3bav - Revision history

OCA at 12:05, 30 August 2023

2023-08-30T12:05:51Z

←Older revision		Revision as of 12:05, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3bav' size='340' side='right'caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='3bav' size='340' side='right'caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BAV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.62Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1jqz\|1jqz]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [https://pdbe.org/3bav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [https://www.ebi.ac.uk/pdbsum/3bav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bav ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [https://pdbe.org/3bav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [https://www.ebi.ac.uk/pdbsum/3bav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bav ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaber, M]]	+	[[Category: Blaber M]]
-	[[Category: Lee, J]]	+	[[Category: Lee J]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Growth factor]]~~	+
-	~~[[Category: Heparin-binding]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Mitogen]]~~	+
-	~~[[Category: Polymorphism~~]]	+

OCA at 18:56, 20 October 2021

2021-10-20T18:56:03Z

←Older revision		Revision as of 18:56, 20 October 2021
Line 1:		Line 1:

	==Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor==		==Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor==
-	<StructureSection load='3bav' size='340' side='right' caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>	+	<StructureSection load='3bav' size='340' side='right'caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BAV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jqz\|1jqz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [~~http~~://pdbe.org/3bav PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bav PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bav ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [https://pdbe.org/3bav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [https://www.ebi.ac.uk/pdbsum/3bav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bav ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]	+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]

OCA at 08:07, 31 October 2018

2018-10-31T08:07:26Z

←Older revision		Revision as of 08:07, 31 October 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3bav_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3bav_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 40:
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]
		+	[[Category: Acetylation]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
Line 48:		Line 49:
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Mitogen]]		[[Category: Mitogen]]
		+	[[Category: Polymorphism]]

OCA at 07:28, 5 August 2016

2016-08-05T07:28:56Z

←Older revision		Revision as of 07:28, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor==		==Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor==
	<StructureSection load='3bav' size='340' side='right' caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='3bav' size='340' side='right' caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [http://www.ebi.ac.uk/pdbsum/3bav PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [http://pdbe.org/3bav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [http://www.ebi.ac.uk/pdbsum/3bav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bav ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bav ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3bav" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]

OCA at 16:53, 25 December 2014

2014-12-25T16:53:23Z

←Older revision		Revision as of 16:53, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [http://www.ebi.ac.uk/pdbsum/3bav PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [http://www.ebi.ac.uk/pdbsum/3bav PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blaber, M.]]	+	[[Category: Blaber, M]]
-	[[Category: Lee, J.]]	+	[[Category: Lee, J]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]

OCA at 21:23, 2 October 2014

2014-10-02T21:23:13Z

←Older revision		Revision as of 21:23, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3bav.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor==
		+	<StructureSection load='3bav' size='340' side='right' caption='[[3bav]], [[Resolution\|resolution]] 1.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bav RCSB], [http://www.ebi.ac.uk/pdbsum/3bav PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3bav_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Turn secondary structure is essential to the formation of globular protein architecture. Turn structures are, however, much more complex than either alpha-helix or beta-sheet, and the thermodynamics and folding kinetics are poorly understood. Type I beta-turns are the most common type of reverse turn, and they exhibit a statistical consensus sequence of Asx-Pro-Asx-Gly (where Asx is Asp or Asn). A comprehensive series of individual and combined Asx mutations has been constructed within three separate type I 3:5 G1 bulge beta-turns in human fibroblast growth factor-1, and their effects on structure, stability, and folding have been determined. The results show a fundamental logical OR relationship between the Asx residues in the motif, involving H-bond interactions with main-chain amides within the turn. These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i+4 and i+6. The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations. The results also show that the stability of the turn is unlikely to be the prime determinant of formation of turn structure in the folding transition state.

-	~~{{STRUCTURE_3bav\| PDB=3bav \| SCENE= }}~~	+	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.,Lee J, Dubey VK, Longo LM, Blaber M J Mol Biol. 2008 Apr 4;377(4):1251-64. Epub 2008 Jan 31. PMID:18308335<ref>PMID:18308335</ref>

-	~~===Crystal structure of L26A~~/~~D28N mutant~~ of ~~Human acidic fibroblast growth factor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18308335}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3bav~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018308335<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]

OCA: Protected "3bav" [edit=sysop:move=sysop]

2013-01-07T20:19:51Z

Protected "3bav" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:19, 7 January 2013

OCA at 20:19, 7 January 2013

2013-01-07T20:19:47Z

←Older revision		Revision as of 20:19, 7 January 2013
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-	{{Seed}}
	[[Image:3bav.png\|left\|200px]]		[[Image:3bav.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bav", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bav\| PDB=3bav \| SCENE= }}		{{STRUCTURE_3bav\| PDB=3bav \| SCENE= }}

	===Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor===		===Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18308335}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18308335 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18308335}}		{{ABSTRACT_PUBMED_18308335}}

	==About this Structure==		==About this Structure==
-	~~3BAV~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA].	+	[[3bav]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18308335~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018308335</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Lee, J.]]		[[Category: Lee, J.]]
-	[[Category: Acetylation]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
Line 36:		Line 23:
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Mitogen]]		[[Category: Mitogen]]
-	[[Category: Polymorphism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:19:23 2009''

OCA at 20:19, 17 February 2009

2009-02-17T20:19:24Z

←Older revision		Revision as of 20:19, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3BAV is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA].	+	3BAV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAV OCA].

	==Reference==		==Reference==
-	~~A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif., Lee J, Dubey VK, Longo LM, Blaber M, J Mol Biol. 2008 Apr 4;377(4):1251-64. Epub 2008 Jan 31.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18308335 18308335]~~	+	<ref group="xtra">PMID:18308335</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Lee, J.]]		[[Category: Lee, J.]]
Line 39:		Line 38:
	[[Category: Polymorphism]]		[[Category: Polymorphism]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:34:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:19:23 2009''

OCA at 03:34, 29 July 2008

2008-07-29T03:34:31Z

←Older revision		Revision as of 03:34, 29 July 2008
Line 1:		Line 1:
-	[[Image:3bav.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3bav.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3bav\| PDB=3bav \| SCENE= }}		{{STRUCTURE_3bav\| PDB=3bav \| SCENE= }}

-	~~'''~~Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor~~'''~~	+	===Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor===


-	~~==Overview==~~	+	<!--
-	~~Turn secondary structure is essential to the formation of globular protein architecture. Turn structures are~~, ~~however, much more complex than either alpha-helix or beta-sheet~~, ~~and~~ the ~~thermodynamics and folding kinetics are poorly understood. Type I beta-turns are~~ the ~~most common type of reverse turn, and they exhibit a statistical consensus sequence of Asx-Pro-Asx-Gly~~ (~~where Asx is Asp or Asn). A comprehensive series of individual and combined Asx mutations has been constructed within three separate type I 3~~:~~5 G1 bulge beta-turns in human fibroblast growth factor-1, and their effects on structure, stability, and folding have been determined~~. ~~The results show a fundamental logical OR relationship between the Asx residues in the motif, involving H-bond interactions with main-chain amides within the turn~~. These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i+4 and i+6. The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, ~~and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations. The results also show that the stability of the turn~~ is ~~unlikely to be~~ the ~~prime determinant of formation of turn structure in the folding transition state~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18308335}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18308335 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18308335}}

	==About this Structure==		==About this Structure==
Line 34:		Line 38:
	[[Category: Mitogen]]		[[Category: Mitogen]]
	[[Category: Polymorphism]]		[[Category: Polymorphism]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 16 23~~:12:19 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:34:24 2008''