2yg9 - Revision history

OCA at 08:13, 23 August 2023

2023-08-23T08:13:42Z

←Older revision		Revision as of 08:13, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2yg9' size='340' side='right'caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2yg9' size='340' side='right'caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus~~ radiodurans~~" raj et al. 1960~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2yg8\|2yg8]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">DR_2584 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [https://pdbe.org/2yg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [https://pdbe.org/2yg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9RRB0_DEIRA Q9RRB0_DEIRA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Micrococcus~~ radiodurans ~~raj et al. 1960~~]]	+	[[Category: Deinococcus radiodurans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hall~~, D R~~]]	+	[[Category: Hall DR]]
-	[[Category: Leiros, I]]	+	[[Category: Leiros I]]
-	[[Category: McSweeney, S]]	+	[[Category: McSweeney S]]
-	[[Category: Moe, E]]	+	[[Category: Moe E]]
-	[[Category: Talstad, V]]	+	[[Category: Talstad V]]
-	[[Category: Timmins, J]]	+	[[Category: Timmins J]]
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 15:05, 17 November 2021

2021-11-17T15:05:13Z

←Older revision		Revision as of 15:05, 17 November 2021
Line 1:		Line 1:

	==Structure of an unusual 3-Methyladenine DNA Glycosylase II (Alka) from Deinococcus radiodurans==		==Structure of an unusual 3-Methyladenine DNA Glycosylase II (Alka) from Deinococcus radiodurans==
-	<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2yg9' size='340' side='right'caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yg8\|2yg8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR_2584 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR_2584 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [~~http~~://pdbe.org/2yg9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [https://pdbe.org/2yg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Micrococcus radiodurans raj et al. 1960]]		[[Category: Micrococcus radiodurans raj et al. 1960]]
		+	[[Category: Large Structures]]
	[[Category: Hall, D R]]		[[Category: Hall, D R]]
	[[Category: Leiros, I]]		[[Category: Leiros, I]]

OCA at 06:55, 5 December 2018

2018-12-05T06:55:08Z

←Older revision		Revision as of 06:55, 5 December 2018
Line 1:		Line 1:

-	==Structure of an unusual 3-~~METHYLADENINE~~ DNA ~~GLYCOSYLASE~~ II (~~ALKA~~) ~~FROM DEINOCOCCUS RADIODURANS~~==	+	==Structure of an unusual 3-Methyladenine DNA Glycosylase II (Alka) from Deinococcus radiodurans==
	<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DR_2584 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://pdbe.org/2yg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://pdbe.org/2yg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Micrococcus radiodurans raj et al. 1960]]
	[[Category: Hall, D R]]		[[Category: Hall, D R]]
	[[Category: Leiros, I]]		[[Category: Leiros, I]]
-	[[Category: ~~Mcsweeney~~, S]]	+	[[Category: McSweeney, S]]
	[[Category: Moe, E]]		[[Category: Moe, E]]
	[[Category: Talstad, V]]		[[Category: Talstad, V]]

OCA at 08:32, 4 August 2016

2016-08-04T08:32:07Z

←Older revision		Revision as of 08:32, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS==		==Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS==
	<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://pdbe.org/2yg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yg9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yg9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:34, 3 January 2015

2015-01-03T22:34:26Z

←Older revision		Revision as of 22:34, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. <br>	+	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YG9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.,Moe E, Hall DR, Leiros I, Monsen VT, Timmins J, McSweeney S Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):703-12. Epub 2012 May 17. PMID:22683793<ref>PMID:22683793</ref>		Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.,Moe E, Hall DR, Leiros I, Monsen VT, Timmins J, McSweeney S Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):703-12. Epub 2012 May 17. PMID:22683793<ref>PMID:22683793</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hall, D R.]]	+	[[Category: Hall, D R]]
-	[[Category: Leiros, I.]]	+	[[Category: Leiros, I]]
-	[[Category: Mcsweeney, S.]]	+	[[Category: Mcsweeney, S]]
-	[[Category: Moe, E.]]	+	[[Category: Moe, E]]
-	[[Category: Talstad, V.]]	+	[[Category: Talstad, V]]
-	[[Category: Timmins, J.]]	+	[[Category: Timmins, J]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:41, 14 May 2014

