2xv7 - Revision history

OCA at 10:39, 20 December 2023

2023-12-20T10:39:49Z

←Older revision		Revision as of 10:39, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xv7' size='340' side='right'caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xv7' size='340' side='right'caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [https://pdbe.org/2xv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [https://pdbe.org/2xv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VEGFD_HUMAN VEGFD_HUMAN]] Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.<ref>PMID:21148085</ref>	+	[https://www.uniprot.org/uniprot/VEGFD_HUMAN VEGFD_HUMAN] Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.<ref>PMID:21148085</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aho, K]]	+	[[Category: Aho K]]
-	[[Category: Alitalo, K]]	+	[[Category: Alitalo K]]
-	[[Category: Anisimov, A]]	+	[[Category: Anisimov A]]
-	[[Category: Ballmer-Hofer, K]]	+	[[Category: Ballmer-Hofer K]]
-	[[Category: Jeltsch, M]]	+	[[Category: Jeltsch M]]
-	[[Category: Kalkkinen, N]]	+	[[Category: Kalkkinen N]]
-	[[Category: Leppanen, V M]]	+	[[Category: Leppanen V-M]]
-	[[Category: Toivanen, P]]	+	[[Category: Toivanen P]]
-	[[Category: Tvorogov, D]]	+	[[Category: Tvorogov D]]
-	[[Category: Yla-Herttuala, S]]	+	[[Category: Yla-Herttuala S]]
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Lymphangiogenesis~~]]	+

OCA at 12:17, 27 April 2022

2022-04-27T12:17:44Z

←Older revision		Revision as of 12:17, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xv7' size='340' side='right'caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xv7' size='340' side='right'caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [~~http~~://pdbe.org/2xv7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [https://pdbe.org/2xv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VEGFD_HUMAN VEGFD_HUMAN]] Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.<ref>PMID:21148085</ref>	+	[[https://www.uniprot.org/uniprot/VEGFD_HUMAN VEGFD_HUMAN]] Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.<ref>PMID:21148085</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:21, 22 July 2020

2020-07-22T12:21:58Z

←Older revision		Revision as of 12:21, 22 July 2020
Line 1:		Line 1:

	==Crystal structure of vascular endothelial growth factor D==		==Crystal structure of vascular endothelial growth factor D==
-	<StructureSection load='2xv7' size='340' side='right' caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2xv7' size='340' side='right'caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://pdbe.org/2xv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://pdbe.org/2xv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[~~Vascular Endothelial Growth Factor~~\|~~Vascular Endothelial Growth Factor~~]]	+	*[[VEGF 3D Structures\|VEGF 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aho, K]]		[[Category: Aho, K]]
	[[Category: Alitalo, K]]		[[Category: Alitalo, K]]

OCA at 09:27, 10 October 2018

2018-10-10T09:27:03Z

←Older revision		Revision as of 09:27, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR~~ D==	+	==Crystal structure of vascular endothelial growth factor D==
	<StructureSection load='2xv7' size='340' side='right' caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xv7' size='340' side='right' caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 16:27, 4 August 2016

2016-08-04T16:27:50Z

←Older revision		Revision as of 16:27, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D==		==CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D==
	<StructureSection load='2xv7' size='340' side='right' caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xv7' size='340' side='right' caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://pdbe.org/2xv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xv7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xv7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aho, K]]		[[Category: Aho, K]]
	[[Category: Alitalo, K]]		[[Category: Alitalo, K]]

OCA at 17:00, 24 December 2014

2014-12-24T17:00:47Z

←Older revision		Revision as of 17:00, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VEGFD_HUMAN VEGFD_HUMAN]] Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.<ref>PMID:21148085</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aho, K.]]	+	[[Category: Aho, K]]
-	[[Category: Alitalo, K.]]	+	[[Category: Alitalo, K]]
-	[[Category: Anisimov, A.]]	+	[[Category: Anisimov, A]]
-	[[Category: Ballmer-Hofer, K.]]	+	[[Category: Ballmer-Hofer, K]]
-	[[Category: Jeltsch, M.]]	+	[[Category: Jeltsch, M]]
-	[[Category: Kalkkinen, N.]]	+	[[Category: Kalkkinen, N]]
-	[[Category: Leppanen, V M.]]	+	[[Category: Leppanen, V M]]
-	[[Category: Toivanen, P.]]	+	[[Category: Toivanen, P]]
-	[[Category: Tvorogov, D.]]	+	[[Category: Tvorogov, D]]
-	[[Category: Yla-Herttuala, S.]]	+	[[Category: Yla-Herttuala, S]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Lymphangiogenesis]]		[[Category: Lymphangiogenesis]]

