3at8 - Revision history

OCA at 14:01, 13 March 2024

2024-03-13T14:01:56Z

←Older revision		Revision as of 14:01, 13 March 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/KCNJ6_MOUSE KCNJ6_MOUSE] This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation, possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.		[https://www.uniprot.org/uniprot/KCNJ6_MOUSE KCNJ6_MOUSE] This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation, possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Ion channels gate at membrane-embedded domains by changing their conformation along the ion conduction pathway. Inward rectifier K(+) (Kir) channels possess a unique extramembrane cytoplasmic domain that extends this pathway. However, the relevance and contribution of this domain to ion permeation remain unclear. By qualitative x-ray crystallographic analysis, we found that the pore in the cytoplasmic domain of Kir3.2 binds cations in a valency-dependent manner and does not allow the displacement of Mg(2+) by monovalent cations or spermine. Electrophysiological analyses revealed that the cytoplasmic pore of Kir3.2 selectively binds positively charged molecules and has a higher affinity for Mg(2+) when it has a low probability of being open. The selective blocking of chemical modification of the side chain of pore-facing residues by Mg(2+) indicates that the mode of binding of Mg(2+) is likely to be similar to that observed in the crystal structure. These results indicate that the Kir3.2 crystal structure has a closed conformation with a negative electrostatic field potential at the cytoplasmic pore, the potential of which may be controlled by conformational changes in the cytoplasmic domain to regulate ion diffusion along the pore.
-
-	Interactions of cations with the cytoplasmic pores of inward rectifier K(+) channels in the closed state.,Inanobe A, Nakagawa A, Kurachi Y J Biol Chem. 2011 Dec 2;286(48):41801-11. Epub 2011 Oct 9. PMID:21982822<ref>PMID:21982822</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3at8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]		*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:54, 4 October 2023

2023-10-04T15:54:42Z

←Older revision		Revision as of 15:54, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='3at8' size='340' side='right'caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3at8' size='340' side='right'caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BA:BARIUM+ION'>BA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3agw\|3agw]], [[2e4f\|2e4f]], [[3at9\|3at9]], [[3ata\|3ata]], [[3atb\|3atb]], [[3atd\|3atd]], [[3ate\|3ate]], [[3atf\|3atf]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [https://pdbe.org/3at8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [https://www.ebi.ac.uk/pdbsum/3at8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3at8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [https://pdbe.org/3at8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [https://www.ebi.ac.uk/pdbsum/3at8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3at8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/KCNJ6_MOUSE KCNJ6_MOUSE] Defects in Kcnj6 are the cause of the weaver (wv) phenotype. Homozygous animals suffer from severe ataxia that is obvious by about the second postnatal week. The cerebellum of these animals is drastically reduced in size due to depletion of the major cell type of cerebellum, the granule cell neuron. Heterozygous animals are not ataxic but have an intermediate number of surviving granule cells. Male homozygotes are sterile, because of complete failure of sperm production. Both hetero- and homozygous animals undergo sporadic tonic-clonic seizures.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KCNJ6_MOUSE KCNJ6_MOUSE] This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation, possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Inanobe, A]]	+	[[Category: Inanobe A]]
-	[[Category: Kurachi, Y]]	+	[[Category: Kurachi Y]]
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Cytoplasmic assembly]]~~	+
-	~~[[Category: G protein beta-gamma subunit]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 15:03, 29 December 2021

2021-12-29T15:03:48Z

←Older revision		Revision as of 15:03, 29 December 2021
Line 3:		Line 3:
	<StructureSection load='3at8' size='340' side='right'caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3at8' size='340' side='right'caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3agw\|3agw]], [[2e4f\|2e4f]], [[3at9\|3at9]], [[3ata\|3ata]], [[3atb\|3atb]], [[3atd\|3atd]], [[3ate\|3ate]], [[3atf\|3atf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3agw\|3agw]], [[2e4f\|2e4f]], [[3at9\|3at9]], [[3ata\|3ata]], [[3atb\|3atb]], [[3atd\|3atd]], [[3ate\|3ate]], [[3atf\|3atf]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [~~http~~://pdbe.org/3at8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3at8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3at8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [https://pdbe.org/3at8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [https://www.ebi.ac.uk/pdbsum/3at8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3at8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:20, 21 August 2019

2019-08-21T07:20:12Z

←Older revision		Revision as of 07:20, 21 August 2019
Line 1:		Line 1:

	==Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)==		==Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)==
-	<StructureSection load='3at8' size='340' side='right' caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='3at8' size='340' side='right'caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3at8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3at8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Inanobe, A]]		[[Category: Inanobe, A]]

OCA at 00:39, 16 November 2017

2017-11-16T00:39:16Z

←Older revision		Revision as of 00:39, 16 November 2017
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3at8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3at8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:58, 5 August 2016

