2yz7 - Revision history

OCA at 09:12, 25 October 2023

2023-10-25T09:12:55Z

←Older revision		Revision as of 09:12, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2yz7' size='340' side='right'caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='2yz7' size='340' side='right'caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [https://pdbe.org/2yz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [https://www.ebi.ac.uk/pdbsum/2yz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [~~http~~://pdbe.org/2yz7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yz7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz7 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D0VWQ0_ALCFA D0VWQ0_ALCFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hoque~~, M M~~]]	+	[[Category: Hoque MM]]
-	[[Category: Hossain~~, M T~~]]	+	[[Category: Hossain MT]]
-	[[Category: Juan~~, E C.M~~]]	+	[[Category: Juan ECM]]
-	[[Category: Shimizu, S]]	+	[[Category: Shimizu S]]
-	[[Category: Takenaka, A]]	+	[[Category: Takenaka A]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:54, 29 July 2020

2020-07-29T11:54:10Z

←Older revision		Revision as of 11:54, 29 July 2020
Line 1:		Line 1:

	==X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis==		==X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis==
-	<StructureSection load='2yz7' size='340' side='right' caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>	+	<StructureSection load='2yz7' size='340' side='right'caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://pdbe.org/2yz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://pdbe.org/2yz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	[[Category: 3-hydroxybutyrate dehydrogenase]]		[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]
		+	[[Category: Large Structures]]
	[[Category: Hoque, M M]]		[[Category: Hoque, M M]]
	[[Category: Hossain, M T]]		[[Category: Hossain, M T]]

OCA at 08:56, 17 October 2018

2018-10-17T08:56:54Z

←Older revision		Revision as of 08:56, 17 October 2018
Line 1:		Line 1:
		+
	==X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis==		==X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis==
	<StructureSection load='2yz7' size='340' side='right' caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='2yz7' size='340' side='right' caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://pdbe.org/2yz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://pdbe.org/2yz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yz7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yz7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:45, 9 February 2016

2016-02-09T05:45:34Z

←Older revision		Revision as of 05:45, 9 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://pdbe.org/2yz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yz7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2yz7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:50, 20 January 2015

2015-01-20T07:50:26Z

←Older revision		Revision as of 07:50, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: 3-hydroxybutyrate dehydrogenase]]		[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]
-	[[Category: Hoque, M M.]]	+	[[Category: Hoque, M M]]
-	[[Category: Hossain, M T.]]	+	[[Category: Hossain, M T]]
-	[[Category: Juan, E C.M.]]	+	[[Category: Juan, E C.M]]
-	[[Category: Shimizu, S.]]	+	[[Category: Shimizu, S]]
-	[[Category: Takenaka, A.]]	+	[[Category: Takenaka, A]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 04:07, 3 October 2014

2014-10-03T04:07:41Z

←Older revision		Revision as of 04:07, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2yz7~~\| ~~PDB~~=2yz7 \| ~~SCENE~~= }}	+	==X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis==
-	===X-~~ray analyses of~~ 3-hydroxybutyrate dehydrogenase from ~~Alcaligenes faecalis~~===	+	<StructureSection load='2yz7' size='340' side='right' caption='[[2yz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18453685}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2yz7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YZ7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hsd\|2hsd]], [[1wmb\|1wmb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxybutyrate_dehydrogenase 3-hydroxybutyrate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.30 1.1.1.30] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2yz7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yz7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	D-3-Hydroxybutyrate dehydrogenase, which catalyzes the reversible reaction between D-3-hydroxybutyrate and acetoacetate, has been classified into the short-chain dehydrogenase/reductase family and is a useful marker in the assay of diabetes mellitus and/or ketoacidosis. The enzyme from Alcaligenes faecalis was crystallized in the apo form and in the holo form with acetate as a substrate analogue. The crystal structures of both forms were determined at 2.2 angstroms resolution. The enzyme is a tetramer composed of four subunits assembled with noncrystallographic 222 point symmetry. Each subunit has two domains. The principal domain adopts the Rossmann fold essential for nucleotide binding, which is a common feature of the SDR family. NAD+ is bound in a large cleft in the domain. The pyrophosphate group of NAD+ is covered by the small additional domain, which is supported by two extended arms allowing domain movement. In the catalytic site, a water molecule is trapped by the catalytic Tyr155 and Ser142 residues in the vicinity of the bound NAD+ and acetate. The substrate analogue acetate is bound above the nicotinamide plane. A substrate (D-3-hydroxybutylate) bound model can reasonably be constructed by adding two C atoms into the void space between the water O atom and the methyl group of the acetate, suggesting a substrate-bound state before enzymatic reaction occurs. Based on these structural features, a reaction mechanism has been proposed.

