3agc - Revision history

OCA at 14:25, 1 November 2023

2023-11-01T14:25:03Z

←Older revision		Revision as of 14:25, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3agc' size='340' side='right'caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3agc' size='340' side='right'caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3agc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3agc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AGC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCC:3-{(2Z,3S,4S)-5-[(Z)-(4-ETHENYL-3-METHYL-5-OXO-1,5-DIHYDRO-2H-PYRROL-2-YLIDENE)METHYL]-2-[(5R)-2-[(3-ETHYL-5-FORMYL-4-METHYL-1H-PYRROL-2-YL)METHYL]-5-(METHOXYCARBONYL)-3-METHYL-4-OXO-4,5-DIHYDROCYCLOPENTA[B]PYRROL-6(1H)-YLIDENE]-4-METHYL-3,4-DIHYDRO-2H-PYRROL-3-YL}PROPANOIC+ACID'>RCC</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zxl\|2zxl]], [[3aga\|3aga]], [[3agb\|3agb]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCC:3-{(2Z,3S,4S)-5-[(Z)-(4-ETHENYL-3-METHYL-5-OXO-1,5-DIHYDRO-2H-PYRROL-2-YLIDENE)METHYL]-2-[(5R)-2-[(3-ETHYL-5-FORMYL-4-METHYL-1H-PYRROL-2-YL)METHYL]-5-(METHOXYCARBONYL)-3-METHYL-4-OXO-4,5-DIHYDROCYCLOPENTA[B]PYRROL-6(1H)-YLIDENE]-4-METHYL-3,4-DIHYDRO-2H-PYRROL-3-YL}PROPANOIC+ACID'>RCC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCCR, ACD2, At4g37000, C7A10_360 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Red_chlorophyll_catabolite_reductase Red chlorophyll catabolite reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.80 1.3.1.80] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [https://pdbe.org/3agc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [https://www.ebi.ac.uk/pdbsum/3agc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3agc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [https://pdbe.org/3agc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [https://www.ebi.ac.uk/pdbsum/3agc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3agc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH]] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>	+	[https://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Red chlorophyll catabolite reductase]]~~	+	[[Category: Fukuyama K]]
-	[[Category: Fukuyama, K]]	+	[[Category: Sugishima M]]
-	[[Category: Sugishima, M]]	+
-	~~[[Category: Chlorophyll catabolism]]~~	+
-	~~[[Category: Chlorophyll degradation]]~~	+
-	~~[[Category: Chloroplast]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Substrate-bound enzyme]]~~	+
-	~~[[Category: Transit peptide~~]]	+

OCA at 14:51, 29 December 2021

2021-12-29T14:51:41Z

←Older revision		Revision as of 14:51, 29 December 2021
Line 1:		Line 1:

	==F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana==		==F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana==
-	<StructureSection load='3agc' size='340' side='right' caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3agc' size='340' side='right'caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3agc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3agc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AGC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCC:3-{(2Z,3S,4S)-5-[(Z)-(4-ETHENYL-3-METHYL-5-OXO-1,5-DIHYDRO-2H-PYRROL-2-YLIDENE)METHYL]-2-[(5R)-2-[(3-ETHYL-5-FORMYL-4-METHYL-1H-PYRROL-2-YL)METHYL]-5-(METHOXYCARBONYL)-3-METHYL-4-OXO-4,5-DIHYDROCYCLOPENTA[B]PYRROL-6(1H)-YLIDENE]-4-METHYL-3,4-DIHYDRO-2H-PYRROL-3-YL}PROPANOIC+ACID'>RCC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCC:3-{(2Z,3S,4S)-5-[(Z)-(4-ETHENYL-3-METHYL-5-OXO-1,5-DIHYDRO-2H-PYRROL-2-YLIDENE)METHYL]-2-[(5R)-2-[(3-ETHYL-5-FORMYL-4-METHYL-1H-PYRROL-2-YL)METHYL]-5-(METHOXYCARBONYL)-3-METHYL-4-OXO-4,5-DIHYDROCYCLOPENTA[B]PYRROL-6(1H)-YLIDENE]-4-METHYL-3,4-DIHYDRO-2H-PYRROL-3-YL}PROPANOIC+ACID'>RCC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zxl\|2zxl]], [[3aga\|3aga]], [[3agb\|3agb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zxl\|2zxl]], [[3aga\|3aga]], [[3agb\|3agb]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCCR, ACD2, At4g37000, C7A10_360 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCCR, ACD2, At4g37000, C7A10_360 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Red_chlorophyll_catabolite_reductase Red chlorophyll catabolite reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.80 1.3.1.80] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Red_chlorophyll_catabolite_reductase Red chlorophyll catabolite reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.80 1.3.1.80] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [~~http~~://pdbe.org/3agc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3agc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3agc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [https://pdbe.org/3agc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [https://www.ebi.ac.uk/pdbsum/3agc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3agc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH]] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>	+	[[https://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH]] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Red chlorophyll catabolite reductase]]		[[Category: Red chlorophyll catabolite reductase]]
	[[Category: Fukuyama, K]]		[[Category: Fukuyama, K]]

