3ax5 - Revision history

OCA at 15:59, 4 October 2023

2023-10-04T15:59:12Z

←Older revision		Revision as of 15:59, 4 October 2023
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	<StructureSection load='3ax5' size='340' side='right'caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ax5' size='340' side='right'caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[3awr\|3awr]], [[3ax2\|3ax2]], [[3ax3\|3ax3]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tomm20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [https://pdbe.org/3ax5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [https://pdbe.org/3ax5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT]] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).	+	[https://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kohda, D~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Maita, Y~~]]	+	[[Category: Kohda D]]
-	[[Category: ~~Saitoh, T~~]]	+	[[Category: Maita Y]]
-	[[Category: ~~Membrane protein-transport protein complex]]~~	+	[[Category: Saitoh T]]
-	~~[[Category: Protein-protein complex~~]]	+

OCA at 15:07, 29 December 2021

2021-12-29T15:07:20Z

←Older revision		Revision as of 15:07, 29 December 2021
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	==Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.==		==Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.==
-	<StructureSection load='3ax5' size='340' side='right' caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3ax5' size='340' side='right'caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3awr\|3awr]], [[3ax2\|3ax2]], [[3ax3\|3ax3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3awr\|3awr]], [[3ax2\|3ax2]], [[3ax3\|3ax3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tomm20 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tomm20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [~~http~~://pdbe.org/3ax5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ax5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [https://pdbe.org/3ax5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ax5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT]] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).	+	[[https://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT]] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]
	[[Category: Maita, Y]]		[[Category: Maita, Y]]

OCA at 01:25, 5 August 2016

2016-08-05T01:25:30Z

←Older revision		Revision as of 01:25, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.==		==Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.==
	<StructureSection load='3ax5' size='340' side='right' caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ax5' size='340' side='right' caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3awr\|3awr]], [[3ax2\|3ax2]], [[3ax3\|3ax3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3awr\|3awr]], [[3ax2\|3ax2]], [[3ax3\|3ax3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tomm20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tomm20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [http://pdbe.org/3ax5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ax5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ax5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]
	[[Category: Maita, Y]]		[[Category: Maita, Y]]

OCA at 14:41, 25 December 2014

2014-12-25T14:41:54Z

←Older revision		Revision as of 14:41, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT]] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:24, 18 December 2014

2014-12-18T13:24:12Z

←Older revision		Revision as of 13:24, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ax5\| PDB=3ax5 \| SCENE= }}~~	+	==Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.==
-	===Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.===	+	<StructureSection load='3ax5' size='340' side='right' caption='[[3ax5]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21591667}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ax5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AX5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3awr\|3awr]], [[3ax2\|3ax2]], [[3ax3\|3ax3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tomm20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ax5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ax5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ax5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Most mitochondrial proteins are synthesized in the cytosol and imported into mitochondria. The Tom20 protein, residing on the mitochondrial surface, recognizes the N-terminal presequences of precursor proteins. We previously determined the crystal structures of the Tom20-presequence complex. The successful crystallization involved tethering the presequence to Tom20 through an intermolecular disulfide bond with an optimized linker. In this work, we assessed the tethering method. The intermolecular disulfide bond was cleaved in crystal with a reducing agent. The pose (i.e., conformation and position) of the presequence was identical to the previously determined pose. In another experiment, a longer linker than the optimized length was used for the tethering. The perturbation of the tether changed the pose slightly, but the interaction mode was preserved. These results argue against the forced interaction of the presequence by its covalent attachment to Tom20. Second, as an alternative method referred to as "molecular stiffening", we introduced a disulfide bond within the presequence peptide to restrict the freedom of the peptide in the unbound states. One presequence analogue exhibited over 100-fold higher affinity than its linear counterpart and generated cocrystals with Tom20. One of the two crystallographic snapshots revealed a known pose previously determined by the tethering method, and the other snapshot depicted a new pose. These results confirmed and extended the dynamic, multiple bound state model of the Tom20-presequence interactions and also demonstrated the validity of the molecular tethering and stiffening techniques in studies of transient protein-peptide interactions.

