2zi8 - Revision history

OCA at 13:36, 1 November 2023

2023-11-01T13:36:37Z

←Older revision		Revision as of 13:36, 1 November 2023
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	<StructureSection load='2zi8' size='340' side='right'caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zi8' size='340' side='right'caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4~~-~~DIHYDROXY-9,10-SECOANDROSTA-1(10)~~,2~~,4-TRIENE-9,17-DIONE'>SDT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2zf1\|2zf1]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Biphenyl-2,~~3~~-diol_1~~,2-~~dioxygenase Biphenyl~~-2,3-~~diol~~ 1,2-~~dioxygenase]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [https://pdbe.org/2zi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [https://pdbe.org/2zi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~HSAC_MYCTO HSAC_MYCTO]~~] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).	+	[https://www.uniprot.org/uniprot/HSAC_MYCTU HSAC_MYCTU] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).<ref>PMID:17264217</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Angelo, I D]]
-	[[Category: Eltis, L D]]
-	[[Category: Strynadka, N]]
-	[[Category: Yam, K C]]
-	[[Category: Aromatic hydrocarbons catabolism]]
-	[[Category: Dhsa]]
-	[[Category: Extradiol dioxygenase]]
-	[[Category: Hsac]]
-	[[Category: Iron]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: D'Angelo I]]
		+	[[Category: Eltis LD]]
		+	[[Category: Strynadka N]]
		+	[[Category: Yam KC]]

OCA at 10:39, 12 January 2022

2022-01-12T10:39:27Z

←Older revision		Revision as of 10:39, 12 January 2022
Line 3:		Line 3:
	<StructureSection load='2zi8' size='340' side='right'caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zi8' size='340' side='right'caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zf1\|2zf1]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [~~http~~://pdbe.org/2zi8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [https://pdbe.org/2zi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [https://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HSAC_MYCTO HSAC_MYCTO]] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).	+	[[https://www.uniprot.org/uniprot/HSAC_MYCTO HSAC_MYCTO]] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:06, 8 April 2020

2020-04-08T07:06:40Z

←Older revision		Revision as of 07:06, 8 April 2020
Line 1:		Line 1:

	==Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)==		==Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)==
-	<StructureSection load='2zi8' size='340' side='right' caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2zi8' size='340' side='right'caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://pdbe.org/2zi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://pdbe.org/2zi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]		[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
		+	[[Category: Large Structures]]
	[[Category: Angelo, I D]]		[[Category: Angelo, I D]]
	[[Category: Eltis, L D]]		[[Category: Eltis, L D]]

OCA at 07:22, 18 October 2018

2018-10-18T07:22:37Z

←Older revision		Revision as of 07:22, 18 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)==		==Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)==
	<StructureSection load='2zi8' size='340' side='right' caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zi8' size='340' side='right' caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://pdbe.org/2zi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://pdbe.org/2zi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2zi8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2zi8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:51, 10 February 2016

2016-02-10T01:51:49Z

←Older revision		Revision as of 01:51, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2zi8' size='340' side='right' caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2zi8' size='340' side='right' caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://pdbe.org/2zi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~P96850_MYCTU P96850_MYCTU~~]] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA~~) (By similarity~~).	+	[[http://www.uniprot.org/uniprot/HSAC_MYCTO HSAC_MYCTO]] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zi8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zi8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]		[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Angelo, I D]]		[[Category: Angelo, I D]]
	[[Category: Eltis, L D]]		[[Category: Eltis, L D]]
Line 43:		Line 43:
	[[Category: Hsac]]		[[Category: Hsac]]
	[[Category: Iron]]		[[Category: Iron]]
		+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 10:58, 25 December 2014

2014-12-25T10:58:26Z

←Older revision		Revision as of 10:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/P96850_MYCTU P96850_MYCTU]] Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]		[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Angelo, I D.]]	+	[[Category: Angelo, I D]]
-	[[Category: Eltis, L D.]]	+	[[Category: Eltis, L D]]
-	[[Category: Strynadka, N.]]	+	[[Category: Strynadka, N]]
-	[[Category: Yam, K C.]]	+	[[Category: Yam, K C]]
	[[Category: Aromatic hydrocarbons catabolism]]		[[Category: Aromatic hydrocarbons catabolism]]
	[[Category: Dhsa]]		[[Category: Dhsa]]
Line 41:		Line 43:
	[[Category: Hsac]]		[[Category: Hsac]]
	[[Category: Iron]]		[[Category: Iron]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 05:34, 2 October 2014

