3cwk - Revision history

OCA at 09:39, 21 February 2024

2024-02-21T09:39:10Z

←Older revision		Revision as of 09:39, 21 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CRABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [https://pdbe.org/3cwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [https://www.ebi.ac.uk/pdbsum/3cwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [https://pdbe.org/3cwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [https://www.ebi.ac.uk/pdbsum/3cwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cwk ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cwk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structural integrity of cellular retinoic acid-binding protein II (CRABPII) has been investigated using the crystal structures of CRABPII mutants. The overall fold was well maintained by these CRABPII mutants, each of which carried multiple different mutations. A water-mediated network is found to be present across the large binding cavity, extending from Arg111 deep inside the cavity to the alpha2 helix at its entrance. This chain of interactions acts as a ;pillar' that maintains the integrity of the protein. The disruption of the water network upon loss of Arg111 leads to decreased structural integrity of the protein. A water-mediated network can be re-established by introducing the hydrophilic Glu121 inside the cavity, which results in a rigid protein with the alpha2 helix adopting an altered conformation compared with wild-type CRABPII.
-
-	Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding.,Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger JH Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1228-39. Epub 2008, Nov 18. PMID:19018099<ref>PMID:19018099</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3cwk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 26:
	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Geiger~~, J H~~]]	+	[[Category: Geiger JH]]
-	[[Category: Vaezeslami, S]]	+	[[Category: Vaezeslami S]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Crabpii]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: High resolution]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Retinoic acid]]~~	+
-	~~[[Category: Retinoid]]~~	+
-	~~[[Category: Retinol-binding]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Vitamin some~~]]	+

OCA at 19:15, 20 October 2021

2021-10-20T19:15:19Z

←Older revision		Revision as of 19:15, 20 October 2021
Line 1:		Line 1:

	==Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution==		==Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution==
-	<StructureSection load='3cwk' size='340' side='right' caption='[[3cwk]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3cwk' size='340' side='right'caption='[[3cwk]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [~~http~~://pdbe.org/3cwk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cwk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [https://pdbe.org/3cwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [https://www.ebi.ac.uk/pdbsum/3cwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3cwk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cwk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein 3D structures\|Cellular retinoic acid-binding protein 3D structures]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 41:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 08:37, 25 October 2017

2017-10-25T08:37:13Z

←Older revision		Revision as of 08:37, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution==		==Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution==
	<StructureSection load='3cwk' size='340' side='right' caption='[[3cwk]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3cwk' size='340' side='right' caption='[[3cwk]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://pdbe.org/3cwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://pdbe.org/3cwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3cwk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3cwk" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
-	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
-	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
-	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>
Line 44:		Line 39:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
		+	[[Category: Cytoplasm]]
	[[Category: High resolution]]		[[Category: High resolution]]
	[[Category: Nucleus]]		[[Category: Nucleus]]

OCA at 13:19, 8 February 2016

2016-02-08T13:19:26Z

←Older revision		Revision as of 13:19, 8 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://pdbe.org/3cwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cwk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cwk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 23:36, 24 December 2014

2014-12-24T23:36:12Z

←Older revision		Revision as of 23:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Geiger, J H.]]	+	[[Category: Geiger, J H]]
-	[[Category: Vaezeslami, S.]]	+	[[Category: Vaezeslami, S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]

OCA at 09:03, 29 September 2014

2014-09-29T09:03:05Z

←Older revision		Revision as of 09:03, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3cwk.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution==
		+	<StructureSection load='3cwk' size='340' side='right' caption='[[3cwk]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cwk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fr3\|2fr3]], [[2frs\|2frs]], [[2fs6\|2fs6]], [[2g7b\|2g7b]], [[2g78\|2g78]], [[2g79\|2g79]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwk RCSB], [http://www.ebi.ac.uk/pdbsum/3cwk PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cwk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structural integrity of cellular retinoic acid-binding protein II (CRABPII) has been investigated using the crystal structures of CRABPII mutants. The overall fold was well maintained by these CRABPII mutants, each of which carried multiple different mutations. A water-mediated network is found to be present across the large binding cavity, extending from Arg111 deep inside the cavity to the alpha2 helix at its entrance. This chain of interactions acts as a ;pillar' that maintains the integrity of the protein. The disruption of the water network upon loss of Arg111 leads to decreased structural integrity of the protein. A water-mediated network can be re-established by introducing the hydrophilic Glu121 inside the cavity, which results in a rigid protein with the alpha2 helix adopting an altered conformation compared with wild-type CRABPII.

-	~~{{STRUCTURE_3cwk\| PDB=3cwk \| SCENE= }}~~	+	Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding.,Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger JH Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1228-39. Epub 2008, Nov 18. PMID:19018099<ref>PMID:19018099</ref>

-	~~===Crystal Structure~~ of the ~~R132K:Y134F:R111L:T54V:L121E Mutant~~ of ~~Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1~~.~~57 Angstroms Resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19018099}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3cwk]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].~~	+

	==See Also==		==See Also==
Line 15:		Line 32:
	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019018099<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]

OCA at 10:16, 20 October 2012

2012-10-20T10:16:26Z

←Older revision		Revision as of 10:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3cwk]] is a 1 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].	+	[[3cwk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].

	==See Also==		==See Also==

OCA: Protected "3cwk" [edit=sysop:move=sysop]

2012-07-26T01:33:46Z

Protected "3cwk" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:33, 26 July 2012

OCA at 01:33, 26 July 2012

2012-07-26T01:33:44Z

←Older revision		Revision as of 01:33, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3cwk.png\|left\|200px]]		[[Image:3cwk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3cwk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3cwk\| PDB=3cwk \| SCENE= }}		{{STRUCTURE_3cwk\| PDB=3cwk \| SCENE= }}

	===Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution===		===Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19018099}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19018099 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19018099}}		{{ABSTRACT_PUBMED_19018099}}

	==About this Structure==		==About this Structure==
-	~~3CWK~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].	+	[[3cwk]] is a 1 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19018099~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019018099</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]
Line 29:		Line 23:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
-	[[Category: Crystallography]]
-	[[Category: Cytoplasm]]
	[[Category: High resolution]]		[[Category: High resolution]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
Line 39:		Line 31:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Vitamin some]]		[[Category: Vitamin some]]
-	[[Category: X-ray]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:46:47 2010''

OCA at 08:37, 22 September 2010

2010-09-22T08:37:49Z

←Older revision		Revision as of 08:37, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3CWK is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].	+	3CWK is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWK OCA].

	==Reference==		==Reference==
-	Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding., Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger JH, Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1228-39. Epub 2008, Nov 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19018099 19018099]~~	+	<ref group="xtra">PMID:19018099</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Geiger, J H.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx:audit_author~~.]]	+	[[Category: Vaezeslami, S.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
Line 41:		Line 41:
	[[Category: X-ray]]		[[Category: X-ray]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar~~ 11 20:10:~~04 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:46:47 2010''