2zcg - Revision history

OCA at 13:31, 1 November 2023

2023-11-01T13:31:49Z

←Older revision		Revision as of 13:31, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zcg' size='340' side='right'caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2zcg' size='340' side='right'caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[http://en.wikipedia.org/wiki/Orotidine~~-~~5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase]~~, ~~with EC number~~ [~~http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.223Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [~~http~~://pdbe.org/2zcg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zcg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [https://pdbe.org/2zcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [https://www.ebi.ac.uk/pdbsum/2zcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8T6J6_PLAFA Q8T6J6_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Orotidine-5'-phosphate decarboxylase]]~~	+	[[Category: Plasmodium falciparum]]
-	~~[[Category: Plafa~~]]	+	[[Category: Christopherson RI]]
-	[[Category: Christopherson~~, R I~~]]	+	[[Category: Guss JM]]
-	[[Category: Guss~~, J M~~]]	+	[[Category: Langley DB]]
-	[[Category: Langley~~, D B~~]]	+	[[Category: Shojaei M]]
-	[[Category: Shojaei, M]]	+
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Pyrimidine biosynthesis]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 12:02, 29 July 2020

2020-07-29T12:02:18Z

←Older revision		Revision as of 12:02, 29 July 2020
Line 1:		Line 1:

	==Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum==		==Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum==
-	<StructureSection load='2zcg' size='340' side='right' caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>	+	<StructureSection load='2zcg' size='340' side='right'caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://pdbe.org/2zcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://pdbe.org/2zcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Plafa]]		[[Category: Plafa]]

OCA at 07:20, 18 October 2018

2018-10-18T07:20:06Z

←Older revision		Revision as of 07:20, 18 October 2018
Line 1:		Line 1:
		+
	==Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum==		==Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum==
	<StructureSection load='2zcg' size='340' side='right' caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2zcg' size='340' side='right' caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://pdbe.org/2zcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://pdbe.org/2zcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:11, 7 February 2016

2016-02-07T05:11:55Z

←Older revision		Revision as of 05:11, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2zcg' size='340' side='right' caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2zcg' size='340' side='right' caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://pdbe.org/2zcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zcg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Christopherson, R I]]		[[Category: Christopherson, R I]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]

OCA at 09:33, 20 January 2015

2015-01-20T09:33:06Z

←Older revision		Revision as of 09:33, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Christopherson, R I.]]	+	[[Category: Christopherson, R I]]
-	[[Category: Guss, J M.]]	+	[[Category: Guss, J M]]
-	[[Category: Langley, D B.]]	+	[[Category: Langley, D B]]
-	[[Category: Shojaei, M.]]	+	[[Category: Shojaei, M]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 05:32, 2 October 2014

2014-10-02T05:32:30Z

←Older revision		Revision as of 05:32, 2 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2zcg.~~png\|left~~\|200px]]	+	==Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum==
		+	<StructureSection load='2zcg' size='340' side='right' caption='[[2zcg]], [[Resolution\|resolution]] 2.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcg RCSB], [http://www.ebi.ac.uk/pdbsum/2zcg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Orotidine 5'-monophosphate (OMP) decarboxylase from Plasmodium falciparum ( PfODCase, EC 4.1.1.23) has been overexpressed, purified, subjected to kinetic and biochemical analysis, and crystallized. The native enzyme is a homodimer with a subunit molecular mass of 38 kDa. The saturation curve for OMP as a substrate conformed to Michaelis-Menten kinetics with K m = 350 +/- 60 nM and V max = 2.70 +/- 0.10 micromol/min/mg protein. Inhibition patterns for nucleoside 5'-monophosphate analogues were linear competitive with respect to OMP with a decreasing potency of inhibition of PfODCase in the order: pyrazofurin 5'-monophosphate ( K i = 3.6 +/- 0.7 nM) > xanthosine 5'-monophosphate (XMP, K i = 4.4 +/- 0.7 nM) > 6-azauridine 5'-monophosphate (AzaUMP, K i = 12 +/- 3 nM) > allopurinol-3-riboside 5'-monophosphate ( K i = 240 +/- 20 nM). XMP is an approximately 150-fold more potent inhibitor of PfODCase compared with the human enzyme. The structure of PfODCase was solved in the absence of ligand and displays a classic TIM-barrel fold characteristic of the enzyme. Both the phosphate-binding loop and the betaalpha5-loop have conformational flexibility, which may be associated with substrate capture and product release along the reaction pathway.

