2y7x - Revision history

OCA at 08:09, 23 August 2023

2023-08-23T08:09:57Z

←Older revision		Revision as of 08:09, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MZA:6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE'>MZA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1msx\|1msx]], [[1lpg\|1lpg]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[2bq6\|2bq6]], [[1fax\|1fax]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2y7z\|2y7z]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[2y82\|2y82]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MZA:6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE'>MZA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [https://pdbe.org/2y7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [https://www.ebi.ac.uk/pdbsum/2y7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [https://pdbe.org/2y7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [https://www.ebi.ac.uk/pdbsum/2y7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams, C]]	+	[[Category: Adams C]]
-	[[Category: Belton, D]]	+	[[Category: Belton D]]
-	[[Category: Brown, D]]	+	[[Category: Brown D]]
-	[[Category: Burns-Kurtis~~, C L~~]]	+	[[Category: Burns-Kurtis CL]]
-	[[Category: Chan, C]]	+	[[Category: Chan C]]
-	[[Category: Chaudry, L]]	+	[[Category: Chaudry L]]
-	[[Category: Convery~~, M A~~]]	+	[[Category: Convery MA]]
-	[[Category: Davies~~, D E~~]]	+	[[Category: Davies DE]]
-	[[Category: Exall~~, A M~~]]	+	[[Category: Exall AM]]
-	[[Category: Harling~~, J D~~]]	+	[[Category: Harling JD]]
-	[[Category: Irvine, S]]	+	[[Category: Irvine S]]
-	[[Category: Irving~~, W R~~]]	+	[[Category: Irving WR]]
-	[[Category: Kleanthous, S]]	+	[[Category: Kleanthous S]]
-	[[Category: McLay~~, I M~~]]	+	[[Category: McLay IM]]
-	[[Category: Pateman~~, A J~~]]	+	[[Category: Pateman AJ]]
-	[[Category: Patikis~~, A N~~]]	+	[[Category: Patikis AN]]
-	[[Category: Roethka~~, T J~~]]	+	[[Category: Roethka TJ]]
-	[[Category: Senger, S]]	+	[[Category: Senger S]]
-	[[Category: Stelman~~, G J~~]]	+	[[Category: Stelman GJ]]
-	[[Category: Toomey~~, J R~~]]	+	[[Category: Toomey JR]]
-	[[Category: Watson~~, N S~~]]	+	[[Category: Watson NS]]
-	[[Category: West~~, R I~~]]	+	[[Category: West RI]]
-	[[Category: Whittaker, C]]	+	[[Category: Whittaker C]]
-	[[Category: Young~~, R J~~]]	+	[[Category: Young RJ]]
-	[[Category: Zhou, P]]	+	[[Category: Zhou P]]
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 15:01, 17 November 2021

2021-11-17T15:01:15Z

OCA at 07:14, 7 August 2019

2019-08-07T07:14:13Z

←Older revision		Revision as of 07:14, 7 August 2019
Line 1:		Line 1:

	==The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs==		==The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs==
-	<StructureSection load='2y7x' size='340' side='right' caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2y7x' size='340' side='right'caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 2y7x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2y7x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Factor Xa\|Factor Xa]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 31:
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Adams, C]]		[[Category: Adams, C]]
	[[Category: Belton, D]]		[[Category: Belton, D]]

OCA at 12:10, 6 November 2017

2017-11-06T12:10:11Z

←Older revision		Revision as of 12:10, 6 November 2017
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 2y7x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2y7x" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Factor Xa\|Factor Xa]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:46, 3 August 2017

2017-08-03T09:46:42Z

←Older revision		Revision as of 09:46, 3 August 2017
Line 1:		Line 1:

-	==~~THE DISCOVERY OF POTENT AND LONG~~-~~ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE~~ P4 ~~MOTIFS~~==	+	==The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs==
	<StructureSection load='2y7x' size='340' side='right' caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2y7x' size='340' side='right' caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 44:		Line 44:
	[[Category: Irving, W R]]		[[Category: Irving, W R]]
	[[Category: Kleanthous, S]]		[[Category: Kleanthous, S]]
-	[[Category: ~~Mclay~~, I M]]	+	[[Category: McLay, I M]]
	[[Category: Pateman, A J]]		[[Category: Pateman, A J]]
	[[Category: Patikis, A N]]		[[Category: Patikis, A N]]

