3avq - Revision history

OCA at 15:58, 4 October 2023

2023-10-04T15:58:03Z

←Older revision		Revision as of 15:58, 4 October 2023
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	<StructureSection load='3avq' size='340' side='right'caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3avq' size='340' side='right'caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [https://pdbe.org/3avq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [https://www.ebi.ac.uk/pdbsum/3avq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3avq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [https://pdbe.org/3avq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [https://www.ebi.ac.uk/pdbsum/3avq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3avq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/COAA_MYCTU COAA_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pantothenate kinase~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Abhinav~~, K V~~]]	+	[[Category: Abhinav KV]]
-	[[Category: Chetnani, B]]	+	[[Category: Chetnani B]]
-	[[Category: Chhibber, M]]	+	[[Category: Chhibber M]]
-	[[Category: Kumar, P]]	+	[[Category: Kumar P]]
-	[[Category: Surolia, A]]	+	[[Category: Surolia A]]
-	[[Category: Vijayan, M]]	+	[[Category: Vijayan M]]
-	~~[[Category: Coa biosynthesis]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Nucleotide binding]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 15:06, 29 December 2021

2021-12-29T15:06:16Z

←Older revision		Revision as of 15:06, 29 December 2021
Line 1:		Line 1:

	==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan==		==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan==
-	<StructureSection load='3avq' size='340' side='right' caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='3avq' size='340' side='right'caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [~~http~~://pdbe.org/3avq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3avq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3avq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [https://pdbe.org/3avq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [https://www.ebi.ac.uk/pdbsum/3avq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3avq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Pantothenate kinase\|Pantothenate kinase]]	+	*[[Pantothenate kinase 3D structures\|Pantothenate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Abhinav, K V]]		[[Category: Abhinav, K V]]

OCA at 13:29, 5 August 2016

2016-08-05T13:29:51Z

←Older revision		Revision as of 13:29, 5 August 2016
Line 1:		Line 1:
		+
	==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan==		==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan==
	<StructureSection load='3avq' size='340' side='right' caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3avq' size='340' side='right' caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [http://www.ebi.ac.uk/pdbsum/3avq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [http://pdbe.org/3avq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [http://www.ebi.ac.uk/pdbsum/3avq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3avq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3avq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
	[[Category: Abhinav, K V]]		[[Category: Abhinav, K V]]

OCA at 21:35, 3 January 2015

2015-01-03T21:35:49Z

←Older revision		Revision as of 21:35, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [http://www.ebi.ac.uk/pdbsum/3avq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [http://www.ebi.ac.uk/pdbsum/3avq PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 15:
	Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action.,Chetnani B, Kumar P, Abhinav KV, Chhibber M, Surolia A, Vijayan M Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):774-83. doi:, 10.1107/S0907444911024462. Epub 2011 Aug 9. PMID:21904030<ref>PMID:21904030</ref>		Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action.,Chetnani B, Kumar P, Abhinav KV, Chhibber M, Surolia A, Vijayan M Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):774-83. doi:, 10.1107/S0907444911024462. Epub 2011 Aug 9. PMID:21904030<ref>PMID:21904030</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Pantothenate kinase\|Pantothenate kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
-	[[Category: Abhinav, K V.]]	+	[[Category: Abhinav, K V]]
-	[[Category: Chetnani, B.]]	+	[[Category: Chetnani, B]]
-	[[Category: Chhibber, M.]]	+	[[Category: Chhibber, M]]
-	[[Category: Kumar, P.]]	+	[[Category: Kumar, P]]
-	[[Category: Surolia, A.]]	+	[[Category: Surolia, A]]
-	[[Category: Vijayan, M.]]	+	[[Category: Vijayan, M]]
	[[Category: Coa biosynthesis]]		[[Category: Coa biosynthesis]]
	[[Category: Homodimer]]		[[Category: Homodimer]]
	[[Category: Nucleotide binding]]		[[Category: Nucleotide binding]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 11:06, 14 May 2014

