3cpr - Revision history

OCA at 12:31, 30 August 2023

2023-08-30T12:31:51Z

←Older revision		Revision as of 12:31, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3cpr' size='340' side='right'caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3cpr' size='340' side='right'caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPR FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=KPI:(2S)-2-AMINO-6~~-[~~(1-HYDROXY-1-OXO-PROPAN-~~2~~-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>dapA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1718~~ "~~Micrococcus glutamicus~~" ~~Kinoshita et al. 1958])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4~~-~~hydroxy~~-~~tetrahydrodipicolinate_synthase 4~~-~~hydroxy~~-~~tetrahydrodipicolinate synthase], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [https://pdbe.org/3cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [https://www.ebi.ac.uk/pdbsum/3cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [https://pdbe.org/3cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [https://www.ebi.ac.uk/pdbsum/3cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DAPA_CORGL DAPA_CORGL] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).[HAMAP-Rule:MF_00418]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Micrococcus glutamicus kinoshita et al. 1958]]~~	+	[[Category: Corynebacterium glutamicum]]
-	~~[[Category: 4-hydroxy-tetrahydrodipicolinate synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rice~~, E A~~]]	+	[[Category: Rice EA]]
-	[[Category: Rydel~~, T J~~]]	+	[[Category: Rydel TJ]]
-	[[Category: Sturman~~, E J]]~~	+	[[Category: Sturman EJ]]
-	~~[[Category: Amino-acid biosynthesis]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Diaminopimelate biosynthesis]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Lysine biosynthesis]]~~	+
-	~~[[Category: Schiff base~~]]	+

OCA at 07:41, 2 February 2022

2022-02-02T07:41:31Z

←Older revision		Revision as of 07:41, 2 February 2022
Line 1:		Line 1:

	==The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution==		==The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution==
-	<StructureSection load='3cpr' size='340' side='right' caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3cpr' size='340' side='right'caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CPR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [~~http~~://pdbe.org/3cpr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cpr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [https://pdbe.org/3cpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [https://www.ebi.ac.uk/pdbsum/3cpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 37:		Line 37:
	[[Category: Micrococcus glutamicus kinoshita et al. 1958]]		[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Rice, E A]]		[[Category: Rice, E A]]
	[[Category: Rydel, T J]]		[[Category: Rydel, T J]]

OCA at 05:44, 30 May 2018

2018-05-30T05:44:13Z

←Older revision		Revision as of 05:44, 30 May 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MCL~~:NZ-(1-~~CARBOXYETHYL)~~-~~LYSINE~~'>~~MCL~~</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3cpr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cpr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:32, 25 October 2017

2017-10-25T08:32:46Z

←Older revision		Revision as of 08:32, 25 October 2017
Line 1:		Line 1:
		+
	==The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution==		==The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution==
	<StructureSection load='3cpr' size='340' side='right' caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3cpr' size='340' side='right' caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCL:NZ-(1-~~CARBOXYETHYLIDENE~~)-LYSINE'>MCL</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCL:NZ-(1-CARBOXYETHYL)-LYSINE'>MCL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [http://pdbe.org/3cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [http://www.ebi.ac.uk/pdbsum/3cpr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [http://pdbe.org/3cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [http://www.ebi.ac.uk/pdbsum/3cpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3cpr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cpr" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 38:
	[[Category: Sturman, E J]]		[[Category: Sturman, E J]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
		+	[[Category: Cytoplasm]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Lysine biosynthesis]]		[[Category: Lysine biosynthesis]]
	[[Category: Schiff base]]		[[Category: Schiff base]]

OCA at 16:36, 8 February 2016

2016-02-08T16:36:39Z

←Older revision		Revision as of 16:36, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3cpr' size='340' side='right' caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3cpr' size='340' side='right' caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Corynebacterium_glutamicum Corynebacterium glutamicum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCL:NZ-(1-~~CARBOXYETHYL~~)-LYSINE'>MCL</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCL:NZ-(1-CARBOXYETHYLIDENE)-LYSINE'>MCL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 ~~Corynebacterium glutamicum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 "Micrococcus glutamicus" Kinoshita et al. 1958])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydrodipicolinate_synthase Dihydrodipicolinate~~ synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [http://www.ebi.ac.uk/pdbsum/3cpr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [http://pdbe.org/3cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [http://www.ebi.ac.uk/pdbsum/3cpr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cpr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cpr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Corynebacterium glutamicum~~]]	+	[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
-	[[Category: ~~Dihydrodipicolinate~~ synthase]]	+	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
	[[Category: Rice, E A]]		[[Category: Rice, E A]]
	[[Category: Rydel, T J]]		[[Category: Rydel, T J]]

