3a8p - Revision history

OCA at 14:15, 1 November 2023

2023-11-01T14:15:57Z

←Older revision		Revision as of 14:15, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3a8p' size='340' side='right'caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3a8p' size='340' side='right'caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A8P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A8P FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3a8n\|3a8n]], [[3a8q\|3a8q]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [https://pdbe.org/3a8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [https://www.ebi.ac.uk/pdbsum/3a8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [https://pdbe.org/3a8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [https://www.ebi.ac.uk/pdbsum/3a8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref>	+	[https://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hakoshima, T]]	+	[[Category: Hakoshima T]]
-	[[Category: Higuchi, Y]]	+	[[Category: Higuchi Y]]
-	[[Category: Itoh, N]]	+	[[Category: Itoh N]]
-	[[Category: Kaibuchi, K]]	+	[[Category: Kaibuchi K]]
-	[[Category: Kitano, K]]	+	[[Category: Kitano K]]
-	[[Category: Mori, T]]	+	[[Category: Mori T]]
-	[[Category: Terawaki, S]]	+	[[Category: Terawaki S]]
-	[[Category: Watanabe, T]]	+	[[Category: Watanabe T]]
-	[[Category: Zhai, Y]]	+	[[Category: Zhai Y]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cell projection]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Guanine nucleotide exchange factor]]~~	+
-	~~[[Category: Guanine-nucleotide releasing factor]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Myristate]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 16:19, 22 December 2021

2021-12-22T16:19:36Z

←Older revision		Revision as of 16:19, 22 December 2021
Line 1:		Line 1:

	==Crystal structure of the Tiam2 PHCCEx domain==		==Crystal structure of the Tiam2 PHCCEx domain==
-	<StructureSection load='3a8p' size='340' side='right' caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3a8p' size='340' side='right'caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3A8P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A8P FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3a8n\|3a8n]], [[3a8q\|3a8q]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [~~http~~://pdbe.org/3a8p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3a8p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [https://pdbe.org/3a8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [https://www.ebi.ac.uk/pdbsum/3a8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref>	+	[[https://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]

OCA at 07:43, 24 October 2018

2018-10-24T07:43:48Z

←Older revision		Revision as of 07:43, 24 October 2018
Line 1:		Line 1:
		+
	==Crystal structure of the Tiam2 PHCCEx domain==		==Crystal structure of the Tiam2 PHCCEx domain==
	<StructureSection load='3a8p' size='340' side='right' caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3a8p' size='340' side='right' caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://pdbe.org/3a8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://pdbe.org/3a8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 42:		Line 43:
	[[Category: Watanabe, T]]		[[Category: Watanabe, T]]
	[[Category: Zhai, Y]]		[[Category: Zhai, Y]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Guanine nucleotide exchange factor]]		[[Category: Guanine nucleotide exchange factor]]
	[[Category: Guanine-nucleotide releasing factor]]		[[Category: Guanine-nucleotide releasing factor]]

OCA at 11:08, 9 February 2016

2016-02-09T11:08:36Z

←Older revision		Revision as of 11:08, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3a8p' size='340' side='right' caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3a8p' size='340' side='right' caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8P FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://pdbe.org/3a8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a8p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3a8p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]
	[[Category: Higuchi, Y]]		[[Category: Higuchi, Y]]

OCA at 06:29, 25 December 2014

2014-12-25T06:29:34Z

←Older revision		Revision as of 06:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8P FirstGlance]. <br>		<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hakoshima, T.]]	+	[[Category: Hakoshima, T]]
-	[[Category: Higuchi, Y.]]	+	[[Category: Higuchi, Y]]
-	[[Category: Itoh, N.]]	+	[[Category: Itoh, N]]
-	[[Category: Kaibuchi, K.]]	+	[[Category: Kaibuchi, K]]
-	[[Category: Kitano, K.]]	+	[[Category: Kitano, K]]
-	[[Category: Mori, T.]]	+	[[Category: Mori, T]]
-	[[Category: Terawaki, S.]]	+	[[Category: Terawaki, S]]
-	[[Category: Watanabe, T.]]	+	[[Category: Watanabe, T]]
-	[[Category: Zhai, Y.]]	+	[[Category: Zhai, Y]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
	[[Category: Guanine nucleotide exchange factor]]		[[Category: Guanine nucleotide exchange factor]]

