2y82 - Revision history

OCA at 08:10, 23 August 2023

2023-08-23T08:10:24Z

←Older revision		Revision as of 08:10, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=930:6-CHLORO-N-((3S)-2-OXO-1-{4-[(2S)-2-PYRROLIDINYL]PHENYL}-3-PYRROLIDINYL)-2-NAPHTHALENESULFONAMIDE'>930</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[2y7x\|2y7x]], [[2y7z\|2y7z]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[2j94\|2j94]], [[1iqj\|1iqj]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=930:6-CHLORO-N-((3S)-2-OXO-1-{4-[(2S)-2-PYRROLIDINYL]PHENYL}-3-PYRROLIDINYL)-2-NAPHTHALENESULFONAMIDE'>930</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [https://pdbe.org/2y82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [https://www.ebi.ac.uk/pdbsum/2y82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y82 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [https://pdbe.org/2y82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [https://www.ebi.ac.uk/pdbsum/2y82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y82 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams, C]]	+	[[Category: Adams C]]
-	[[Category: Blows, M]]	+	[[Category: Blows M]]
-	[[Category: Brown, D]]	+	[[Category: Brown D]]
-	[[Category: Burns-Kurtis~~, C L~~]]	+	[[Category: Burns-Kurtis CL]]
-	[[Category: Chan, C]]	+	[[Category: Chan C]]
-	[[Category: Chaudry, L]]	+	[[Category: Chaudry L]]
-	[[Category: Convery~~, M A~~]]	+	[[Category: Convery MA]]
-	[[Category: Davies~~, D E~~]]	+	[[Category: Davies DE]]
-	[[Category: Exall~~, A M~~]]	+	[[Category: Exall AM]]
-	[[Category: Foster, G]]	+	[[Category: Foster G]]
-	[[Category: Harling~~, J D~~]]	+	[[Category: Harling JD]]
-	[[Category: Hortense, E]]	+	[[Category: Hortense E]]
-	[[Category: Irvine, S]]	+	[[Category: Irvine S]]
-	[[Category: Irving~~, W R~~]]	+	[[Category: Irving WR]]
-	[[Category: Jackson, S]]	+	[[Category: Jackson S]]
-	[[Category: Kleanthous, S]]	+	[[Category: Kleanthous S]]
-	[[Category: Pateman~~, A J~~]]	+	[[Category: Pateman AJ]]
-	[[Category: Patikis~~, A N~~]]	+	[[Category: Patikis AN]]
-	[[Category: Roethka~~, T J~~]]	+	[[Category: Roethka TJ]]
-	[[Category: Senger, S]]	+	[[Category: Senger S]]
-	[[Category: Stelman~~, G J~~]]	+	[[Category: Stelman GJ]]
-	[[Category: Toomey~~, J R~~]]	+	[[Category: Toomey JR]]
-	[[Category: Watson~~, N S~~]]	+	[[Category: Watson NS]]
-	[[Category: West~~, R I~~]]	+	[[Category: West RI]]
-	[[Category: Whittaker, C]]	+	[[Category: Whittaker C]]
-	[[Category: Young~~, R J~~]]	+	[[Category: Young RJ]]
-	[[Category: Zhou, P]]	+	[[Category: Zhou P]]
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Blood coagulation]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 15:01, 17 November 2021

2021-11-17T15:01:35Z

OCA at 06:13, 16 October 2019

2019-10-16T06:13:24Z

←Older revision		Revision as of 06:13, 16 October 2019
Line 1:		Line 1:

	==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs==		==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs==
-	<StructureSection load='2y82' size='340' side='right' caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2y82' size='340' side='right'caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>
Line 31:		Line 31:
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Adams, C]]		[[Category: Adams, C]]
	[[Category: Blows, M]]		[[Category: Blows, M]]

OCA at 08:56, 10 October 2018

2018-10-10T08:56:44Z

←Older revision		Revision as of 08:56, 10 October 2018
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-	==~~STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS~~: ~~PYRROLIDIN~~-2-~~ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE~~ P4 ~~MOTIFS~~==	+	==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs==
	<StructureSection load='2y82' size='340' side='right' caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2y82' size='340' side='right' caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 09:52, 4 August 2016

