2yn9 - Revision history

OCA at 14:06, 1 February 2024

2024-02-01T14:06:16Z

←Older revision		Revision as of 14:06, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1iwc\|1iwc]]~~, [[~~1iwf~~\|~~1iwf~~]]~~, [[2xzb\|2xzb]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution\|Resolution]] 8Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [https://pdbe.org/2yn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [https://pdbe.org/2yn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.	+	[https://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hydrogen/potassium-exchanging ATPase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Abe, K]]	+	[[Category: Abe K]]
-	[[Category: Friedrich, T]]	+	[[Category: Friedrich T]]
-	[[Category: Fujiyoshi, Y]]	+	[[Category: Fujiyoshi Y]]
-	[[Category: Tani, K]]	+	[[Category: Tani K]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: P-type atpase]]~~	+
-	~~[[Category: Proton pump~~]]	+

OCA at 12:33, 27 April 2022

2022-04-27T12:33:25Z

OCA at 12:58, 22 July 2020

2020-07-22T12:58:40Z

←Older revision		Revision as of 12:58, 22 July 2020
Line 1:		Line 1:

	==Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium==		==Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium==
-	<StructureSection load='2yn9' size='340' side='right' caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>	+	<StructureSection load='2yn9' size='340' side='right'caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://pdbe.org/2yn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://pdbe.org/2yn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</StructureSection>		</StructureSection>
	[[Category: Hydrogen/potassium-exchanging ATPase]]		[[Category: Hydrogen/potassium-exchanging ATPase]]
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Abe, K]]		[[Category: Abe, K]]

OCA at 07:13, 11 August 2016

2016-08-11T07:13:52Z

←Older revision		Revision as of 07:13, 11 August 2016
Line 1:		Line 1:
		+
	==Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium==		==Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium==
	<StructureSection load='2yn9' size='340' side='right' caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>		<StructureSection load='2yn9' size='340' side='right' caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://pdbe.org/2yn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yn9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:24, 5 January 2015

2015-01-05T12:24:33Z

←Older revision		Revision as of 12:24, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.		[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.
Line 25:		Line 25:
	[[Category: Hydrogen/potassium-exchanging ATPase]]		[[Category: Hydrogen/potassium-exchanging ATPase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Abe, K.]]	+	[[Category: Abe, K]]
-	[[Category: Friedrich, T.]]	+	[[Category: Friedrich, T]]
-	[[Category: Fujiyoshi, Y.]]	+	[[Category: Fujiyoshi, Y]]
-	[[Category: Tani, K.]]	+	[[Category: Tani, K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: P-type atpase]]		[[Category: P-type atpase]]
	[[Category: Proton pump]]		[[Category: Proton pump]]

OCA at 09:06, 16 July 2014

2014-07-16T09:06:56Z

←Older revision		Revision as of 09:06, 16 July 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yn9\| PDB=2yn9 \| SCENE= }}~~	+	==Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium==
-	===Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium===	+	<StructureSection load='2yn9' size='340' side='right' caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23091039}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [http://www.ebi.ac.uk/pdbsum/2yn9 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.		[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gastric H(+),K(+)-ATPase is responsible for gastric acid secretion. ATP-driven H(+) uptake into the stomach is efficiently accomplished by the exchange of an equal amount of K(+), resulting in a luminal pH close to 1. Because of the limited free energy available for ATP hydrolysis, the stoichiometry of transported cations is thought to vary from 2H(+)/2K(+) to 1H(+)/1K(+) per hydrolysis of one ATP molecule as the luminal pH decreases, although direct evidence for this hypothesis has remained elusive. Here, we show, using the phosphate analog aluminum fluoride (AlF) and a K(+) congener (Rb(+)), the 8-A resolution structure of H(+),K(+)-ATPase in the transition state of dephosphorylation, (Rb(+))E2 approximately AlF, which is distinct from the preceding Rb(+)-free E2P state. A strong density located in the transmembrane cation-binding site of (Rb(+))E2 approximately AlF highly likely represents a single bound Rb(+) ion, which is clearly different from the Rb(+)-free E2AlF or K(+)-bound (K(+))E2 approximately AlF structures. Measurement of radioactive (86)Rb(+) binding suggests that the binding stoichiometry varies depending on the pH, and approximately half of the amount of Rb(+) is bound under acidic crystallization conditions compared with at a neutral pH. These data represent structural and biochemical evidence for the 1H(+)/1K(+)/1ATP transport mode of H(+),K(+)-ATPase, which is a prerequisite for generation of the 10(6)-fold proton gradient in terms of thermodynamics. Together with the released E2P-stabilizing interaction between the beta subunit's N terminus and the P domain observed in the (Rb(+))E2 approximately AlF structure, we propose a refined vectorial transport model of H(+),K(+)-ATPase, which must prevail against the highly acidic state of the gastric lumen.

