3cl2 - Revision history

OCA at 18:10, 1 November 2023

2023-11-01T18:10:04Z

←Older revision		Revision as of 18:10, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3cl2' size='340' side='right'caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='3cl2' size='340' side='right'caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~viet_nam~~/1203/2004(~~h5n1~~)) Influenza a virus (a/~~viet nam~~/1203/2004(~~h5n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Viet_Nam/1203/2004(H5N1)) Influenza A virus (A/Viet Nam/1203/2004(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=G39:(3R~~,~~4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.538Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3ckz\|3ckz]], [[3cl0\|3cl0]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>NA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=284218 Influenza A virus (A/Viet Nam/1203/2004(H5N1))])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Exo~~-~~alpha~~-~~sialidase Exo~~-~~alpha~~-~~sialidase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~3~~.2.1.18~~ 3~~.2.~~1~~.18]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [https://pdbe.org/3cl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [https://pdbe.org/3cl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]	+	[https://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Exo-alpha-sialidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Collins, P]]	+	[[Category: Collins P]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Haire~~, L F~~]]	+	[[Category: Haire LF]]
-	[[Category: Hay~~, A J~~]]	+	[[Category: Hay AJ]]
-	[[Category: Lin~~, Y P~~]]	+	[[Category: Lin YP]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Martin~~, S R~~]]	+	[[Category: Martin SR]]
-	[[Category: Russell~~, R J~~]]	+	[[Category: Russell RJ]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Walker~~, P A]]~~	+	[[Category: Walker PA]]
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: N1]]~~	+
-	~~[[Category: N294]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Oseltamivir]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virion~~]]	+

OCA at 08:00, 27 January 2022

2022-01-27T08:00:06Z

←Older revision		Revision as of 08:00, 27 January 2022
Line 1:		Line 1:

	==N1 Neuraminidase N294S + Oseltamivir==		==N1 Neuraminidase N294S + Oseltamivir==
-	<StructureSection load='3cl2' size='340' side='right' caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>	+	<StructureSection load='3cl2' size='340' side='right'caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckz\|3ckz]], [[3cl0\|3cl0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ckz\|3ckz]], [[3cl0\|3cl0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284218 Influenza A virus (A/Viet Nam/1203/2004(H5N1))])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284218 Influenza A virus (A/Viet Nam/1203/2004(H5N1))])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [~~http~~://pdbe.org/3cl2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [https://pdbe.org/3cl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]	+	[[https://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: Large Structures]]
	[[Category: Collins, P]]		[[Category: Collins, P]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 06:22, 22 August 2018

2018-08-22T06:22:45Z

←Older revision		Revision as of 06:22, 22 August 2018
Line 3:		Line 3:
	<StructureSection load='3cl2' size='340' side='right' caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='3cl2' size='340' side='right' caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckz\|3ckz]], [[3cl0\|3cl0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckz\|3ckz]], [[3cl0\|3cl0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284218 Influenza A virus (A/Viet Nam/1203/2004(H5N1))])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [http://pdbe.org/3cl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [http://pdbe.org/3cl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>
Line 28:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: Influenza a virus]]
	[[Category: Collins, P]]		[[Category: Collins, P]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 09:41, 11 August 2016

2016-08-11T09:41:40Z

←Older revision		Revision as of 09:41, 11 August 2016
Line 1:		Line 1:
		+
	==N1 Neuraminidase N294S + Oseltamivir==		==N1 Neuraminidase N294S + Oseltamivir==
	<StructureSection load='3cl2' size='340' side='right' caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='3cl2' size='340' side='right' caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckz\|3ckz]], [[3cl0\|3cl0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckz\|3ckz]], [[3cl0\|3cl0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [http://pdbe.org/3cl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q6DPL2_9INFA Q6DPL2_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cl2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:43, 25 January 2015

2015-01-25T10:43:14Z

←Older revision		Revision as of 10:43, 25 January 2015
Line 25:		Line 25:
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Collins, P.]]	+	[[Category: Collins, P]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Hay, A J.]]	+	[[Category: Hay, A J]]
-	[[Category: Lin, Y P.]]	+	[[Category: Lin, Y P]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Martin, S R.]]	+	[[Category: Martin, S R]]
-	[[Category: Russell, R J.]]	+	[[Category: Russell, R J]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Walker, P A.]]	+	[[Category: Walker, P A]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:29, 5 November 2014

