3bjl - Revision history

OCA at 10:44, 12 January 2022

2022-01-12T10:44:21Z

←Older revision		Revision as of 10:44, 12 January 2022
Line 3:		Line 3:
	<StructureSection load='3bjl' size='340' side='right'caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3bjl' size='340' side='right'caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BJL FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [~~http~~://pdbe.org/3bjl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bjl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [https://pdbe.org/3bjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [https://www.ebi.ac.uk/pdbsum/3bjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:46, 25 December 2019

2019-12-25T09:46:24Z

←Older revision		Revision as of 09:46, 25 December 2019
Line 1:		Line 1:

	==LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE==		==LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE==
-	<StructureSection load='3bjl' size='340' side='right' caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3bjl' size='340' side='right'caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Huang, D B]]		[[Category: Huang, D B]]
	[[Category: Schiffer, M]]		[[Category: Schiffer, M]]

OCA at 07:56, 31 October 2018

2018-10-31T07:56:08Z

←Older revision		Revision as of 07:56, 31 October 2018
Line 1:		Line 1:
		+
	==LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE==		==LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE==
	<StructureSection load='3bjl' size='340' side='right' caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3bjl' size='340' side='right' caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://pdbe.org/3bjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://pdbe.org/3bjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bjl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:42, 7 February 2016

2016-02-07T18:42:43Z

←Older revision		Revision as of 18:42, 7 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://pdbe.org/3bjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bjl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3bjl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:09, 20 January 2015

2015-01-20T08:09:04Z

←Older revision		Revision as of 08:09, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Huang, D B.]]	+	[[Category: Huang, D B]]
-	[[Category: Schiffer, M.]]	+	[[Category: Schiffer, M]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Bence jone]]		[[Category: Bence jone]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
	[[Category: Multiple quaternary structure]]		[[Category: Multiple quaternary structure]]

OCA at 21:10, 2 October 2014

2014-10-02T21:10:23Z

←Older revision		Revision as of 21:10, 2 October 2014
Line 1:		Line 1:
-	[[~~Image~~:3bjl.~~png\|left~~\|200px]]	+	==LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE==
		+	<StructureSection load='3bjl' size='340' side='right' caption='[[3bjl]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BJL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bjl RCSB], [http://www.ebi.ac.uk/pdbsum/3bjl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bjl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of a multisubunit protein (immunoglobulin light chain) was solved in three crystal forms, differing only in the solvent of crystallization. The three structures were obtained at high ionic strength and low pH, high ionic strength and high pH, and low ionic strength and neutral pH. The three resulting "snapshots" of possible structures show that their variable-domain interactions differ, reflecting their stabilities under specific solvent conditions. In the three crystal forms, the variable domains had different rotational and translational relationships, whereas no alteration of the constant domains was found. The critical residues involved in the observed effect of the solvent are tryptophans and histidines located between the two variable domains in the dimeric structure. Tryptophan residues are commonly found in interfaces between proteins and their subunits, and histidines have been implicated in pH-dependent conformation changes. The quaternary structure observed for a multisubunit protein or protein complex in a crystal may be influenced by the interactions of the constituents within the molecule or complex and/or by crystal packing interactions. The comparison of buried surface areas and hydrogen bonds between the domains forming the molecule and between the molecules forming the crystals suggest that, for this system, the interactions within the molecule are most likely the determining factors.

-	~~{{STRUCTURE_3bjl\| PDB=3bjl \| SCENE= }}~~	+	Three quaternary structures for a single protein.,Huang DB, Ainsworth CF, Stevens FJ, Schiffer M Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7017-21. PMID:8692936<ref>PMID:8692936</ref>

-	~~===LOC~~, ~~A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8692936}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3bjl]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008692936<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Huang, D B.]]		[[Category: Huang, D B.]]

OCA: Protected "3bjl" [edit=sysop:move=sysop]

2013-01-07T18:03:32Z

Protected "3bjl" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:03, 7 January 2013

OCA at 18:03, 7 January 2013

2013-01-07T18:03:30Z

←Older revision		Revision as of 18:03, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3bjl.png\|left\|200px]]		[[Image:3bjl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bjl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bjl\| PDB=3bjl \| SCENE= }}		{{STRUCTURE_3bjl\| PDB=3bjl \| SCENE= }}

	===LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE===		===LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8692936}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8692936 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8692936}}		{{ABSTRACT_PUBMED_8692936}}

	==About this Structure==		==About this Structure==
-	~~3BJL~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA].	+	[[3bjl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8692936~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008692936</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Huang, D B.]]		[[Category: Huang, D B.]]
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	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Bence jone]]		[[Category: Bence jone]]
		+	[[Category: Immunoglobulin]]
	[[Category: Multiple quaternary structure]]		[[Category: Multiple quaternary structure]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:50:05 2009''

OCA at 13:50, 16 February 2009

2009-02-16T13:50:07Z

←Older revision		Revision as of 13:50, 16 February 2009
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	==About this Structure==		==About this Structure==
-	3BJL is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA].	+	3BJL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bjl 1bjl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJL OCA].

	==Reference==		==Reference==
-	~~Three quaternary structures for a single protein., Huang DB, Ainsworth CF, Stevens FJ, Schiffer M, Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7017-21.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/8692936 8692936]~~	+	<ref group="xtra">PMID:8692936</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Huang, D B.]]		[[Category: Huang, D B.]]
	[[Category: Schiffer, M.]]		[[Category: Schiffer, M.]]
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	[[Category: Multiple quaternary structure]]		[[Category: Multiple quaternary structure]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 18~~:50:~~11 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:50:05 2009''

OCA at 15:50, 27 July 2008

2008-07-27T15:50:12Z

←Older revision		Revision as of 15:50, 27 July 2008
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-	[[Image:3bjl.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3bjl.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3bjl\| PDB=3bjl \| SCENE= }}		{{STRUCTURE_3bjl\| PDB=3bjl \| SCENE= }}

-	~~'''~~LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE~~'''~~	+	===LOC, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN AMMONIUM SULFATE===


-	~~==Overview==~~	+	<!--
-	The ~~structure of a multisubunit protein (immunoglobulin light chain) was solved in three crystal forms~~, ~~differing only in~~ the ~~solvent of crystallization. The three structures were obtained~~ at ~~high ionic strength and low pH, high ionic strength and high pH, and low ionic strength and neutral pH~~. ~~The three resulting "snapshots" of possible structures show that their variable-domain interactions differ, reflecting their stabilities under specific solvent conditions~~. ~~In the three crystal forms~~, the ~~variable domains had different rotational and translational relationships, whereas no alteration of the constant domains was found~~. The critical residues involved in the observed effect of the solvent are tryptophans and histidines located between the two variable domains in the dimeric structure. Tryptophan residues are commonly found in interfaces between proteins and their subunits, and histidines have been implicated in pH-dependent conformation changes. The quaternary structure observed for a multisubunit protein or protein complex in a crystal may be influenced by the interactions of the constituents within the molecule or complex and/or by crystal packing interactions. The comparison of buried surface areas and hydrogen bonds between the domains forming the molecule and between the molecules forming the crystals suggest that, for this system, the interactions within the molecule are most likely the determining factors.	+	The line below this paragraph, {{ABSTRACT_PUBMED_8692936}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8692936 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8692936}}

	==About this Structure==		==About this Structure==
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	[[Category: Bence jone]]		[[Category: Bence jone]]
	[[Category: Multiple quaternary structure]]		[[Category: Multiple quaternary structure]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 20~~:51:14 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:50:11 2008''