-	~~==About this Structure==~~	+	The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family.,Hoque MM, Shimizu S, Hossain MT, Yamamoto T, Imamura S, Suzuki K, Tsunoda M, Amano H, Sekiguchi T, Takenaka A Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):496-505. Epub 2008, Apr 19. PMID:18453685<ref>PMID:18453685</ref>
-	~~[[2yz7]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2YZ7 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:018453685</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 3-hydroxybutyrate dehydrogenase]]		[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]

OCA at 06:17, 2 October 2013

2013-10-02T06:17:38Z

←Older revision		Revision as of 06:17, 2 October 2013
Line 1:		Line 1:
-	[[Image:2yz7.png\|left\|200px]]
-
	{{STRUCTURE_2yz7\| PDB=2yz7 \| SCENE= }}		{{STRUCTURE_2yz7\| PDB=2yz7 \| SCENE= }}
-
	===X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis===		===X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis===
-
	{{ABSTRACT_PUBMED_18453685}}		{{ABSTRACT_PUBMED_18453685}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018453685</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018453685</ref><references group="xtra"/><references/>
	[[Category: 3-hydroxybutyrate dehydrogenase]]		[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]

OCA: Protected "2yz7" [edit=sysop:move=sysop]

2013-01-07T20:42:01Z

Protected "2yz7" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:42, 7 January 2013

OCA at 20:41, 7 January 2013

2013-01-07T20:41:59Z

←Older revision		Revision as of 20:41, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2yz7.png\|left\|200px]]		[[Image:2yz7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2yz7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2yz7\| PDB=2yz7 \| SCENE= }}		{{STRUCTURE_2yz7\| PDB=2yz7 \| SCENE= }}

	===X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis===		===X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18453685}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18453685 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18453685}}		{{ABSTRACT_PUBMED_18453685}}

	==About this Structure==		==About this Structure==
-	~~2YZ7~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA].	+	[[2yz7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18453685~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018453685</ref><references group="xtra"/>
	[[Category: 3-hydroxybutyrate dehydrogenase]]		[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]
Line 32:		Line 20:
	[[Category: Takenaka, A.]]		[[Category: Takenaka, A.]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:56:51 2009''

OCA at 04:56, 17 February 2009

2009-02-17T04:56:52Z

←Older revision		Revision as of 04:56, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2YZ7 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA].	+	2YZ7 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Alcaligenes_faecalis Alcaligenes faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ7 OCA].

	==Reference==		==Reference==
-	The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family., Hoque MM, Shimizu S, Hossain MT, Yamamoto T, Imamura S, Suzuki K, Tsunoda M, Amano H, Sekiguchi T, Takenaka A, Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):496-505. Epub 2008, Apr 19. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18453685 18453685]~~	+	<ref group="xtra">PMID:18453685</ref><references group="xtra"/>
	[[Category: 3-hydroxybutyrate dehydrogenase]]		[[Category: 3-hydroxybutyrate dehydrogenase]]
	[[Category: Alcaligenes faecalis]]		[[Category: Alcaligenes faecalis]]
-	[[Category: Single protein]]
	[[Category: Hoque, M M.]]		[[Category: Hoque, M M.]]
	[[Category: Hossain, M T.]]		[[Category: Hossain, M T.]]
Line 34:		Line 33:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 10~~:36:~~04 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:56:51 2009''