2016-08-05T10:58:21Z

←Older revision		Revision as of 10:58, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)==		==Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)==
	<StructureSection load='3at8' size='340' side='right' caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3at8' size='340' side='right' caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3agw\|3agw]], [[2e4f\|2e4f]], [[3at9\|3at9]], [[3ata\|3ata]], [[3atb\|3atb]], [[3atd\|3atd]], [[3ate\|3ate]], [[3atf\|3atf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3agw\|3agw]], [[2e4f\|2e4f]], [[3at9\|3at9]], [[3ata\|3ata]], [[3atb\|3atb]], [[3atd\|3atd]], [[3ate\|3ate]], [[3atf\|3atf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [http://www.ebi.ac.uk/pdbsum/3at8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [http://pdbe.org/3at8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [http://www.ebi.ac.uk/pdbsum/3at8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3at8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3at8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Inanobe, A]]		[[Category: Inanobe, A]]
	[[Category: Kurachi, Y]]		[[Category: Kurachi, Y]]

OCA at 13:39, 18 December 2014

2014-12-18T13:39:31Z

←Older revision		Revision as of 13:39, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3at8\| PDB=3at8 \| SCENE= }}~~	+	==Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)==
-	===Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)===	+	<StructureSection load='3at8' size='340' side='right' caption='[[3at8]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21982822}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AT8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3agw\|3agw]], [[2e4f\|2e4f]], [[3at9\|3at9]], [[3ata\|3ata]], [[3atb\|3atb]], [[3atd\|3atd]], [[3ate\|3ate]], [[3atf\|3atf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3at8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3at8 RCSB], [http://www.ebi.ac.uk/pdbsum/3at8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ion channels gate at membrane-embedded domains by changing their conformation along the ion conduction pathway. Inward rectifier K(+) (Kir) channels possess a unique extramembrane cytoplasmic domain that extends this pathway. However, the relevance and contribution of this domain to ion permeation remain unclear. By qualitative x-ray crystallographic analysis, we found that the pore in the cytoplasmic domain of Kir3.2 binds cations in a valency-dependent manner and does not allow the displacement of Mg(2+) by monovalent cations or spermine. Electrophysiological analyses revealed that the cytoplasmic pore of Kir3.2 selectively binds positively charged molecules and has a higher affinity for Mg(2+) when it has a low probability of being open. The selective blocking of chemical modification of the side chain of pore-facing residues by Mg(2+) indicates that the mode of binding of Mg(2+) is likely to be similar to that observed in the crystal structure. These results indicate that the Kir3.2 crystal structure has a closed conformation with a negative electrostatic field potential at the cytoplasmic pore, the potential of which may be controlled by conformational changes in the cytoplasmic domain to regulate ion diffusion along the pore.

-	~~==About this Structure==~~	+	Interactions of cations with the cytoplasmic pores of inward rectifier K(+) channels in the closed state.,Inanobe A, Nakagawa A, Kurachi Y J Biol Chem. 2011 Dec 2;286(48):41801-11. Epub 2011 Oct 9. PMID:21982822<ref>PMID:21982822</ref>
-	~~[[3at8]] is a 1 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3AT8 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:021982822</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Inanobe, A.]]	+	[[Category: Inanobe, A]]
-	[[Category: Kurachi, Y.]]	+	[[Category: Kurachi, Y]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Cytoplasmic assembly]]		[[Category: Cytoplasmic assembly]]

OCA at 13:55, 19 June 2013

2013-06-19T13:55:43Z

←Older revision		Revision as of 13:55, 19 June 2013
Line 1:		Line 1:
	{{STRUCTURE_3at8\| PDB=3at8 \| SCENE= }}		{{STRUCTURE_3at8\| PDB=3at8 \| SCENE= }}
	===Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)===		===Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)===
-	{{~~ABSTRACT_PUBMED_021982822~~}}	+	{{ABSTRACT_PUBMED_21982822}}

	==About this Structure==		==About this Structure==
	[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA].		[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA].

-	==~~See Also~~==	+	==Reference==
-	*[[Potassium Channel\|Potassium Channel]]	+	<ref group="xtra">PMID:021982822</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Inanobe, A.]]		[[Category: Inanobe, A.]]

OCA at 20:49, 24 March 2013

2013-03-24T20:49:23Z

←Older revision		Revision as of 20:49, 24 March 2013
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-	[[Image:3at8.png\|left\|200px]]
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	{{STRUCTURE_3at8\| PDB=3at8 \| SCENE= }}		{{STRUCTURE_3at8\| PDB=3at8 \| SCENE= }}
-
	===Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)===		===Crystal Structure of the Kir3.2 Cytoplasmic Domain (Na+-free crystal soaked in 10 mM barium chloride)===
-		+	{{ABSTRACT_PUBMED_021982822}}

	==About this Structure==		==About this Structure==

OCA at 19:51, 20 October 2012

2012-10-20T19:51:05Z

←Older revision		Revision as of 19:51, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3at8]] is a 1 chain structure ~~of [[Potassium Channel]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA].	+	[[3at8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AT8 OCA].

	==See Also==		==See Also==