3cld - Revision history

OCA at 12:30, 30 August 2023

2023-08-30T12:30:06Z

←Older revision		Revision as of 12:30, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CLD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.84Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m2z\|1m2z]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [https://pdbe.org/3cld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [https://www.ebi.ac.uk/pdbsum/3cld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cld ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [https://pdbe.org/3cld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [https://www.ebi.ac.uk/pdbsum/3cld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cld ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>	+	[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>	+	[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 41:		Line 40:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Biggadike~~, K B~~]]	+	[[Category: Biggadike KB]]
-	[[Category: Bledsoe~~, R K~~]]	+	[[Category: Bledsoe RK]]
-	[[Category: Hassell~~, A M~~]]	+	[[Category: Hassell AM]]
-	[[Category: McLay, I]]	+	[[Category: McLay I]]
-	[[Category: Shewchuk~~, L M~~]]	+	[[Category: Shewchuk LM]]
-	[[Category: Stewart, E]]	+	[[Category: Stewart E]]
-	~~[[Category: Alternative initiation]]~~	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Glucocorticoid receptor]]~~	+
-	~~[[Category: Gr]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Pseudohermaphroditism]]~~	+
-	~~[[Category: Steroid-binding]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 19:10, 20 October 2021

2021-10-20T19:10:53Z

←Older revision		Revision as of 19:10, 20 October 2021
Line 1:		Line 1:

	==Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate==		==Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate==
-	<StructureSection load='3cld' size='340' side='right' caption='[[3cld]], [[Resolution\|resolution]] 2.84Å' scene=''>	+	<StructureSection load='3cld' size='340' side='right'caption='[[3cld]], [[Resolution\|resolution]] 2.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CLD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m2z\|1m2z]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [~~http~~://pdbe.org/3cld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cld ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [https://pdbe.org/3cld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [https://www.ebi.ac.uk/pdbsum/3cld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cld ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[~~http~~://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>	+	[[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>	+	[[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Glucocorticoid receptor\|Glucocorticoid receptor]]	+	*[[Glucocorticoid receptor 3D structures\|Glucocorticoid receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Biggadike, K B]]		[[Category: Biggadike, K B]]
	[[Category: Bledsoe, R K]]		[[Category: Bledsoe, R K]]

OCA at 13:32, 7 November 2018

2018-11-07T13:32:05Z

←Older revision		Revision as of 13:32, 7 November 2018
Line 1:		Line 1:
		+
	==Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate==		==Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate==
	<StructureSection load='3cld' size='340' side='right' caption='[[3cld]], [[Resolution\|resolution]] 2.84Å' scene=''>		<StructureSection load='3cld' size='340' side='right' caption='[[3cld]], [[Resolution\|resolution]] 2.84Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://pdbe.org/3cld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://pdbe.org/3cld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cld ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cld_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cld_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:48, 7 February 2016

2016-02-07T22:48:35Z

←Older revision		Revision as of 22:48, 7 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://pdbe.org/3cld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cld ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cld" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:18, 20 January 2015

2015-01-20T10:18:54Z

←Older revision		Revision as of 10:18, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CLD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>		[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Biggadike, K B.]]	+	[[Category: Biggadike, K B]]
-	[[Category: Bledsoe, R K.]]	+	[[Category: Bledsoe, R K]]
-	[[Category: Hassell, A M.]]	+	[[Category: Hassell, A M]]
-	[[Category: McLay, I.]]	+	[[Category: McLay, I]]
-	[[Category: Shewchuk, L M.]]	+	[[Category: Shewchuk, L M]]
-	[[Category: Stewart, E.]]	+	[[Category: Stewart, E]]
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]

OCA at 21:05, 2 October 2014

2014-10-02T21:05:27Z

←Older revision		Revision as of 21:05, 2 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3cld\| PDB=3cld \| SCENE= }}~~	+	==Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate==
-	===Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate===	+	<StructureSection load='3cld' size='340' side='right' caption='[[3cld]], [[Resolution\|resolution]] 2.84Å' scene=''>
-	{~~{ABSTRACT_PUBMED_18522385}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CLD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m2z\|1m2z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [http://www.ebi.ac.uk/pdbsum/3cld PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cld_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An X-ray crystal structure is reported for the novel enhanced-affinity glucocorticoid agonist fluticasone furoate (FF) in the ligand binding domain of the glucocorticoid receptor. Comparison of this structure with those of dexamethasone and fluticasone propionate shows the 17alpha furoate ester to occupy more fully the lipophilic 17alpha pocket on the receptor, which may account for the enhanced glucocorticoid receptor binding of FF.

