3cl7 - Revision history

OCA at 14:58, 1 November 2023

2023-11-01T14:58:52Z

←Older revision		Revision as of 14:58, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3cl7' size='340' side='right'caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3cl7' size='340' side='right'caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus~~ fluorescens ~~liquefaciens" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HYN:IMIDAZOLIDINE~~-2,~~4-DIONE'>HYN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Allantoinase Allantoinase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [https://pdbe.org/3cl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [~~http~~://pdbe.org/3cl7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cl7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl7 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3KFK7_PSEPF Q3KFK7_PSEPF]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
-	[[Category: Allantoinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berni, R]]	+	[[Category: Pseudomonas fluorescens]]
-	[[Category: Cendron, L]]	+	[[Category: Berni R]]
-	[[Category: Folli, C]]	+	[[Category: Cendron L]]
-	[[Category: Monteverdi, D]]	+	[[Category: Folli C]]
-	[[Category: Percudani, R]]	+	[[Category: Monteverdi D]]
-	[[Category: Ramazzina, I]]	+	[[Category: Percudani R]]
-	[[Category: Zanotti, G]]	+	[[Category: Ramazzina I]]
-	~~[[Category: Hydantoin]]~~	+	[[Category: Zanotti G]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Uric acid degradation~~]]	+

OCA at 10:27, 12 August 2020

2020-08-12T10:27:49Z

←Older revision		Revision as of 10:27, 12 August 2020
Line 1:		Line 1:

	==Crystal structure of Puue Allantoinase in complex with Hydantoin==		==Crystal structure of Puue Allantoinase in complex with Hydantoin==
-	<StructureSection load='3cl7' size='340' side='right' caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3cl7' size='340' side='right'caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://pdbe.org/3cl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://pdbe.org/3cl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]		[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
		+	[[Category: Large Structures]]
	[[Category: Berni, R]]		[[Category: Berni, R]]
	[[Category: Cendron, L]]		[[Category: Cendron, L]]

OCA at 13:32, 7 November 2018

2018-11-07T13:32:17Z

←Older revision		Revision as of 13:32, 7 November 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:49, 11 August 2016

2016-08-11T20:49:15Z

←Older revision		Revision as of 20:49, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Puue Allantoinase in complex with Hydantoin==		==Crystal structure of Puue Allantoinase in complex with Hydantoin==
	<StructureSection load='3cl7' size='340' side='right' caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3cl7' size='340' side='right' caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_fluorescens Pseudomonas~~ fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://pdbe.org/3cl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cl7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cl7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
-	[[Category: Pseudomonas fluorescens]]
	[[Category: Berni, R]]		[[Category: Berni, R]]
	[[Category: Cendron, L]]		[[Category: Cendron, L]]

OCA at 11:22, 20 January 2015

2015-01-20T11:22:23Z

←Older revision		Revision as of 11:22, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
-	[[Category: Berni, R.]]	+	[[Category: Berni, R]]
-	[[Category: Cendron, L.]]	+	[[Category: Cendron, L]]
-	[[Category: Folli, C.]]	+	[[Category: Folli, C]]
-	[[Category: Monteverdi, D.]]	+	[[Category: Monteverdi, D]]
-	[[Category: Percudani, R.]]	+	[[Category: Percudani, R]]
-	[[Category: Ramazzina, I.]]	+	[[Category: Ramazzina, I]]
-	[[Category: Zanotti, G~~.]]~~	+	[[Category: Zanotti, G]]
-	~~[[Category: Allantoinase~~]]	+
	[[Category: Hydantoin]]		[[Category: Hydantoin]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Uric acid degradation]]		[[Category: Uric acid degradation]]

OCA at 21:05, 2 October 2014

2014-10-02T21:05:48Z

←Older revision		Revision as of 21:05, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~3cl7.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Puue Allantoinase in complex with Hydantoin==
		+	<StructureSection load='3cl7' size='340' side='right' caption='[[3cl7]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CL7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYN:IMIDAZOLIDINE-2,4-DIONE'>HYN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1z7a\|1z7a]], [[3cl6\|3cl6]], [[3cl8\|3cl8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoinase Allantoinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.5 3.5.2.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cl7 RCSB], [http://www.ebi.ac.uk/pdbsum/3cl7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The hydrolytic cleavage of the hydantoin ring of allantoin, catalyzed by allantoinase, is required for the utilization of the nitrogen present in purine-derived compounds. The allantoinase gene (DAL1), however, is missing in many completely sequenced organisms able to use allantoin as a nitrogen source. Here we show that an alternative allantoinase gene (puuE) can be precisely identified by analyzing its logic relationship with three other genes of the pathway. The novel allantoinase is annotated in structure and sequence data bases as polysaccharide deacetylase for its homology with enzymes that catalyze hydrolytic reactions on chitin or peptidoglycan substrates. The recombinant PuuE protein from Pseudomonas fluorescens exhibits metal-independent allantoinase activity and stereospecificity for the S enantiomer of allantoin. The crystal structures of the protein and of protein-inhibitor complexes reveal an overall similarity with the polysaccharide deacetylase beta/alpha barrel and remarkable differences in oligomeric assembly and active site geometry. The conserved Asp-His-His metal-binding triad is replaced by Glu-His-Trp, a configuration that is distinctive of PuuE proteins within the protein family. An extra domain at the top of the barrel offers a scaffold for protein tetramerization and forms a small substrate-binding cleft by hiding the large binding groove of polysaccharide deacetylases. Substrate positioning at the active site suggests an acid/base mechanism of catalysis in which only one member of the catalytic pair of polysaccharide deacetylases has been conserved. These data provide a structural rationale for the shifting of substrate specificity that occurred during evolution.

