3anq - Revision history

OCA at 15:49, 4 October 2023

2023-10-04T15:49:58Z

←Older revision		Revision as of 15:49, 4 October 2023
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	<StructureSection load='3anq' size='340' side='right'caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3anq' size='340' side='right'caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EHB:(1Z)~~-~~1-(3-ETHYL-5-HYDROXY-1~~,~~3-BENZOTHIAZOL-~~2~~(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~PTR~~:O-~~PHOSPHOTYROSINE'>PTR</scene></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EHB:(1Z)-1-(3-ETHYL-5-HYDROXY-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3anr\|3anr]]</div></td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYRK1A~~, ~~DYRK, MNB, MNBH~~ (~~[https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]~~)~~</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [https://pdbe.org/3anq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [https://www.ebi.ac.uk/pdbsum/3anq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3anq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [https://pdbe.org/3anq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [https://www.ebi.ac.uk/pdbsum/3anq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3anq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>	+	[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>	+	[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3anq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3anq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dual specificity tyrosine-phosphorylation-regulated kinase\|Dual specificity tyrosine-phosphorylation-regulated kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dual-specificity kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hagiwara, M]]	+	[[Category: Hagiwara M]]
-	[[Category: Hosoya, T]]	+	[[Category: Hosoya T]]
-	[[Category: Ito, N]]	+	[[Category: Ito N]]
-	[[Category: Nonaka, Y]]	+	[[Category: Nonaka Y]]
-	~~[[Category: Protein kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 14:58, 29 December 2021

2021-12-29T14:58:23Z

←Older revision		Revision as of 14:58, 29 December 2021
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	==human DYRK1A/inhibitor complex==		==human DYRK1A/inhibitor complex==
-	<StructureSection load='3anq' size='340' side='right' caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3anq' size='340' side='right'caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EHB:(1Z)-1-(3-ETHYL-5-HYDROXY-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EHB:(1Z)-1-(3-ETHYL-5-HYDROXY-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3anr\|3anr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3anr\|3anr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYRK1A, DYRK, MNB, MNBH ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYRK1A, DYRK, MNB, MNBH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [~~http~~://pdbe.org/3anq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3anq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3anq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [https://pdbe.org/3anq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [https://www.ebi.ac.uk/pdbsum/3anq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3anq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[~~http~~://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>	+	[[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>	+	[[https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</div>		</div>
	<div class="pdbe-citations 3anq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3anq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dual specificity tyrosine-phosphorylation-regulated kinase\|Dual specificity tyrosine-phosphorylation-regulated kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 33:
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hagiwara, M]]		[[Category: Hagiwara, M]]
	[[Category: Hosoya, T]]		[[Category: Hosoya, T]]

OCA at 10:53, 5 August 2016

2016-08-05T10:53:34Z

←Older revision		Revision as of 10:53, 5 August 2016
Line 1:		Line 1:
		+
	==human DYRK1A/inhibitor complex==		==human DYRK1A/inhibitor complex==
	<StructureSection load='3anq' size='340' side='right' caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3anq' size='340' side='right' caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EHB:(1Z)-1-(3-ETHYL-5-HYDROXY-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EHB:(1Z)-1-(3-ETHYL-5-HYDROXY-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3anr\|3anr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3anr\|3anr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYRK1A, DYRK, MNB, MNBH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYRK1A, DYRK, MNB, MNBH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [http://www.ebi.ac.uk/pdbsum/3anq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [http://pdbe.org/3anq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [http://www.ebi.ac.uk/pdbsum/3anq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3anq ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 22:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3anq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hagiwara, M]]		[[Category: Hagiwara, M]]
	[[Category: Hosoya, T]]		[[Category: Hosoya, T]]

OCA at 13:34, 18 December 2014

2014-12-18T13:34:41Z

←Older revision		Revision as of 13:34, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3anq~~\| ~~PDB~~=3anq \| ~~SCENE~~= }}	+	==human DYRK1A/inhibitor complex==
-	===~~human~~ DYRK1A/~~inhibitor complex~~===	+	<StructureSection load='3anq' size='340' side='right' caption='[[3anq]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20981014}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3anq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ANQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EHB:(1Z)-1-(3-ETHYL-5-HYDROXY-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)PROPAN-2-ONE'>EHB</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3anr\|3anr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYRK1A, DYRK, MNB, MNBH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3anq RCSB], [http://www.ebi.ac.uk/pdbsum/3anq PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) is a serine/threonine kinase essential for brain development and function, and its excessive activity is considered a pathogenic factor in Down syndrome. The development of potent, selective inhibitors of Dyrk1A would help to elucidate the molecular mechanisms of normal and diseased brains, and may provide a new lead compound for molecular-targeted drug discovery. Here, we report a novel Dyrk1A inhibitor, INDY, a benzothiazole derivative showing a potent ATP-competitive inhibitory effect with IC(50) and K(i) values of 0.24 and 0.18 muM, respectively. X-ray crystallography of the Dyrk1A/INDY complex revealed the binding of INDY in the ATP pocket of the enzyme. INDY effectively reversed the aberrant tau-phosphorylation and rescued the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A overexpression. Importantly, proINDY, a prodrug of INDY, effectively recovered Xenopus embryos from head malformation induced by Dyrk1A overexpression, resulting in normally developed embryos and demonstrating the utility of proINDY in vivo.

