2zcu - Revision history

OCA at 13:57, 13 March 2024

2024-03-13T13:57:03Z

←Older revision		Revision as of 13:57, 13 March 2024
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	<StructureSection load='2zcu' size='340' side='right'caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2zcu' size='340' side='right'caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2zcv\|2zcv]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [https://pdbe.org/2zcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [https://www.ebi.ac.uk/pdbsum/2zcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [~~http~~://pdbe.org/2zcu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zcu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/QOR2_ECOLI QOR2_ECOLI]] Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.	+	[https://www.uniprot.org/uniprot/QOR2_ECOLI QOR2_ECOLI] Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcu ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Escherichia coli QOR2 [NAD(P)H-dependent quinone oxidoreductase; a ytfG gene product], which catalyzes two-electron reduction of methyl-1,4-benzoquinone, is a new type of quinone-reducing enzyme with distinct primary sequence and oligomeric conformation from previously known quinone oxidoreductases. The crystal structures of native QOR2 and the QOR2-NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) complex reveal that QOR2 consists of two domains (N-domain and C-domain) resembling those of NmrA, a negative transcriptional regulator that belongs to the short-chain dehydrogenase/reductase family. The N-domain, which adopts the Rossmann fold, provides a platform for NADPH binding, whereas the C-domain, which contains a hydrophobic pocket connected to the NADPH-binding site, appears to play important roles in substrate binding. Asn143 near the NADPH-binding site has been identified to be involved in substrate binding and catalysis from structural and mutational analyses. Moreover, compared with wild-type strain, the qor2-overexpressing strain shows growth retardation and remarkable decrease in several enzymes involved in carbon metabolism, suggesting that QOR2 could play some physiological roles in addition to quinone reduction.
-
-	Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli.,Kim IK, Yim HS, Kim MK, Kim DW, Kim YM, Cha SS, Kang SO J Mol Biol. 2008 May 30;379(2):372-84. Epub 2008 Apr 8. PMID:18455185<ref>PMID:18455185</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2zcu" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: NADPH:quinone reductase]]~~	+	[[Category: Cha SS]]
-	[[Category: Cha~~, S S~~]]	+	[[Category: Kang SO]]
-	[[Category: Kang~~, S O~~]]	+	[[Category: Kim DW]]
-	[[Category: Kim~~, D W~~]]	+	[[Category: Kim IK]]
-	[[Category: Kim~~, I K~~]]	+	[[Category: Kim MK]]
-	[[Category: Kim~~, M K~~]]	+	[[Category: Kim YM]]
-	[[Category: Kim~~, Y M~~]]	+	[[Category: Yim HS]]
-	[[Category: Yim~~, H S]]~~	+
-	~~[[Category: Alpha-beta sandwich]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 12:02, 29 July 2020

2020-07-29T12:02:36Z

←Older revision		Revision as of 12:02, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli==		==Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli==
-	<StructureSection load='2zcu' size='340' side='right' caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2zcu' size='340' side='right'caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://pdbe.org/2zcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://pdbe.org/2zcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
	[[Category: NADPH:quinone reductase]]		[[Category: NADPH:quinone reductase]]
	[[Category: Cha, S S]]		[[Category: Cha, S S]]

OCA at 07:07, 18 October 2018

2018-10-18T07:07:53Z

←Older revision		Revision as of 07:07, 18 October 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:44, 5 August 2016

2016-08-05T01:44:50Z

←Older revision		Revision as of 01:44, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli==		==Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli==
	<StructureSection load='2zcu' size='340' side='right' caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2zcu' size='340' side='right' caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://pdbe.org/2zcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zcu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~YTFG_ECOLI YTFG_ECOLI~~]] Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.	+	[[http://www.uniprot.org/uniprot/QOR2_ECOLI QOR2_ECOLI]] Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zcu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zcu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:48, 25 December 2014

2014-12-25T14:48:25Z

←Older revision		Revision as of 14:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YTFG_ECOLI YTFG_ECOLI]] Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: NADPH:quinone reductase]]		[[Category: NADPH:quinone reductase]]
-	[[Category: Cha, S S.]]	+	[[Category: Cha, S S]]
-	[[Category: Kang, S O.]]	+	[[Category: Kang, S O]]
-	[[Category: Kim, D W.]]	+	[[Category: Kim, D W]]
-	[[Category: Kim, I K.]]	+	[[Category: Kim, I K]]
-	[[Category: Kim, M K.]]	+	[[Category: Kim, M K]]
-	[[Category: Kim, Y M.]]	+	[[Category: Kim, Y M]]
-	[[Category: Yim, H S.]]	+	[[Category: Yim, H S]]
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 05:26, 2 October 2014

