3bim - Revision history

OCA at 12:09, 30 August 2023

2023-08-30T12:09:23Z

←Older revision		Revision as of 12:09, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3bim' size='340' side='right'caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3bim' size='340' side='right'caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BCL6~~, ~~BCL5, LAZ3, ZBTB27, ZNF51 (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN~~]~~), BCOR ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [https://pdbe.org/3bim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [https://www.ebi.ac.uk/pdbsum/3bim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [https://pdbe.org/3bim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [https://www.ebi.ac.uk/pdbsum/3bim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[https://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[https://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>	+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> [[https://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).<ref>PMID:10898795</ref> <ref>PMID:15004558</ref> <ref>PMID:19578371</ref> <ref>PMID:18280243</ref>	+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ghetu~~, A F~~]]	+	[[Category: Ghetu AF]]
-	[[Category: Prive~~, G G]]~~	+	[[Category: Prive GG]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Ank repeat]]~~	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Chromosomal rearrangement]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein-peptide compex]]~~	+
-	~~[[Category: Proto-oncogene]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription repressor]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 18:58, 20 October 2021

2021-10-20T18:58:13Z

←Older revision		Revision as of 18:58, 20 October 2021
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	==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==		==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==
-	<StructureSection load='3bim' size='340' side='right' caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3bim' size='340' side='right'caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), BCOR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), BCOR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [~~http~~://pdbe.org/3bim PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bim PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [https://pdbe.org/3bim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [https://www.ebi.ac.uk/pdbsum/3bim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[~~http~~://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[~~http~~://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>	+	[[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[https://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[https://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> [[~~http~~://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).<ref>PMID:10898795</ref> <ref>PMID:15004558</ref> <ref>PMID:19578371</ref> <ref>PMID:18280243</ref>	+	[[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> [[https://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).<ref>PMID:10898795</ref> <ref>PMID:15004558</ref> <ref>PMID:19578371</ref> <ref>PMID:18280243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bim_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bim_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3bim" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3bim" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ghetu, A F]]		[[Category: Ghetu, A F]]
	[[Category: Prive, G G]]		[[Category: Prive, G G]]

OCA at 08:04, 25 October 2017

2017-10-25T08:04:05Z

←Older revision		Revision as of 08:04, 25 October 2017
Line 38:		Line 38:
	[[Category: Prive, G G]]		[[Category: Prive, G G]]
	[[Category: Activator]]		[[Category: Activator]]
		+	[[Category: Alternative splicing]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
		+	[[Category: Chromosomal rearrangement]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
Line 45:		Line 47:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Protein-peptide compex]]		[[Category: Protein-peptide compex]]
	[[Category: Proto-oncogene]]		[[Category: Proto-oncogene]]
Line 51:		Line 54:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription repressor]]		[[Category: Transcription repressor]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 10:30, 11 August 2016

2016-08-11T10:30:06Z

←Older revision		Revision as of 10:30, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==		==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==
	<StructureSection load='3bim' size='340' side='right' caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3bim' size='340' side='right' caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), BCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), BCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [http://www.ebi.ac.uk/pdbsum/3bim PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [http://pdbe.org/3bim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [http://www.ebi.ac.uk/pdbsum/3bim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bim ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3bim" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ghetu, A F]]		[[Category: Ghetu, A F]]
	[[Category: Prive, G G]]		[[Category: Prive, G G]]

OCA at 11:43, 20 January 2015

2015-01-20T11:43:17Z

←Older revision		Revision as of 11:43, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [http://www.ebi.ac.uk/pdbsum/3bim PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [http://www.ebi.ac.uk/pdbsum/3bim PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[http://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>		[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[http://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ghetu, A F.]]	+	[[Category: Ghetu, A F]]
-	[[Category: Prive, G G.]]	+	[[Category: Prive, G G]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]

OCA at 21:29, 2 October 2014

2014-10-02T21:29:18Z

←Older revision		Revision as of 21:29, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3bim\| PDB=3bim \| SCENE= }}~~	+	==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==
-	===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===	+	<StructureSection load='3bim' size='340' side='right' caption='[[3bim]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18280243}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [http://www.ebi.ac.uk/pdbsum/3bim PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[http://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).<ref>PMID:10898795</ref> <ref>PMID:15004558</ref> <ref>PMID:19578371</ref> <ref>PMID:18280243</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bim_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The transcriptional corepressors BCOR, SMRT, and NCoR are known to bind competitively to the BCL6 BTB domain despite the fact that BCOR has no detectable sequence similarity to the other two corepressors. We have identified a 17 residue motif from BCOR that binds directly to the BCL6 BTB domain and determined the crystal structure of the complex to a resolution of 2.6 A. Remarkably, the BCOR BCL6 binding domain (BCOR(BBD)) peptide binds in the same BCL6 binding site as the SMRT(BBD) peptide despite the lack of any significant sequence similarity between the two peptides. Mutations of critical BCOR(BBD) residues cause the disruption of the BCL6 corepression activities of BCOR, and a BCOR(BBD) peptide blocks BCL6-mediated transcriptional repression and kills lymphoma cells.

