3cqe - Revision history

OCA at 14:59, 1 November 2023

2023-11-01T14:59:37Z

←Older revision		Revision as of 14:59, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3cqe' size='340' side='right'caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3cqe' size='340' side='right'caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CQE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x8b\|1x8b]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [https://pdbe.org/3cqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [https://www.ebi.ac.uk/pdbsum/3cqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [https://pdbe.org/3cqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [https://www.ebi.ac.uk/pdbsum/3cqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/WEE1_HUMAN WEE1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.	+	[https://www.uniprot.org/uniprot/WEE1_HUMAN WEE1_HUMAN] Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific protein-tyrosine kinase]]~~	+	[[Category: Baker EN]]
-	[[Category: Baker~~, E N~~]]	+	[[Category: Squire CJ]]
-	[[Category: Squire~~, C J]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Kinase domain]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:41, 2 February 2022

2022-02-02T07:41:58Z

←Older revision		Revision as of 07:41, 2 February 2022
Line 1:		Line 1:

	==Wee1 kinase complex with inhibitor PD074291==		==Wee1 kinase complex with inhibitor PD074291==
-	<StructureSection load='3cqe' size='340' side='right' caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3cqe' size='340' side='right'caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CQE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8b\|1x8b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x8b\|1x8b]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [~~http~~://pdbe.org/3cqe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cqe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [https://pdbe.org/3cqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [https://www.ebi.ac.uk/pdbsum/3cqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/WEE1_HUMAN WEE1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.	+	[[https://www.uniprot.org/uniprot/WEE1_HUMAN WEE1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/3cqe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/3cqe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Baker, E N]]		[[Category: Baker, E N]]

OCA at 08:33, 25 October 2017

2017-10-25T08:33:09Z

←Older revision		Revision as of 08:33, 25 October 2017
Line 1:		Line 1:
		+
	==Wee1 kinase complex with inhibitor PD074291==		==Wee1 kinase complex with inhibitor PD074291==
	<StructureSection load='3cqe' size='340' side='right' caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3cqe' size='340' side='right' caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://pdbe.org/3cqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://pdbe.org/3cqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:48, 8 February 2016

2016-02-08T02:48:57Z

←Older revision		Revision as of 02:48, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3cqe' size='340' side='right' caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3cqe' size='340' side='right' caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CQE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8b\|1x8b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8b\|1x8b]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://pdbe.org/3cqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cqe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
	[[Category: Baker, E N]]		[[Category: Baker, E N]]

OCA at 20:01, 24 December 2014

2014-12-24T20:01:20Z

←Older revision		Revision as of 20:01, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/WEE1_HUMAN WEE1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
-	[[Category: Baker, E N.]]	+	[[Category: Baker, E N]]
-	[[Category: Squire, C J.]]	+	[[Category: Squire, C J]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Kinase domain]]		[[Category: Kinase domain]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:00, 10 October 2014

2014-10-10T06:00:53Z

←Older revision		Revision as of 06:00, 10 October 2014
Line 1:		Line 1:
-	~~[[Image:3cqe.png\|left\|200px]]~~	+	==Wee1 kinase complex with inhibitor PD074291==
-		+	<StructureSection load='3cqe' size='340' side='right' caption='[[3cqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{STRUCTURE_3cqe\| PDB=3cqe \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3cqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CQE FirstGlance]. <br>
-	===Wee1 kinase complex with inhibitor PD074291===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P91:8-BROMO-4-(2-CHLOROPHENYL)-N-(2-HYDROXYETHYL)-6-METHYL-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-E]INDOLE-7-CARBOXAMIDE'>P91</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8b\|1x8b]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wee1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==~~About this Structure~~==	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-	[[3cqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA].	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cqe RCSB], [http://www.ebi.ac.uk/pdbsum/3cqe PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/3cqe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]

OCA: Protected "3cqe" [edit=sysop:move=sysop]

2013-01-07T20:54:19Z

Protected "3cqe" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:54, 7 January 2013

OCA at 20:54, 7 January 2013

2013-01-07T20:54:12Z

←Older revision		Revision as of 20:54, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3cqe.png\|left\|200px]]
-	[[Image:3cqe.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cqe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cqe\| PDB=3cqe \| SCENE= }}		{{STRUCTURE_3cqe\| PDB=3cqe \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3CQE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA].	+	[[3cqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]
Line 22:		Line 15:
	[[Category: Kinase domain]]		[[Category: Kinase domain]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:27:56 2009''

OCA at 07:27, 25 February 2009

2009-02-25T07:27:58Z

←Older revision		Revision as of 07:27, 25 February 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3cqe.jpg\|left\|200px]]

-	The ~~entry 3cqe~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3cqe", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3cqe\| PDB=3cqe \| SCENE= }}

-	~~Authors: Squire, C.J., Baker, E.N., Dickson, J.M., Ivanovic, I., Smaill, J., Denny, W.A., Palmer, B., Thompson, A.~~	+	===Wee1 kinase complex with inhibitor PD074291===

-	Description: Wee1 kinase complex with inhibitor PD074291

		+	==About this Structure==
		+	3CQE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CQE OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific protein-tyrosine kinase]]
		+	[[Category: Baker, E N.]]
		+	[[Category: Squire, C J.]]
		+	[[Category: Inhibitor]]
		+	[[Category: Kinase domain]]
		+	[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 11~~ 09:33:~~26 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:27:56 2009''

OCA: New page: '''Unreleased structure''' The entry 3cqe is ON HOLD until Paper Publication Authors: Squire, C.J., Baker, E.N., Dickson, J.M., Ivanovic, I., Smaill, J., Denny, W.A., Palmer, B., Thomps...

2008-06-11T06:33:26Z

New page: '''Unreleased structure''' The entry 3cqe is ON HOLD until Paper Publication Authors: Squire, C.J., Baker, E.N., Dickson, J.M., Ivanovic, I., Smaill, J., Denny, W.A., Palmer, B., Thomps...

New page

'''Unreleased structure'''

The entry 3cqe is ON HOLD until Paper Publication

Authors: Squire, C.J., Baker, E.N., Dickson, J.M., Ivanovic, I., Smaill, J., Denny, W.A., Palmer, B., Thompson, A.

Description: Wee1 kinase complex with inhibitor PD074291

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 09:33:26 2008''