3cj7 - Revision history

OCA at 07:58, 27 January 2022

2022-01-27T07:58:14Z

←Older revision		Revision as of 07:58, 27 January 2022
Line 1:		Line 1:

	==Structure of Rattus norvegicus NTPDase2 in complex with AMP==		==Structure of Rattus norvegicus NTPDase2 in complex with AMP==
-	<StructureSection load='3cj7' size='340' side='right' caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3cj7' size='340' side='right'caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [~~http~~://pdbe.org/3cj7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cj7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cj7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [https://pdbe.org/3cj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3cj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cj7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.	+	[[https://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 40:		Line 40:
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Strater, N]]		[[Category: Strater, N]]
	[[Category: Zebisch, M]]		[[Category: Zebisch, M]]

OCA at 13:46, 7 November 2018

2018-11-07T13:46:48Z

←Older revision		Revision as of 13:46, 7 November 2018
Line 1:		Line 1:
		+
	==Structure of Rattus norvegicus NTPDase2 in complex with AMP==		==Structure of Rattus norvegicus NTPDase2 in complex with AMP==
	<StructureSection load='3cj7' size='340' side='right' caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3cj7' size='340' side='right' caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://pdbe.org/3cj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://pdbe.org/3cj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cj7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cj7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cj7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 44:
	[[Category: Actin-like fold]]		[[Category: Actin-like fold]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Calcium]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 18:43, 8 February 2016

2016-02-08T18:43:57Z

←Older revision		Revision as of 18:43, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3cj7' size='340' side='right' caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3cj7' size='340' side='right' caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://pdbe.org/3cj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cj7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cj7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Apyrase]]		[[Category: Apyrase]]
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Strater, N]]		[[Category: Strater, N]]
	[[Category: Zebisch, M]]		[[Category: Zebisch, M]]

OCA at 01:24, 25 December 2014

2014-12-25T01:24:13Z

←Older revision		Revision as of 01:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENTP2_RAT ENTP2_RAT]] In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Strater, N.]]	+	[[Category: Strater, N]]
-	[[Category: Zebisch, M.]]	+	[[Category: Zebisch, M]]
	[[Category: Actin-like fold]]		[[Category: Actin-like fold]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]

OCA at 21:21, 2 October 2014

2014-10-02T21:21:12Z

←Older revision		Revision as of 21:21, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3cj7.~~png~~\|~~left~~\|200px]]	+	==Structure of Rattus norvegicus NTPDase2 in complex with AMP==
		+	<StructureSection load='3cj7' size='340' side='right' caption='[[3cj7]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CJ7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cj1\|3cj1]], [[3cj9\|3cj9]], [[3cja\|3cja]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Entpd2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Apyrase Apyrase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.5 3.6.1.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cj7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/3cj7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell surface-located nucleoside triphosphate diphosphohydrolases (NTPDase1, -2, -3, and -8) are oligomeric integral membrane proteins responsible for signal conversion and inactivation in extracellular nucleotide-mediated "purinergic" signaling. They catalyze the sequential hydrolysis of the signaling molecule ATP via ADP to AMP. Here we present the structure of the extracellular domain of Rattus norvegicus NTPDase2 in an active state at resolutions between 1.7 A and 2.1 A in four different forms: (i) apo form, (ii) ternary complex with the nonhydrolyzable ATP analog AMPPNP and cofactor Ca(2+), (iii) quaternary complex with Ca(2+) and bound products AMP and phosphate, and (iv) binary product complex with AMP only. Analysis of the ATP (analog) binding mode explains the importance of several residues for activity and allows suggestion of a catalytic mechanism. The carboxylate group of E165 serves as a catalytic base and activates a water molecule, which is well positioned for nucleophilic attack on the terminal phosphate. Based on analysis of the two product complex structures in which AMP adopts different conformations, a substrate binding mode for ADP hydrolysis is proposed. This allows for an understanding of how the same hydrolytic site can be engaged in ATP and ADP but not AMP hydrolysis.

-	~~{{STRUCTURE_3cj7\| PDB=3cj7 \| SCENE= }}~~	+	Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling.,Zebisch M, Strater N Proc Natl Acad Sci U S A. 2008 May 13;105(19):6882-7. Epub 2008 May 5. PMID:18458329<ref>PMID:18458329</ref>

-	~~===Structure~~ of ~~Rattus norvegicus NTPDase2 in complex with AMP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18458329}}~~	+	==See Also==
-		+	*[[Ectonucleoside triphosphate diphosphohydrolase\|Ectonucleoside triphosphate diphosphohydrolase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3cj7~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018458329<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA: Protected "3cj7" [edit=sysop:move=sysop]

2013-01-07T21:35:38Z

Protected "3cj7" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:35, 7 January 2013

OCA at 21:35, 7 January 2013

2013-01-07T21:35:36Z

←Older revision		Revision as of 21:35, 7 January 2013
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-	{{Seed}}
	[[Image:3cj7.png\|left\|200px]]		[[Image:3cj7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cj7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cj7\| PDB=3cj7 \| SCENE= }}		{{STRUCTURE_3cj7\| PDB=3cj7 \| SCENE= }}

	===Structure of Rattus norvegicus NTPDase2 in complex with AMP===		===Structure of Rattus norvegicus NTPDase2 in complex with AMP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18458329}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18458329 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18458329}}		{{ABSTRACT_PUBMED_18458329}}

	==About this Structure==		==About this Structure==
-	~~3CJ7~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].	+	[[3cj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18458329~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018458329</ref><references group="xtra"/>
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
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	[[Category: Actin-like fold]]		[[Category: Actin-like fold]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
-	[[Category: Alternative splicing]]
-	[[Category: Calcium]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
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	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:50:46 2009''

OCA at 23:50, 16 February 2009

2009-02-16T23:50:47Z

←Older revision		Revision as of 23:50, 16 February 2009
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	==About this Structure==		==About this Structure==
-	3CJ7 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].	+	3CJ7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].

