2z66 - Revision history

OCA at 13:23, 1 November 2023

2023-11-01T13:23:15Z

←Older revision		Revision as of 13:23, 1 November 2023
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	<StructureSection load='2z66' size='340' side='right'caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2z66' size='340' side='right'caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bdellostoma_burgeri Bdellostoma~~ burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4~~</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [https://pdbe.org/2z66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [https://www.ebi.ac.uk/pdbsum/2z66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z66 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [https://pdbe.org/2z66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [https://www.ebi.ac.uk/pdbsum/2z66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z66 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN] Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:[https://omim.org/entry/611488 611488]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.<ref>PMID:20711192</ref> [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bdellostoma~~ burgeri]]	+	[[Category: Eptatretus burgeri]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kim~~, H M~~]]	+	[[Category: Kim HM]]
-	[[Category: Lee, J O]]	+	[[Category: Lee J-O]]
-	[[Category: Park~~, B S]]~~	+	[[Category: Park BS]]
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Leucine-rich repeat]]~~	+
-	~~[[Category: Lp]]~~	+
-	~~[[Category: Md-2]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Tlr4]]~~	+
-	~~[[Category: Toll-like receptor]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 10:46, 8 December 2021

2021-12-08T10:46:43Z

←Older revision		Revision as of 10:46, 8 December 2021
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	==Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61==		==Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61==
-	<StructureSection load='2z66' size='340' side='right' caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2z66' size='340' side='right'caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~FUL~~:~~BETA-L-FUCOSE~~'>~~FUL~~</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [~~http~~://pdbe.org/2z66 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2z66 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2z66 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [https://pdbe.org/2z66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [https://www.ebi.ac.uk/pdbsum/2z66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z66 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z66_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z66_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Toll-like ~~Receptors~~\|Toll-like ~~Receptors~~]]	+	*[[Toll-like Receptor 3D structures\|Toll-like Receptor 3D structures]]
-	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]	+	*[[Variable lymphocyte receptor 3D structures\|Variable lymphocyte receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bdellostoma burgeri]]		[[Category: Bdellostoma burgeri]]
		+	[[Category: Large Structures]]
	[[Category: Kim, H M]]		[[Category: Kim, H M]]
	[[Category: Lee, J O]]		[[Category: Lee, J O]]

OCA at 11:24, 7 October 2017

2017-10-07T11:24:58Z

←Older revision		Revision as of 11:24, 7 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61==		==Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61==
	<StructureSection load='2z66' size='340' side='right' caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2z66' size='340' side='right' caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~FUL~~:~~BETA~~-L-~~FUCOSE~~'>~~FUL~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://pdbe.org/2z66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://pdbe.org/2z66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z66 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 01:50, 10 February 2016

2016-02-10T01:50:44Z

←Older revision		Revision as of 01:50, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2z66' size='340' side='right' caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2z66' size='340' side='right' caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Eptatretus_burgeri Eptatretus~~ burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 ~~Eptatretus~~ burgeri])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://pdbe.org/2z66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z66 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2z66" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Eptatretus~~ burgeri]]	+	[[Category: Bdellostoma burgeri]]
	[[Category: Kim, H M]]		[[Category: Kim, H M]]
	[[Category: Lee, J O]]		[[Category: Lee, J O]]

OCA at 11:37, 20 January 2015

2015-01-20T11:37:07Z

←Older revision		Revision as of 11:37, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Eptatretus burgeri])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Eptatretus burgeri])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Eptatretus burgeri]]		[[Category: Eptatretus burgeri]]
-	[[Category: Kim, H M.]]	+	[[Category: Kim, H M]]
-	[[Category: Lee, J O.]]	+	[[Category: Lee, J O]]
-	[[Category: Park, B S.]]	+	[[Category: Park, B S]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Immune response]]		[[Category: Immune response]]

OCA at 05:34, 2 October 2014

2014-10-02T05:34:02Z

←Older revision		Revision as of 05:34, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2z66\| PDB=2z66 \| SCENE= }}~~	+	==Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61==
-	===Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61===	+	<StructureSection load='2z66' size='340' side='right' caption='[[2z66]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17803912}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Z66 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2z62\|2z62]], [[2z63\|2z63]], [[2z64\|2z64]], [[2z65\|2z65]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Eptatretus burgeri])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2z66 RCSB], [http://www.ebi.ac.uk/pdbsum/2z66 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z66_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its activity by binding to the TLR4-MD-2 complex. We determined the structure of the full-length ectodomain of the mouse TLR4 and MD-2 complex. We also produced a series of hybrids of human TLR4 and hagfish VLR and determined their structures with and without bound MD-2 and Eritoran. TLR4 is an atypical member of the LRR family and is composed of N-terminal, central, and C-terminal domains. The beta sheet of the central domain shows unusually small radii and large twist angles. MD-2 binds to the concave surface of the N-terminal and central domains. The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS.

