2ykj - Revision history

OCA at 10:28, 27 September 2023

2023-09-27T10:28:17Z

←Older revision		Revision as of 10:28, 27 September 2023
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	<StructureSection load='2ykj' size='340' side='right'caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='2ykj' size='340' side='right'caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=YKJ:2-AMINO-N~~-[~~4-(3H-IMIDAZO~~[~~4,5-C~~]~~PYRIDIN-2-YL)--9H-FLUOREN-9-YL~~]~~-ISONICOTINAMIDE'>YKJ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[[~~2yi0\|2yi0]]~~, [[2yk9\|2yk9]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2ye4\|2ye4]], [[2yi5\|2yi5]], [[2ye5\|2ye5]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1uyf\|1uyf]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2yi6\|2yi6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2yef\|2yef]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[2yke\|2yke]], [[2yi7\|2yi7]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2yeb\|2yeb]], [[2ye7\|2ye7]], [[2ykc\|2ykc]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2yej\|2yej]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[2yec\|2yec]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2ye9\|2ye9]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2yk2\|2yk2]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[2yea\|2yea]], [[1yc1\|1yc1]], [[2ye6\|2ye6]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2yjx\|2yjx]], [[2jjc\|2jjc]], [[2ye8\|2ye8]], [[2ykb\|2ykb]], [[2yki\|2yki]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YKJ:2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE'>YKJ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [https://pdbe.org/2ykj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [https://www.ebi.ac.uk/pdbsum/2ykj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [https://pdbe.org/2ykj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [https://www.ebi.ac.uk/pdbsum/2ykj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dupuy, A]]	+	[[Category: Dupuy A]]
-	[[Category: Vallee, F]]	+	[[Category: Vallee F]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Inhibition~~]]	+

OCA at 16:10, 22 December 2021

2021-12-22T16:10:01Z

←Older revision		Revision as of 16:10, 22 December 2021
Line 3:		Line 3:
	<StructureSection load='2ykj' size='340' side='right'caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='2ykj' size='340' side='right'caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YKJ:2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE'>YKJ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YKJ:2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE'>YKJ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yi0\|2yi0]], [[2yk9\|2yk9]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2ye4\|2ye4]], [[2yi5\|2yi5]], [[2ye5\|2ye5]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1uyf\|1uyf]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2yi6\|2yi6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2yef\|2yef]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[2yke\|2yke]], [[2yi7\|2yi7]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2yeb\|2yeb]], [[2ye7\|2ye7]], [[2ykc\|2ykc]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2yej\|2yej]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[2yec\|2yec]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2ye9\|2ye9]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2yk2\|2yk2]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[2yea\|2yea]], [[1yc1\|1yc1]], [[2ye6\|2ye6]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2yjx\|2yjx]], [[2jjc\|2jjc]], [[2ye8\|2ye8]], [[2ykb\|2ykb]], [[2yki\|2yki]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yi0\|2yi0]], [[2yk9\|2yk9]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2ye4\|2ye4]], [[2yi5\|2yi5]], [[2ye5\|2ye5]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1uyf\|1uyf]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2yi6\|2yi6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2yef\|2yef]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[2yke\|2yke]], [[2yi7\|2yi7]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2yeb\|2yeb]], [[2ye7\|2ye7]], [[2ykc\|2ykc]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2yej\|2yej]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[2yec\|2yec]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2ye9\|2ye9]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2yk2\|2yk2]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[2yea\|2yea]], [[1yc1\|1yc1]], [[2ye6\|2ye6]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2yjx\|2yjx]], [[2jjc\|2jjc]], [[2ye8\|2ye8]], [[2ykb\|2ykb]], [[2yki\|2yki]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [~~http~~://pdbe.org/2ykj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ykj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [https://pdbe.org/2ykj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [https://www.ebi.ac.uk/pdbsum/2ykj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:54, 18 March 2020

2020-03-18T10:54:30Z

←Older revision		Revision as of 10:54, 18 March 2020
Line 1:		Line 1:

	==Tricyclic series of Hsp90 inhibitors==		==Tricyclic series of Hsp90 inhibitors==
-	<StructureSection load='2ykj' size='340' side='right' caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>	+	<StructureSection load='2ykj' size='340' side='right'caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dupuy, A]]		[[Category: Dupuy, A]]
	[[Category: Vallee, F]]		[[Category: Vallee, F]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Inhibition]]		[[Category: Inhibition]]

OCA at 07:53, 14 June 2018

2018-06-14T07:53:50Z

←Older revision		Revision as of 07:53, 14 June 2018
Line 1:		Line 1:

-	==~~TRICYCLIC SERIES OF HSP90 INHIBITORS~~==	+	==Tricyclic series of Hsp90 inhibitors==
	<StructureSection load='2ykj' size='340' side='right' caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='2ykj' size='340' side='right' caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 20:18, 5 August 2016

2016-08-05T20:18:07Z

←Older revision		Revision as of 20:18, 5 August 2016
Line 1:		Line 1:
		+
	==TRICYCLIC SERIES OF HSP90 INHIBITORS==		==TRICYCLIC SERIES OF HSP90 INHIBITORS==
	<StructureSection load='2ykj' size='340' side='right' caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='2ykj' size='340' side='right' caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YKJ:2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE'>YKJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YKJ:2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE'>YKJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yi0\|2yi0]], [[2yk9\|2yk9]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2ye4\|2ye4]], [[2yi5\|2yi5]], [[2ye5\|2ye5]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1uyf\|1uyf]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2yi6\|2yi6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2yef\|2yef]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[2yke\|2yke]], [[2yi7\|2yi7]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2yeb\|2yeb]], [[2ye7\|2ye7]], [[2ykc\|2ykc]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2yej\|2yej]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[2yec\|2yec]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2ye9\|2ye9]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2yk2\|2yk2]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[2yea\|2yea]], [[1yc1\|1yc1]], [[2ye6\|2ye6]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2yjx\|2yjx]], [[2jjc\|2jjc]], [[2ye8\|2ye8]], [[2ykb\|2ykb]], [[2yki\|2yki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yi0\|2yi0]], [[2yk9\|2yk9]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2ye4\|2ye4]], [[2yi5\|2yi5]], [[2ye5\|2ye5]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1uyf\|1uyf]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2yi6\|2yi6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2yef\|2yef]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[2yke\|2yke]], [[2yi7\|2yi7]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2yeb\|2yeb]], [[2ye7\|2ye7]], [[2ykc\|2ykc]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2yej\|2yej]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[2yec\|2yec]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2ye9\|2ye9]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2yk2\|2yk2]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[2yea\|2yea]], [[1yc1\|1yc1]], [[2ye6\|2ye6]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2yjx\|2yjx]], [[2jjc\|2jjc]], [[2ye8\|2ye8]], [[2ykb\|2ykb]], [[2yki\|2yki]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [http://www.ebi.ac.uk/pdbsum/2ykj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [http://pdbe.org/2ykj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [http://www.ebi.ac.uk/pdbsum/2ykj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ykj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dupuy, A]]		[[Category: Dupuy, A]]
	[[Category: Vallee, F]]		[[Category: Vallee, F]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Inhibition]]		[[Category: Inhibition]]

OCA at 05:32, 25 December 2014

2014-12-25T05:32:48Z

←Older revision		Revision as of 05:32, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [http://www.ebi.ac.uk/pdbsum/2ykj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [http://www.ebi.ac.uk/pdbsum/2ykj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dupuy, A.]]	+	[[Category: Dupuy, A]]
-	[[Category: Vallee, F.]]	+	[[Category: Vallee, F]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Inhibition]]		[[Category: Inhibition]]