OCA at 08:13, 4 August 2016

2016-08-04T08:13:28Z

←Older revision		Revision as of 08:13, 4 August 2016
Line 1:		Line 1:
		+
	==THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS==		==THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS==
	<StructureSection load='2y7x' size='340' side='right' caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2y7x' size='340' side='right' caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1msx\|1msx]], [[1lpg\|1lpg]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[2bq6\|2bq6]], [[1fax\|1fax]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2y7z\|2y7z]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[2y82\|2y82]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1msx\|1msx]], [[1lpg\|1lpg]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[2bq6\|2bq6]], [[1fax\|1fax]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2y7z\|2y7z]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[2y82\|2y82]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [http://www.ebi.ac.uk/pdbsum/2y7x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [http://pdbe.org/2y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [http://www.ebi.ac.uk/pdbsum/2y7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y7x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:16, 18 December 2014

2014-12-18T14:16:31Z

←Older revision		Revision as of 14:16, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2y7x\| PDB=2y7x \| SCENE= }}~~	+	==THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS==
-	===THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS===	+	<StructureSection load='2y7x' size='340' side='right' caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21349711}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MZA:6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE'>MZA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1msx\|1msx]], [[1lpg\|1lpg]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[2bq6\|2bq6]], [[1fax\|1fax]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2y7z\|2y7z]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[2y82\|2y82]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [http://www.ebi.ac.uk/pdbsum/2y7x PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discovery and evaluation of potent and long-acting oral sulfonamidopyrrolidin-2-one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are described. Unexpected selectivity issues versus tissue plasminogen activator in the former series were addressed in the later, delivering a robust candidate for progression towards clinical studies.

-	~~==Disease==~~	+	The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.,Watson NS, Adams C, Belton D, Brown D, Burns-Kurtis CL, Chaudry L, Chan C, Convery MA, Davies DE, Exall AM, Harling JD, Irvine S, Irving WR, Kleanthous S, McLay IM, Pateman AJ, Patikis AN, Roethke TJ, Senger S, Stelman GJ, Toomey JR, West RI, Whittaker C, Zhou P, Young RJ Bioorg Med Chem Lett. 2011 Mar 15;21(6):1588-92. Epub 2011 Feb 2. PMID:21349711<ref>PMID:21349711</ref>
-	~~[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause~~ of factor ~~X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease~~ with ~~variable presentation~~. ~~Affected individuals can manifest prolonged nasal and mucosal hemorrhage~~, ~~menorrhagia~~, ~~hematuria~~, ~~and occasionally hemarthrosis~~. ~~Some patients do not have clinical bleeding diathesis~~.~~<ref>~~PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:~~19135706~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence~~ of ~~factor Va, calcium and phospholipid during blood clotting~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2y7x]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA].~~	+

