3boc - Revision history

OCA at 09:58, 14 February 2024

2024-02-14T09:58:18Z

←Older revision		Revision as of 09:58, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3boc' size='340' side='right'caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3boc' size='340' side='right'caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conticribra_weissflogii Conticribra weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3bob\|3bob]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [https://pdbe.org/3boc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [https://www.ebi.ac.uk/pdbsum/3boc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [https://pdbe.org/3boc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [https://www.ebi.ac.uk/pdbsum/3boc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q50EL4_THAWE Q50EL4_THAWE]
-	Carbonic anhydrase, a zinc enzyme found in organisms from all kingdoms, catalyses the reversible hydration of carbon dioxide and is used for inorganic carbon acquisition by phytoplankton. In the oceans, where zinc is nearly depleted, diatoms use cadmium as a catalytic metal atom in cadmium carbonic anhydrase (CDCA). Here we report the crystal structures of CDCA in four distinct forms: cadmium-bound, zinc-bound, metal-free and acetate-bound. Despite lack of sequence homology, CDCA is a structural mimic of a functional beta-carbonic anhydrase dimer, with striking similarity in the spatial organization of the active site residues. CDCA readily exchanges cadmium and zinc at its active site--an apparently unique adaptation to oceanic life that is explained by a stable opening of the metal coordinating site in the absence of metal. Given the central role of diatoms in exporting carbon to the deep sea, their use of cadmium in an enzyme critical for carbon acquisition establishes a remarkable link between the global cycles of cadmium and carbon.	+
-		+
-	~~Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.,Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM Nature. 2008 Mar 6;452(7183):56-61. PMID:18322527<ref>PMID:18322527<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3boc" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]		*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase~~]]	+	[[Category: Conticribra weissflogii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Feng, L]]	+	[[Category: Feng L]]
-	[[Category: Jeffrey~~, P D~~]]	+	[[Category: Jeffrey PD]]
-	[[Category: Morel~~, F M.M~~]]	+	[[Category: Morel FMM]]
-	[[Category: Shi, Y]]	+	[[Category: Shi Y]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	~~[[Category: Carbonic anhydrase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Marine diatom]]~~	+
-	~~[[Category: Zinc-bound~~]]	+

OCA at 06:49, 12 May 2022

2022-05-12T06:49:44Z

←Older revision		Revision as of 06:49, 12 May 2022
Line 3:		Line 3:
	<StructureSection load='3boc' size='340' side='right'caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3boc' size='340' side='right'caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3BOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bob\|3bob]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [~~http~~://pdbe.org/3boc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3boc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [https://pdbe.org/3boc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [https://www.ebi.ac.uk/pdbsum/3boc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:19, 5 August 2020

2020-08-05T06:19:05Z

←Older revision		Revision as of 06:19, 5 August 2020
Line 1:		Line 1:

	==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)==		==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)==
-	<StructureSection load='3boc' size='340' side='right' caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3boc' size='340' side='right'caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3BOC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://pdbe.org/3boc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://pdbe.org/3boc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Large Structures]]
	[[Category: Feng, L]]		[[Category: Feng, L]]
	[[Category: Jeffrey, P D]]		[[Category: Jeffrey, P D]]

OCA at 07:38, 31 October 2018

2018-10-31T07:38:37Z

←Older revision		Revision as of 07:38, 31 October 2018
Line 3:		Line 3:
	<StructureSection load='3boc' size='340' side='right' caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3boc' size='340' side='right' caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Marine_diatom Marine diatom]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdca1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67004 Marine diatom])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://pdbe.org/3boc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://pdbe.org/3boc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: Marine diatom]]
	[[Category: Feng, L]]		[[Category: Feng, L]]
	[[Category: Jeffrey, P D]]		[[Category: Jeffrey, P D]]
Line 35:		Line 33:
	[[Category: Carbonic anhydrase]]		[[Category: Carbonic anhydrase]]
	[[Category: Lyase]]		[[Category: Lyase]]
		+	[[Category: Marine diatom]]
	[[Category: Zinc-bound]]		[[Category: Zinc-bound]]

OCA at 09:06, 11 August 2016

2016-08-11T09:06:56Z

←Older revision		Revision as of 09:06, 11 August 2016
Line 1:		Line 1:
		+
	==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)==		==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)==
	<StructureSection load='3boc' size='340' side='right' caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3boc' size='340' side='right' caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thalassiosira_weissflogii Thalassiosira weissflogii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Marine_diatom Marine diatom]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdca1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67004 ~~Thalassiosira weissflogii~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdca1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67004 Marine diatom])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://pdbe.org/3boc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3boc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3boc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: ~~Thalassiosira weissflogii~~]]	+	[[Category: Marine diatom]]
	[[Category: Feng, L]]		[[Category: Feng, L]]
	[[Category: Jeffrey, P D]]		[[Category: Jeffrey, P D]]
Line 33:		Line 35:
	[[Category: Carbonic anhydrase]]		[[Category: Carbonic anhydrase]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	[[Category: Marine diatom]]
	[[Category: Zinc-bound]]		[[Category: Zinc-bound]]

