3cyy - Revision history

OCA at 15:01, 1 November 2023

2023-11-01T15:01:22Z

←Older revision		Revision as of 15:01, 1 November 2023
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	<StructureSection load='3cyy' size='340' side='right'caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3cyy' size='340' side='right'caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [https://pdbe.org/3cyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [https://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [https://pdbe.org/3cyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [https://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [[https://www.uniprot.org/uniprot/CXA1_RAT CXA1_RAT]] Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).	+	[https://www.uniprot.org/uniprot/CXA1_RAT CXA1_RAT] Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pan, L~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Zhang, M~~]]	+	[[Category: Pan L]]
-	[[Category: ~~Cell junction]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Gap junction]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Tight junction]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 07:30, 10 November 2021

2021-11-10T07:30:17Z

←Older revision		Revision as of 07:30, 10 November 2021
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	<StructureSection load='3cyy' size='340' side='right'caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3cyy' size='340' side='right'caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3CYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [~~http~~://pdbe.org/3cyy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [https://pdbe.org/3cyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [https://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [[~~http~~://www.uniprot.org/uniprot/CXA1_RAT CXA1_RAT]] Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).	+	[[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [[https://www.uniprot.org/uniprot/CXA1_RAT CXA1_RAT]] Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:30, 12 August 2020

2020-08-12T10:30:58Z

←Older revision		Revision as of 10:30, 12 August 2020
Line 1:		Line 1:

	==The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide==		==The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide==
-	<StructureSection load='3cyy' size='340' side='right' caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3cyy' size='340' side='right'caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3CYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://pdbe.org/3cyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://pdbe.org/3cyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pan, L]]		[[Category: Pan, L]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]

OCA at 13:25, 7 November 2018

2018-11-07T13:25:33Z

←Older revision		Revision as of 13:25, 7 November 2018
Line 1:		Line 1:
		+
	==The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide==		==The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide==
	<StructureSection load='3cyy' size='340' side='right' caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3cyy' size='340' side='right' caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CYY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://pdbe.org/3cyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://pdbe.org/3cyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cyy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/3cyy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/3cyy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:04, 8 February 2016

2016-02-08T11:04:56Z

←Older revision		Revision as of 11:04, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3cyy' size='340' side='right' caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3cyy' size='340' side='right' caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CYY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CYY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://pdbe.org/3cyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cyy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3cyy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Pan, L]]		[[Category: Pan, L]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]

OCA at 22:51, 24 December 2014

2014-12-24T22:51:51Z

←Older revision		Revision as of 22:51, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [[http://www.uniprot.org/uniprot/CXA1_RAT CXA1_RAT]] Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Pan, L.]]	+	[[Category: Pan, L]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Gap junction]]		[[Category: Gap junction]]

OCA at 09:26, 5 November 2014

2014-11-05T09:26:42Z

←Older revision		Revision as of 09:26, 5 November 2014
Line 1:		Line 1:
-	[[~~Image~~:3cyy.~~png\|left~~\|200px]]	+	==The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide==
		+	<StructureSection load='3cyy' size='340' side='right' caption='[[3cyy]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CYY FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cyy RCSB], [http://www.ebi.ac.uk/pdbsum/3cyy PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/3cyy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PDZ domain scaffold proteins are capable of assembling macromolecular protein complexes in diverse cellular processes through PDZ-mediated binding to a short peptide fragment at the carboxyl tail of target proteins. How each PDZ domain specifically recognizes its target protein(s) remains a major conceptual question, as at least a few out of the several hundred PDZ domains in each eukaryotic genome share overlapping binding properties with any given target protein. Here, we show that the domain-swapped dimerization of zonula occludens-1 PDZ2 generates a distinct interface that functions together with the well-separated canonical carboxyl tail-binding pocket in each PDZ unit in binding to connexin43 (Cx43). We further demonstrate that the charge-charge interaction network formed by residues in the PDZ dimer interface and upstream residues of the Cx43 peptide not only provides the unprecedented interaction specificity for the complex but may also function as a phosphorylation-mediated regulatory switch for the dynamics of the Cx43 gap junctions. Finally, we provide evidence that such domain-swapped dimer assembly also occurs in other PDZ domain scaffold proteins. Therefore, our findings present a new paradigm for understanding how some PDZ domain proteins specifically bind to and regulate the functions of their target proteins.

-	~~{{STRUCTURE_3cyy\| PDB=3cyy \| SCENE= }}~~	+	Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites.,Chen J, Pan L, Wei Z, Zhao Y, Zhang M EMBO J. 2008 Aug 6;27(15):2113-23. Epub 2008 Jul 17. PMID:18636092<ref>PMID:18636092</ref>

-	~~===The crystal structure~~ of ~~ZO-1 PDZ2 in complex with~~ the ~~Cx43 peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18636092}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3cyy]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018636092<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pan, L.]]		[[Category: Pan, L.]]

OCA: Protected "3cyy" [edit=sysop:move=sysop]

2013-01-07T18:36:33Z

Protected "3cyy" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:36, 7 January 2013

OCA at 18:36, 7 January 2013

2013-01-07T18:36:31Z

←Older revision		Revision as of 18:36, 7 January 2013
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	[[Image:3cyy.png\|left\|200px]]		[[Image:3cyy.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3cyy\| PDB=3cyy \| SCENE= }}		{{STRUCTURE_3cyy\| PDB=3cyy \| SCENE= }}

	===The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide===		===The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide===

-
-	<!--
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	{{ABSTRACT_PUBMED_18636092}}		{{ABSTRACT_PUBMED_18636092}}

	==About this Structure==		==About this Structure==
-	~~3CYY~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA].	+	[[3cyy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18636092~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018636092</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Pan, L.]]		[[Category: Pan, L.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Gap junction]]		[[Category: Gap junction]]
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	[[Category: Peptide binding protein]]		[[Category: Peptide binding protein]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]
	[[Category: Tight junction]]		[[Category: Tight junction]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:31:38 2009''

OCA at 19:31, 16 February 2009

2009-02-16T19:31:39Z

←Older revision		Revision as of 19:31, 16 February 2009
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-	[[Image:3cyy.~~jpg~~\|left\|200px]]	+	[[Image:3cyy.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	3CYY is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA].	+	3CYY is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CYY OCA].

	==Reference==		==Reference==
-	~~Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites., Chen J, Pan L, Wei Z, Zhao Y, Zhang M, EMBO J. 2008 Aug 6;27(15):2113-23. Epub 2008 Jul 17.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18636092 18636092]~~	+	<ref group="xtra">PMID:18636092</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Pan, L.]]		[[Category: Pan, L.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 24 10~~:40:~~21 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:31:38 2009''