2xw1 - Revision history

OCA at 10:40, 20 December 2023

2023-12-20T10:40:11Z

←Older revision		Revision as of 10:40, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xw1' size='340' side='right'caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xw1' size='340' side='right'caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=9NV:DANSYL~~-~~L-NORVALINE'>9NV</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [https://pdbe.org/2xw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [https://pdbe.org/2xw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Curry, S]]	+	[[Category: Curry S]]
-	[[Category: Ryan~~, A J]]~~	+	[[Category: Ryan AJ]]
-	~~[[Category: Transport protein~~]]	+

OCA at 12:18, 27 April 2022

2022-04-27T12:18:16Z

OCA at 12:23, 22 July 2020

2020-07-22T12:23:12Z

←Older revision		Revision as of 12:23, 22 July 2020
Line 1:		Line 1:

	==Human serum albumin complexed with dansyl-L-norvaline==		==Human serum albumin complexed with dansyl-L-norvaline==
-	<StructureSection load='2xw1' size='340' side='right' caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2xw1' size='340' side='right'caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [http://pdbe.org/2xw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [http://pdbe.org/2xw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Albumin\|Albumin]]	+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Curry, S]]		[[Category: Curry, S]]
	[[Category: Ryan, A J]]		[[Category: Ryan, A J]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 09:22, 10 October 2018

2018-10-10T09:22:37Z

←Older revision		Revision as of 09:22, 10 October 2018
Line 1:		Line 1:

-	==~~HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL~~-L-~~NORVALINE~~==	+	==Human serum albumin complexed with dansyl-L-norvaline==
	<StructureSection load='2xw1' size='340' side='right' caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xw1' size='340' side='right' caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 14:04, 4 August 2016

2016-08-04T14:04:14Z

←Older revision		Revision as of 14:04, 4 August 2016
Line 1:		Line 1:
		+
	==HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE==		==HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE==
	<StructureSection load='2xw1' size='340' side='right' caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xw1' size='340' side='right' caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xw1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [http://pdbe.org/2xw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xw1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Curry, S]]		[[Category: Curry, S]]
	[[Category: Ryan, A J]]		[[Category: Ryan, A J]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 14:00, 18 December 2014

2014-12-18T14:00:37Z

←Older revision		Revision as of 14:00, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2xw1\| PDB~~=2xw1 \| ~~SCENE~~= }}	+	==HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE==
-	===~~HUMAN SERUM ALBUMIN COMPLEXED WITH~~ DANSYL-L-NORVALINE===	+	<StructureSection load='2xw1' size='340' side='right' caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20940056}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xw1 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human serum albumin (HSA) has two primary binding sites for drug molecules. These sites selectively bind different dansylated amino acid compounds, which-due to their intrinsic fluorescence-have long been used as specific markers for the drug pockets on HSA. We present here the co-crystal structures of HSA in complex with six dansylated amino acids that are specific for either drug site 1 (dansyl-l-asparagine, dansyl-l-arginine, dansyl-l-glutamate) or drug site 2 (dansyl-l-norvaline, dansyl-l-phenylalanine, dansyl-l-sarcosine). Our results explain the structural basis of the site-specificity of different dansylated amino acids. They also show that fatty acid binding has only a modest effect on binding of dansylated amino acids to drug site 1 and identify the location of secondary binding sites.

-	~~==Disease==~~	+	Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.,Ryan AJ, Ghuman J, Zunszain PA, Chung CW, Curry S J Struct Biol. 2010 Oct 18. PMID:20940056<ref>PMID:20940056</ref>
-	~~[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause~~ of ~~familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form~~ of ~~euthyroid hyperthyroxinemia that is due~~ to ~~increased affinity of ALB for T(4)~~. ~~It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population~~.~~<ref>~~PMID:~~8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref>~~<ref>PMID:~~9589637~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~ALBU_HUMAN ALBU_HUMAN]] Serum albumin~~, ~~the main protein of plasma, has~~ a ~~good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation~~ of the ~~colloidal osmotic pressure of blood~~. ~~Major zinc transporter in plasma, typically binds about 80%~~ of ~~all plasma zinc~~.<~~ref~~>~~PMID:19021548~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA].	+