2014-10-02T05:34:25Z

←Older revision		Revision as of 05:34, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zi8.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)==
		+	<StructureSection load='2zi8' size='340' side='right' caption='[[2zi8]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZI8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SDT:3,4-DIHYDROXY-9,10-SECOANDROSTA-1(10),2,4-TRIENE-9,17-DIONE'>SDT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zf1\|2zf1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biphenyl-2,3-diol_1,2-dioxygenase Biphenyl-2,3-diol 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.39 1.13.11.39] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zi8 RCSB], [http://www.ebi.ac.uk/pdbsum/2zi8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zi/2zi8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic pathway implicated in pathogenesis. This pathway includes an iron-dependent extradiol dioxygenase, HsaC, that cleaves catechols. Immuno-compromised mice infected with a DeltahsaC mutant of M. tuberculosis H37Rv survived 50% longer than mice infected with the wild-type strain. In guinea pigs, the mutant disseminated more slowly to the spleen, persisted less successfully in the lung, and caused little pathology. These data establish that, while cholesterol metabolism by M. tuberculosis appears to be most important during the chronic stage of infection, it begins much earlier and may contribute to the pathogen's dissemination within the host. Purified HsaC efficiently cleaved the catecholic cholesterol metabolite, DHSA (3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione; k(cat)/K(m) = 14.4+/-0.5 microM(-1) s(-1)), and was inactivated by a halogenated substrate analogue (partition coefficient<50). Remarkably, cholesterol caused loss of viability in the DeltahsaC mutant, consistent with catechol toxicity. Structures of HsaC:DHSA binary complexes at 2.1 A revealed two catechol-binding modes: bidentate binding to the active site iron, as has been reported in similar enzymes, and, unexpectedly, monodentate binding. The position of the bicyclo-alkanone moiety of DHSA was very similar in the two binding modes, suggesting that this interaction is a determinant in the initial substrate-binding event. These data provide insights into the binding of catechols by extradiol dioxygenases and facilitate inhibitor design.

-	~~{{STRUCTURE_2zi8\| PDB=2zi8 \| SCENE= }}~~	+	Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.,Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD PLoS Pathog. 2009 Mar;5(3):e1000344. Epub 2009 Mar 20. PMID:19300498<ref>PMID:19300498</ref>

-	~~===Crystal structure~~ of the ~~HsaC extradiol dioxygenase from M~~. ~~tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19300498}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2zi8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019300498<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]		[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "2zi8" [edit=sysop:move=sysop]

2013-01-07T23:06:58Z

Protected "2zi8" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:06, 7 January 2013

OCA at 23:06, 7 January 2013

2013-01-07T23:06:55Z

←Older revision		Revision as of 23:06, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2zi8.png\|left\|200px]]		[[Image:2zi8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zi8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zi8\| PDB=2zi8 \| SCENE= }}		{{STRUCTURE_2zi8\| PDB=2zi8 \| SCENE= }}

	===Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)===		===Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19300498}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19300498 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19300498}}		{{ABSTRACT_PUBMED_19300498}}

	==About this Structure==		==About this Structure==
-	~~2ZI8~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA].	+	[[2zi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19300498~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019300498</ref><references group="xtra"/>
	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]		[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 37:		Line 25:
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:05:38 2010''

OCA at 07:05, 3 February 2010

2010-02-03T07:05:39Z

←Older revision		Revision as of 07:05, 3 February 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2zi8.~~jpg~~\|left\|200px]]	+	[[Image:2zi8.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)===		===Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19300498}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19300498 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19300498}}

	==About this Structure==		==About this Structure==
-	2ZI8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA].	+	2ZI8 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZI8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19300498</ref><references group="xtra"/>
	[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]		[[Category: Biphenyl-2,3-diol 1,2-dioxygenase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Angelo, I D.]]		[[Category: Angelo, I D.]]
-	[[Category: Eltis, L.]]	+	[[Category: Eltis, L D.]]
	[[Category: Strynadka, N.]]		[[Category: Strynadka, N.]]
-	[[Category: Yam, K.]]	+	[[Category: Yam, K C.]]
	[[Category: Aromatic hydrocarbons catabolism]]		[[Category: Aromatic hydrocarbons catabolism]]
	[[Category: Dhsa]]		[[Category: Dhsa]]
Line 29:		Line 38:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:21:~~23 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:05:38 2010''