3bin - Revision history

OCA at 14:03, 13 March 2024

2024-03-13T14:03:47Z

←Older revision		Revision as of 14:03, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='3bin' size='340' side='right'caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3bin' size='340' side='right'caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2he7\|2he7]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [https://pdbe.org/3bin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [https://www.ebi.ac.uk/pdbsum/3bin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bin ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [https://pdbe.org/3bin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [https://www.ebi.ac.uk/pdbsum/3bin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bin ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas. [[https://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]	+	[https://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN] Critical growth regulator in the pathogenesis of meningiomas.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bin ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bin ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Perturbed cell-adhesion mechanisms are crucial for tumor invasion and metastasis. A cell-adhesion protein, Tumor Suppressor in Lung Cancer 1 (TSLC1), is inactivated in a majority of metastatic cancers. DAL-1 (differentially expressed in adenocarcinoma of the lung protein), another tumor suppressor, binds through its FERM domain to the TSLC1 C-terminal, 4.1 glycophorin C-like, cytoplasmic domain. However, the molecular basis for this interaction is unknown. Here, we describe the crystal structure of a complex between the DAL-1 FERM domain and a portion of the TSLC1 cytoplasmic domain. DAL-1 binds to TSLC1 through conserved residues in a well-defined hydrophobic pocket in the DAL-1 FERM domain's structural C-lobe. From the crystal structure, it is apparent that Tyr406 and Thr408 in the TSLC1 cytoplasmic domain form the most important interactions with DAL-1 and this was also confirmed by surface plasmon resonance studies. Our results refute earlier exon deletion experiments that indicated that glycophorin-C interacts with the alpha-lobe of 4.1 FERM domains.
-
-	Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).,Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM J Biol Chem. 2010 Dec 3. PMID:21131357<ref>PMID:21131357</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3bin" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Arrowsmith CH]]
-	~~[[Category: Berg, S Van Den~~]]	+	[[Category: Berglund H]]
-	[[Category: Berglund, H]]	+	[[Category: Busam RD]]
-	[[Category: Busam~~, R D~~]]	+	[[Category: Collins R]]
-	[[Category: Collins, R]]	+	[[Category: Dahlgren LG]]
-	[[Category: Dahlgren~~, L G~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Flodin S]]
-	[[Category: Flodin, S]]	+	[[Category: Flores A]]
-	[[Category: Flores, A]]	+	[[Category: Graslund S]]
-	[[Category: Graslund, S]]	+	[[Category: Hallberg BM]]
-	[[Category: Hallberg~~, B M~~]]	+	[[Category: Hammarstrom M]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Johansson A]]
-	[[Category: Johansson, A]]	+	[[Category: Johansson I]]
-	[[Category: Johansson, I]]	+	[[Category: Kallas A]]
-	[[Category: Kallas, A]]	+	[[Category: Karlberg T]]
-	[[Category: Karlberg, T]]	+	[[Category: Kotenyova T]]
-	[[Category: Kotenyova, T]]	+	[[Category: Lehtio L]]
-	[[Category: Lehtio, L]]	+	[[Category: Moche M]]
-	[[Category: Moche, M]]	+	[[Category: Nilsson ME]]
-	[[Category: Nilsson~~, M E~~]]	+	[[Category: Nordlund P]]
-	[[Category: Nordlund, P]]	+	[[Category: Nyman T]]
-	[[Category: Nyman, T]]	+	[[Category: Persson C]]
-	[[Category: Persson, C]]	+	[[Category: Sagemark J]]
-	[[Category: Sagemark, J]]	+	[[Category: Svensson L]]
-	[[Category: Svensson, L]]	+	[[Category: Thorsell AG]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Tresaugues L]]
-	[[Category: Tresaugues, L]]	+	[[Category: Van Den Berg S]]
-	[[Category: ~~Weigelt, J~~]]	+	[[Category: Weigelt J]]
-	[[Category: ~~Welin, M~~]]	+	[[Category: Welin M]]
-	[[Category: ~~Actin-binding]]~~	+
-	~~[[Category: Anti-oncogene]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Dal-1]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Ferm domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Spermatogenesis]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Tslc1~~]]	+