	==Reference==		==Reference==
-	~~Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling., Zebisch M, Strater N, Proc Natl Acad Sci U S A. 2008 May 13;105(19):6882-7. Epub 2008 May 5.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18458329 18458329]~~	+	<ref group="xtra">PMID:18458329</ref><references group="xtra"/>
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Strater, N.]]		[[Category: Strater, N.]]
	[[Category: Zebisch, M.]]		[[Category: Zebisch, M.]]
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 05~~:49:~~29 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:50:46 2009''

OCA at 02:49, 28 July 2008

2008-07-28T02:49:34Z

←Older revision		Revision as of 02:49, 28 July 2008
Line 1:		Line 1:
-	[[Image:3cj7.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3cj7.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3cj7\| PDB=3cj7 \| SCENE= }}		{{STRUCTURE_3cj7\| PDB=3cj7 \| SCENE= }}

-	~~'''~~Structure of Rattus norvegicus NTPDase2 in complex with AMP~~'''~~	+	===Structure of Rattus norvegicus NTPDase2 in complex with AMP===


-	~~==Overview==~~	+	<!--
-	~~Cell surface~~-~~located nucleoside triphosphate diphosphohydrolases (NTPDase1,~~ -2, -3, ~~and -8) are oligomeric integral membrane proteins responsible for signal conversion and inactivation in extracellular nucleotide-mediated "purinergic" signaling. They catalyze~~ the ~~sequential hydrolysis of the signaling molecule ATP via ADP~~ to ~~AMP. Here we present~~ the ~~structure of the extracellular domain of Rattus norvegicus NTPDase2 in an active state~~ at ~~resolutions between 1~~.~~7 A and 2~~.~~1 A in four different forms: (i~~) apo form, (ii) ternary complex with the nonhydrolyzable ATP analog AMPPNP and cofactor Ca(2+), (iii) quaternary complex with Ca(2+) and bound products AMP and phosphate, and (iv) binary product complex with AMP only. Analysis of the ATP (analog) binding mode explains the importance of several residues for activity and allows suggestion of a catalytic mechanism. The carboxylate group of E165 serves as a catalytic base and activates a water molecule, ~~which~~ is ~~well positioned for nucleophilic attack on~~ the terminal phosphate. Based on analysis of the two product complex structures in which AMP adopts different conformations, a substrate binding mode for ADP hydrolysis is proposed. This allows for an understanding of how the same hydrolytic site can be engaged in ATP and ADP but not AMP hydrolysis.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18458329}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18458329 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18458329}}

	==About this Structure==		==About this Structure==
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	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May~~ 28 09:39:04 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:49:29 2008''

OCA at 06:39, 28 May 2008

2008-05-28T06:39:07Z

←Older revision		Revision as of 06:39, 28 May 2008
Line 11:		Line 11:
	'''Structure of Rattus norvegicus NTPDase2 in complex with AMP'''		'''Structure of Rattus norvegicus NTPDase2 in complex with AMP'''

		+
		+	==Overview==
		+	Cell surface-located nucleoside triphosphate diphosphohydrolases (NTPDase1, -2, -3, and -8) are oligomeric integral membrane proteins responsible for signal conversion and inactivation in extracellular nucleotide-mediated "purinergic" signaling. They catalyze the sequential hydrolysis of the signaling molecule ATP via ADP to AMP. Here we present the structure of the extracellular domain of Rattus norvegicus NTPDase2 in an active state at resolutions between 1.7 A and 2.1 A in four different forms: (i) apo form, (ii) ternary complex with the nonhydrolyzable ATP analog AMPPNP and cofactor Ca(2+), (iii) quaternary complex with Ca(2+) and bound products AMP and phosphate, and (iv) binary product complex with AMP only. Analysis of the ATP (analog) binding mode explains the importance of several residues for activity and allows suggestion of a catalytic mechanism. The carboxylate group of E165 serves as a catalytic base and activates a water molecule, which is well positioned for nucleophilic attack on the terminal phosphate. Based on analysis of the two product complex structures in which AMP adopts different conformations, a substrate binding mode for ADP hydrolysis is proposed. This allows for an understanding of how the same hydrolytic site can be engaged in ATP and ADP but not AMP hydrolysis.

	==About this Structure==		==About this Structure==
	3CJ7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].		3CJ7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CJ7 OCA].
		+
		+	==Reference==
		+	Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling., Zebisch M, Strater N, Proc Natl Acad Sci U S A. 2008 May 13;105(19):6882-7. Epub 2008 May 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18458329 18458329]
	[[Category: Apyrase]]		[[Category: Apyrase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
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	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 30 13~~:36:50 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:39:04 2008''