-	~~==Disease==~~	+	Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.,Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243<ref>PMID:18280243</ref>
-	~~[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause~~ of ~~B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be~~ a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[http://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in ~~association~~ with ~~syndromes that include non-ocular abnormalities~~. ~~MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract~~, ~~microphthalmia~~, ~~or secondary glaucoma)~~, ~~facial abnormalities (long narrow face~~, ~~high nasal bridge~~, ~~pointed nose with cartilages separated at the tip~~, ~~cleft palate, or submucous cleft palate), cardiac anomalies~~ (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:~~15004558~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~//www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref><ref>PMID:18280243</ref> [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; ~~impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as~~ a ~~negative regulator~~ of ~~osteo-dentiogenic capacity in adult stem cells;~~ the ~~function implies inhibition~~ of ~~methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2)~~.<~~ref~~>~~PMID:10898795~~</~~ref~~>~~<ref>PMID:15004558</ref><ref>PMID:19578371</ref><ref>PMID:18280243</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:018280243</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghetu, A F.]]		[[Category: Ghetu, A F.]]

OCA at 17:50, 24 March 2013

2013-03-24T17:50:20Z

←Older revision		Revision as of 17:50, 24 March 2013
Line 1:		Line 1:
-	[[Image:3bim.png\|left\|200px]]
-
	{{STRUCTURE_3bim\| PDB=3bim \| SCENE= }}		{{STRUCTURE_3bim\| PDB=3bim \| SCENE= }}
-
	===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===		===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===
		+	{{ABSTRACT_PUBMED_18280243}}

-	~~{{ABSTRACT_PUBMED_18280243}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:[http://omim.org/entry/300166 300166]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).<ref>PMID:15004558</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref><ref>PMID:18280243</ref> [[http://www.uniprot.org/uniprot/BCOR_HUMAN BCOR_HUMAN]] Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).<ref>PMID:10898795</ref><ref>PMID:15004558</ref><ref>PMID:19578371</ref><ref>PMID:18280243</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018280243</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018280243</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghetu, A F.]]		[[Category: Ghetu, A F.]]

OCA: Protected "3bim" [edit=sysop:move=sysop]

2013-01-07T20:24:27Z

Protected "3bim" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:24, 7 January 2013

OCA at 20:24, 7 January 2013

2013-01-07T20:24:25Z

←Older revision		Revision as of 20:24, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3bim.png\|left\|200px]]		[[Image:3bim.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bim", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bim\| PDB=3bim \| SCENE= }}		{{STRUCTURE_3bim\| PDB=3bim \| SCENE= }}

	===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===		===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18280243}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18280243 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18280243}}		{{ABSTRACT_PUBMED_18280243}}
-
-	==Disease==
-	Known disease associated with this structure: Microphthalmia, syndromic 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300485 300485]]

	==About this Structure==		==About this Structure==
-	~~3BIM~~ is a 16 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].	+	[[3bim]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18280243~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018280243</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghetu, A F.]]		[[Category: Ghetu, A F.]]
	[[Category: Prive, G G.]]		[[Category: Prive, G G.]]
	[[Category: Activator]]		[[Category: Activator]]
-	[[Category: Alternative splicing]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
-	[[Category: Chromosomal rearrangement]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
Line 40:		Line 23:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Protein-peptide compex]]		[[Category: Protein-peptide compex]]
	[[Category: Proto-oncogene]]		[[Category: Proto-oncogene]]
Line 47:		Line 29:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription repressor]]		[[Category: Transcription repressor]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 16:23:02 2010''

OCA at 14:23, 20 January 2010

2010-01-20T14:23:03Z

←Older revision		Revision as of 14:23, 20 January 2010
Line 12:		Line 12:
	===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===		===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18280243}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18280243 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18280243}}

	==Disease==		==Disease==
Line 17:		Line 23:

	==About this Structure==		==About this Structure==
-	3BIM is a 16 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].	+	3BIM is a 16 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18280243</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghetu, A F.]]		[[Category: Ghetu, A F.]]
Line 41:		Line 50:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 22~~:30:~~41 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 16:23:02 2010''