-	~~==About this Structure==~~	+	Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.,Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO Cell. 2007 Sep 7;130(5):906-17. PMID:17803912<ref>PMID:17803912</ref>
-	~~[[2z66]] is a 4 chain~~ structure with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Eptatretus_burgeri Eptatretus burgeri]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2Z66 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Toll-like Receptors\|Toll-like Receptors]]		*[[Toll-like Receptors\|Toll-like Receptors]]
	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]		*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017803912</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Eptatretus burgeri]]		[[Category: Eptatretus burgeri]]
	[[Category: Kim, H M.]]		[[Category: Kim, H M.]]

OCA at 22:17, 24 March 2013

2013-03-24T22:17:08Z

←Older revision		Revision as of 22:17, 24 March 2013
Line 1:		Line 1:
-	[[Image:2z66.png\|left\|200px]]
-
	{{STRUCTURE_2z66\| PDB=2z66 \| SCENE= }}		{{STRUCTURE_2z66\| PDB=2z66 \| SCENE= }}
-
	===Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61===		===Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61===
-
	{{ABSTRACT_PUBMED_17803912}}		{{ABSTRACT_PUBMED_17803912}}

Line 15:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017803912</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017803912</ref><references group="xtra"/><references/>
	[[Category: Eptatretus burgeri]]		[[Category: Eptatretus burgeri]]
	[[Category: Kim, H M.]]		[[Category: Kim, H M.]]

OCA at 15:54, 20 October 2012

2012-10-20T15:54:07Z

←Older revision		Revision as of 15:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2z66]] is a 4 chain structure ~~of [[Toll-like Receptors]] and [[Variable lymphocyte receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri~~,_homo_sapiens~~ Eptatretus burgeri~~, homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA].	+	[[2z66]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA].

	==See Also==		==See Also==
Line 16:		Line 16:
	==Reference==		==Reference==
	<ref group="xtra">PMID:017803912</ref><references group="xtra"/>		<ref group="xtra">PMID:017803912</ref><references group="xtra"/>
-	[[Category: Eptatretus burgeri~~, homo sapiens~~]]	+	[[Category: Eptatretus burgeri]]
	[[Category: Kim, H M.]]		[[Category: Kim, H M.]]
	[[Category: Lee, J O.]]		[[Category: Lee, J O.]]

OCA: Protected "2z66" [edit=sysop:move=sysop]

2012-07-26T19:51:20Z

Protected "2z66" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:51, 26 July 2012

OCA at 19:51, 26 July 2012

2012-07-26T19:51:19Z

←Older revision		Revision as of 19:51, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2z66.png\|left\|200px]]		[[Image:2z66.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2z66", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2z66\| PDB=2z66 \| SCENE= }}		{{STRUCTURE_2z66\| PDB=2z66 \| SCENE= }}

	===Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61===		===Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17803912}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17803912 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17803912}}		{{ABSTRACT_PUBMED_17803912}}

	==About this Structure==		==About this Structure==
-	~~2Z66~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Eptatretus_burgeri,_homo_sapiens Eptatretus burgeri, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA].	+	[[2z66]] is a 4 chain structure of [[Toll-like Receptors]] and [[Variable lymphocyte receptor]] with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri,_homo_sapiens Eptatretus burgeri, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA].
		+
		+	==See Also==
		+	*[[Toll-like Receptors\|Toll-like Receptors]]
		+	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17803912~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017803912</ref><references group="xtra"/>
	[[Category: Eptatretus burgeri, homo sapiens]]		[[Category: Eptatretus burgeri, homo sapiens]]
	[[Category: Kim, H M.]]		[[Category: Kim, H M.]]
Line 40:		Line 32:
	[[Category: Toll-like receptor]]		[[Category: Toll-like receptor]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 09:50:12 2010''