-	~~{{STRUCTURE_3cl7\| PDB=3cl7 \| SCENE= }}~~	+	Logical identification of an allantoinase analog (puuE) recruited from polysaccharide deacetylases.,Ramazzina I, Cendron L, Folli C, Berni R, Monteverdi D, Zanotti G, Percudani R J Biol Chem. 2008 Aug 22;283(34):23295-304. Epub 2008 Jun 12. PMID:18550550<ref>PMID:18550550</ref>

-	~~===Crystal structure~~ of ~~Puue Allantoinase in complex with Hydantoin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18550550}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cl7]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018550550<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]

OCA: Protected "3cl7" [edit=sysop:move=sysop]

2013-01-07T22:54:39Z

Protected "3cl7" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:54, 7 January 2013

OCA at 22:54, 7 January 2013

2013-01-07T22:54:35Z

←Older revision		Revision as of 22:54, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3cl7.png\|left\|200px]]		[[Image:3cl7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cl7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cl7\| PDB=3cl7 \| SCENE= }}		{{STRUCTURE_3cl7\| PDB=3cl7 \| SCENE= }}

	===Crystal structure of Puue Allantoinase in complex with Hydantoin===		===Crystal structure of Puue Allantoinase in complex with Hydantoin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18550550}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18550550 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18550550}}		{{ABSTRACT_PUBMED_18550550}}

	==About this Structure==		==About this Structure==
-	~~3CL7~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].	+	[[3cl7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18550550~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018550550</ref><references group="xtra"/>
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
Line 37:		Line 25:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Uric acid degradation]]		[[Category: Uric acid degradation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:51:01 2009''

OCA at 07:51, 18 February 2009

2009-02-18T07:51:01Z

←Older revision		Revision as of 07:51, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CL7 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].	+	3CL7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].

	==Reference==		==Reference==
-	Logical Identification of an Allantoinase Analog (puuE) Recruited from Polysaccharide Deacetylases., Ramazzina I, Cendron L, Folli C, Berni R, Monteverdi D, Zanotti G, Percudani R, J Biol Chem. 2008 Aug 22;283(34):23295-304. Epub 2008 Jun 12. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18550550 18550550]~~	+	<ref group="xtra">PMID:18550550</ref><references group="xtra"/>
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
-	[[Category: Single protein]]
	[[Category: Berni, R.]]		[[Category: Berni, R.]]
	[[Category: Cendron, L.]]		[[Category: Cendron, L.]]
Line 39:		Line 38:
	[[Category: Uric acid degradation]]		[[Category: Uric acid degradation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 27 10~~:34:~~35 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:51:01 2009''

OCA at 07:34, 27 August 2008

2008-08-27T07:34:35Z

←Older revision		Revision as of 07:34, 27 August 2008
Line 1:		Line 1:
-	[[Image:3cl7.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3cl7.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_3cl7\| PDB=3cl7 \| SCENE= }}		{{STRUCTURE_3cl7\| PDB=3cl7 \| SCENE= }}

-	~~'''~~Crystal structure of Puue Allantoinase in complex with Hydantoin~~'''~~	+	===Crystal structure of Puue Allantoinase in complex with Hydantoin===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18550550}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18550550 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18550550}}

	==About this Structure==		==About this Structure==
	3CL7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].		3CL7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL7 OCA].
		+
		+	==Reference==
		+	Logical Identification of an Allantoinase Analog (puuE) Recruited from Polysaccharide Deacetylases., Ramazzina I, Cendron L, Folli C, Berni R, Monteverdi D, Zanotti G, Percudani R, J Biol Chem. 2008 Aug 22;283(34):23295-304. Epub 2008 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18550550 18550550]
	[[Category: Allantoinase]]		[[Category: Allantoinase]]
	[[Category: Pseudomonas fluorescens]]		[[Category: Pseudomonas fluorescens]]
Line 28:		Line 38:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Uric acid degradation]]		[[Category: Uric acid degradation]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11~~ 10:49:47 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 10:34:35 2008''