XSF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://pdbe.org/2xsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://pdbe.org/2xsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Edwards, T A]]		[[Category: Edwards, T A]]
	[[Category: Jenkins, H T]]		[[Category: Jenkins, H T]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 09:17, 10 October 2018

2018-10-10T09:17:10Z

←Older revision		Revision as of 09:17, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE~~ RRM ~~DOMAIN OF MOUSE DELETED IN AZOOSPERMIA~~-~~LIKE~~==	+	==Crystal structure of the RRM domain of mouse Deleted in azoospermia- like==
	<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 18:29, 4 August 2016

2016-08-04T18:29:31Z

←Older revision		Revision as of 18:29, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE==		==CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE==
	<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XSF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://pdbe.org/2xsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAZL_MOUSE DAZL_MOUSE]] RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts.<ref>PMID:22021443</ref> <ref>PMID:9288969</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xsf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Edwards, T A]]		[[Category: Edwards, T A]]
	[[Category: Jenkins, H T]]		[[Category: Jenkins, H T]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 23:02, 3 January 2015

2015-01-03T23:02:01Z

←Older revision		Revision as of 23:02, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. <br>	+	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XSF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	Kinked {beta}-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.,Jenkins HT, Malkova B, Edwards TA Proc Natl Acad Sci U S A. 2011 Oct 20. PMID:22021443<ref>PMID:22021443</ref>		Kinked {beta}-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.,Jenkins HT, Malkova B, Edwards TA Proc Natl Acad Sci U S A. 2011 Oct 20. PMID:22021443<ref>PMID:22021443</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Edwards, T A.]]	+	[[Category: Edwards, T A]]
-	[[Category: Jenkins, H T.]]	+	[[Category: Jenkins, H T]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 07:39, 14 May 2014

2014-05-14T07:39:05Z

←Older revision		Revision as of 07:39, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xsf.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE==
		+	<StructureSection load='2xsf' size='340' side='right' caption='[[2xsf]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xs5\|2xs5]], [[2xs2\|2xs2]], [[2xs7\|2xs7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xsf RCSB], [http://www.ebi.ac.uk/pdbsum/2xsf PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A defect in germ-cell (sperm and oocyte) development is the leading cause of male and female infertility. Control of translation through the binding of deleted in azoospermia (DAZ)-like (DAZL) to the 3'-UTRs of mRNAs, via a highly conserved RNA recognition motif (RRM), has been shown to be essential in germ-cell development. Crystal structures of the RRM from murine DAZL (Dazl), both alone and in complex with RNA sequences from the 3'-UTRs of mRNAs regulated by Dazl, reveal high-affinity sequence-specific recognition of a GUU triplet involving an extended, kinked, pair of beta-strands. Recognition of the GUU triplet is maintained, whereas the identity and position of bases flanking this triplet varies. The Dazl RRM is thus able to recognize GUU triplets in different sequence contexts. Mutation of bases within the GUU triplet reduces the affinity of binding. Together with the demonstration that multiple Dazl RRMs can bind to a single RNA containing multiple GUU triplets, these structures suggest that the number of DAZL molecules bound to GUU triplets in the 3'-UTR provides a method for modulating the translation of a target RNA. The conservation of RNA binding and structurally important residues between members of the DAZ family, together with the demonstration that mutation of these residues severely impairs RNA binding, indicate that the mode of RNA binding revealed by these structures is conserved in proteins essential for gamete development from flies to humans.

-	<!--	+	Kinked {beta}-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.,Jenkins HT, Malkova B, Edwards TA Proc Natl Acad Sci U S A. 2011 Oct 20. PMID:22021443<ref>PMID:22021443</ref>
-	~~The line below this paragraph, containing "STRUCTURE_2xsf", creates~~ the ~~"Structure Box" on the page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xsf\| PDB=2xsf \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22021443}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22021443 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22021443}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xsf]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022021443<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Edwards, T A.]]		[[Category: Edwards, T A.]]
	[[Category: Jenkins, H T.]]		[[Category: Jenkins, H T.]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 07:26, 2 November 2011

2011-11-02T07:26:34Z

←Older revision		Revision as of 07:26, 2 November 2011
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-	[[Image:2xsf.~~jpg~~\|left\|200px]]	+	[[Image:2xsf.png\|left\|200px]]

	<!--		<!--
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	===CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE===		===CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22021443}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22021443 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22021443}}

	==About this Structure==		==About this Structure==
	[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA].		[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022021443</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Edwards, T A.]]		[[Category: Edwards, T A.]]
	[[Category: Jenkins, H T.]]		[[Category: Jenkins, H T.]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA: Protected "2xsf" [edit=sysop:move=sysop]

2011-10-05T06:42:14Z

Protected "2xsf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 5 October 2011

OCA at 06:42, 5 October 2011

2011-10-05T06:42:09Z

←Older revision		Revision as of 06:42, 5 October 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2xsf.jpg\|left\|200px]]

-	The ~~entry 2xsf~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xsf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xsf\| PDB=2xsf \| SCENE= }}

-	~~Authors: Jenkins, H.T., Edwards, T.A.~~	+	===CRYSTAL STRUCTURE OF THE RRM DOMAIN OF MOUSE DELETED IN AZOOSPERMIA-LIKE===

-	Description: Crystal structure of the RRM domain of mouse Deleted in azoospermia-like

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Oct 13 10~~:25:~~13 2010''~~	+	==About this Structure==
		+	[[2xsf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSF OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Edwards, T A.]]
		+	[[Category: Jenkins, H T.]]
		+	[[Category: Rna binding protein]]