3anx - Revision history

OCA at 14:31, 1 November 2023

2023-11-01T14:31:04Z

←Older revision		Revision as of 14:31, 1 November 2023
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	<StructureSection load='3anx' size='340' side='right'caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3anx' size='340' side='right'caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MTA:5-DEOXY~~-5~~-METHYLTHIOADENOSINE'>MTA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.~~5~~.1.16 2.5.1.16]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [https://pdbe.org/3anx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [https://www.ebi.ac.uk/pdbsum/3anx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [https://pdbe.org/3anx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [https://www.ebi.ac.uk/pdbsum/3anx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>	+	[https://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Spermidine synthase]]~~	+	[[Category: Thermus thermophilus HB8]]
-	~~[[Category: Thet8~~]]	+	[[Category: Ganbe T]]
-	[[Category: Ganbe, T]]	+	[[Category: Kumasaka T]]
-	[[Category: Kumasaka, T]]	+	[[Category: Ohnuma M]]
-	[[Category: Ohnuma, M]]	+	[[Category: Oshima T]]
-	[[Category: Oshima, T]]	+	[[Category: Sato T]]
-	[[Category: Sato, T]]	+	[[Category: Tanaka N]]
-	[[Category: Tanaka, N]]	+
-	~~[[Category: Polyamine]]~~	+
-	~~[[Category: Spee]]~~	+
-	~~[[Category: Spermidine biosynthesis]]~~	+
-	~~[[Category: Spermine synthase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 13:26, 4 May 2022

2022-05-04T13:26:46Z

←Older revision		Revision as of 13:26, 4 May 2022
Line 3:		Line 3:
	<StructureSection load='3anx' size='340' side='right'caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3anx' size='340' side='right'caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3ANX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [~~http~~://pdbe.org/3anx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3anx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [https://pdbe.org/3anx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [https://www.ebi.ac.uk/pdbsum/3anx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>	+	[[https://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:24, 29 July 2020

2020-07-29T12:24:23Z

←Older revision		Revision as of 12:24, 29 July 2020
Line 1:		Line 1:

	==Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA==		==Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA==
-	<StructureSection load='3anx' size='340' side='right' caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3anx' size='340' side='right'caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ANX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3ANX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [http://pdbe.org/3anx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [http://www.ebi.ac.uk/pdbsum/3anx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [http://pdbe.org/3anx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [http://www.ebi.ac.uk/pdbsum/3anx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Spermidine ~~Synthase~~\|Spermidine ~~Synthase~~]]	+	*[[Spermidine synthase 3D structures\|Spermidine synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Spermidine synthase]]		[[Category: Spermidine synthase]]
	[[Category: Thet8]]		[[Category: Thet8]]

OCA at 07:51, 4 August 2016

2016-08-04T07:51:57Z

←Older revision		Revision as of 07:51, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA==		==Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA==
	<StructureSection load='3anx' size='340' side='right' caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3anx' size='340' side='right' caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [http://www.ebi.ac.uk/pdbsum/3anx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [http://pdbe.org/3anx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [http://www.ebi.ac.uk/pdbsum/3anx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3anx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3anx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:05, 25 December 2014

2014-12-25T07:05:10Z

←Older revision		Revision as of 07:05, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3anx\| PDB=3anx \| SCENE= }}~~	+	==Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA==
-	===Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA===	+	<StructureSection load='3anx' size='340' side='right' caption='[[3anx]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21458463}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3anx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ANX FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3anx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3anx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3anx RCSB], [http://www.ebi.ac.uk/pdbsum/3anx PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>		[[http://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To maintain functional conformations of DNA and RNA in high-temperature environments, an extremely thermophilic bacterium, Thermus thermophilus, employs a unique polyamine biosynthetic pathway and produces more than 16 types of polyamines. In the thermophile genome, only one spermidine synthase homolog (SpeE) was found and it was shown to be a key enzyme in the pathway. The catalytic assay of the purified enzyme revealed that it utilizes triamines (norspermidine and spermidine) and agmatine as acceptors in its aminopropyl transfer reaction; therefore, the enzyme was denoted as a triamine/agmatine aminopropyltransferase (TAAPT). We determined the crystal structures of the enzyme complexed with and without the aminopropyl group donor S-adenosylmethionine. Despite sequence and structural similarity with spermidine synthases from other organisms, a novel C-terminal beta-sheet and differences in the catalytic site were observed. The C-terminal module interacts with the gatekeeping loop and fixes the open conformation of the loop to recognize larger polyamine substrates such as agmatine and spermidine. Additional computational docking studies suggest that the structural differences of the catalytic site also contribute to recognition of the aminopropyl/aminobutyl or guanidium moiety of the substrates of TAAPT. These results explain in part the extraordinarily diverse polyamine spectrum found in T. thermophilus.

