2zyg - Revision history

OCA at 14:02, 1 November 2023

2023-11-01T14:02:31Z

←Older revision		Revision as of 14:02, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='2zyg' size='340' side='right'caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2zyg' size='340' side='right'caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2zyd\|2zyd]], [[2zya\|2zya]], [[3fwn\|3fwn]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">gnd ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [https://pdbe.org/2zyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [https://www.ebi.ac.uk/pdbsum/2zyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [https://pdbe.org/2zyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [https://www.ebi.ac.uk/pdbsum/2zyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~Q762L5_KLEPN Q762L5_KLEPN]~~] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH ~~(By similarity)~~.[PIRNR:PIRNR000109]	+	[https://www.uniprot.org/uniprot/A0A0J9WZ66_KLEPN A0A0J9WZ66_KLEPN] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.[ARBA:ARBA00002526][PIRNR:PIRNR000109]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y Y]]	+	[[Category: Chen Y-Y]]
-	[[Category: Ko, T P]]	+	[[Category: Ko T-P]]
-	[[Category: Lin, C H]]	+	[[Category: Lin C-H]]
-	[[Category: Lo, L P]]	+	[[Category: Lo L-P]]
-	[[Category: Wang~~, A H.~~J]]	+	[[Category: Wang AH-J]]
-	~~[[Category: 6-phosphogluconate]]~~	+
-	~~[[Category: 6-phosphogluconate dehydrogenase]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pentose phosphate pathway~~]]	+

OCA at 07:21, 10 November 2021

2021-11-10T07:21:04Z

←Older revision		Revision as of 07:21, 10 November 2021
Line 1:		Line 1:

	==Apo-form of dimeric 6-phosphogluconate dehydrogenase==		==Apo-form of dimeric 6-phosphogluconate dehydrogenase==
-	<StructureSection load='2zyg' size='340' side='right' caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2zyg' size='340' side='right'caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zyd\|2zyd]], [[2zya\|2zya]], [[3fwn\|3fwn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zyd\|2zyd]], [[2zya\|2zya]], [[3fwn\|3fwn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [~~http~~://pdbe.org/2zyg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2zyg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [https://pdbe.org/2zyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [https://www.ebi.ac.uk/pdbsum/2zyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q762L5_KLEPN Q762L5_KLEPN]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).[PIRNR:PIRNR000109]	+	[[https://www.uniprot.org/uniprot/Q762L5_KLEPN Q762L5_KLEPN]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).[PIRNR:PIRNR000109]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/2zyg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/2zyg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2zyg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zyg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[6-phosphogluconate dehydrogenase 3D structures\|6-phosphogluconate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, Y Y]]		[[Category: Chen, Y Y]]
	[[Category: Ko, T P]]		[[Category: Ko, T P]]

OCA at 08:44, 12 October 2017

2017-10-12T08:44:48Z

←Older revision		Revision as of 08:44, 12 October 2017
Line 1:		Line 1:
		+
	==Apo-form of dimeric 6-phosphogluconate dehydrogenase==		==Apo-form of dimeric 6-phosphogluconate dehydrogenase==
	<StructureSection load='2zyg' size='340' side='right' caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2zyg' size='340' side='right' caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://pdbe.org/2zyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://pdbe.org/2zyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2zyg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2zyg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:36, 8 February 2016

2016-02-08T02:36:49Z

←Older revision		Revision as of 02:36, 8 February 2016
Line 6:		Line 6:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://pdbe.org/2zyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zyg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2zyg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 19:57, 24 December 2014

2014-12-24T19:57:12Z

←Older revision		Revision as of 19:57, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zyd\|2zyd]], [[2zya\|2zya]], [[3fwn\|3fwn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zyd\|2zyd]], [[2zya\|2zya]], [[3fwn\|3fwn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q762L5_KLEPN Q762L5_KLEPN]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).[PIRNR:PIRNR000109]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chen, Y Y.]]	+	[[Category: Chen, Y Y]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Lin, C H.]]	+	[[Category: Lin, C H]]
-	[[Category: Lo, L P.]]	+	[[Category: Lo, L P]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: 6-phosphogluconate]]		[[Category: 6-phosphogluconate]]
	[[Category: 6-phosphogluconate dehydrogenase]]		[[Category: 6-phosphogluconate dehydrogenase]]

