2zsb - Revision history

OCA at 13:52, 1 November 2023

2023-11-01T13:52:13Z

←Older revision		Revision as of 13:52, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zsb' size='340' side='right'caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2zsb' size='340' side='right'caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>coaA (Rv1092c) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [https://pdbe.org/2zsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [https://www.ebi.ac.uk/pdbsum/2zsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [https://pdbe.org/2zsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [https://www.ebi.ac.uk/pdbsum/2zsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/COAA_MYCTU COAA_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pantothenate kinase~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Chetnani, B]]	+	[[Category: Chetnani B]]
-	[[Category: Das, S]]	+	[[Category: Das S]]
-	[[Category: Kumar, P]]	+	[[Category: Kumar P]]
-	[[Category: Surolia, A]]	+	[[Category: Surolia A]]
-	[[Category: Vijayan, M]]	+	[[Category: Vijayan M]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Coa biosynthesis]]~~	+
-	~~[[Category: Coenzyme a biosynthesis]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide binding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 17:36, 15 December 2021

2021-12-15T17:36:25Z

←Older revision		Revision as of 17:36, 15 December 2021
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	==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand==		==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand==
-	<StructureSection load='2zsb' size='340' side='right' caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='2zsb' size='340' side='right'caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [~~http~~://pdbe.org/2zsb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zsb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [https://pdbe.org/2zsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [https://www.ebi.ac.uk/pdbsum/2zsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Pantothenate kinase\|Pantothenate kinase]]	+	*[[Pantothenate kinase 3D structures\|Pantothenate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Chetnani, B]]		[[Category: Chetnani, B]]

OCA at 07:18, 18 October 2018

2018-10-18T07:18:43Z

←Older revision		Revision as of 07:18, 18 October 2018
Line 1:		Line 1:
		+
	==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand==		==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand==
	<StructureSection load='2zsb' size='340' side='right' caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2zsb' size='340' side='right' caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://pdbe.org/2zsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://pdbe.org/2zsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zsb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/2zsb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/2zsb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:49, 9 February 2016

2016-02-09T11:49:30Z

←Older revision		Revision as of 11:49, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2zsb' size='340' side='right' caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2zsb' size='340' side='right' caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://pdbe.org/2zsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zsb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zsb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Chetnani, B]]		[[Category: Chetnani, B]]

OCA at 11:33, 20 January 2015

2015-01-20T11:33:52Z

←Older revision		Revision as of 11:33, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
-	[[Category: Chetnani, B.]]	+	[[Category: Chetnani, B]]
-	[[Category: Das, S.]]	+	[[Category: Das, S]]
-	[[Category: Kumar, P.]]	+	[[Category: Kumar, P]]
-	[[Category: Surolia, A.]]	+	[[Category: Surolia, A]]
-	[[Category: Vijayan, M.]]	+	[[Category: Vijayan, M]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Coa biosynthesis]]		[[Category: Coa biosynthesis]]

OCA at 05:31, 2 October 2014

2014-10-02T05:31:32Z

←Older revision		Revision as of 05:31, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2zsb.~~png~~\|~~left~~\|200px]]	+	==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand==
		+	<StructureSection load='2zsb' size='340' side='right' caption='[[2zsb]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zsb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZSB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gev\|2gev]], [[2geu\|2geu]], [[2get\|2get]], [[2ges\|2ges]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA (Rv1092c) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zsb RCSB], [http://www.ebi.ac.uk/pdbsum/2zsb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/2zsb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structures of complexes of Mycobacterium tuberculosis pantothenate kinase with the following ligands have been determined: (i) citrate; (ii) the nonhydrolysable ATP analogue AMPPCP and pantothenate (the initiation complex); (iii) ADP and phosphopantothenate resulting from phosphorylation of pantothenate by ATP in the crystal (the end complex); (iv) ATP and ADP, each with half occupancy, resulting from a quick soak of crystals in ATP (the intermediate complex); (v) CoA; (vi) ADP prepared by soaking and cocrystallization, which turned out to have identical structures, and (vii) ADP and pantothenate. Solution studies on CoA binding and catalytic activity have also been carried out. Unlike in the case of the homologous Escherichia coli enzyme, AMPPCP and ADP occupy different, though overlapping, locations in the respective complexes; the same is true of pantothenate in the initiation complex and phosphopantothenate in the end complex. The binding site of MtPanK is substantially preformed, while that of EcPanK exhibits considerable plasticity. The difference in the behaviour of the E. coli and M. tuberculosis enzymes could be explained in terms of changes in local structure resulting from substitutions. It is unusual for two homologous enzymes to exhibit such striking differences in action. Therefore, the results have to be treated with caution. However, the changes in the locations of ligands exhibited by M. tuberculosis pantothenate kinase are remarkable and novel.