	==See Also==		==See Also==
	*[[Albumin\|Albumin]]		*[[Albumin\|Albumin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020940056</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Curry, S.]]	+	[[Category: Curry, S]]
-	[[Category: Ryan, A J.]]	+	[[Category: Ryan, A J]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 19:59, 24 March 2013

2013-03-24T19:59:13Z

←Older revision		Revision as of 19:59, 24 March 2013
Line 1:		Line 1:
-	[[Image:2xw1.png\|left\|200px]]
-
	{{STRUCTURE_2xw1\| PDB=2xw1 \| SCENE= }}		{{STRUCTURE_2xw1\| PDB=2xw1 \| SCENE= }}
-
	===HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE===		===HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE===
		+	{{ABSTRACT_PUBMED_20940056}}

-	~~{{ABSTRACT_PUBMED_20940056}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020940056</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020940056</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Curry, S.]]		[[Category: Curry, S.]]
	[[Category: Ryan, A J.]]		[[Category: Ryan, A J.]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 06:46, 20 October 2012

2012-10-20T06:46:44Z

←Older revision		Revision as of 06:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xw1]] is a 2 chain structure ~~of [[Albumin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA].	+	[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA].

	==See Also==		==See Also==

OCA at 14:15, 25 July 2012

2012-07-25T14:15:41Z

←Older revision		Revision as of 14:15, 25 July 2012
Line 1:		Line 1:
	[[Image:2xw1.png\|left\|200px]]		[[Image:2xw1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xw1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xw1\| PDB=2xw1 \| SCENE= }}		{{STRUCTURE_2xw1\| PDB=2xw1 \| SCENE= }}

	===HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE===		===HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-NORVALINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20940056}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20940056 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20940056}}		{{ABSTRACT_PUBMED_20940056}}

	==About this Structure==		==About this Structure==
-	[[2xw1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA].	+	[[2xw1]] is a 2 chain structure of [[Albumin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA].
		+
		+	==See Also==
		+	*[[Albumin\|Albumin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20940056~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020940056</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Curry, S.]]		[[Category: Curry, S.]]
	[[Category: Ryan, A J.]]		[[Category: Ryan, A J.]]
		+	[[Category: Transport protein]]

OCA: Protected "2xw1" [edit=sysop:move=sysop]

2011-03-30T07:26:30Z

Protected "2xw1" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 30 March 2011

←Older revision		Revision as of 12:18, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xw1' size='340' side='right'caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xw1' size='340' side='right'caption='[[2xw1]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XW1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9NV:DANSYL-L-NORVALINE'>9NV</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bxq\|2bxq]], [[1hk4\|1hk4]], [[2bxi\|2bxi]], [[2xvu\|2xvu]], [[2vuf\|2vuf]], [[2xvv\|2xvv]], [[1o9x\|1o9x]], [[1bke\|1bke]], [[2bxk\|2bxk]], [[1hk1\|1hk1]], [[1uor\|1uor]], [[1h9z\|1h9z]], [[1e7b\|1e7b]], [[1hk2\|1hk2]], [[1hk5\|1hk5]], [[2esg\|2esg]], [[1e7e\|1e7e]], [[2xvq\|2xvq]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxo\|2bxo]], [[2bxf\|2bxf]], [[1ysx\|1ysx]], [[1e7g\|1e7g]], [[1ao6\|1ao6]], [[2bxc\|2bxc]], [[1tf0\|1tf0]], [[2bxn\|2bxn]], [[2bxe\|2bxe]], [[1e7c\|1e7c]], [[1gnj\|1gnj]], [[1e7h\|1e7h]], [[2bxa\|2bxa]], [[1hk3\|1hk3]], [[2xvw\|2xvw]], [[1e7i\|1e7i]], [[2bxb\|2bxb]], [[2bxl\|2bxl]], [[1gni\|1gni]], [[1ha2\|1ha2]], [[1bj5\|1bj5]], [[1e7a\|1e7a]], [[2bxp\|2bxp]], [[1bm0\|1bm0]], [[2bxd\|2bxd]], [[1e78\|1e78]], [[2vdb\|2vdb]], [[1e7f\|1e7f]], [[1n5u\|1n5u]], [[2bx8\|2bx8]], [[2bxm\|2bxm]], [[2vue\|2vue]], [[2xw0\|2xw0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [~~http~~://pdbe.org/2xw1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xw1 OCA], [https://pdbe.org/2xw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xw1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xw1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[~~http~~://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==