2ye7 - Revision history

OCA at 10:50, 20 December 2023

2023-12-20T10:50:54Z

←Older revision		Revision as of 10:50, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2ye7' size='340' side='right'caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ye7' size='340' side='right'caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2GA:2~~-[~~(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL~~]~~-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[2bsm\|2bsm]]~~, ~~[[1osf\|1osf]~~], ~~[[2wi3\|2wi3]]~~, [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [https://pdbe.org/2ye7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [https://pdbe.org/2ye7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, L M~~]]	+	[[Category: Baker LM]]
-	[[Category: Hubbard~~, R E~~]]	+	[[Category: Hubbard RE]]
-	[[Category: Roughley~~, S D]]~~	+	[[Category: Roughley SD]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Pu3]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 12:27, 27 April 2022

2022-04-27T12:27:50Z

←Older revision		Revision as of 12:27, 27 April 2022
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	<StructureSection load='2ye7' size='340' side='right'caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ye7' size='340' side='right'caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [~~http~~://pdbe.org/2ye7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [https://pdbe.org/2ye7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

	==See Also==		==See Also==

OCA at 12:46, 22 July 2020

2020-07-22T12:46:23Z

←Older revision		Revision as of 12:46, 22 July 2020
Line 1:		Line 1:

	==HSP90 inhibitors and drugs from fragment and virtual screening==		==HSP90 inhibitors and drugs from fragment and virtual screening==
-	<StructureSection load='2ye7' size='340' side='right' caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2ye7' size='340' side='right'caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://pdbe.org/2ye7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://pdbe.org/2ye7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 12:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baker, L M]]		[[Category: Baker, L M]]
	[[Category: Hubbard, R E]]		[[Category: Hubbard, R E]]

OCA at 09:31, 10 October 2018

2018-10-10T09:31:00Z

←Older revision		Revision as of 09:31, 10 October 2018
Line 1:		Line 1:

-	==HSP90 ~~INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING~~==	+	==HSP90 inhibitors and drugs from fragment and virtual screening==
	<StructureSection load='2ye7' size='340' side='right' caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ye7' size='340' side='right' caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 10:38, 4 August 2016

2016-08-04T10:38:48Z

←Older revision		Revision as of 10:38, 4 August 2016
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		+
	==HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING==		==HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING==
	<StructureSection load='2ye7' size='340' side='right' caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2ye7' size='340' side='right' caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://pdbe.org/2ye7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Baker, L M]]		[[Category: Baker, L M]]
	[[Category: Hubbard, R E]]		[[Category: Hubbard, R E]]

OCA at 08:25, 25 December 2014

2014-12-25T08:25:54Z

←Older revision		Revision as of 08:25, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Baker, L M.]]	+	[[Category: Baker, L M]]
-	[[Category: Hubbard, R E.]]	+	[[Category: Hubbard, R E]]
-	[[Category: Roughley, S D.]]	+	[[Category: Roughley, S D]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA at 11:59, 29 October 2014

2014-10-29T11:59:18Z

←Older revision		Revision as of 11:59, 29 October 2014
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-	~~[[Image:2ye7.png\|left\|200px]]~~	+	==HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING==
-		+	<StructureSection load='2ye7' size='340' side='right' caption='[[2ye7]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{STRUCTURE_2ye7\| PDB=2ye7 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YE7 FirstGlance]. <br>
-	===HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GA:2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE'>2GA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[2yej\|2yej]], [[1yer\|1yer]], [[2yec\|2yec]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2ye9\|2ye9]], [[2yeb\|2yeb]], [[2ye4\|2ye4]], [[2ye5\|2ye5]], [[2yea\|2yea]], [[2ye6\|2ye6]], [[2yef\|2yef]], [[2ye8\|2ye8]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ye7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ye7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ye7 PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	</table>
-	[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA].	+	__TOC__
-		+	</StructureSection>
-	==~~See Also==~~	+
-	*[[~~Heat Shock Proteins~~\|~~Heat Shock Proteins~~]]	+
-		+
-	==~~Reference~~==	+
-	<~~ref group~~="~~xtra~~">~~PMID~~:~~021561141~~</~~ref~~><~~references group~~="~~xtra~~"/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Baker, L M.]]		[[Category: Baker, L M.]]

OCA at 14:37, 20 October 2012

2012-10-20T14:37:12Z

←Older revision		Revision as of 14:37, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2ye7]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA].	+	[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA].

	==See Also==		==See Also==

OCA at 15:43, 26 July 2012

2012-07-26T15:43:28Z

←Older revision		Revision as of 15:43, 26 July 2012
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	[[Image:2ye7.png\|left\|200px]]		[[Image:2ye7.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2ye7\| PDB=2ye7 \| SCENE= }}		{{STRUCTURE_2ye7\| PDB=2ye7 \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	[[2ye7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA].	+	[[2ye7]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE7 OCA].
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==

OCA at 05:16, 29 June 2011

2011-06-29T05:16:03Z

←Older revision		Revision as of 05:16, 29 June 2011
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-	[[Image:2ye7.~~jpg~~\|left\|200px]]	+	[[Image:2ye7.png\|left\|200px]]

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