OCA at 12:43, 5 January 2015

2015-01-05T12:43:37Z

←Older revision		Revision as of 12:43, 5 January 2015
Line 1:		Line 1:
-	[[~~Image:~~3cpr.~~png~~\|~~left~~\|200px]]	+	==The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution==
		+	<StructureSection load='3cpr' size='340' side='right' caption='[[3cpr]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CPR FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MCL:NZ-(1-CARBOXYETHYL)-LYSINE'>MCL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 Corynebacterium glutamicum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cpr RCSB], [http://www.ebi.ac.uk/pdbsum/3cpr PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase enzyme (cDHDPS) was recently successfully introduced into maize plants to enhance the level of lysine in the grain. To better understand lysine insensitivity of the cDHDPS, we expressed, purified, kinetically characterized the protein, and solved its X-ray crystal structure. The cDHDPS enzyme has a fold and overall structure that is highly similar to other DHDPS proteins. A noteworthy feature of the active site is the evidence that the catalytic lysine residue forms a Schiff base adduct with pyruvate. Analyses of the cDHDPS structure in the vicinity of the putative binding site for S-lysine revealed that the allosteric binding site in the Escherichia coli DHDPS protein does not exist in cDHDPS due to three non-conservative amino acids substitutions, and this is likely why cDHDPS is not feedback inhibited by lysine.

-	~~{{STRUCTURE_3cpr\| PDB=3cpr \| SCENE= }}~~	+	Characterization and crystal structure of lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase (cDHDPS) protein.,Rice EA, Bannon GA, Glenn KC, Jeong SS, Sturman EJ, Rydel TJ Arch Biochem Biophys. 2008 Dec 15;480(2):111-21. Epub 2008 Oct 7. PMID:18930704<ref>PMID:18930704</ref>

-	~~===The crystal structure~~ of ~~Corynebacterium glutamicum dihydrodipicolinate synthase to 2~~.~~2 A resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18930704}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cpr]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].~~	+

	==See Also==		==See Also==
-	*[[Dihydrodipicolinate ~~Synthase~~\|Dihydrodipicolinate ~~Synthase~~]]	+	*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Corynebacterium glutamicum]]		[[Category: Corynebacterium glutamicum]]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
-	[[Category: Rice, E A.]]	+	[[Category: Rice, E A]]
-	[[Category: Rydel, T J.]]	+	[[Category: Rydel, T J]]
-	[[Category: Sturman, E J.]]	+	[[Category: Sturman, E J]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]

OCA: Protected "3cpr" [edit=sysop:move=sysop]

2012-10-20T10:46:35Z

Protected "3cpr" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:46, 20 October 2012

OCA at 10:46, 20 October 2012

2012-10-20T10:46:32Z

←Older revision		Revision as of 10:46, 20 October 2012
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-	~~{{Seed}}~~	+	[[Image:3cpr.png\|left\|200px]]
-	[[Image:3cpr.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cpr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cpr\| PDB=3cpr \| SCENE= }}		{{STRUCTURE_3cpr\| PDB=3cpr \| SCENE= }}

	===The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution===		===The crystal structure of Corynebacterium glutamicum dihydrodipicolinate synthase to 2.2 A resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18930704}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18930704 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18930704}}		{{ABSTRACT_PUBMED_18930704}}

	==About this Structure==		==About this Structure==
-	~~3CPR~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].	+	[[3cpr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].

-	==~~Reference~~==	+	==See Also==
-	Characterization and crystal structure of lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase (cDHDPS) protein., Rice EA, Bannon GA, Glenn KC, Jeong SS, Sturman EJ, Rydel TJ, Arch Biochem Biophys. 2008 Dec 15;480(2):111-21. Epub 2008 Oct 7. PMID:[~~http://www.ncbi.nlm.nih.gov/pubmed/18930704 18930704~~]	+	*[[Dihydrodipicolinate Synthase\|Dihydrodipicolinate Synthase]]
	[[Category: Corynebacterium glutamicum]]		[[Category: Corynebacterium glutamicum]]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
Line 30:		Line 18:
	[[Category: Sturman, E J.]]		[[Category: Sturman, E J.]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
-	[[Category: Cytoplasm]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Lysine biosynthesis]]		[[Category: Lysine biosynthesis]]
	[[Category: Schiff base]]		[[Category: Schiff base]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:51:36 2008''

OCA at 11:51, 27 November 2008

2008-11-27T11:51:37Z

←Older revision		Revision as of 11:51, 27 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CPR is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].	+	3CPR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].

	==Reference==		==Reference==
Line 26:		Line 26:
	[[Category: Corynebacterium glutamicum]]		[[Category: Corynebacterium glutamicum]]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
-	[[Category: Single protein]]
	[[Category: Rice, E A.]]		[[Category: Rice, E A.]]
	[[Category: Rydel, T J.]]		[[Category: Rydel, T J.]]
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	[[Category: Schiff base]]		[[Category: Schiff base]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Nov ~~26 20~~:05:52 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:51:36 2008''

OCA at 00:20, 27 November 2008

2008-11-27T00:20:39Z

←Older revision		Revision as of 00:20, 27 November 2008
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CPR is a ~~2 chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].	+	3CPR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPR OCA].

	==Reference==		==Reference==
Line 26:		Line 26:
	[[Category: Corynebacterium glutamicum]]		[[Category: Corynebacterium glutamicum]]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
		+	[[Category: Single protein]]
	[[Category: Rice, E A.]]		[[Category: Rice, E A.]]
	[[Category: Rydel, T J.]]		[[Category: Rydel, T J.]]
Line 36:		Line 37:
	[[Category: Schiff base]]		[[Category: Schiff base]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Nov 20 07:43:16 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 26 20:05:52 2008''