2014-10-02T05:26:17Z

←Older revision		Revision as of 05:26, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zcu.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli==
		+	<StructureSection load='2zcu' size='340' side='right' caption='[[2zcu]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZCU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zcv\|2zcv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH:quinone_reductase NADPH:quinone reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.5.5 1.6.5.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zcu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zcu RCSB], [http://www.ebi.ac.uk/pdbsum/2zcu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zcu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Escherichia coli QOR2 [NAD(P)H-dependent quinone oxidoreductase; a ytfG gene product], which catalyzes two-electron reduction of methyl-1,4-benzoquinone, is a new type of quinone-reducing enzyme with distinct primary sequence and oligomeric conformation from previously known quinone oxidoreductases. The crystal structures of native QOR2 and the QOR2-NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) complex reveal that QOR2 consists of two domains (N-domain and C-domain) resembling those of NmrA, a negative transcriptional regulator that belongs to the short-chain dehydrogenase/reductase family. The N-domain, which adopts the Rossmann fold, provides a platform for NADPH binding, whereas the C-domain, which contains a hydrophobic pocket connected to the NADPH-binding site, appears to play important roles in substrate binding. Asn143 near the NADPH-binding site has been identified to be involved in substrate binding and catalysis from structural and mutational analyses. Moreover, compared with wild-type strain, the qor2-overexpressing strain shows growth retardation and remarkable decrease in several enzymes involved in carbon metabolism, suggesting that QOR2 could play some physiological roles in addition to quinone reduction.

-	~~{{STRUCTURE_2zcu\| PDB=2zcu \| SCENE= }}~~	+	Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli.,Kim IK, Yim HS, Kim MK, Kim DW, Kim YM, Cha SS, Kang SO J Mol Biol. 2008 May 30;379(2):372-84. Epub 2008 Apr 8. PMID:18455185<ref>PMID:18455185</ref>

-	~~===Crystal structure of~~ a ~~new type~~ of ~~NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18455185}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zcu]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018455185<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: NADPH:quinone reductase]]		[[Category: NADPH:quinone reductase]]

OCA: Protected "2zcu" [edit=sysop:move=sysop]

2013-01-07T22:54:53Z

Protected "2zcu" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:54, 7 January 2013

OCA at 22:54, 7 January 2013

2013-01-07T22:54:50Z

←Older revision		Revision as of 22:54, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zcu.png\|left\|200px]]		[[Image:2zcu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zcu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zcu\| PDB=2zcu \| SCENE= }}		{{STRUCTURE_2zcu\| PDB=2zcu \| SCENE= }}

	===Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli===		===Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18455185}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18455185 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18455185}}		{{ABSTRACT_PUBMED_18455185}}

	==About this Structure==		==About this Structure==
-	~~2ZCU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA].	+	[[2zcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18455185~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018455185</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: NADPH:quinone reductase]]		[[Category: NADPH:quinone reductase]]
Line 35:		Line 23:
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:06:34 2009''

OCA at 17:06, 17 February 2009

2009-02-17T17:06:35Z

←Older revision		Revision as of 17:06, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ZCU is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA].	+	2ZCU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCU OCA].

	==Reference==		==Reference==
-	Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli., Kim IK, Yim HS, Kim MK, Kim DW, Kim YM, Cha SS, Kang SO, J Mol Biol. 2008 May 30;379(2):372-84. Epub 2008 Apr 8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18455185 18455185]~~	+	<ref group="xtra">PMID:18455185</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: NADPH:quinone reductase]]		[[Category: NADPH:quinone reductase]]
-	[[Category: Single protein]]
	[[Category: Cha, S S.]]		[[Category: Cha, S S.]]
	[[Category: Kang, S O.]]		[[Category: Kang, S O.]]
Line 37:		Line 36:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 03~~:13:~~42 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:06:34 2009''

OCA at 00:13, 29 July 2008

2008-07-29T00:13:50Z

←Older revision		Revision as of 00:13, 29 July 2008
Line 1:		Line 1:
-	[[Image:2zcu.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2zcu.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2zcu\| PDB=2zcu \| SCENE= }}		{{STRUCTURE_2zcu\| PDB=2zcu \| SCENE= }}

-	~~'''~~Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli~~'''~~	+	===Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from escherichia coli===


-	~~==Overview==~~	+	<!--
-	~~Escherichia coli QOR2 [NAD(P)H~~-~~dependent quinone oxidoreductase; a ytfG gene product], which catalyzes two~~-~~electron reduction of methyl-1~~,~~4-benzoquinone~~, ~~is a new type of quinone-reducing enzyme with distinct primary sequence and oligomeric conformation from previously known quinone oxidoreductases. The crystal structures of native QOR2 and~~ the QOR2-NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) complex reveal that QOR2 consists of two domains (N-domain and C-domain) resembling those of NmrA, a negative transcriptional regulator that belongs to the ~~short-chain dehydrogenase~~/~~reductase family~~. ~~The N-domain~~, ~~which adopts~~ the Rossmann fold, provides a platform for NADPH binding, whereas the C-domain, which contains a hydrophobic pocket connected to the NADPH-binding site, appears to play important roles in substrate binding. ~~Asn143 near the NADPH~~-~~binding site has been identified to be involved in substrate binding and catalysis from structural and mutational analyses. Moreover, compared with wild~~-type strain, the qor2-overexpressing strain shows growth retardation and remarkable decrease in several enzymes involved in carbon metabolism, suggesting that QOR2 could play some physiological roles in addition to quinone reduction.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18455185}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18455185 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18455185}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 28 09~~:18:07 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:13:42 2008''