OCA at 08:03, 24 October 2018

2018-10-24T08:03:47Z

←Older revision		Revision as of 08:03, 24 October 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/3agc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/3agc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:30, 4 August 2016

2016-08-04T16:30:00Z

←Older revision		Revision as of 16:30, 4 August 2016
Line 1:		Line 1:
		+
	==F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana==		==F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana==
	<StructureSection load='3agc' size='340' side='right' caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3agc' size='340' side='right' caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCCR, ACD2, At4g37000, C7A10_360 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCCR, ACD2, At4g37000, C7A10_360 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Red_chlorophyll_catabolite_reductase Red chlorophyll catabolite reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.80 1.3.1.80] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Red_chlorophyll_catabolite_reductase Red chlorophyll catabolite reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.80 1.3.1.80] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [http://www.ebi.ac.uk/pdbsum/3agc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [http://pdbe.org/3agc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [http://www.ebi.ac.uk/pdbsum/3agc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3agc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3agc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3agc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:02, 24 December 2014

2014-12-24T17:02:03Z

←Older revision		Revision as of 17:02, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3agc\| PDB=3agc \| SCENE= }}~~	+	==F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana==
-	===F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana===	+	<StructureSection load='3agc' size='340' side='right' caption='[[3agc]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	{~~{ABSTRACT_PUBMED_20727901}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3agc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AGC FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RCC:3-{(2Z,3S,4S)-5-[(Z)-(4-ETHENYL-3-METHYL-5-OXO-1,5-DIHYDRO-2H-PYRROL-2-YLIDENE)METHYL]-2-[(5R)-2-[(3-ETHYL-5-FORMYL-4-METHYL-1H-PYRROL-2-YL)METHYL]-5-(METHOXYCARBONYL)-3-METHYL-4-OXO-4,5-DIHYDROCYCLOPENTA[B]PYRROL-6(1H)-YLIDENE]-4-METHYL-3,4-DIHYDRO-2H-PYRROL-3-YL}PROPANOIC+ACID'>RCC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zxl\|2zxl]], [[3aga\|3aga]], [[3agb\|3agb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RCCR, ACD2, At4g37000, C7A10_360 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Red_chlorophyll_catabolite_reductase Red chlorophyll catabolite reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.80 1.3.1.80] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3agc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3agc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3agc RCSB], [http://www.ebi.ac.uk/pdbsum/3agc PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH]] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>		[[http://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH]] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/3agc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Red chlorophyll catabolite reductase (RCCR) catalyzes the ferredoxin-dependent reduction of the C20/C1 double bond of red chlorophyll catabolite (RCC), the catabolic intermediate produced in chlorophyll degradation. The crystal structure of substrate-free Arabidopsis thaliana RCCR (AtRCCR) demonstrated that RCCR folds into a characteristic alpha/beta/alpha sandwich, similar to that observed in the ferredoxin-dependent bilin reductase (FDBR) family. Here we have determined the crystal structures of RCC-bound AtRCCR, RCC-bound F218 V AtRCCR, and substrate-free F218 V AtRCCR, a mutant protein that produces the stereoisomer of primary fluorescent chlorophyll catabolites at the C1 position. RCC is bound to the pocket between the beta-sheet and the C-terminal alpha-helices, as seen in substrate-bound FDBRs, but RCC binding to RCCR is much looser than substrate binding to FDBRs. The loose binding seems beneficial to the large conformational change in RCC upon reduction. Two conserved acidic residues, Glu154 and Asp291, sandwich the C20/C1 double bond of RCC, suggesting that these two residues are involved in site-specific reduction. The RCC in F218V AtRCCR rotates slightly compared with that in wild type to fill in the space generated by the substitution of Phe218 with valine. Concomitantly, the two carboxy groups of Glu154 and Asp291 move slightly away from the C20/C1 double bond. The geometrical arrangement of RCC and the carboxy groups of Glu154 and Asp291 in RCCR would appear to be essential for the stereospecificity of the RCCR reaction.