OCA at 11:48, 29 October 2014

2014-10-29T11:48:56Z

←Older revision		Revision as of 11:48, 29 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2ykj.~~png~~\|~~left~~\|~~200px~~]]	+	==TRICYCLIC SERIES OF HSP90 INHIBITORS==
		+	<StructureSection load='2ykj' size='340' side='right' caption='[[2ykj]], [[Resolution\|resolution]] 1.46Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YKJ:2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE'>YKJ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yi0\|2yi0]], [[2yk9\|2yk9]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[2ye4\|2ye4]], [[2yi5\|2yi5]], [[2ye5\|2ye5]], [[2bz5\|2bz5]], [[2ccs\|2ccs]], [[2yei\|2yei]], [[2yeg\|2yeg]], [[1uyf\|1uyf]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[2ye3\|2ye3]], [[2byi\|2byi]], [[2yi6\|2yi6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2xjx\|2xjx]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2yeh\|2yeh]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2yef\|2yef]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2cdd\|2cdd]], [[1uy9\|1uy9]], [[1yes\|1yes]], [[1byq\|1byq]], [[2yke\|2yke]], [[2yi7\|2yi7]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2yeb\|2yeb]], [[2ye7\|2ye7]], [[2ykc\|2ykc]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2yej\|2yej]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[2yec\|2yec]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2xk2\|2xk2]], [[2xjj\|2xjj]], [[1uyd\|1uyd]], [[2wi2\|2wi2]], [[2xdl\|2xdl]], [[1uy6\|1uy6]], [[2yee\|2yee]], [[2ye2\|2ye2]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2ye9\|2ye9]], [[2c2l\|2c2l]], [[1uyk\|1uyk]], [[2yk2\|2yk2]], [[2cct\|2cct]], [[2wi6\|2wi6]], [[2yea\|2yea]], [[1yc1\|1yc1]], [[2ye6\|2ye6]], [[2yed\|2yed]], [[1uyc\|1uyc]], [[1yet\|1yet]], [[2yjx\|2yjx]], [[2jjc\|2jjc]], [[2ye8\|2ye8]], [[2ykb\|2ykb]], [[2yki\|2yki]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykj RCSB], [http://www.ebi.ac.uk/pdbsum/2ykj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel class of heat shock protein 90 (Hsp90) inhibitors was developed after a low throughput screen (LTS) of a focused library containing approximately 21K compounds selected by virtual screening. The initial [1-{3-H-imidazo[4-5-c]pyridin-2-yl}-3,4-dihydro-2H-pyrido[2,1-a]isoindole- 6-one] (1) compound showed moderate activity (IC(50) = 7.6 muM on Hsp82, the yeast homologue of Hsp90). A high-resolution X-ray structure shows that compound 1 binds into an "induced" hydrophobic pocket, 10-15 A away from the ATP/resorcinol binding site. Iterative cycles of structure-based drug design (SBDD) and chemical synthesis led to the design and preparation of analogues with improved affinity. These optimized molecules make productive interactions within the ATP binding site as reported by other Hsp90 inhibitors. This resulted in compound 8, which is a highly potent inhibitor in biochemical and cellular assays (K(d) = 0.35 nM on Hsp90; IC(50) = 30 nM on SKBr3 mammary carcinoma cells) and in an in vivo leukemia model.

-	~~{{STRUCTURE_2ykj\| PDB=2ykj \| SCENE= }}~~	+	Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.,Vallee F, Carrez C, Pilorge F, Dupuy A, Parent A, Bertin L, Thompson F, Ferrari P, Fassy F, Lamberton A, Thomas A, Arrebola R, Guerif S, Rohaut A, Certal V, Ruxer JM, Delorme C, Jouanen A, Dumas J, Grepin C, Combeau C, Goulaouic H, Dereu N, Mikol V, Mailliet P, Minoux H J Med Chem. 2011 Oct 27;54(20):7206-19. Epub 2011 Oct 5. PMID:21972823<ref>PMID:21972823</ref>

-	~~===TRICYCLIC SERIES OF HSP90 INHIBITORS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21972823}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ykj]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA].~~	+	</StructureSection>
-		+
-	==~~See Also==~~	+
-	*[[Heat Shock Proteins\|Heat Shock Proteins]]	+
-		+
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:021972823<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dupuy, A.]]		[[Category: Dupuy, A.]]

OCA at 13:12, 20 October 2012

2012-10-20T13:12:09Z

←Older revision		Revision as of 13:12, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ykj]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA].	+	[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA].

	==See Also==		==See Also==

OCA at 11:13, 26 July 2012

2012-07-26T11:13:13Z

←Older revision		Revision as of 11:13, 26 July 2012
Line 1:		Line 1:
	[[Image:2ykj.png\|left\|200px]]		[[Image:2ykj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ykj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ykj\| PDB=2ykj \| SCENE= }}		{{STRUCTURE_2ykj\| PDB=2ykj \| SCENE= }}

	===TRICYCLIC SERIES OF HSP90 INHIBITORS===		===TRICYCLIC SERIES OF HSP90 INHIBITORS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21972823}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21972823 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21972823}}		{{ABSTRACT_PUBMED_21972823}}

	==About this Structure==		==About this Structure==
-	[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA].	+	[[2ykj]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA].
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==

OCA at 10:11, 30 October 2011

2011-10-30T10:11:31Z

←Older revision		Revision as of 10:11, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2ykj.png\|left\|200px]]

-	The ~~entry 2ykj~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2ykj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2ykj\| PDB=2ykj \| SCENE= }}

-	~~Authors: Vallee, F., Dupuy, A.~~	+	===TRICYCLIC SERIES OF HSP90 INHIBITORS===

-	~~Description~~: ~~Tricyclic series of Hsp90 inhibitors~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21972823}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21972823 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21972823}}
		+
		+	==About this Structure==
		+	[[2ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021972823</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Dupuy, A.]]
		+	[[Category: Vallee, F.]]
		+	[[Category: Chaperone]]
		+	[[Category: Inhibition]]