2016-08-04T09:52:55Z

←Older revision		Revision as of 09:52, 4 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS==		==STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS==
	<StructureSection load='2y82' size='340' side='right' caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2y82' size='340' side='right' caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[2y7x\|2y7x]], [[2y7z\|2y7z]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[2j94\|2j94]], [[1iqj\|1iqj]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[2y7x\|2y7x]], [[2y7z\|2y7z]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[2j94\|2j94]], [[1iqj\|1iqj]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [http://www.ebi.ac.uk/pdbsum/2y82 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [http://pdbe.org/2y82 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [http://www.ebi.ac.uk/pdbsum/2y82 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y82 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y82" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:25, 18 December 2014

2014-12-18T13:25:17Z

←Older revision		Revision as of 13:25, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2y82\| PDB=2y82 \| SCENE= }}~~	+	==STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS==
-	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===	+	<StructureSection load='2y82' size='340' side='right' caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	{~~{ABSTRACT_PUBMED_21349710}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=930:6-CHLORO-N-((3S)-2-OXO-1-{4-[(2S)-2-PYRROLIDINYL]PHENYL}-3-PYRROLIDINYL)-2-NAPHTHALENESULFONAMIDE'>930</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[2y7x\|2y7x]], [[2y7z\|2y7z]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[2j94\|2j94]], [[1iqj\|1iqj]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [http://www.ebi.ac.uk/pdbsum/2y82 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The rational design, syntheses and evaluation of potent sulfonamidopyrrolidin-2-one-based factor Xa inhibitors incorporating aminoindane and phenylpyrrolidine P4 motifs are described. These series delivered highly potent anticoagulant compounds with excellent oral pharmacokinetic profiles; however, significant time dependant P450 inhibition was an issue for the aminoindane series, but this was not observed with the phenylpyrrolidine motif, which produced candidate quality molecules with potential for once-daily oral dosing in humans.

-	~~==Disease==~~	+	Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.,Young RJ, Adams C, Blows M, Brown D, Burns-Kurtis CL, Chan C, Chaudry L, Convery MA, Davies DE, Exall AM, Foster G, Harling JD, Hortense E, Irvine S, Irving WR, Jackson S, Kleanthous S, Pateman AJ, Patikis AN, Roethka TJ, Senger S, Stelman GJ, Toomey JR, West RI, Whittaker C, Zhou P, Watson NS Bioorg Med Chem Lett. 2011 Mar 15;21(6):1582-7. Epub 2011 Feb 1. PMID:21349710<ref>PMID:21349710</ref>
-	~~[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause~~ of factor ~~X deficiency (FA10D) [MIM~~:~~[http://omim.org/entry/227600 227600]]. A hemorrhagic disease~~ with ~~variable presentation~~. ~~Affected individuals can manifest prolonged nasal and mucosal hemorrhage~~, ~~menorrhagia~~, ~~hematuria~~, ~~and occasionally hemarthrosis~~. ~~Some patients do not have clinical bleeding diathesis~~.~~<ref>~~PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:~~19135706~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence~~ of ~~factor Va, calcium and phospholipid during blood clotting~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2y82]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA].~~	+