2014-11-05T09:29:20Z

←Older revision		Revision as of 09:29, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3cl2.~~png~~\|~~left~~\|~~200px~~]]	+	==N1 Neuraminidase N294S + Oseltamivir==
		+	<StructureSection load='3cl2' size='340' side='right' caption='[[3cl2]], [[Resolution\|resolution]] 2.54Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cl2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ckz\|3ckz]], [[3cl0\|3cl0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cl2 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl2 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The potential impact of pandemic influenza makes effective measures to limit the spread and morbidity of virus infection a public health priority. Antiviral drugs are seen as essential requirements for control of initial influenza outbreaks caused by a new virus, and in pre-pandemic plans there is a heavy reliance on drug stockpiles. The principal target for these drugs is a virus surface glycoprotein, neuraminidase, which facilitates the release of nascent virus and thus the spread of infection. Oseltamivir (Tamiflu) and zanamivir (Relenza) are two currently used neuraminidase inhibitors that were developed using knowledge of the enzyme structure. It has been proposed that the closer such inhibitors resemble the natural substrate, the less likely they are to select drug-resistant mutant viruses that retain viability. However, there have been reports of drug-resistant mutant selection in vitro and from infected humans. We report here the enzymatic properties and crystal structures of neuraminidase mutants from H5N1-infected patients that explain the molecular basis of resistance. Our results show that these mutants are resistant to oseltamivir but still strongly inhibited by zanamivir owing to an altered hydrophobic pocket in the active site of the enzyme required for oseltamivir binding. Together with recent reports of the viability and pathogenesis of H5N1 (ref. 7) and H1N1 (ref. 8) viruses with neuraminidases carrying these mutations, our results indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivir.

-	~~{{STRUCTURE_3cl2\| PDB=3cl2 \| SCENE= }}~~	+	Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.,Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Skehel JJ, Martin SR, Hay AJ, Gamblin SJ Nature. 2008 Jun 26;453(7199):1258-61. Epub 2008 May 14. PMID:18480754<ref>PMID:18480754</ref>

-	~~===N1 Neuraminidase N294S + Oseltamivir===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18480754}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cl2]] is a 8 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Influenza_a_virus Influenza~~ a ~~virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3CL2 OCA].~~	+

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018480754<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]

OCA at 14:38, 20 October 2012

2012-10-20T14:38:26Z

←Older revision		Revision as of 14:38, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3cl2]] is a 8 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA].	+	[[3cl2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA].

	==See Also==		==See Also==

OCA: Protected "3cl2" [edit=sysop:move=sysop]

2012-07-26T15:46:49Z

Protected "3cl2" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:46, 26 July 2012

OCA at 15:46, 26 July 2012

2012-07-26T15:46:47Z

←Older revision		Revision as of 15:46, 26 July 2012
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-	{{Seed}}
	[[Image:3cl2.png\|left\|200px]]		[[Image:3cl2.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3cl2\| PDB=3cl2 \| SCENE= }}		{{STRUCTURE_3cl2\| PDB=3cl2 \| SCENE= }}

	===N1 Neuraminidase N294S + Oseltamivir===		===N1 Neuraminidase N294S + Oseltamivir===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18480754}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18480754 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18480754}}		{{ABSTRACT_PUBMED_18480754}}

	==About this Structure==		==About this Structure==
-	~~3CL2 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA].	+	[[3cl2]] is a 8 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA].
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]

	==Reference==		==Reference==
-	Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants., Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Skehel JJ, Martin SR, Hay AJ, Gamblin SJ, Nature. 2008 Jun 26;453(7199):1258-61. Epub 2008 May 14. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18480754 18480754]~~	+	<ref group="xtra">PMID:018480754</ref><references group="xtra"/>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Single protein]]
	[[Category: Collins, P.]]		[[Category: Collins, P.]]
	[[Category: Gamblin, S J.]]		[[Category: Gamblin, S J.]]
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	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virion]]		[[Category: Virion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 9 10:11:06 2008''

OCA at 07:11, 9 July 2008

2008-07-09T07:11:07Z

←Older revision		Revision as of 07:11, 9 July 2008
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-	[[Image:3cl2.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3cl2.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3cl2\| PDB=3cl2 \| SCENE= }}		{{STRUCTURE_3cl2\| PDB=3cl2 \| SCENE= }}

-	~~'''~~N1 Neuraminidase N294S + Oseltamivir~~'''~~	+	===N1 Neuraminidase N294S + Oseltamivir===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18480754}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18480754 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18480754}}

	==About this Structure==		==About this Structure==
	3CL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA].		3CL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL2 OCA].
		+
		+	==Reference==
		+	Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants., Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Skehel JJ, Martin SR, Hay AJ, Gamblin SJ, Nature. 2008 Jun 26;453(7199):1258-61. Epub 2008 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18480754 18480754]
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
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	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virion]]		[[Category: Virion]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu May 22 22~~:05:32 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 9 10:11:06 2008''