OCA at 10:43, 12 January 2022

2022-01-12T10:43:18Z

←Older revision		Revision as of 10:43, 12 January 2022
Line 1:		Line 1:

	==Structure of the DAL-1 and TSLC1 (372-383) complex==		==Structure of the DAL-1 and TSLC1 (372-383) complex==
-	<StructureSection load='3bin' size='340' side='right' caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3bin' size='340' side='right'caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2he7\|2he7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [~~http~~://pdbe.org/3bin PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bin PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bin ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [https://pdbe.org/3bin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [https://www.ebi.ac.uk/pdbsum/3bin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bin ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas. [[~~http~~://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]	+	[[https://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas. [[https://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Den]]		[[Category: Berg, S Van Den]]

OCA at 07:53, 31 October 2018

2018-10-31T07:53:46Z

←Older revision		Revision as of 07:53, 31 October 2018
Line 1:		Line 1:
		+
	==Structure of the DAL-1 and TSLC1 (372-383) complex==		==Structure of the DAL-1 and TSLC1 (372-383) complex==
	<StructureSection load='3bin' size='340' side='right' caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3bin' size='340' side='right' caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://pdbe.org/3bin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://pdbe.org/3bin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bin ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bin_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bin_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:47, 9 February 2016

2016-02-09T02:47:38Z

←Older revision		Revision as of 02:47, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3bin' size='340' side='right' caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3bin' size='340' side='right' caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://pdbe.org/3bin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bin ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3bin" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Berg, S Van Den]]		[[Category: Berg, S Van Den]]

OCA at 03:53, 25 December 2014

2014-12-25T03:53:16Z

←Older revision		Revision as of 03:53, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas. [[http://www.uniprot.org/uniprot/CADM1_HUMAN CADM1_HUMAN]] Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.<ref>PMID:11279526</ref> <ref>PMID:12234973</ref> <ref>PMID:12050160</ref> <ref>PMID:12920246</ref> <ref>PMID:15811952</ref> <ref>PMID:15905536</ref> [UniProtKB:Q8R5M8]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S Van Den.]]	+	[[Category: Berg, S Van Den]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Busam, R D.]]	+	[[Category: Busam, R D]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Dahlgren, L G.]]	+	[[Category: Dahlgren, L G]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hallberg, B M.]]	+	[[Category: Hallberg, B M]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Johansson, A.]]	+	[[Category: Johansson, A]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Kallas, A.]]	+	[[Category: Kallas, A]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nilsson, M E.]]	+	[[Category: Nilsson, M E]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: Sagemark, J.]]	+	[[Category: Sagemark, J]]
-	[[Category: Svensson, L.]]	+	[[Category: Svensson, L]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Anti-oncogene]]		[[Category: Anti-oncogene]]

OCA at 21:08, 2 October 2014

2014-10-02T21:08:59Z

←Older revision		Revision as of 21:08, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3bin.~~png~~\|~~left~~\|200px]]	+	==Structure of the DAL-1 and TSLC1 (372-383) complex==
		+	<StructureSection load='3bin' size='340' side='right' caption='[[3bin]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2he7\|2he7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPB41L3, DAL1, KIAA0987 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bin RCSB], [http://www.ebi.ac.uk/pdbsum/3bin PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bin_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Perturbed cell-adhesion mechanisms are crucial for tumor invasion and metastasis. A cell-adhesion protein, Tumor Suppressor in Lung Cancer 1 (TSLC1), is inactivated in a majority of metastatic cancers. DAL-1 (differentially expressed in adenocarcinoma of the lung protein), another tumor suppressor, binds through its FERM domain to the TSLC1 C-terminal, 4.1 glycophorin C-like, cytoplasmic domain. However, the molecular basis for this interaction is unknown. Here, we describe the crystal structure of a complex between the DAL-1 FERM domain and a portion of the TSLC1 cytoplasmic domain. DAL-1 binds to TSLC1 through conserved residues in a well-defined hydrophobic pocket in the DAL-1 FERM domain's structural C-lobe. From the crystal structure, it is apparent that Tyr406 and Thr408 in the TSLC1 cytoplasmic domain form the most important interactions with DAL-1 and this was also confirmed by surface plasmon resonance studies. Our results refute earlier exon deletion experiments that indicated that glycophorin-C interacts with the alpha-lobe of 4.1 FERM domains.