OCA at 10:16, 25 January 2015

2015-01-25T10:16:34Z

←Older revision		Revision as of 10:16, 25 January 2015
Line 26:		Line 26:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Thalassiosira weissflogii]]		[[Category: Thalassiosira weissflogii]]
-	[[Category: Feng, L.]]	+	[[Category: Feng, L]]
-	[[Category: Jeffrey, P D.]]	+	[[Category: Jeffrey, P D]]
-	[[Category: Morel, F M.M.]]	+	[[Category: Morel, F M.M]]
-	[[Category: Shi, Y.]]	+	[[Category: Shi, Y]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
	[[Category: Carbonic anhydrase]]		[[Category: Carbonic anhydrase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Marine diatom]]		[[Category: Marine diatom]]
	[[Category: Zinc-bound]]		[[Category: Zinc-bound]]

OCA at 09:24, 5 November 2014

2014-11-05T09:24:45Z

←Older revision		Revision as of 09:24, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3boc.~~png~~\|~~left~~\|~~200px~~]]	+	==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)==
		+	<StructureSection load='3boc' size='340' side='right' caption='[[3boc]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3boc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bob\|3bob]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdca1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67004 Thalassiosira weissflogii])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3boc RCSB], [http://www.ebi.ac.uk/pdbsum/3boc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbonic anhydrase, a zinc enzyme found in organisms from all kingdoms, catalyses the reversible hydration of carbon dioxide and is used for inorganic carbon acquisition by phytoplankton. In the oceans, where zinc is nearly depleted, diatoms use cadmium as a catalytic metal atom in cadmium carbonic anhydrase (CDCA). Here we report the crystal structures of CDCA in four distinct forms: cadmium-bound, zinc-bound, metal-free and acetate-bound. Despite lack of sequence homology, CDCA is a structural mimic of a functional beta-carbonic anhydrase dimer, with striking similarity in the spatial organization of the active site residues. CDCA readily exchanges cadmium and zinc at its active site--an apparently unique adaptation to oceanic life that is explained by a stable opening of the metal coordinating site in the absence of metal. Given the central role of diatoms in exporting carbon to the deep sea, their use of cadmium in an enzyme critical for carbon acquisition establishes a remarkable link between the global cycles of cadmium and carbon.

-	~~{{STRUCTURE_3boc\| PDB=3boc \| SCENE= }}~~	+	Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.,Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM Nature. 2008 Mar 6;452(7183):56-61. PMID:18322527<ref>PMID:18322527</ref>

-	~~===Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18322527}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3boc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA].~~	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase\|Carbonic anhydrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018322527<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Thalassiosira weissflogii]]		[[Category: Thalassiosira weissflogii]]

OCA at 05:50, 20 October 2012

2012-10-20T05:50:21Z

←Older revision		Revision as of 05:50, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3boc]] is a 1 chain structure ~~of [[Carbonic anhydrase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA].	+	[[3boc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA].

	==See Also==		==See Also==

OCA: Protected "3boc" [edit=sysop:move=sysop]

2012-07-25T11:17:42Z

Protected "3boc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 25 July 2012

OCA at 11:17, 25 July 2012

2012-07-25T11:17:41Z

←Older revision		Revision as of 11:17, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3boc.png\|left\|200px]]		[[Image:3boc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3boc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3boc\| PDB=3boc \| SCENE= }}		{{STRUCTURE_3boc\| PDB=3boc \| SCENE= }}

	===Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)===		===Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18322527}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18322527 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18322527}}		{{ABSTRACT_PUBMED_18322527}}

	==About this Structure==		==About this Structure==
-	~~3BOC~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA].	+	[[3boc]] is a 1 chain structure of [[Carbonic anhydrase]] with sequence from [http://en.wikipedia.org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOC OCA].
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18322527~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018322527</ref><references group="xtra"/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Thalassiosira weissflogii]]		[[Category: Thalassiosira weissflogii]]
Line 35:		Line 26:
	[[Category: Marine diatom]]		[[Category: Marine diatom]]
	[[Category: Zinc-bound]]		[[Category: Zinc-bound]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:38:19 2010''