2014-05-14T11:06:57Z

←Older revision		Revision as of 11:06, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3avq.~~png~~\|~~left~~\|~~200px~~]]	+	==Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan==
		+	<StructureSection load='3avq' size='340' side='right' caption='[[3avq]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AVQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MV1:(2S)-2,4-DIHYDROXY-3,3-DIMETHYL-N-[3-(NONYLAMINO)-3-OXOPROPYL]BUTANAMIDE'>MV1</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3aez\|3aez]], [[3af0\|3af0]], [[3af1\|3af1]], [[3af2\|3af2]], [[3af3\|3af3]], [[3af4\|3af4]], [[3avo\|3avo]], [[3avp\|3avp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaA, Rv1092c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3avq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3avq RCSB], [http://www.ebi.ac.uk/pdbsum/3avq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Previous studies of complexes of Mycobacterium tuberculosis PanK (MtPanK) with nucleotide diphosphates and nonhydrolysable analogues of nucleoside triphosphates in the presence or the absence of pantothenate established that the enzyme has dual specificity for ATP and GTP, revealed the unusual movement of ligands during enzyme action and provided information on the effect of pantothenate on the location and conformation of the nucleotides at the beginning and the end of enzyme action. The X-ray analyses of the binary complexes of MtPanK with pantothenate, pantothenol and N-nonylpantothenamide reported here demonstrate that in the absence of nucleotide these ligands occupy, with a somewhat open conformation, a location similar to that occupied by phosphopantothenate in the `end' complexes, which differs distinctly from the location of pantothenate in the closed conformation in the ternary `initiation' complexes. The conformation and the location of the nucleotide were also different in the initiation and end complexes. An invariant arginine appears to play a critical role in the movement of ligands that takes place during enzyme action. The work presented here completes the description of the locations and conformations of nucleoside diphosphates and triphosphates and pantothenate in different binary and ternary complexes, and suggests a structural rationale for the movement of ligands during enzyme action. The present investigation also suggests that N-alkylpantothenamides could be phosphorylated by the enzyme in the same manner as pantothenate.

-	~~<!--~~	+	Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action.,Chetnani B, Kumar P, Abhinav KV, Chhibber M, Surolia A, Vijayan M Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):774-83. doi:, 10.1107/S0907444911024462. Epub 2011 Aug 9. PMID:21904030<ref>PMID:21904030</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3avq"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3avq\| PDB=3avq \| SCENE= }}~~	+

-	~~===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21904030}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21904030 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21904030}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3avq]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021904030<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]

OCA at 07:38, 2 November 2011

2011-11-02T07:38:57Z

←Older revision		Revision as of 07:38, 2 November 2011
Line 1:		Line 1:
-	[[Image:3avq.~~jpg~~\|left\|200px]]	+	[[Image:3avq.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan===		===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21904030}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21904030 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21904030}}

	==About this Structure==		==About this Structure==
	[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA].		[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021904030</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Pantothenate kinase]]		[[Category: Pantothenate kinase]]
		+	[[Category: Abhinav, K V.]]
	[[Category: Chetnani, B.]]		[[Category: Chetnani, B.]]
	[[Category: Chhibber, M.]]		[[Category: Chhibber, M.]]

OCA at 06:24, 17 August 2011

2011-08-17T06:24:50Z

←Older revision		Revision as of 06:24, 17 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3avq.jpg\|left\|200px]]

-	The ~~entry 3avq~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3avq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3avq\| PDB=3avq \| SCENE= }}

-	~~Authors: Chetnani, B., Kumar, P., Chhibber, M., Surolia, A., Vijayan, M.~~	+	===Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan===

-	~~Description~~: ~~Pantothenate kinase~~ from Mycobacterium tuberculosis ~~(MtPanK) in complex with N9~~-~~Pan~~	+
		+	==About this Structure==
		+	[[3avq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVQ OCA].
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Pantothenate kinase]]
		+	[[Category: Chetnani, B.]]
		+	[[Category: Chhibber, M.]]
		+	[[Category: Kumar, P.]]
		+	[[Category: Surolia, A.]]
		+	[[Category: Vijayan, M.]]
		+	[[Category: Coa biosynthesis]]
		+	[[Category: Homodimer]]
		+	[[Category: Nucleotide binding]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:37, 23 March 2011

2011-03-23T06:37:05Z

←Older revision		Revision as of 06:37, 23 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3avq is ON HOLD	+	The entry 3avq is ON HOLD until Paper Publication

-	Authors: Chetnani, B. , Kumar, P., Chhibber, M. , Surolia, A., Vijayan, M.	+	Authors: Chetnani, B., Kumar, P., Chhibber, M., Surolia, A., Vijayan, M.

	Description: Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan		Description: Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan

OCA: Protected "3avq" [edit=sysop:move=sysop]

2011-03-16T07:55:49Z

Protected "3avq" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:55, 16 March 2011

OCA: New page: '''Unreleased structure''' The entry 3avq is ON HOLD Authors: Chetnani, B. , Kumar, P., Chhibber, M. , Surolia, A., Vijayan, M. Description: Pantothenate kinase from Mycobacterium tube...

2011-03-16T07:55:48Z

New page: '''Unreleased structure''' The entry 3avq is ON HOLD Authors: Chetnani, B. , Kumar, P., Chhibber, M. , Surolia, A., Vijayan, M. Description: Pantothenate kinase from Mycobacterium tube...

New page

'''Unreleased structure'''

The entry 3avq is ON HOLD

Authors: Chetnani, B. , Kumar, P., Chhibber, M. , Surolia, A., Vijayan, M.

Description: Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with N9-Pan