2yxm - Revision history

OCA at 13:55, 13 March 2024

2024-03-13T13:55:17Z

←Older revision		Revision as of 13:55, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='2yxm' size='340' side='right'caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>		<StructureSection load='2yxm' size='340' side='right'caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [~~http~~://pdbe.org/2yxm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxm ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.51Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [https://pdbe.org/2yxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [https://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxm ProSAT], [https://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[~~http~~://omim.org/entry/614335 614335]]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>	+	[https://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[https://omim.org/entry/614335 614335]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.	+	[https://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, L]]	+	[[Category: Chen L]]
-	[[Category: Kishishita, S]]	+	[[Category: Kishishita S]]
-	[[Category: Liu, Z]]	+	[[Category: Liu Z]]
-	[[Category: Murayama, K]]	+	[[Category: Murayama K]]
-	[[Category: Ohsawa, N]]	+	[[Category: Ohsawa N]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shirouzu M]]
-	[[Category: Shirouzu, M]]	+	[[Category: Terada T]]
-	[[Category: Terada, T]]	+	[[Category: Wang B]]
-	[[Category: Wang, B]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell adhesionn]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: I-set domain]]~~	+
-	~~[[Category: Myosin binding protein c]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Rsgi~~]]	+

OCA at 13:07, 22 July 2020

2020-07-22T13:07:25Z

←Older revision		Revision as of 13:07, 22 July 2020
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	==Crystal structure of I-set domain of human Myosin Binding ProteinC==		==Crystal structure of I-set domain of human Myosin Binding ProteinC==
-	<StructureSection load='2yxm' size='340' side='right' caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>	+	<StructureSection load='2yxm' size='340' side='right'caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://pdbe.org/2yxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxm ProSAT], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://pdbe.org/2yxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxm ProSAT], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Kishishita, S]]		[[Category: Kishishita, S]]

OCA at 09:18, 17 October 2018

2018-10-17T09:18:36Z

←Older revision		Revision as of 09:18, 17 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of I-set domain of human Myosin Binding ProteinC==		==Crystal structure of I-set domain of human Myosin Binding ProteinC==
	<StructureSection load='2yxm' size='340' side='right' caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>		<StructureSection load='2yxm' size='340' side='right' caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://pdbe.org/2yxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://pdbe.org/2yxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxm ProSAT], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:14, 7 February 2016

2016-02-07T07:14:03Z

←Older revision		Revision as of 07:14, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2yxm' size='340' side='right' caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>		<StructureSection load='2yxm' size='340' side='right' caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://pdbe.org/2yxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Kishishita, S]]		[[Category: Kishishita, S]]

OCA at 10:35, 20 January 2015

2015-01-20T10:35:45Z

←Older revision		Revision as of 10:35, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[http://omim.org/entry/614335 614335]]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>		[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[http://omim.org/entry/614335 614335]]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, L.]]	+	[[Category: Chen, L]]
-	[[Category: Kishishita, S.]]	+	[[Category: Kishishita, S]]
-	[[Category: Liu, Z.]]	+	[[Category: Liu, Z]]
-	[[Category: Murayama, K.]]	+	[[Category: Murayama, K]]
-	[[Category: Ohsawa, N.]]	+	[[Category: Ohsawa, N]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shirouzu, M.]]	+	[[Category: Shirouzu, M]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Wang, B.]]	+	[[Category: Wang, B]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell adhesionn]]		[[Category: Cell adhesionn]]
Line 41:		Line 41:
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]

OCA at 05:01, 2 October 2014

2014-10-02T05:01:28Z

←Older revision		Revision as of 05:01, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yxm\| PDB=2yxm \| SCENE= }}~~	+	==Crystal structure of I-set domain of human Myosin Binding ProteinC==
-	===Crystal structure of I-set domain of human Myosin Binding ProteinC===	+	<StructureSection load='2yxm' size='340' side='right' caption='[[2yxm]], [[Resolution\|resolution]] 1.51Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YXM FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[http://omim.org/entry/614335 614335]]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>	+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yxm RCSB], [http://www.ebi.ac.uk/pdbsum/2yxm PDBsum], [http://www.topsan.org/Proteins/RSGI/2yxm TOPSAN]</span></td></tr>
-		+	<table>
-	==Function==	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[http://omim.org/entry/614335 614335]]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.		[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[~~2yxm~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2YXM OCA~~].	+	Check<jmol>
-		+	<jmolCheckbox>
-	==~~Reference~~==	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxm_consurf.spt"</scriptWhenChecked>
-	<references ~~group="xtra"~~/><~~references~~/>	+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]

OCA at 16:28, 24 March 2013

2013-03-24T16:28:40Z

←Older revision		Revision as of 16:28, 24 March 2013
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-	[[Image:2yxm.png\|left\|200px]]
-
	{{STRUCTURE_2yxm\| PDB=2yxm \| SCENE= }}		{{STRUCTURE_2yxm\| PDB=2yxm \| SCENE= }}
-
	===Crystal structure of I-set domain of human Myosin Binding ProteinC===		===Crystal structure of I-set domain of human Myosin Binding ProteinC===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B) [MIM:[http://omim.org/entry/614335 614335]]. A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.<ref>PMID:20045868</ref> Note=Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis.<ref>PMID:22610851</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MYPC1_HUMAN MYPC1_HUMAN]] Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

	==About this Structure==		==About this Structure==
	[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].		[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]

OCA: Protected "2yxm" [edit=sysop:move=sysop]

2013-01-07T19:36:03Z

Protected "2yxm" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:36, 7 January 2013

OCA at 19:36, 7 January 2013

2013-01-07T19:36:00Z

←Older revision		Revision as of 19:36, 7 January 2013
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-	{{Seed}}
	[[Image:2yxm.png\|left\|200px]]		[[Image:2yxm.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2yxm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2yxm\| PDB=2yxm \| SCENE= }}		{{STRUCTURE_2yxm\| PDB=2yxm \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2YXM~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].	+	[[2yxm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
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	[[Category: Wang, B.]]		[[Category: Wang, B.]]
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
		+	[[Category: Cell adhesion]]
	[[Category: Cell adhesionn]]		[[Category: Cell adhesionn]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:46:27 2008''

OCA at 10:46, 16 November 2008

2008-11-16T10:46:29Z

←Older revision		Revision as of 10:46, 16 November 2008
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	2YXM is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].	+	2YXM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXM OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
	[[Category: Kishishita, S.]]		[[Category: Kishishita, S.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Sep 28 19~~:13:34 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:46:27 2008''