-	~~==About this Structure==~~	+	Crystal structures and enzymatic properties of a triamine/agmatine aminopropyltransferase from Thermus thermophilus.,Ohnuma M, Ganbe T, Terui Y, Niitsu M, Sato T, Tanaka N, Tamakoshi M, Samejima K, Kumasaka T, Oshima T J Mol Biol. 2011 May 20;408(5):971-86. Epub 2011 Mar 31. PMID:21458463<ref>PMID:21458463</ref>
-	~~[[3anx]] is~~ a ~~2 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3ANX OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:021458463</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Spermidine Synthase\|Spermidine Synthase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Spermidine synthase]]		[[Category: Spermidine synthase]]
	[[Category: Thet8]]		[[Category: Thet8]]
-	[[Category: Ganbe, T.]]	+	[[Category: Ganbe, T]]
-	[[Category: Kumasaka, T.]]	+	[[Category: Kumasaka, T]]
-	[[Category: Ohnuma, M.]]	+	[[Category: Ohnuma, M]]
-	[[Category: Oshima, T.]]	+	[[Category: Oshima, T]]
-	[[Category: Sato, T.]]	+	[[Category: Sato, T]]
-	[[Category: Tanaka, N.]]	+	[[Category: Tanaka, N]]
	[[Category: Polyamine]]		[[Category: Polyamine]]
	[[Category: Spee]]		[[Category: Spee]]
	[[Category: Spermidine biosynthesis]]		[[Category: Spermidine biosynthesis]]
-	[[Category: Spermidine synthase]]
	[[Category: Spermine synthase]]		[[Category: Spermine synthase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:31, 29 January 2014

2014-01-29T06:31:40Z

←Older revision		Revision as of 06:31, 29 January 2014
Line 1:		Line 1:
-	[[Image:3anx.png\|left\|200px]]
-
	{{STRUCTURE_3anx\| PDB=3anx \| SCENE= }}		{{STRUCTURE_3anx\| PDB=3anx \| SCENE= }}
-
	===Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA===		===Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA===
		+	{{ABSTRACT_PUBMED_21458463}}

-	~~{{ABSTRACT_PUBMED_021458463}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SPEE_THET8 SPEE_THET8]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor. Has broad substrate specificity. Is also active with agmatine and norspermidine. Has lower activity with homospermidine, mitsubishine and thermine.<ref>PMID:21458463</ref>

	==About this Structure==		==About this Structure==
-	[[3anx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA].	+	[[3anx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021458463</ref><references group="xtra"/><references/>
	[[Category: Spermidine synthase]]		[[Category: Spermidine synthase]]
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Thet8]]
	[[Category: Ganbe, T.]]		[[Category: Ganbe, T.]]
	[[Category: Kumasaka, T.]]		[[Category: Kumasaka, T.]]

OCA at 14:52, 20 February 2013

2013-02-20T14:52:48Z

←Older revision		Revision as of 14:52, 20 February 2013
Line 1:		Line 1:
-	[[Image:3anx.~~jpg~~\|left\|200px]]	+	[[Image:3anx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3anx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3anx\| PDB=3anx \| SCENE= }}		{{STRUCTURE_3anx\| PDB=3anx \| SCENE= }}

	===Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA===		===Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA===

		+	{{ABSTRACT_PUBMED_021458463}}

	==About this Structure==		==About this Structure==
Line 22:		Line 17:
	[[Category: Sato, T.]]		[[Category: Sato, T.]]
	[[Category: Tanaka, N.]]		[[Category: Tanaka, N.]]
		+	[[Category: Polyamine]]
		+	[[Category: Spee]]
		+	[[Category: Spermidine biosynthesis]]
		+	[[Category: Spermidine synthase]]
		+	[[Category: Spermine synthase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "3anx" [edit=sysop:move=sysop]

2011-04-13T05:21:45Z

Protected "3anx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 13 April 2011

OCA at 05:21, 13 April 2011

2011-04-13T05:21:41Z

←Older revision		Revision as of 05:21, 13 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3anx.jpg\|left\|200px]]

-	The ~~entry 3anx~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3anx", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3anx\| PDB=3anx \| SCENE= }}

-	~~Authors: Ganbe~~, ~~T., Ohnuma, M., Sato, T., Tanaka, N., Oshima, T., Kumasaka, T.~~	+	===Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA===

-	Description: Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 8 11~~:26:~~10 2010''~~	+	==About this Structure==
		+	[[3anx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANX OCA].
		+	[[Category: Spermidine synthase]]
		+	[[Category: Thermus thermophilus]]
		+	[[Category: Ganbe, T.]]
		+	[[Category: Kumasaka, T.]]
		+	[[Category: Ohnuma, M.]]
		+	[[Category: Oshima, T.]]
		+	[[Category: Sato, T.]]
		+	[[Category: Tanaka, N.]]

OCA at 08:14, 8 December 2010

2010-12-08T08:14:06Z

←Older revision		Revision as of 08:14, 8 December 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3anx is ON HOLD	+	The entry 3anx is ON HOLD until Paper Publication

	Authors: Ganbe, T., Ohnuma, M., Sato, T., Tanaka, N., Oshima, T., Kumasaka, T.		Authors: Ganbe, T., Ohnuma, M., Sato, T., Tanaka, N., Oshima, T., Kumasaka, T.
Line 7:		Line 7:
	Description: Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA		Description: Crystal structure of triamine/agmatine aminopropyltransferase (SPEE) from thermus thermophilus, complexed with MTA

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct~~ ~~6 05~~:43:03 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:26:10 2010''