-	~~{{STRUCTURE_3bin\| PDB=3bin \| SCENE= }}~~	+	Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).,Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM J Biol Chem. 2010 Dec 3. PMID:21131357<ref>PMID:21131357</ref>

-	~~===Structure~~ of the ~~DAL-1 and TSLC1 (372-383) complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21131357}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3bin]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021131357<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA at 19:27, 7 January 2013

2013-01-07T19:27:45Z

←Older revision		Revision as of 19:27, 7 January 2013
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	[[Image:3bin.png\|left\|200px]]		[[Image:3bin.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bin", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bin\| PDB=3bin \| SCENE= }}		{{STRUCTURE_3bin\| PDB=3bin \| SCENE= }}

	===Structure of the DAL-1 and TSLC1 (372-383) complex===		===Structure of the DAL-1 and TSLC1 (372-383) complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21131357}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21131357 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21131357}}		{{ABSTRACT_PUBMED_21131357}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21131357~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021131357</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 53:		Line 42:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Welin, M.]]		[[Category: Welin, M.]]
		+	[[Category: Actin-binding]]
		+	[[Category: Anti-oncogene]]
		+	[[Category: Apoptosis]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Dal-1]]
		+	[[Category: Developmental protein]]
		+	[[Category: Differentiation]]
		+	[[Category: Ferm domain]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immune response]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Membrane]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Spermatogenesis]]
		+	[[Category: Structural protein]]
		+	[[Category: Transmembrane]]
		+	[[Category: Tslc1]]

OCA: Protected "3bin" [edit=sysop:move=sysop]

2011-01-12T05:22:26Z

Protected "3bin" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 12 January 2011

OCA at 05:22, 12 January 2011

2011-01-12T05:22:23Z

←Older revision		Revision as of 05:22, 12 January 2011
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-	{{Seed}}
	[[Image:3bin.png\|left\|200px]]		[[Image:3bin.png\|left\|200px]]

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	===Structure of the DAL-1 and TSLC1 (372-383) complex===		===Structure of the DAL-1 and TSLC1 (372-383) complex===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21131357}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21131357 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21131357}}

	==About this Structure==		==About this Structure==
-	~~3BIN~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA].	+	[[3bin]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21131357</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 45:		Line 53:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Welin, M.]]		[[Category: Welin, M.]]
-	[[Category: Actin-binding]]
-	[[Category: Alternative splicing]]
-	[[Category: Anti-oncogene]]
-	[[Category: Apoptosis]]
-	[[Category: Cell adhesion]]
-	[[Category: Cell cycle]]
-	[[Category: Cytoplasm]]
-	[[Category: Cytoskeleton]]
-	[[Category: Dal-1]]
-	[[Category: Developmental protein]]
-	[[Category: Differentiation]]
-	[[Category: Ferm domain]]
-	[[Category: Glycoprotein]]
-	[[Category: Immune response]]
-	[[Category: Immunoglobulin domain]]
-	[[Category: Membrane]]
-	[[Category: Phosphoprotein]]
-	[[Category: Spermatogenesis]]
-	[[Category: Structural protein]]
-	[[Category: Transmembrane]]
-	[[Category: Tslc1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:50:55 2009''

OCA at 03:50, 17 February 2009

2009-02-17T03:50:55Z

←Older revision		Revision as of 03:50, 17 February 2009
Line 1:		Line 1:
-	[[Image:3bin.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3bin.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3bin\| PDB=3bin \| SCENE= }}		{{STRUCTURE_3bin\| PDB=3bin \| SCENE= }}

-	~~'''~~Structure of the DAL-1 and TSLC1 (372-383) complex~~'''~~	+	===Structure of the DAL-1 and TSLC1 (372-383) complex===


	==About this Structure==		==About this Structure==
-	3BIN is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA].	+	3BIN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIN OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
	[[Category: Berg, S Van Den.]]		[[Category: Berg, S Van Den.]]
Line 66:		Line 66:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Tslc1]]		[[Category: Tslc1]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 20~~:48:~~54 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:50:55 2009''