-	~~==About this Structure==~~	+	Crystal Structures of the Substrate-Bound Forms of Red Chlorophyll Catabolite Reductase: Implications for Site-Specific and Stereospecific Reaction.,Sugishima M, Okamoto Y, Noguchi M, Kohchi T, Tamiaki H, Fukuyama K J Mol Biol. 2010 Aug 19. PMID:20727901<ref>PMID:20727901</ref>
-	~~[[3agc]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Arath Arath]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020727901</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Red chlorophyll catabolite reductase]]		[[Category: Red chlorophyll catabolite reductase]]
-	[[Category: Fukuyama, K.]]	+	[[Category: Fukuyama, K]]
-	[[Category: Sugishima, M.]]	+	[[Category: Sugishima, M]]
	[[Category: Chlorophyll catabolism]]		[[Category: Chlorophyll catabolism]]
	[[Category: Chlorophyll degradation]]		[[Category: Chlorophyll degradation]]

OCA at 06:02, 22 January 2014

2014-01-22T06:02:34Z

←Older revision		Revision as of 06:02, 22 January 2014
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-	[[Image:3agc.png\|left\|200px]]
-
	{{STRUCTURE_3agc\| PDB=3agc \| SCENE= }}		{{STRUCTURE_3agc\| PDB=3agc \| SCENE= }}
-
	===F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana===		===F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana===
		+	{{ABSTRACT_PUBMED_20727901}}

-	~~{{ABSTRACT_PUBMED_20727901}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/RCCR_ARATH RCCR_ARATH]] Catalyzes the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of pheophorbide a (pheide a) to a primary fluorescent catabolite (pFCC). Works in a two-step reaction with pheophorbide a oxygenase (PaO) by reducing the C20/C1 double bond of the intermediate, RCC.<ref>PMID:10743659</ref>

	==About this Structure==		==About this Structure==
-	[[3agc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA].	+	[[3agc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020727901</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020727901</ref><references group="xtra"/><references/>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Red chlorophyll catabolite reductase]]		[[Category: Red chlorophyll catabolite reductase]]
	[[Category: Fukuyama, K.]]		[[Category: Fukuyama, K.]]

OCA: Protected "3agc" [edit=sysop:move=sysop]

2013-01-07T23:09:05Z

Protected "3agc" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:09, 7 January 2013

OCA at 23:09, 7 January 2013

2013-01-07T23:09:00Z

←Older revision		Revision as of 23:09, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3agc.png\|left\|200px]]
-	[[Image:3agc.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3agc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3agc\| PDB=3agc \| SCENE= }}		{{STRUCTURE_3agc\| PDB=3agc \| SCENE= }}

	===F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana===		===F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20727901}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20727901 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20727901}}		{{ABSTRACT_PUBMED_20727901}}

	==About this Structure==		==About this Structure==
-	~~3AGC~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA].	+	[[3agc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20727901~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020727901</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Red chlorophyll catabolite reductase]]		[[Category: Red chlorophyll catabolite reductase]]
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	[[Category: Substrate-bound enzyme]]		[[Category: Substrate-bound enzyme]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:47:00 2010''

OCA at 05:38, 1 September 2010

2010-09-01T05:38:53Z

←Older revision		Revision as of 05:38, 1 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3agc.jpg\|left\|200px]]

-	The ~~entry 3agc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3agc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3agc\| PDB=3agc \| SCENE= }}

-	~~Authors: Sugishima, M., Fukuyama, K.~~	+	===F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana===

-	Description: F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 12 10~~:41:20 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20727901}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20727901 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20727901}}
		+
		+	==About this Structure==
		+	3AGC is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AGC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20727901</ref><references group="xtra"/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Red chlorophyll catabolite reductase]]
		+	[[Category: Fukuyama, K.]]
		+	[[Category: Sugishima, M.]]
		+	[[Category: Chlorophyll catabolism]]
		+	[[Category: Chlorophyll degradation]]
		+	[[Category: Chloroplast]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Substrate-bound enzyme]]
		+	[[Category: Transit peptide]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:47:00 2010''

OCA at 07:41, 12 May 2010

2010-05-12T07:41:21Z

←Older revision		Revision as of 07:41, 12 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3agc is ON HOLD	+	The entry 3agc is ON HOLD until Paper Publication

	Authors: Sugishima, M., Fukuyama, K.		Authors: Sugishima, M., Fukuyama, K.
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	Description: F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana		Description: F218V mutant of the substrate-bound red chlorophyll catabolite reductase from Arabidopsis thaliana

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 7~~ 10:16:52 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:41:20 2010''