2014-05-14T07:41:32Z

←Older revision		Revision as of 07:41, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2yg9.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS==
		+	<StructureSection load='2yg9' size='340' side='right' caption='[[2yg9]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yg8\|2yg8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yg9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yg9 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	3-Methyladenine DNA glycosylase II (AlkA) is a DNA-repair enzyme that removes alkylated bases in DNA via the base-excision repair (BER) pathway. The enzyme belongs to the helix-hairpin-helix (HhH) superfamily of DNA glycosylases and possesses broad substrate specificity. In the genome of Deinococcus radiodurans, two genes encoding putative AlkA have been identified (Dr_2074 and Dr_2584). Dr_2074 is a homologue of human AlkA (MPG or AAG) and Dr_2584 is a homologue of bacterial AlkAs. Here, the three-dimensional structure of Dr_2584 (DrAlkA2) is presented and compared with the previously determined structure of Escherichia coli AlkA (EcAlkA). The results show that the enzyme consists of two helical-bundle domains separated by a wide DNA-binding cleft and contains an HhH motif. Overall, the protein fold is similar to the two helical-bundle domains of EcAlkA, while the third N-terminal mixed alpha/beta domain observed in EcAlkA is absent. Substrate-specificity analyses show that DrAlkA2, like EcAlkA, is able to remove both 3-methyladenine (3meA) and 7-methylguanine (7meG) from DNA; however, the enzyme possesses no activity towards 1,N(6)-ethenoadenine (A) and hypoxanthine (Hx). In addition, it shows activity towards the AlkB dioxygenase substrates 3-methylcytosine (3meC) and 1-methyladenine (1meA). Thus, the enzyme seems to preferentially repair methylated bases with weakened N-glycosidic bonds; this is an unusual specificity for a bacterial AlkA protein and is probably dictated by a combination of the wide DNA-binding cleft and a highly accessible specificity pocket.

-	~~{{STRUCTURE_2yg9\| PDB=2yg9 \| SCENE= }}~~	+	Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.,Moe E, Hall DR, Leiros I, Monsen VT, Timmins J, McSweeney S Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):703-12. Epub 2012 May 17. PMID:22683793<ref>PMID:22683793</ref>

-	~~===Structure~~ of ~~an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22683793}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2yg9]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2YG9 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022683793<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Hall, D R.]]		[[Category: Hall, D R.]]
	[[Category: Leiros, I.]]		[[Category: Leiros, I.]]

OCA at 07:44, 20 June 2012

2012-06-20T07:44:57Z

←Older revision		Revision as of 07:44, 20 June 2012
Line 1:		Line 1:
	[[Image:2yg9.png\|left\|200px]]		[[Image:2yg9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2yg9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2yg9\| PDB=2yg9 \| SCENE= }}		{{STRUCTURE_2yg9\| PDB=2yg9 \| SCENE= }}

	===Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===		===Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22683793}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22683793 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22683793}}		{{ABSTRACT_PUBMED_22683793}}

OCA at 06:49, 20 June 2012

2012-06-20T06:49:10Z

←Older revision		Revision as of 06:49, 20 June 2012
Line 11:		Line 11:
	===Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===		===Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22683793}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22683793 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22683793}}

	==About this Structure==		==About this Structure==
	[[2yg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA].		[[2yg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YG9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022683793</ref><references group="xtra"/>
	[[Category: Hall, D R.]]		[[Category: Hall, D R.]]
	[[Category: Leiros, I.]]		[[Category: Leiros, I.]]

OCA at 04:53, 30 May 2012

2012-05-30T04:53:00Z

←Older revision		Revision as of 04:53, 30 May 2012
Line 1:		Line 1:
-	[[Image:2yg9.~~jpg~~\|left\|200px]]	+	[[Image:2yg9.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 9:
	{{STRUCTURE_2yg9\| PDB=2yg9 \| SCENE= }}		{{STRUCTURE_2yg9\| PDB=2yg9 \| SCENE= }}

-	===~~STRUCTURE OF AN UNUSUAL~~ 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===	+	===Structure of an unusual 3-METHYLADENINE DNA GLYCOSYLASE II (ALKA) FROM DEINOCOCCUS RADIODURANS===


Line 20:		Line 20:
	[[Category: Talstad, V.]]		[[Category: Talstad, V.]]
	[[Category: Timmins, J.]]		[[Category: Timmins, J.]]
		+	[[Category: Dna repair]]
		+	[[Category: Hydrolase]]

OCA: Protected "2yg9" [edit=sysop:move=sysop]

2011-04-21T10:45:48Z

Protected "2yg9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:45, 21 April 2011