	==See Also==		==See Also==
	*[[Factor Xa\|Factor Xa]]		*[[Factor Xa\|Factor Xa]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021349710</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Adams, C.]]	+	[[Category: Adams, C]]
-	[[Category: Blows, M.]]	+	[[Category: Blows, M]]
-	[[Category: Brown, D.]]	+	[[Category: Brown, D]]
-	[[Category: Burns-Kurtis, C L.]]	+	[[Category: Burns-Kurtis, C L]]
-	[[Category: Chan, C.]]	+	[[Category: Chan, C]]
-	[[Category: Chaudry, L.]]	+	[[Category: Chaudry, L]]
-	[[Category: Convery, M A.]]	+	[[Category: Convery, M A]]
-	[[Category: Davies, D E.]]	+	[[Category: Davies, D E]]
-	[[Category: Exall, A M.]]	+	[[Category: Exall, A M]]
-	[[Category: Foster, G.]]	+	[[Category: Foster, G]]
-	[[Category: Harling, J D.]]	+	[[Category: Harling, J D]]
-	[[Category: Hortense, E.]]	+	[[Category: Hortense, E]]
-	[[Category: Irvine, S.]]	+	[[Category: Irvine, S]]
-	[[Category: Irving, W R.]]	+	[[Category: Irving, W R]]
-	[[Category: Jackson, S.]]	+	[[Category: Jackson, S]]
-	[[Category: Kleanthous, S.]]	+	[[Category: Kleanthous, S]]
-	[[Category: Pateman, A J.]]	+	[[Category: Pateman, A J]]
-	[[Category: Patikis, A N.]]	+	[[Category: Patikis, A N]]
-	[[Category: Roethka, T J.]]	+	[[Category: Roethka, T J]]
-	[[Category: Senger, S.]]	+	[[Category: Senger, S]]
-	[[Category: Stelman, G J.]]	+	[[Category: Stelman, G J]]
-	[[Category: Toomey, J R.]]	+	[[Category: Toomey, J R]]
-	[[Category: Watson, N S.]]	+	[[Category: Watson, N S]]
-	[[Category: West, R I.]]	+	[[Category: West, R I]]
-	[[Category: Whittaker, C.]]	+	[[Category: Whittaker, C]]
-	[[Category: Young, R J.]]	+	[[Category: Young, R J]]
-	[[Category: Zhou, P.]]	+	[[Category: Zhou, P]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Blood coagulation]]		[[Category: Blood coagulation]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 12:12, 24 March 2013

2013-03-24T12:12:32Z

←Older revision		Revision as of 12:12, 24 March 2013
Line 1:		Line 1:
-	[[Image:2y82.png\|left\|200px]]
-
	{{STRUCTURE_2y82\| PDB=2y82 \| SCENE= }}		{{STRUCTURE_2y82\| PDB=2y82 \| SCENE= }}
-
	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===		===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===
		+	{{ABSTRACT_PUBMED_21349710}}

-	~~{{ABSTRACT_PUBMED_21349710}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021349710</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021349710</ref><references group="xtra"/><references/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:50, 20 October 2012

2012-10-20T05:50:01Z

←Older revision		Revision as of 05:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2y82]] is a 2 chain structure ~~of [[Factor Xa]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA].	+	[[2y82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA].

	==See Also==		==See Also==

OCA at 11:16, 25 July 2012

2012-07-25T11:16:27Z

←Older revision		Revision as of 11:16, 25 July 2012
Line 1:		Line 1:
-	[[Image:2y82.~~jpg~~\|left\|200px]]	+	[[Image:2y82.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2y82", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2y82\| PDB=2y82 \| SCENE= }}		{{STRUCTURE_2y82\| PDB=2y82 \| SCENE= }}

	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===		===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21349710}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21349710 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21349710}}		{{ABSTRACT_PUBMED_21349710}}

	==About this Structure==		==About this Structure==
-	[[2y82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA].	+	[[2y82]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA].
		+
		+	==See Also==
		+	*[[Factor Xa\|Factor Xa]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21349710~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021349710</ref><references group="xtra"/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 52:		Line 44:
	[[Category: Young, R J.]]		[[Category: Young, R J.]]
	[[Category: Zhou, P.]]		[[Category: Zhou, P.]]
		+	[[Category: Blood clotting]]
		+	[[Category: Blood coagulation]]
		+	[[Category: Hydrolase]]
		+	[[Category: Serine protease]]

OCA at 08:23, 16 March 2011

2011-03-16T08:23:40Z

←Older revision		Revision as of 08:23, 16 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y82.jpg\|left\|200px]]

-	The ~~entry 2y82~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y82", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y82\| PDB=2y82 \| SCENE= }}