-	~~==Function==~~	+	Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site.,Abe K, Tani K, Friedrich T, Fujiyoshi Y Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18401-6. doi:, 10.1073/pnas.1212294109. Epub 2012 Oct 22. PMID:23091039<ref>PMID:23091039</ref>
-	~~[[http://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange~~ of H(+~~) and~~ K(+) ~~ions across the plasma membrane~~. ~~Responsible for acid production in the stomach~~.	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2yn9]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA].~~	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hydrogen/potassium-exchanging ATPase]]		[[Category: Hydrogen/potassium-exchanging ATPase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 08:54, 24 March 2013

2013-03-24T08:54:43Z

←Older revision		Revision as of 08:54, 24 March 2013
Line 1:		Line 1:
-	[[Image:2yn9.png\|left\|200px]]
-
	{{STRUCTURE_2yn9\| PDB=2yn9 \| SCENE= }}		{{STRUCTURE_2yn9\| PDB=2yn9 \| SCENE= }}
-
	===Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium===		===Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium===
		+	{{ABSTRACT_PUBMED_23091039}}

-	~~{{ABSTRACT_PUBMED_23091039}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

	==About this Structure==		==About this Structure==

OCA at 09:17, 16 January 2013

2013-01-16T09:17:28Z

←Older revision		Revision as of 09:17, 16 January 2013
Line 1:		Line 1:
-	[[Image:2yn9.~~jpg~~\|left\|200px]]	+	[[Image:2yn9.png\|left\|200px]]

	{{STRUCTURE_2yn9\| PDB=2yn9 \| SCENE= }}		{{STRUCTURE_2yn9\| PDB=2yn9 \| SCENE= }}
Line 5:		Line 5:
	===Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium===		===Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium===

		+	{{ABSTRACT_PUBMED_23091039}}

	==About this Structure==		==About this Structure==

OCA at 13:44, 8 November 2012

2012-11-08T13:44:09Z

←Older revision		Revision as of 13:44, 8 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2yn9.jpg\|left\|200px]]

-	~~The entry~~ 2yn9 ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_2yn9\| PDB=2yn9 \| SCENE= }}

-	~~Authors: Abe~~, K~~., Tani, K., Friedrich, T., Fujiyoshi, Y.~~	+	===Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium===

-	~~Description~~: ~~Cryo~~-~~EM structure of gastric H+~~,K+-~~ATPase with bound rubidium~~	+
		+	==About this Structure==
		+	[[2yn9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA].
		+	[[Category: Hydrogen/potassium-exchanging ATPase]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Abe, K.]]
		+	[[Category: Friedrich, T.]]
		+	[[Category: Fujiyoshi, Y.]]
		+	[[Category: Tani, K.]]
		+	[[Category: Hydrolase]]
		+	[[Category: P-type atpase]]
		+	[[Category: Proton pump]]

OCA at 08:22, 31 October 2012

2012-10-31T08:22:04Z

←Older revision		Revision as of 08:22, 31 October 2012
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2yn9 is ON HOLD	+	The entry 2yn9 is ON HOLD until Paper Publication

	Authors: Abe, K., Tani, K., Friedrich, T., Fujiyoshi, Y.		Authors: Abe, K., Tani, K., Friedrich, T., Fujiyoshi, Y.

-	Description: Cryo-EM structure of gastric H,K-ATPase with bound rubidium	+	Description: Cryo-EM structure of gastric H+,K+-ATPase with bound rubidium

←Older revision		Revision as of 12:33, 27 April 2022
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	<StructureSection load='2yn9' size='340' side='right'caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>		<StructureSection load='2yn9' size='340' side='right'caption='[[2yn9]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YN9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iwc\|1iwc]], [[1iwf\|1iwf]], [[2xzb\|2xzb]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [~~http~~://pdbe.org/2yn9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yn9 OCA], [https://pdbe.org/2yn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yn9 RCSB], [https://www.ebi.ac.uk/pdbsum/2yn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yn9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.	+	[[https://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.	+	[[https://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==