2y3x - Revision history

OCA at 10:44, 20 December 2023

2023-12-20T10:44:56Z

←Older revision		Revision as of 10:44, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2y3x' size='340' side='right'caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y3x' size='340' side='right'caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [https://pdbe.org/2y3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [https://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [https://pdbe.org/2y3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [https://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>	+	[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Kursula, P]]	+	[[Category: Kursula P]]
-	[[Category: Myllykoski, M]]	+	[[Category: Myllykoski M]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Myelin]]~~	+
-	~~[[Category: Nervous system~~]]	+

OCA at 12:22, 27 April 2022

2022-04-27T12:22:39Z

←Older revision		Revision as of 12:22, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2y3x' size='340' side='right'caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y3x' size='340' side='right'caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [~~http~~://pdbe.org/2y3x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [https://pdbe.org/2y3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [https://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>	+	[[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:33, 22 July 2020

2020-07-22T12:33:38Z

←Older revision		Revision as of 12:33, 22 July 2020
Line 1:		Line 1:

	==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate==		==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate==
-	<StructureSection load='2y3x' size='340' side='right' caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2y3x' size='340' side='right'caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://pdbe.org/2y3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://pdbe.org/2y3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]

OCA at 16:06, 5 August 2016

2016-08-05T16:06:24Z

←Older revision		Revision as of 16:06, 5 August 2016
Line 1:		Line 1:
		+
	==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate==		==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate==
	<StructureSection load='2y3x' size='340' side='right' caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y3x' size='340' side='right' caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://pdbe.org/2y3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y3x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y3x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Myllykoski, M]]		[[Category: Myllykoski, M]]

OCA at 03:50, 25 December 2014

2014-12-25T03:50:36Z

←Older revision		Revision as of 03:50, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2y3x' size='340' side='right' caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y3x' size='340' side='right' caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. <br>	+	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y3X FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.7~~.1.~~2 2~~.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.,Myllykoski M, Raasakka A, Han H, Kursula P PLoS One. 2012;7(2):e32336. Epub 2012 Feb 29. PMID:22393399<ref>PMID:22393399</ref>		Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.,Myllykoski M, Raasakka A, Han H, Kursula P PLoS One. 2012;7(2):e32336. Epub 2012 Feb 29. PMID:22393399<ref>PMID:22393399</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Myllykoski, M.]]	+	[[Category: Myllykoski, M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Myelin]]		[[Category: Myelin]]
	[[Category: Nervous system]]		[[Category: Nervous system]]

OCA at 07:49, 14 May 2014

2014-05-14T07:49:33Z

←Older revision		Revision as of 07:49, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2y3x.~~png~~\|~~left~~\|~~200px~~]]	+	==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate==
		+	<StructureSection load='2y3x' size='340' side='right' caption='[[2y3x]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xmi\|2xmi]], [[2y1p\|2y1p]], [[2ydb\|2ydb]], [[2ydc\|2ydc]], [[2ydd\|2ydd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y3x RCSB], [http://www.ebi.ac.uk/pdbsum/2y3x PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is a highly abundant membrane-associated enzyme in the myelin sheath of the vertebrate nervous system. CNPase is a member of the 2H phosphoesterase family and catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates; however, its physiological substrate and function remain unknown. It is likely that CNPase participates in RNA metabolism in the myelinating cell. We solved crystal structures of the phosphodiesterase domain of mouse CNPase, showing the binding mode of nucleotide ligands in the active site. The binding mode of the product 2'-AMP provides a detailed view of the reaction mechanism. Comparisons of CNPase crystal structures highlight flexible loops, which could play roles in substrate recognition; large differences in the active-site vicinity are observed when comparing more distant members of the 2H family. We also studied the full-length CNPase, showing its N-terminal domain is involved in RNA binding and dimerization. Our results provide a detailed picture of the CNPase active site during its catalytic cycle, and suggest a specific function for the previously uncharacterized N-terminal domain.

-	<!--	+	Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.,Myllykoski M, Raasakka A, Han H, Kursula P PLoS One. 2012;7(2):e32336. Epub 2012 Feb 29. PMID:22393399<ref>PMID:22393399</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2y3x"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2y3x\| PDB=2y3x \| SCENE= }}~~	+

-	~~===Catalytic domain~~ of ~~mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22393399}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22393399 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22393399}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2y3x]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022393399<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 06:39, 21 March 2012

2012-03-21T06:39:16Z

←Older revision		Revision as of 06:39, 21 March 2012
Line 11:		Line 11:
	===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate===		===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22393399}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22393399 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22393399}}

	==About this Structure==		==About this Structure==
	[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA].		[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022393399</ref><references group="xtra"/>
	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]		[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 07:25, 1 February 2012

2012-02-01T07:25:04Z

←Older revision		Revision as of 07:25, 1 February 2012
Line 1:		Line 1:
-	[[Image:2y3x.~~jpg~~\|left\|200px]]	+	[[Image:2y3x.png\|left\|200px]]

	<!--		<!--

OCA at 06:37, 25 January 2012

2012-01-25T06:37:00Z

←Older revision		Revision as of 06:37, 25 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y3x.jpg\|left\|200px]]

-	The ~~entry 2y3x~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y3x", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y3x\| PDB=2y3x \| SCENE= }}

-	~~Authors: Myllykoski~~, M., ~~Kursula, P.~~	+	===Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate===

-	~~Description~~: ~~Catalytic domain of mouse~~ 2',3'-cyclic nucleotide 3'-phosphodiesterase, ~~complexed with sulfate~~	+
		+	==About this Structure==
		+	[[2y3x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y3X OCA].
		+	[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Kursula, P.]]
		+	[[Category: Myllykoski, M.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Myelin]]
		+	[[Category: Nervous system]]

OCA: Protected "2y3x" [edit=sysop:move=sysop]

2011-01-12T04:41:21Z

Protected "2y3x" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:41, 12 January 2011