OCA at 05:26, 2 October 2014

2014-10-02T05:26:00Z

←Older revision		Revision as of 05:26, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3a8p.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the Tiam2 PHCCEx domain==
		+	<StructureSection load='3a8p' size='340' side='right' caption='[[3a8p]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3a8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a8n\|3a8n]], [[3a8q\|3a8q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tiam2, Kiaa2016, Stef ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a8p RCSB], [http://www.ebi.ac.uk/pdbsum/3a8p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tiam1 and Tiam2 (Tiam1/2) are guanine nucleotide-exchange factors that possess the PH-CC-Ex (pleckstrin homology, coiled coil and extra) region that mediates binding to plasma membranes and signalling proteins in the activation of Rac GTPases. Crystal structures of the PH-CC-Ex regions revealed a single globular domain, PHCCEx domain, comprising a conventional PH subdomain associated with an antiparallel coiled coil of CC subdomain and a novel three-helical globular Ex subdomain. The PH subdomain resembles the beta-spectrin PH domain, suggesting non-canonical phosphatidylinositol binding. Mutational and binding studies indicated that CC and Ex subdomains form a positively charged surface for protein binding. We identified two unique acidic sequence motifs in Tiam1/2-interacting proteins for binding to PHCCEx domain, Motif-I in CD44 and ephrinB's and the NMDA receptor, and Motif-II in Par3 and JIP2. Our results suggest the molecular basis by which the Tiam1/2 PHCCEx domain facilitates dual binding to membranes and signalling proteins.

-	~~{{STRUCTURE_3a8p\| PDB=3a8p \| SCENE= }}~~	+	The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.,Terawaki S, Kitano K, Mori T, Zhai Y, Higuchi Y, Itoh N, Watanabe T, Kaibuchi K, Hakoshima T EMBO J. 2010 Jan 6;29(1):236-50. Epub 2009 Nov 5. PMID:19893486<ref>PMID:19893486</ref>

-	~~===Crystal structure~~ of the ~~Tiam2 PHCCEx domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19893486}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3a8p]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019893486<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]

OCA: Protected "3a8p" [edit=sysop:move=sysop]

2013-01-07T22:54:29Z

Protected "3a8p" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:54, 7 January 2013

OCA at 22:54, 7 January 2013

2013-01-07T22:54:27Z

←Older revision		Revision as of 22:54, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3a8p.png\|left\|200px]]		[[Image:3a8p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3a8p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3a8p\| PDB=3a8p \| SCENE= }}		{{STRUCTURE_3a8p\| PDB=3a8p \| SCENE= }}

	===Crystal structure of the Tiam2 PHCCEx domain===		===Crystal structure of the Tiam2 PHCCEx domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19893486}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19893486 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19893486}}		{{ABSTRACT_PUBMED_19893486}}

	==About this Structure==		==About this Structure==
-	~~3A8P~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA].	+	[[3a8p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19893486~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019893486</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hakoshima, T.]]		[[Category: Hakoshima, T.]]
Line 34:		Line 22:
	[[Category: Watanabe, T.]]		[[Category: Watanabe, T.]]
	[[Category: Zhai, Y.]]		[[Category: Zhai, Y.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell projection]]		[[Category: Cell projection]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Guanine nucleotide exchange factor]]		[[Category: Guanine nucleotide exchange factor]]
	[[Category: Guanine-nucleotide releasing factor]]		[[Category: Guanine-nucleotide releasing factor]]
Line 44:		Line 29:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 16:22:22 2010''

OCA at 14:22, 20 January 2010

2010-01-20T14:22:23Z

←Older revision		Revision as of 14:22, 20 January 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3a8p.~~jpg~~\|left\|200px]]	+	[[Image:3a8p.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3A8P is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA].	+	3A8P is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA].

	==Reference==		==Reference==
Line 45:		Line 45:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 25 09~~:59:~~19 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 16:22:22 2010''

OCA at 07:59, 25 November 2009

2009-11-25T07:59:20Z

←Older revision		Revision as of 07:59, 25 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3a8p.jpg\|left\|200px]]

-	The ~~entry 3a8p~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3a8p", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3a8p\| PDB=3a8p \| SCENE= }}

-	~~Authors: Terawaki, S., Kitano, K., Mori, T., Zhai, Y., Higuchi, Y., Itoh, N., Watanabe, T., Kaibuchi, K., Hakoshima, T.~~	+	===Crystal structure of the Tiam2 PHCCEx domain===

-	Description: Crystal structure of the Tiam2 PHCCEx domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov ~~18 18~~:38:35 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19893486}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19893486 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19893486}}
		+
		+	==About this Structure==
		+	3A8P is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8P OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19893486</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Hakoshima, T.]]
		+	[[Category: Higuchi, Y.]]
		+	[[Category: Itoh, N.]]
		+	[[Category: Kaibuchi, K.]]
		+	[[Category: Kitano, K.]]
		+	[[Category: Mori, T.]]
		+	[[Category: Terawaki, S.]]
		+	[[Category: Watanabe, T.]]
		+	[[Category: Zhai, Y.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cell projection]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Guanine nucleotide exchange factor]]
		+	[[Category: Guanine-nucleotide releasing factor]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Myristate]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Signaling protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:59:19 2009''