-	~~==Function==~~	+	Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.,Saitoh T, Igura M, Miyazaki Y, Ose T, Maita N, Kohda D Biochemistry. 2011 Jun 21;50(24):5487-96. Epub 2011 May 26. PMID:21591667<ref>PMID:21591667</ref>
-	~~[[http://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT]] Central component of the receptor complex responsible for the recognition and translocation~~ of ~~cytosolically synthesized~~ mitochondrial ~~preproteins~~. ~~Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ax5]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021591667</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Kohda, D.]]	+	[[Category: Kohda, D]]
-	[[Category: Maita, Y.]]	+	[[Category: Maita, Y]]
-	[[Category: Saitoh, T.]]	+	[[Category: Saitoh, T]]
	[[Category: Membrane protein-transport protein complex]]		[[Category: Membrane protein-transport protein complex]]
	[[Category: Protein-protein complex]]		[[Category: Protein-protein complex]]

OCA at 08:15, 8 May 2013

2013-05-08T08:15:14Z

←Older revision		Revision as of 08:15, 8 May 2013
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-	[[Image:3ax5.jpg\|left\|200px]]
-
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	{{STRUCTURE_3ax5\| PDB=3ax5 \| SCENE= }}		{{STRUCTURE_3ax5\| PDB=3ax5 \| SCENE= }}
-
	===Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.===		===Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.===
		+	{{ABSTRACT_PUBMED_21591667}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/TOM20_RAT TOM20_RAT]] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21591667}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21591667 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21591667}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021591667</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021591667</ref><references group="xtra"/><references/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Kohda, D.]]		[[Category: Kohda, D.]]

OCA at 18:49, 6 July 2011

2011-07-06T18:49:14Z

←Older revision		Revision as of 18:49, 6 July 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ax5.jpg\|left\|200px]]

-	The ~~entry 3ax5~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ax5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ax5\| PDB=3ax5 \| SCENE= }}

-	~~Authors~~: ~~Saitoh, T., Maita, Y., Kohda,~~ D.	+	===Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.===

-	~~Description: Crystal structure of rat TOM20~~-~~ALDH presequence complex: A complex~~ (~~form1~~) ~~between Tom20 and~~ a ~~disulfide~~-~~bridged presequence peptide containing~~ D-~~Cys and L~~-~~Cys at the i and i+3 positions.~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21591667}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21591667 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21591667}}
		+
		+	==About this Structure==
		+	[[3ax5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AX5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021591667</ref><references group="xtra"/>
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Kohda, D.]]
		+	[[Category: Maita, Y.]]
		+	[[Category: Saitoh, T.]]
		+	[[Category: Membrane protein-transport protein complex]]
		+	[[Category: Protein-protein complex]]

OCA at 04:57, 25 May 2011

2011-05-25T04:57:23Z

←Older revision		Revision as of 04:57, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ax5 is ON HOLD	+	The entry 3ax5 is ON HOLD until Paper Publication

	Authors: Saitoh, T., Maita, Y., Kohda, D.		Authors: Saitoh, T., Maita, Y., Kohda, D.

-	Description: ~~CRYSTAL STRUCTURE OF RAT~~ TOM20-ALDH ~~PRESEQUENCE COMPLEX~~: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.	+	Description: Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.

OCA: Protected "3ax5" [edit=sysop:move=sysop]

2011-04-06T08:30:00Z

Protected "3ax5" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 6 April 2011

OCA: New page: '''Unreleased structure''' The entry 3ax5 is ON HOLD Authors: Saitoh, T., Maita, Y., Kohda, D. Description: CRYSTAL STRUCTURE OF RAT TOM20-ALDH PRESEQUENCE COMPLEX: A complex (form1) b...

2011-04-06T08:29:59Z

New page: '''Unreleased structure''' The entry 3ax5 is ON HOLD Authors: Saitoh, T., Maita, Y., Kohda, D. Description: CRYSTAL STRUCTURE OF RAT TOM20-ALDH PRESEQUENCE COMPLEX: A complex (form1) b...

New page

'''Unreleased structure'''

The entry 3ax5 is ON HOLD

Authors: Saitoh, T., Maita, Y., Kohda, D.

Description: CRYSTAL STRUCTURE OF RAT TOM20-ALDH PRESEQUENCE COMPLEX: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.