3bp6 - Revision history

OCA at 12:11, 30 August 2023

2023-08-30T12:11:41Z

←Older revision		Revision as of 12:11, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3bp5\|3bp5]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">Pdcd1, Pd1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [https://pdbe.org/3bp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [https://pdbe.org/3bp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[https://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>	+	[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]		*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Almo SC]]
-	[[Category: Cao, E]]	+	[[Category: Cao E]]
-	[[Category: Lazar-Molnar, E]]	+	[[Category: Lazar-Molnar E]]
-	[[Category: Nathenson~~, S G~~]]	+	[[Category: Nathenson SG]]
-	[[Category: Ramagopal~~, U A~~]]	+	[[Category: Ramagopal UA]]
-	[[Category: Toro, R]]	+	[[Category: Toro R]]
-	[[Category: Yan, Q]]	+	[[Category: Yan Q]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Costimulation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Pd-1]]~~	+
-	~~[[Category: Pd-l2]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 18:59, 20 October 2021

2021-10-20T18:59:59Z

←Older revision		Revision as of 18:59, 20 October 2021
Line 1:		Line 1:

	==Crystal structure of the mouse PD-1 Mutant and PD-L2 complex==		==Crystal structure of the mouse PD-1 Mutant and PD-L2 complex==
-	<StructureSection load='3bp6' size='340' side='right' caption='[[3bp6]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3bp6' size='340' side='right'caption='[[3bp6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bp5\|3bp5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bp5\|3bp5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [~~http~~://pdbe.org/3bp6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3bp6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [https://pdbe.org/3bp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[~~http~~://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>	+	[[https://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[https://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bp6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bp6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bp6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bp6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 08:07, 25 October 2017

2017-10-25T08:07:45Z

←Older revision		Revision as of 08:07, 25 October 2017
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bp6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bp6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:14, 5 August 2016

2016-08-05T21:14:23Z

←Older revision		Revision as of 21:14, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the mouse PD-1 Mutant and PD-L2 complex==		==Crystal structure of the mouse PD-1 Mutant and PD-L2 complex==
	<StructureSection load='3bp6' size='340' side='right' caption='[[3bp6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3bp6' size='340' side='right' caption='[[3bp6]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bp5\|3bp5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bp5\|3bp5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3bp6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [http://pdbe.org/3bp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3bp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bp6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bp6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 21:57, 25 December 2014

2014-12-25T21:57:01Z

←Older revision		Revision as of 21:57, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bp5\|3bp5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bp5\|3bp5]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3bp6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3bp6 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity). [[http://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE]] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 23:
	==See Also==		==See Also==
	*[[Cell death protein\|Cell death protein]]		*[[Cell death protein\|Cell death protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Cao, E.]]	+	[[Category: Cao, E]]
-	[[Category: Lazar-Molnar, E.]]	+	[[Category: Lazar-Molnar, E]]
-	[[Category: Nathenson, S G.]]	+	[[Category: Nathenson, S G]]
-	[[Category: Ramagopal, U A.]]	+	[[Category: Ramagopal, U A]]
-	[[Category: Toro, R.]]	+	[[Category: Toro, R]]
-	[[Category: Yan, Q.]]	+	[[Category: Yan, Q]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Costimulation]]		[[Category: Costimulation]]

OCA at 08:32, 29 September 2014

2014-09-29T08:32:57Z

←Older revision		Revision as of 08:32, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:3bp6.png\|left\|200px]]~~	+	==Crystal structure of the mouse PD-1 Mutant and PD-L2 complex==
-		+	<StructureSection load='3bp6' size='340' side='right' caption='[[3bp6]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{STRUCTURE_3bp6\| PDB=3bp6 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3bp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BP6 FirstGlance]. <br>
-	===Crystal structure of the mouse PD-1 Mutant and PD-L2 complex===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bp5\|3bp5]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd1, Pd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bp6 RCSB], [http://www.ebi.ac.uk/pdbsum/3bp6 PDBsum]</span></td></tr>
-	[[3bp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA].	+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/3bp6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Cell death protein\|Cell death protein]]		*[[Cell death protein\|Cell death protein]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]

OCA: Protected "3bp6" [edit=sysop:move=sysop]

2012-10-20T22:07:58Z

Protected "3bp6" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:07, 20 October 2012

OCA at 22:07, 20 October 2012

2012-10-20T22:07:55Z

←Older revision		Revision as of 22:07, 20 October 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3bp6.png\|left\|200px]]
-	[[Image:3bp6.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3bp6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3bp6\| PDB=3bp6 \| SCENE= }}		{{STRUCTURE_3bp6\| PDB=3bp6 \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~3BP6~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA].	+	[[3bp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA].
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
Line 33:		Line 29:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:26:23 2009''

OCA at 07:26, 25 February 2009

2009-02-25T07:26:25Z

←Older revision		Revision as of 07:26, 25 February 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3bp6.jpg\|left\|200px]]

-	The ~~entry 3bp6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3bp6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3bp6\| PDB=3bp6 \| SCENE= }}

-	~~Authors: Yan, Q., Lazar~~-~~Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C.~~	+	===Crystal structure of the mouse PD-1 Mutant and PD-L2 complex===

-	Description: Crystal structure of the mouse PD-1 Mutant and PD-L2 complex

		+	==About this Structure==
		+	3BP6 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BP6 OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Almo, S C.]]
		+	[[Category: Cao, E.]]
		+	[[Category: Lazar-Molnar, E.]]
		+	[[Category: Nathenson, S G.]]
		+	[[Category: Ramagopal, U A.]]
		+	[[Category: Toro, R.]]
		+	[[Category: Yan, Q.]]
		+	[[Category: Complex]]
		+	[[Category: Costimulation]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Membrane]]
		+	[[Category: Pd-1]]
		+	[[Category: Pd-l2]]
		+	[[Category: Receptor]]
		+	[[Category: Signaling protein]]
		+	[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11~~ 09:27:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:26:23 2009''

OCA: New page: '''Unreleased structure''' The entry 3bp6 is ON HOLD until Paper Publication Authors: Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C. Descrip...

2008-06-11T06:27:31Z

New page: '''Unreleased structure''' The entry 3bp6 is ON HOLD until Paper Publication Authors: Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C. Descrip...

New page

'''Unreleased structure'''

The entry 3bp6 is ON HOLD until Paper Publication

Authors: Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C.

Description: Crystal structure of the mouse PD-1 Mutant and PD-L2 complex

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:27:31 2008''