OCA at 13:07, 22 October 2014

2014-10-22T13:07:35Z

←Older revision		Revision as of 13:07, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xv7.~~png~~\|~~left\|200px~~]]	+	==CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D==
		+	<StructureSection load='2xv7' size='340' side='right' caption='[[2xv7]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XV7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xv7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xv7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vascular endothelial growth factors (VEGFs) and their tyrosine kinase receptors (VEGFR-1-3) are central mediators of angiogenesis and lymphangiogenesis. VEGFR-3 ligands VEGF-C and VEGF-D are produced as precursor proteins with long N- and C-terminal propeptides and show enhanced VEGFR-2 and VEGFR-3 binding upon proteolytic removal of the propeptides. Two different proteolytic cleavage sites have been reported in the VEGF-D N-terminus. We report here the crystal structure of the human VEGF-D Cys117Ala mutant at 2.9 A resolution. Comparison of the VEGF-D and VEGF-C structures shows similar extended N-terminal helices, conserved overall folds and VEGFR-2 interacting residues. Consistent with this, the affinity and the thermodynamic parameters for VEGFR-2 binding are very similar. In comparison with VEGF-C structures, however, the VEGF-D N-terminal helix was extended by two more turns because of a better resolution. Both receptor binding and functional assays of N-terminally truncated VEGF-D polypeptides indicated that the residues between the reported proteolytic cleavage sites are important for VEGF-D binding and activation of VEGFR-3, but not of VEGFR-2. Thus, we define here a VEGFR-2 specific form of VEGF-D that is angiogenic, but not lymphangiogenic. These results provide important new insights into VEGF-D structure and function.

-	~~{{STRUCTURE_2xv7\| PDB=2xv7 \| SCENE= }}~~	+	Structural determinants of vascular endothelial growth factor-D - receptor binding and specificity.,Leppanen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Yla-Herttuala S, Ballmer-Hofer K, Alitalo K Blood. 2010 Dec 8. PMID:21148085<ref>PMID:21148085</ref>

-	~~===CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21148085}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xv7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA].~~	+

	==See Also==		==See Also==
	*[[Vascular Endothelial Growth Factor\|Vascular Endothelial Growth Factor]]		*[[Vascular Endothelial Growth Factor\|Vascular Endothelial Growth Factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021148085<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aho, K.]]		[[Category: Aho, K.]]

OCA at 07:21, 20 October 2012

2012-10-20T07:21:38Z

←Older revision		Revision as of 07:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xv7]] is a 1 chain structure ~~of [[Vascular Endothelial Growth Factor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA].	+	[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA].

	==See Also==		==See Also==

OCA at 16:04, 25 July 2012

2012-07-25T16:04:13Z

←Older revision		Revision as of 16:04, 25 July 2012
Line 1:		Line 1:
	[[Image:2xv7.png\|left\|200px]]		[[Image:2xv7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xv7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xv7\| PDB=2xv7 \| SCENE= }}		{{STRUCTURE_2xv7\| PDB=2xv7 \| SCENE= }}

	===CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D===		===CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21148085}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21148085 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21148085}}		{{ABSTRACT_PUBMED_21148085}}

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	==See Also==		==See Also==
-	*[[Vascular Endothelial Growth Factor]]	+	*[[Vascular Endothelial Growth Factor\|Vascular Endothelial Growth Factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21148085~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021148085</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aho, K.]]		[[Category: Aho, K.]]
Line 37:		Line 26:
	[[Category: Tvorogov, D.]]		[[Category: Tvorogov, D.]]
	[[Category: Yla-Herttuala, S.]]		[[Category: Yla-Herttuala, S.]]
		+	[[Category: Angiogenesis]]
		+	[[Category: Hormone]]
		+	[[Category: Lymphangiogenesis]]

OCA at 08:19, 6 April 2011

2011-04-06T08:19:46Z

←Older revision		Revision as of 08:19, 6 April 2011
Line 1:		Line 1:
-	[[Image:2xv7.~~jpg~~\|left\|200px]]	+	[[Image:2xv7.png\|left\|200px]]

	<!--		<!--
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[2xv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA].	+	[[2xv7]] is a 1 chain structure of [[Vascular Endothelial Growth Factor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XV7 OCA].
		+
		+	==See Also==
		+	*[[Vascular Endothelial Growth Factor]]

	==Reference==		==Reference==