2xvm - Revision history

OCA at 10:40, 20 December 2023

2023-12-20T10:40:02Z

←Older revision		Revision as of 10:40, 20 December 2023
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	<StructureSection load='2xvm' size='340' side='right'caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='2xvm' size='340' side='right'caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SAH:S~~-~~ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2xva\|2xva]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [https://pdbe.org/2xvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [https://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [https://pdbe.org/2xvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [https://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TEHB_ECOLI TEHB_ECOLI]] S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds.<ref>PMID:11053398</ref> <ref>PMID:21244361</ref>	+	[https://www.uniprot.org/uniprot/TEHB_ECOLI TEHB_ECOLI] S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds.<ref>PMID:11053398</ref> <ref>PMID:21244361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beis, K]]	+	[[Category: Beis K]]
-	[[Category: Cameron~~, A D~~]]	+	[[Category: Cameron AD]]
-	[[Category: Choudhury~~, H G~~]]	+	[[Category: Choudhury HG]]
-	[[Category: Iwata, S]]	+	[[Category: Iwata S]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:17, 27 April 2022

2022-04-27T12:17:59Z

←Older revision		Revision as of 12:17, 27 April 2022
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	<StructureSection load='2xvm' size='340' side='right'caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='2xvm' size='340' side='right'caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xva\|2xva]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xva\|2xva]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [~~http~~://pdbe.org/2xvm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [https://pdbe.org/2xvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [https://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TEHB_ECOLI TEHB_ECOLI]] S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds.<ref>PMID:11053398</ref> <ref>PMID:21244361</ref>	+	[[https://www.uniprot.org/uniprot/TEHB_ECOLI TEHB_ECOLI]] S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds.<ref>PMID:11053398</ref> <ref>PMID:21244361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:22, 22 July 2020

2020-07-22T12:22:33Z

←Older revision		Revision as of 12:22, 22 July 2020
Line 1:		Line 1:

	==Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with SAH==		==Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with SAH==
-	<StructureSection load='2xvm' size='340' side='right' caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='2xvm' size='340' side='right'caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XVM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xva\|2xva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xva\|2xva]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://pdbe.org/2xvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://pdbe.org/2xvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Beis, K]]		[[Category: Beis, K]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]

OCA at 09:04, 10 October 2018

2018-10-10T09:04:42Z

←Older revision		Revision as of 09:04, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM~~ E. ~~COLI IN COMPLEX WITH~~ SAH==	+	==Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with SAH==
	<StructureSection load='2xvm' size='340' side='right' caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='2xvm' size='340' side='right' caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 15:56, 4 August 2016

2016-08-04T15:56:31Z

←Older revision		Revision as of 15:56, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH==		==CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH==
	<StructureSection load='2xvm' size='340' side='right' caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='2xvm' size='340' side='right' caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xva\|2xva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xva\|2xva]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://pdbe.org/2xvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xvm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beis, K]]		[[Category: Beis, K]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]

OCA at 10:47, 25 December 2014

2014-12-25T10:47:05Z

←Older revision		Revision as of 10:47, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TEHB_ECOLI TEHB_ECOLI]] S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds.<ref>PMID:11053398</ref> <ref>PMID:21244361</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:29, 19 November 2014

2014-11-19T13:29:06Z

←Older revision		Revision as of 13:29, 19 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2xvm.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH==
		+	<StructureSection load='2xvm' size='340' side='right' caption='[[2xvm]], [[Resolution\|resolution]] 1.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xva\|2xva]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvm RCSB], [http://www.ebi.ac.uk/pdbsum/2xvm PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The oxyanion derivatives of the chalcogens tellurium and selenium are toxic to living organisms even at very low levels. Bacteria have developed mechanisms to overcome their toxicity by methylating them. The structure of the TehB from Escherichia coli has been determined in the presence of the co-factor analogues S-adenosyl-homocysteine (SAH) and sinefungin (non-hydrolysable form of S-adenosyl-L-methionine) at 1.48 A and 1.9 A respectively. Interestingly, our kinetic data show that TehB does not discriminate between selenium or tellurite oxyanions, making it a very powerful detoxifying protein. Analysis of the active site has identified three conserved residues that are capable of binding and orientating the metals for nucleophilic attack, His176, Arg177 and Arg184. Mutagenesis studies revealed that the His176Ala and Arg184Ala mutants retained most of their activity, whereas the Arg177Ala mutant had 65 % of its activity abolished. Based on the structure and kinetic data we propose an SN2 nucleophilic attack reaction mechanism. These data provide the first molecular understanding on the detoxification of chalcogens by bacteria.

-	~~{{STRUCTURE_2xvm\| PDB=2xvm \| SCENE= }}~~	+	Structure and mechanism of the chalcogen detoxifying protein TehB from Escherichia coli.,Choudhury HG, Cameron AD, Iwata S, Beis K Biochem J. 2011 Jan 18. PMID:21244361<ref>PMID:21244361</ref>

-	~~===CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21244361}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2xvm]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XVM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021244361<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Beis, K.]]	+	[[Category: Beis, K]]
-	[[Category: Cameron, A D.]]	+	[[Category: Cameron, A D]]
-	[[Category: Choudhury, H G.]]	+	[[Category: Choudhury, H G]]
-	[[Category: Iwata, S.]]	+	[[Category: Iwata, S]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:10, 13 February 2013

2013-02-13T11:10:55Z

←Older revision		Revision as of 11:10, 13 February 2013
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	[[Image:2xvm.png\|left\|200px]]		[[Image:2xvm.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xvm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xvm\| PDB=2xvm \| SCENE= }}		{{STRUCTURE_2xvm\| PDB=2xvm \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH===		===CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21244361}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21244361 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21244361}}		{{ABSTRACT_PUBMED_21244361}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21244361~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021244361</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Beis, K.]]		[[Category: Beis, K.]]
Line 28:		Line 17:
	[[Category: Choudhury, H G.]]		[[Category: Choudhury, H G.]]
	[[Category: Iwata, S.]]		[[Category: Iwata, S.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Transferase]]

OCA at 08:08, 6 April 2011

2011-04-06T08:08:06Z

←Older revision		Revision as of 08:08, 6 April 2011
Line 1:		Line 1:
-	[[Image:2xvm.~~jpg~~\|left\|200px]]	+	[[Image:2xvm.png\|left\|200px]]

	<!--		<!--

OCA: Protected "2xvm" [edit=sysop:move=sysop]

2011-02-16T05:36:05Z

Protected "2xvm" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 16 February 2011