2y4p - Revision history

OCA at 10:45, 20 December 2023

2023-12-20T10:45:23Z

←Older revision		Revision as of 10:45, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2y4p' size='340' side='right'caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2y4p' size='340' side='right'caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2yak\|2yak]]~~, [[~~1jkk~~\|~~1jkk~~]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.~~7.11.1 2.7.11.1] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [https://pdbe.org/2y4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [https://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [https://pdbe.org/2y4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [https://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>	+	[https://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>

	==See Also==		==See Also==
Line 17:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Lehmann F]]
-	~~[[Category: Diego, I de]]~~	+	[[Category: Wilmanns M]]
-	[[Category: Lehmann, F]]	+	[[Category: De Diego I]]
-	[[Category: Wilmanns, M]]	+
-	[[Category: ~~Apoptosis]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Serine/threonine-protein kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:23, 27 April 2022

2022-04-27T12:23:05Z

←Older revision		Revision as of 12:23, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2y4p' size='340' side='right'caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2y4p' size='340' side='right'caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [~~http~~://pdbe.org/2y4p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [https://pdbe.org/2y4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [https://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>	+	[[https://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>

	==See Also==		==See Also==

OCA at 12:34, 22 July 2020

2020-07-22T12:34:27Z

←Older revision		Revision as of 12:34, 22 July 2020
Line 1:		Line 1:

	==Dimeric structure of DAPK-1 catalytic domain==		==Dimeric structure of DAPK-1 catalytic domain==
-	<StructureSection load='2y4p' size='340' side='right' caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='2y4p' size='340' side='right'caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://pdbe.org/2y4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://pdbe.org/2y4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 12:

	==See Also==		==See Also==
-	*[[Death-associated protein kinase\|Death-associated protein kinase]]	+	*[[Death-associated protein kinase 3D structures\|Death-associated protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Diego, I de]]		[[Category: Diego, I de]]

OCA at 09:05, 10 October 2018

2018-10-10T09:05:36Z

←Older revision		Revision as of 09:05, 10 October 2018
Line 19:		Line 19:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Diego, I De]]	+	[[Category: Diego, I de]]
	[[Category: Lehmann, F]]		[[Category: Lehmann, F]]
	[[Category: Wilmanns, M]]		[[Category: Wilmanns, M]]

OCA at 15:57, 4 August 2016

2016-08-04T15:57:47Z

←Older revision		Revision as of 15:57, 4 August 2016
Line 1:		Line 1:
		+
	==Dimeric structure of DAPK-1 catalytic domain==		==Dimeric structure of DAPK-1 catalytic domain==
	<StructureSection load='2y4p' size='340' side='right' caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2y4p' size='340' side='right' caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://pdbe.org/2y4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Diego, I De]]		[[Category: Diego, I De]]

OCA at 16:45, 24 December 2014

2014-12-24T16:45:12Z

←Older revision		Revision as of 16:45, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAPK1_HUMAN DAPK1_HUMAN]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref> Isoform 2 cannot induce apoptosis but can induce membrane blebbing.<ref>PMID:7828849</ref> <ref>PMID:10629061</ref> <ref>PMID:11579085</ref> <ref>PMID:11980920</ref> <ref>PMID:12730201</ref> <ref>PMID:15367680</ref> <ref>PMID:17703233</ref> <ref>PMID:17895359</ref> <ref>PMID:18422656</ref> <ref>PMID:18195017</ref> <ref>PMID:18995835</ref> <ref>PMID:19180116</ref> <ref>PMID:18974095</ref> <ref>PMID:21497122</ref> <ref>PMID:21408167</ref>

	==See Also==		==See Also==
	*[[Death-associated protein kinase\|Death-associated protein kinase]]		*[[Death-associated protein kinase\|Death-associated protein kinase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Diego, I De.]]	+	[[Category: Diego, I De]]
-	[[Category: Lehmann, F.]]	+	[[Category: Lehmann, F]]
-	[[Category: Wilmanns, M.]]	+	[[Category: Wilmanns, M]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 13:14, 22 October 2014

2014-10-22T13:14:24Z

←Older revision		Revision as of 13:14, 22 October 2014
Line 1:		Line 1:
-	~~[[Image:2y4p.png\|left\|200px]]~~	+	==Dimeric structure of DAPK-1 catalytic domain==
-		+	<StructureSection load='2y4p' size='340' side='right' caption='[[2y4p]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~{{STRUCTURE_2y4p\| PDB=2y4p \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y4P FirstGlance]. <br>
-	===Dimeric structure of DAPK-1 catalytic domain===	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yak\|2yak]], [[1jkk\|1jkk]], [[1p4f\|1p4f]], [[2y0a\|2y0a]], [[2w4j\|2w4j]], [[2x0g\|2x0g]], [[2y4v\|2y4v]], [[3zxt\|3zxt]], [[2w4k\|2w4k]], [[1jkt\|1jkt]], [[1ig1\|1ig1]], [[2xuu\|2xuu]], [[1jks\|1jks]], [[1jkl\|1jkl]], [[2xzs\|2xzs]]</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y4p RCSB], [http://www.ebi.ac.uk/pdbsum/2y4p PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	</table>
-	[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA].	+

	==See Also==		==See Also==
	*[[Death-associated protein kinase\|Death-associated protein kinase]]		*[[Death-associated protein kinase\|Death-associated protein kinase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 07:14, 20 October 2012

2012-10-20T07:14:55Z

←Older revision		Revision as of 07:14, 20 October 2012
Line 1:		Line 1:
-	[[Image:2y4p.~~jpg~~\|left\|200px]]	+	[[Image:2y4p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2y4p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2y4p\| PDB=2y4p \| SCENE= }}		{{STRUCTURE_2y4p\| PDB=2y4p \| SCENE= }}

Line 14:		Line 8:
	==About this Structure==		==About this Structure==
	[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA].		[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA].
		+
		+	==See Also==
		+	*[[Death-associated protein kinase\|Death-associated protein kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 10:48, 18 January 2012

2012-01-18T10:48:51Z

←Older revision		Revision as of 10:48, 18 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y4p.jpg\|left\|200px]]

-	The ~~entry 2y4p~~ is ~~ON HOLD~~ ~~until Jan 07 2013~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y4p", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y4p\| PDB=2y4p \| SCENE= }}

-	~~Authors: de Diego, I., Lehmann, F., Wilmanns, M.~~	+	===Dimeric structure of DAPK-1 catalytic domain===

-	~~Description: Dimeric~~ structure ~~of DAPK~~-~~1 catalytic domain~~	+
		+	==About this Structure==
		+	[[2y4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4P OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Diego, I De.]]
		+	[[Category: Lehmann, F.]]
		+	[[Category: Wilmanns, M.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Atp-binding]]
		+	[[Category: Calmodulin-binding]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Serine/threonine-protein kinase]]
		+	[[Category: Transferase]]

OCA: Protected "2y4p" [edit=sysop:move=sysop]

2011-01-19T05:41:35Z

Protected "2y4p" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 19 January 2011