-	~~{{STRUCTURE_2zsb\| PDB=2zsb \| SCENE= }}~~	+	Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action.,Chetnani B, Das S, Kumar P, Surolia A, Vijayan M Acta Crystallogr D Biol Crystallogr. 2009 Apr;65(Pt 4):312-25. Epub 2009, Mar 19. PMID:19307712<ref>PMID:19307712</ref>

-	~~===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP~~, ~~obtained through soaking~~ of ~~native enzyme crystals with~~ the ~~ligand===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19307712}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2zsb]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA].~~	+

	==See Also==		==See Also==
	*[[Pantothenate kinase\|Pantothenate kinase]]		*[[Pantothenate kinase\|Pantothenate kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019307712<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]

OCA: Protected "2zsb" [edit=sysop:move=sysop]

2013-01-07T23:04:05Z

Protected "2zsb" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:04, 7 January 2013

OCA at 23:04, 7 January 2013

2013-01-07T23:04:02Z

←Older revision		Revision as of 23:04, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zsb.png\|left\|200px]]
-	[[Image:2zsb.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zsb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zsb\| PDB=2zsb \| SCENE= }}		{{STRUCTURE_2zsb\| PDB=2zsb \| SCENE= }}

	===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand===		===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19307712}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19307712 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19307712}}		{{ABSTRACT_PUBMED_19307712}}

	==About this Structure==		==About this Structure==
-	~~2ZSB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA].	+	[[2zsb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA].
		+
		+	==See Also==
		+	*[[Pantothenate kinase\|Pantothenate kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19307712~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019307712</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
Line 34:		Line 25:
	[[Category: Coa biosynthesis]]		[[Category: Coa biosynthesis]]
	[[Category: Coenzyme a biosynthesis]]		[[Category: Coenzyme a biosynthesis]]
-	[[Category: Cytoplasm]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nucleotide binding]]		[[Category: Nucleotide binding]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:32:50 2009''

OCA at 17:32, 22 July 2009

2009-07-22T17:32:52Z

←Older revision		Revision as of 17:32, 22 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2zsb.jpg\|left\|200px]]

-	The ~~entry 2zsb~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2zsb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2zsb\| PDB=2zsb \| SCENE= }}

-	~~Authors: Chetnani~~, ~~B., Das, S., Kumar, P., Surolia, A., Vijayan, M.~~	+	===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand===

-	Description: Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 24 10~~:11:~~02 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19307712}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19307712 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19307712}}
		+
		+	==About this Structure==
		+	2ZSB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZSB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19307712</ref><references group="xtra"/>
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Pantothenate kinase]]
		+	[[Category: Chetnani, B.]]
		+	[[Category: Das, S.]]
		+	[[Category: Kumar, P.]]
		+	[[Category: Surolia, A.]]
		+	[[Category: Vijayan, M.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Coa biosynthesis]]
		+	[[Category: Coenzyme a biosynthesis]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Homodimer]]
		+	[[Category: Kinase]]
		+	[[Category: Nucleotide binding]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:32:50 2009''

OCA at 07:11, 24 September 2008

2008-09-24T07:11:02Z

←Older revision		Revision as of 07:11, 24 September 2008
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2zsb is ON HOLD	+	The entry 2zsb is ON HOLD until Paper Publication

	Authors: Chetnani, B., Das, S., Kumar, P., Surolia, A., Vijayan, M.		Authors: Chetnani, B., Das, S., Kumar, P., Surolia, A., Vijayan, M.
Line 7:		Line 7:
	Description: Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand		Description: Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~17 13~~:34:59 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:11:02 2008''