-	~~Authors~~: ~~Young, R.J., Adams, C., Blows, M., Brown, D., Burns~~-Kurtis, C.L., Chaudry, L., Chan, C., Convery, M.A., Davies, D.E., Exall, A.M., Foster, G., Harling, J.D., Hortense, E., Irving, W.R., Irvine, S., Jackson, S., Kleanthous, S., Pateman, A.J., Patikis, A.N., Roethka, T.J., Senger, S., Stelman, G.J., Toomey, J.R., West, R.I., Whittaker, C., Zhou, P., Watson, N.S.	+	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH AMINOINDANE AND PHENYLPYRROLIDINE P4 MOTIFS===

-	~~Description~~: Structure ~~and property based design of~~ factor Xa ~~inhibitors~~: ~~pyrrolidin~~-~~2-ones with aminoindane and phenylpyrrolidine P4 motifs~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21349710}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21349710 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21349710}}
		+
		+	==About this Structure==
		+	[[2y82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21349710</ref><references group="xtra"/>
		+	[[Category: Coagulation factor Xa]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Adams, C.]]
		+	[[Category: Blows, M.]]
		+	[[Category: Brown, D.]]
		+	[[Category: Burns-Kurtis, C L.]]
		+	[[Category: Chan, C.]]
		+	[[Category: Chaudry, L.]]
		+	[[Category: Convery, M A.]]
		+	[[Category: Davies, D E.]]
		+	[[Category: Exall, A M.]]
		+	[[Category: Foster, G.]]
		+	[[Category: Harling, J D.]]
		+	[[Category: Hortense, E.]]
		+	[[Category: Irvine, S.]]
		+	[[Category: Irving, W R.]]
		+	[[Category: Jackson, S.]]
		+	[[Category: Kleanthous, S.]]
		+	[[Category: Pateman, A J.]]
		+	[[Category: Patikis, A N.]]
		+	[[Category: Roethka, T J.]]
		+	[[Category: Senger, S.]]
		+	[[Category: Stelman, G J.]]
		+	[[Category: Toomey, J R.]]
		+	[[Category: Watson, N S.]]
		+	[[Category: West, R I.]]
		+	[[Category: Whittaker, C.]]
		+	[[Category: Young, R J.]]
		+	[[Category: Zhou, P.]]

←Older revision		Revision as of 15:01, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2y82' size='340' side='right'caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2y82' size='340' side='right'caption='[[2y82]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y82 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=930:6-CHLORO-N-((3S)-2-OXO-1-{4-[(2S)-2-PYRROLIDINYL]PHENYL}-3-PYRROLIDINYL)-2-NAPHTHALENESULFONAMIDE'>930</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=930:6-CHLORO-N-((3S)-2-OXO-1-{4-[(2S)-2-PYRROLIDINYL]PHENYL}-3-PYRROLIDINYL)-2-NAPHTHALENESULFONAMIDE'>930</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[2y7x\|2y7x]], [[2y7z\|2y7z]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[2j94\|2j94]], [[1iqj\|1iqj]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wu1\|1wu1]], [[2j34\|2j34]], [[2bq7\|2bq7]], [[2y5g\|2y5g]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2y5f\|2y5f]], [[2vvv\|2vvv]], [[2gd4\|2gd4]], [[2xbx\|2xbx]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[2jkh\|2jkh]], [[1z6e\|1z6e]], [[2uwp\|2uwp]], [[2xc4\|2xc4]], [[2y81\|2y81]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[2xc0\|2xc0]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[2y7x\|2y7x]], [[2y7z\|2y7z]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[2xby\|2xby]], [[2xc5\|2xc5]], [[2bmg\|2bmg]], [[1mq5\|1mq5]], [[1iqn\|1iqn]], [[2xbv\|2xbv]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[2y5h\|2y5h]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[2j94\|2j94]], [[1iqj\|1iqj]], [[2j95\|2j95]], [[2cji\|2cji]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[2y80\|2y80]], [[1iqk\|1iqk]], [[2wyj\|2wyj]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[2xbw\|2xbw]], [[2wyg\|2wyg]], [[1iql\|1iql]], [[1ksn\|1ksn]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [~~http~~://pdbe.org/2y82 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y82 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y82 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y82 OCA], [https://pdbe.org/2y82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y82 RCSB], [https://www.ebi.ac.uk/pdbsum/2y82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y82 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[~~http~~://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==