OCA at 05:24, 3 October 2014

2014-10-03T05:24:29Z

←Older revision		Revision as of 05:24, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2zyg~~\| ~~PDB~~=2zyg \| ~~SCENE~~= }}	+	==Apo-form of dimeric 6-phosphogluconate dehydrogenase==
-	===~~Apo~~-~~form~~ of ~~dimeric 6~~-~~phosphogluconate dehydrogenase~~===	+	<StructureSection load='2zyg' size='340' side='right' caption='[[2zyg]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19686854}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2zyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZYG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zyd\|2zyd]], [[2zya\|2zya]], [[3fwn\|3fwn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zyg RCSB], [http://www.ebi.ac.uk/pdbsum/2zyg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/2zyg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	6-Phosphogluconate dehydrogenase (6PGDH), the third enzyme of the pentose phosphate pathway, catalyzes the oxidative decarboxylation of 6-phosphogluconate, making ribulose 5-phosphate, along with the reduction of NADP(+) to NADPH and the release of CO(2). Here, we report the first apo-form crystal structure of the pathogenic Klebsiella pneumoniae 6PGDH (Kp6PGDH) and the structures of the highly homologous Escherichia coli K12 6PGDH (Ec6PGDH) complexed with substrate, substrate/NADPH and glucose at high resolution. The binding of NADPH to one subunit of the homodimeric structure triggered a 10 degrees rotation and resulting in a 7A movement of the coenzyme-binding domain. The coenzyme was thus trapped in a closed enzyme conformation, in contrast to the open conformation of the neighboring subunit. Comparison of our Ec/Kp6PGDH structures with those of other species illustrated how the domain conformation can be affected upon binding of the coenzyme, which in turn gives rise to concomitant movements of two important NADP(+)-interacting amino acids, M14 and N102. We propose that the catalysis follows an ordered binding mechanism with alternating conformational changes in the corresponding subunits, involving several related amino acid residues.

-	~~==Function==~~	+	Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism.,Chen YY, Ko TP, Chen WH, Lo LP, Lin CH, Wang AH J Struct Biol. 2010 Jan;169(1):25-35. Epub 2009 Aug 15. PMID:19686854<ref>PMID:19686854</ref>
-	~~[[http:/~~/~~www.uniprot.org/uniprot/Q762L5_KLEPN Q762L5_KLEPN]] Catalyzes the oxidative decarboxylation~~ of 6-phosphogluconate ~~to ribulose 5-phosphate~~ and ~~CO(2)~~, ~~with concomitant reduction of NADP to NADPH~~ (~~By similarity~~).~~[PIRNR~~:~~PIRNR000109]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2zyg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]		*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019686854</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Chen, Y Y.]]		[[Category: Chen, Y Y.]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]

OCA at 06:27, 22 January 2014

2014-01-22T06:27:51Z

←Older revision		Revision as of 06:27, 22 January 2014
Line 1:		Line 1:
-	[[Image:2zyg.png\|left\|200px]]
-
	{{STRUCTURE_2zyg\| PDB=2zyg \| SCENE= }}		{{STRUCTURE_2zyg\| PDB=2zyg \| SCENE= }}
-
	===Apo-form of dimeric 6-phosphogluconate dehydrogenase===		===Apo-form of dimeric 6-phosphogluconate dehydrogenase===
		+	{{ABSTRACT_PUBMED_19686854}}

-	~~{{ABSTRACT_PUBMED_19686854}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q762L5_KLEPN Q762L5_KLEPN]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).[PIRNR:PIRNR000109]

	==About this Structure==		==About this Structure==
-	[[2zyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae Klebsiella~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].	+	[[2zyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019686854</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019686854</ref><references group="xtra"/><references/>
-	~~[[Category: Klebsiella pneumoniae]]~~	+
	[[Category: Chen, Y Y.]]		[[Category: Chen, Y Y.]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]

OCA at 08:37, 20 October 2012

2012-10-20T08:37:05Z

←Older revision		Revision as of 08:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2zyg]] is a 2 chain structure ~~of [[6-phosphogluconate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].	+	[[2zyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].

	==See Also==		==See Also==

OCA: Protected "2zyg" [edit=sysop:move=sysop]

2012-07-25T20:11:44Z

Protected "2zyg" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:11, 25 July 2012

OCA at 20:11, 25 July 2012

2012-07-25T20:11:42Z

←Older revision		Revision as of 20:11, 25 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2zyg.png\|left\|200px]]
-	[[Image:2zyg.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2zyg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2zyg\| PDB=2zyg \| SCENE= }}		{{STRUCTURE_2zyg\| PDB=2zyg \| SCENE= }}

	===Apo-form of dimeric 6-phosphogluconate dehydrogenase===		===Apo-form of dimeric 6-phosphogluconate dehydrogenase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19686854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19686854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19686854}}		{{ABSTRACT_PUBMED_19686854}}

	==About this Structure==		==About this Structure==
-	~~2ZYG~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].	+	[[2zyg]] is a 2 chain structure of [[6-phosphogluconate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYG OCA].
		+
		+	==See Also==
		+	*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19686854~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019686854</ref><references group="xtra"/>
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
	[[Category: Chen, Y Y.]]		[[Category: Chen, Y Y.]]
Line 35:		Line 26:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pentose phosphate pathway]]		[[Category: Pentose phosphate pathway]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:59:11 2009''