	==See Also==		==See Also==
	*[[Factor Xa\|Factor Xa]]		*[[Factor Xa\|Factor Xa]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021349711</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Adams, C.]]	+	[[Category: Adams, C]]
-	[[Category: Belton, D.]]	+	[[Category: Belton, D]]
-	[[Category: Brown, D.]]	+	[[Category: Brown, D]]
-	[[Category: Burns-Kurtis, C L.]]	+	[[Category: Burns-Kurtis, C L]]
-	[[Category: Chan, C.]]	+	[[Category: Chan, C]]
-	[[Category: Chaudry, L.]]	+	[[Category: Chaudry, L]]
-	[[Category: Convery, M A.]]	+	[[Category: Convery, M A]]
-	[[Category: Davies, D E.]]	+	[[Category: Davies, D E]]
-	[[Category: Exall, A M.]]	+	[[Category: Exall, A M]]
-	[[Category: Harling, J D.]]	+	[[Category: Harling, J D]]
-	[[Category: Irvine, S.]]	+	[[Category: Irvine, S]]
-	[[Category: Irving, W R.]]	+	[[Category: Irving, W R]]
-	[[Category: Kleanthous, S.]]	+	[[Category: Kleanthous, S]]
-	[[Category: Mclay, I M.]]	+	[[Category: Mclay, I M]]
-	[[Category: Pateman, A J.]]	+	[[Category: Pateman, A J]]
-	[[Category: Patikis, A N.]]	+	[[Category: Patikis, A N]]
-	[[Category: Roethka, T J.]]	+	[[Category: Roethka, T J]]
-	[[Category: Senger, S.]]	+	[[Category: Senger, S]]
-	[[Category: Stelman, G J.]]	+	[[Category: Stelman, G J]]
-	[[Category: Toomey, J R.]]	+	[[Category: Toomey, J R]]
-	[[Category: Watson, N S.]]	+	[[Category: Watson, N S]]
-	[[Category: West, R I.]]	+	[[Category: West, R I]]
-	[[Category: Whittaker, C.]]	+	[[Category: Whittaker, C]]
-	[[Category: Young, R J.]]	+	[[Category: Young, R J]]
-	[[Category: Zhou, P.]]	+	[[Category: Zhou, P]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 10:18, 24 March 2013

2013-03-24T10:18:39Z

←Older revision		Revision as of 10:18, 24 March 2013
Line 1:		Line 1:
-	[[Image:2y7x.png\|left\|200px]]
-
	{{STRUCTURE_2y7x\| PDB=2y7x \| SCENE= }}		{{STRUCTURE_2y7x\| PDB=2y7x \| SCENE= }}
-
	===THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS===		===THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS===
		+	{{ABSTRACT_PUBMED_21349711}}

-	~~{{ABSTRACT_PUBMED_21349711}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021349711</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021349711</ref><references group="xtra"/><references/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 14:04, 20 October 2012

2012-10-20T14:04:18Z

←Older revision		Revision as of 14:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2y7x]] is a 2 chain structure ~~of [[Factor Xa]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA].	+	[[2y7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA].

	==See Also==		==See Also==

OCA at 13:57, 26 July 2012

2012-07-26T13:57:56Z

←Older revision		Revision as of 13:57, 26 July 2012
Line 1:		Line 1:
-	[[Image:2y7x.~~jpg~~\|left\|200px]]	+	[[Image:2y7x.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2y7x", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2y7x\| PDB=2y7x \| SCENE= }}		{{STRUCTURE_2y7x\| PDB=2y7x \| SCENE= }}

	===THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS===		===THE DISCOVERY OF POTENT AND LONG-ACTING ORAL FACTOR XA INHIBITORS WITH TETRAHYDROISOQUINOLINE AND BENZAZEPINE P4 MOTIFS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21349711}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21349711 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21349711}}		{{ABSTRACT_PUBMED_21349711}}

	==About this Structure==		==About this Structure==
-	[[2y7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA].	+	[[2y7x]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA].
		+
		+	==See Also==
		+	*[[Factor Xa\|Factor Xa]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21349711~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021349711</ref><references group="xtra"/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 50:		Line 42:
	[[Category: Young, R J.]]		[[Category: Young, R J.]]
	[[Category: Zhou, P.]]		[[Category: Zhou, P.]]
		+	[[Category: Blood clotting]]
		+	[[Category: Hydrolase]]
		+	[[Category: Serine protease]]

←Older revision		Revision as of 15:01, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2y7x' size='340' side='right'caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2y7x' size='340' side='right'caption='[[2y7x]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MZA:6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE'>MZA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MZA:6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE'>MZA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1msx\|1msx]], [[1lpg\|1lpg]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[2bq6\|2bq6]], [[1fax\|1fax]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2y7z\|2y7z]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[2y82\|2y82]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1msx\|1msx]], [[1lpg\|1lpg]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[2bq6\|2bq6]], [[1fax\|1fax]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2y7z\|2y7z]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[2y82\|2y82]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [~~http~~://pdbe.org/2y7x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y7x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7x ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7x OCA], [https://pdbe.org/2y7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7x RCSB], [https://www.ebi.ac.uk/pdbsum/2y7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[~~http~~://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==