-	~~==Disease==~~	+	X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor-Ligand Binding Domain.,Biggadike K, Bledsoe RK, Hassell AM, Kirk BE, McLay IM, Shewchuk LM, Stewart EL J Med Chem. 2008 Jun 26;51(12):3349-52. Epub 2008 Jun 4. PMID:18522385<ref>PMID:18522385</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance~~ (~~GCRES~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/138040 138040]]; also known as cortisol resistance~~. ~~It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>~~PMID:~~12050230</ref><ref>PMID:1704018</ref><ref>PMID:7683692</ref><ref>PMID:11589680</ref>~~<ref>PMID:~~11701741~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE)~~, ~~both for nuclear and mitochondrial DNA, and as~~ a ~~modulator~~ of ~~other transcription factors~~. ~~Affects inflammatory responses, cellular proliferation and differentiation in target tissues~~. ~~Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role~~ of ~~hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation~~.<~~ref~~>~~PMID:21664385~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3cld]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA].	+

	==See Also==		==See Also==
	*[[Glucocorticoid receptor\|Glucocorticoid receptor]]		*[[Glucocorticoid receptor\|Glucocorticoid receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018522385</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biggadike, K B.]]		[[Category: Biggadike, K B.]]

OCA at 01:19, 25 March 2013

2013-03-25T01:19:18Z

←Older revision		Revision as of 01:19, 25 March 2013
Line 1:		Line 1:
-	[[Image:3cld.png\|left\|200px]]
-
	{{STRUCTURE_3cld\| PDB=3cld \| SCENE= }}		{{STRUCTURE_3cld\| PDB=3cld \| SCENE= }}
-
	===Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate===		===Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate===
		+	{{ABSTRACT_PUBMED_18522385}}

-	~~{{ABSTRACT_PUBMED_18522385}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref><ref>PMID:1704018</ref><ref>PMID:7683692</ref><ref>PMID:11589680</ref><ref>PMID:11701741</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018522385</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018522385</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biggadike, K B.]]		[[Category: Biggadike, K B.]]

OCA at 08:04, 20 October 2012

2012-10-20T08:04:31Z

←Older revision		Revision as of 08:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3cld]] is a 4 chain structure ~~of [[Glucocorticoid receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA].	+	[[3cld]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA].

	==See Also==		==See Also==

OCA: Protected "3cld" [edit=sysop:move=sysop]

2012-07-25T18:21:54Z

Protected "3cld" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:21, 25 July 2012

OCA at 18:21, 25 July 2012

2012-07-25T18:21:53Z

←Older revision		Revision as of 18:21, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3cld.png\|left\|200px]]		[[Image:3cld.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cld", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cld\| PDB=3cld \| SCENE= }}		{{STRUCTURE_3cld\| PDB=3cld \| SCENE= }}

	===Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate===		===Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18522385}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18522385 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18522385}}		{{ABSTRACT_PUBMED_18522385}}

	==About this Structure==		==About this Structure==
-	~~3CLD~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA].	+	[[3cld]] is a 4 chain structure of [[Glucocorticoid receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA].
		+
		+	==See Also==
		+	*[[Glucocorticoid receptor\|Glucocorticoid receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18522385~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018522385</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Biggadike, K B.]]		[[Category: Biggadike, K B.]]
Line 32:		Line 23:
	[[Category: Stewart, E.]]		[[Category: Stewart, E.]]
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]
-	[[Category: Alternative splicing]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
-	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
Line 44:		Line 33:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Pseudohermaphroditism]]		[[Category: Pseudohermaphroditism]]
	[[Category: Steroid-binding]]		[[Category: Steroid-binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:00:03 2009''