-	~~==Disease==~~	+	Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.,Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M Nat Commun. 2010 Oct;1(7):1-9. PMID:20981014<ref>PMID:20981014</ref>
-	~~[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause~~ of ~~mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]~~. ~~A disease characterized by primary microcephaly~~, ~~severe mental retardation without speech~~, ~~anxious autistic behavior~~, ~~and dysmorphic features~~, ~~including bitemporal narrowing~~, ~~deep-set eyes~~, ~~large simple ears~~, ~~and a pointed nasal tip~~. ~~Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period~~.<ref>PMID:~~21294719~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions~~ of ~~cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates~~.<~~ref~~>~~PMID:8769099~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3anq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:020981014</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hagiwara, M.]]	+	[[Category: Hagiwara, M]]
-	[[Category: Hosoya, T.]]	+	[[Category: Hosoya, T]]
-	[[Category: Ito, N.]]	+	[[Category: Ito, N]]
-	[[Category: Nonaka, Y.]]	+	[[Category: Nonaka, Y]]
	[[Category: Protein kinase]]		[[Category: Protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 20:44, 24 March 2013

2013-03-24T20:44:55Z

←Older revision		Revision as of 20:44, 24 March 2013
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-	[[Image:3anq.png\|left\|200px]]
-
	{{STRUCTURE_3anq\| PDB=3anq \| SCENE= }}		{{STRUCTURE_3anq\| PDB=3anq \| SCENE= }}
-
	===human DYRK1A/inhibitor complex===		===human DYRK1A/inhibitor complex===
		+	{{ABSTRACT_PUBMED_20981014}}

-	~~{{ABSTRACT_PUBMED_20981014}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[http://omim.org/entry/614104 614104]]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN]] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020981014</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020981014</ref><references group="xtra"/><references/>
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "3anq" [edit=sysop:move=sysop]

2013-01-07T22:02:18Z

Protected "3anq" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:02, 7 January 2013

OCA at 22:02, 7 January 2013

2013-01-07T22:02:14Z

←Older revision		Revision as of 22:02, 7 January 2013
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-	{{Seed}}
	[[Image:3anq.png\|left\|200px]]		[[Image:3anq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3anq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3anq\| PDB=3anq \| SCENE= }}		{{STRUCTURE_3anq\| PDB=3anq \| SCENE= }}

	===human DYRK1A/inhibitor complex===		===human DYRK1A/inhibitor complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20981014}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20981014 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20981014}}		{{ABSTRACT_PUBMED_20981014}}

	==About this Structure==		==About this Structure==
-	~~3ANQ~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA].	+	[[3anq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20981014~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020981014</ref><references group="xtra"/>
	[[Category: Dual-specificity kinase]]		[[Category: Dual-specificity kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 12:49:57 2010''

OCA at 09:38, 24 November 2010

2010-11-24T09:38:48Z

←Older revision		Revision as of 09:38, 24 November 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3anq.~~jpg~~\|left\|200px]]	+	[[Image:3anq.png\|left\|200px]]

	<!--		<!--
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	[[Category: Protein kinase]]		[[Category: Protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov ~~10 06~~:46:45 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 12:49:57 2010''

OCA at 03:35, 10 November 2010

2010-11-10T03:35:51Z

←Older revision		Revision as of 03:35, 10 November 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3anq.jpg\|left\|200px]]

-	The ~~entry 3anq~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3anq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3anq\| PDB=3anq \| SCENE= }}

-	~~Authors: Nonaka, Y., Hosoya, T., Hagiwara, M., Ito, N.~~	+	===human DYRK1A/inhibitor complex===

-	Description: human DYRK1A/inhibitor complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 15~~ 10:30:25 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20981014}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20981014 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20981014}}
		+
		+	==About this Structure==
		+	3ANQ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20981014</ref><references group="xtra"/>
		+	[[Category: Dual-specificity kinase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Hagiwara, M.]]
		+	[[Category: Hosoya, T.]]
		+	[[Category: Ito, N.]]
		+	[[Category: Nonaka, Y.]]
		+	[[Category: Protein kinase]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:46:45 2010''

OCA: New page: '''Unreleased structure''' The entry 3anq is ON HOLD Authors: Nonaka, Y., Hosoya, T., Hagiwara, M., Ito, N. Description: human DYRK1A/inhibitor complex ''Page seeded by [http://oca.we...

2010-09-15T07:21:43Z

New page: '''Unreleased structure''' The entry 3anq is ON HOLD Authors: Nonaka, Y., Hosoya, T., Hagiwara, M., Ito, N. Description: human DYRK1A/inhibitor complex ''Page seeded by [http://oca.we...

New page

'''Unreleased structure'''

The entry 3anq is ON HOLD

Authors: Nonaka, Y., Hosoya, T., Hagiwara, M., Ito, N.

Description: human DYRK1A/inhibitor complex

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:30:25 2010''