-	~~{{STRUCTURE_2zcg\| PDB=2zcg \| SCENE= }}~~	+	Structure and Inhibition of Orotidine 5'-Monophosphate Decarboxylase from Plasmodium falciparum.,Langley DB, Shojaei M, Chan C, Lok HC, Mackay JP, Traut TW, Guss JM, Christopherson RI Biochemistry. 2008 Feb 28;. PMID:18303855<ref>PMID:18303855</ref>

-	~~===Structure and inhibition~~ of ~~orotidine 5'-phosphate decarboxylase from plasmodium falciparum===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18303855}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zcg]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018303855<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA: Protected "2zcg" [edit=sysop:move=sysop]

2013-01-07T18:52:38Z

Protected "2zcg" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:52, 7 January 2013

OCA at 18:52, 7 January 2013

2013-01-07T18:52:33Z

←Older revision		Revision as of 18:52, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zcg.png\|left\|200px]]		[[Image:2zcg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zcg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zcg\| PDB=2zcg \| SCENE= }}		{{STRUCTURE_2zcg\| PDB=2zcg \| SCENE= }}

	===Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum===		===Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18303855}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18303855 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18303855}}		{{ABSTRACT_PUBMED_18303855}}

	==About this Structure==		==About this Structure==
-	~~2ZCG~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA].	+	[[2zcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18303855~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018303855</ref><references group="xtra"/>
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
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	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:32:59 2009''

OCA at 09:33, 16 February 2009

2009-02-16T09:33:01Z

←Older revision		Revision as of 09:33, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZCG is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA].	+	2ZCG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCG OCA].

	==Reference==		==Reference==
-	Structure and Inhibition of Orotidine 5'-Monophosphate Decarboxylase from Plasmodium falciparum., Langley DB, Shojaei M, Chan C, Lok HC, Mackay JP, Traut TW, Guss JM, Christopherson RI, Biochemistry. 2008 Feb 28;. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18303855 18303855]~~	+	<ref group="xtra">PMID:18303855</ref><references group="xtra"/>
	[[Category: Orotidine-5'-phosphate decarboxylase]]		[[Category: Orotidine-5'-phosphate decarboxylase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Single protein]]
	[[Category: Christopherson, R I.]]		[[Category: Christopherson, R I.]]
	[[Category: Guss, J M.]]		[[Category: Guss, J M.]]
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	[[Category: Tim barrel]]		[[Category: Tim barrel]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 13~~:35:~~49 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:32:59 2009''

OCA at 10:35, 27 July 2008

2008-07-27T10:35:51Z

←Older revision		Revision as of 10:35, 27 July 2008
Line 1:		Line 1:
-	[[Image:2zcg.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2zcg.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2zcg\| PDB=2zcg \| SCENE= }}		{{STRUCTURE_2zcg\| PDB=2zcg \| SCENE= }}

-	~~'''~~Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum~~'''~~	+	===Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum===


-	~~==Overview==~~	+	<!--
-	~~Orotidine 5'-monophosphate (OMP) decarboxylase from Plasmodium falciparum ( PfODCase~~, ~~EC 4.1.1.23) has been overexpressed~~, ~~purified, subjected~~ to ~~kinetic and biochemical analysis, and crystallized. The native enzyme is a homodimer with a subunit molecular mass of 38 kDa. The saturation curve for OMP~~ as ~~a substrate conformed to Michaelis-Menten kinetics with K m = 350 +~~/~~- 60 nM and V max = 2.70 +~~/~~- 0~~.~~10 micromol/min/mg protein~~. Inhibition patterns for nucleoside 5'-monophosphate analogues were linear competitive with respect to OMP with a decreasing potency of inhibition of PfODCase in the order: pyrazofurin 5'-monophosphate ( K i = 3.6 +/- 0.7 nM) ~~> xanthosine 5'-monophosphate (XMP~~, ~~K i = 4.4 +/- 0.7 nM) > 6-azauridine 5'-monophosphate (AzaUMP, K i = 12 +/- 3 nM) > allopurinol-3-riboside 5'-monophosphate ( K i = 240 +/- 20 nM). XMP~~ is ~~an approximately 150-fold more potent inhibitor of PfODCase compared with~~ the ~~human enzyme~~. ~~The structure of PfODCase was solved in the absence of ligand and displays a classic TIM~~-~~barrel fold characteristic of the enzyme. Both the phosphate~~-~~binding loop and the betaalpha5-loop have conformational flexibility, which may be associated with substrate capture and product release along the reaction pathway.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18303855}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18303855 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18303855}}

	==About this Structure==		==About this Structure==
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	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 20~~:08:40 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:35:49 2008''