3di0 - Revision history

OCA at 15:09, 1 November 2023

2023-11-01T15:09:19Z

←Older revision		Revision as of 15:09, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3di0' size='340' side='right'caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='3di0' size='340' side='right'caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staac Staac~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.38Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3di1\|3di1]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>DHDPS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~93062 STAAC])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [https://pdbe.org/3di0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [https://www.ebi.ac.uk/pdbsum/3di0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3di0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [https://pdbe.org/3di0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [https://www.ebi.ac.uk/pdbsum/3di0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3di0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DAPA_STAAC DAPA_STAAC]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18671976</ref>	+	[https://www.uniprot.org/uniprot/DAPA_STAAC DAPA_STAAC] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18671976</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staac~~]]	+	[[Category: Staphylococcus aureus subsp. aureus COL]]
-	[[Category: Tavarekere~~, G S]]~~	+	[[Category: Tavarekere GS]]
-	~~[[Category: Amino-acid biosynthesis]]~~	+
-	~~[[Category: Diaminopimelate biosynthesis]]~~	+
-	~~[[Category: Dihydrodipicolinate synthase]]~~	+
-	~~[[Category: Feeb-back inhibition]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Lysine biosynthesis]]~~	+
-	~~[[Category: Ping-pong mechanism]]~~	+
-	~~[[Category: Schiff base~~]]	+

OCA at 07:59, 9 February 2022

2022-02-09T07:59:32Z

←Older revision		Revision as of 07:59, 9 February 2022
Line 1:		Line 1:

	==Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus==		==Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus==
-	<StructureSection load='3di0' size='340' side='right' caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>	+	<StructureSection load='3di0' size='340' side='right'caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3di1\|3di1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3di1\|3di1]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [~~http~~://pdbe.org/3di0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3di0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3di0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [https://pdbe.org/3di0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [https://www.ebi.ac.uk/pdbsum/3di0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3di0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DAPA_STAAC DAPA_STAAC]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18671976</ref>	+	[[https://www.uniprot.org/uniprot/DAPA_STAAC DAPA_STAAC]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18671976</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Staac]]		[[Category: Staac]]
	[[Category: Tavarekere, G S]]		[[Category: Tavarekere, G S]]

OCA at 09:50, 14 November 2018

2018-11-14T09:50:24Z

←Older revision		Revision as of 09:50, 14 November 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus==		==Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus==
	<StructureSection load='3di0' size='340' side='right' caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='3di0' size='340' side='right' caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [http://pdbe.org/3di0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [http://www.ebi.ac.uk/pdbsum/3di0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [http://pdbe.org/3di0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [http://www.ebi.ac.uk/pdbsum/3di0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3di0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/3di0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/3di0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:06, 8 February 2016

2016-02-08T03:06:17Z

←Older revision		Revision as of 03:06, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3di0' size='340' side='right' caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='3di0' size='340' side='right' caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3di1\|3di1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3di1\|3di1]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~46170 Staphylococcus aureus subsp. aureus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydrodipicolinate_synthase Dihydrodipicolinate~~ synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_synthase 4-hydroxy-tetrahydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.7 4.3.3.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [http://www.ebi.ac.uk/pdbsum/3di0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [http://pdbe.org/3di0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [http://www.ebi.ac.uk/pdbsum/3di0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3di0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3di0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrodipicolinate~~ synthase]]	+	[[Category: 4-hydroxy-tetrahydrodipicolinate synthase]]
-	[[Category: ~~Staphylococcus aureus subsp. aureus~~]]	+	[[Category: Staac]]
	[[Category: Tavarekere, G S]]		[[Category: Tavarekere, G S]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
		+	[[Category: Dihydrodipicolinate synthase]]
	[[Category: Feeb-back inhibition]]		[[Category: Feeb-back inhibition]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 13:02, 5 January 2015

2015-01-05T13:02:00Z

←Older revision		Revision as of 13:02, 5 January 2015
Line 1:		Line 1:
-	[[~~Image:~~3di0.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus==
		+	<StructureSection load='3di0' size='340' side='right' caption='[[3di0]], [[Resolution\|resolution]] 2.38Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3di0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DI0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3di1\|3di1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHDPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_synthase Dihydrodipicolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.52 4.2.1.52] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3di0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3di0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3di0 RCSB], [http://www.ebi.ac.uk/pdbsum/3di0 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAPA_STAAC DAPA_STAAC]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).<ref>PMID:18671976</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/3di0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine biosynthesis is crucial for cell-wall formation in bacteria. Enzymes involved in lysine biosynthesis are thus potential targets for anti-microbial therapeutics. Dihydrodipicolinate synthase (DHDPS) catalyzes the first step of this pathway. Unlike its homologues, Staphylococcus aureus DHDPS is a dimer both in solution and in the crystal and is not feedback inhibited by lysine. The crystal structure of S. aureus DHDPS in the free and substrate bound forms provides a structural rationale for its catalytic mechanism. The structure also reveals unique conformational features of the S. aureus enzyme that could be crucial for the design of specific non-competitive inhibitors.

-	~~{{STRUCTURE_3di0\| PDB=3di0 \| SCENE= }}~~	+	Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase.,Girish TS, Sharma E, Gopal B FEBS Lett. 2008 Aug 20;582(19):2923-30. Epub 2008 Jul 29. PMID:18671976<ref>PMID:18671976</ref>

-	~~===Crystal Structure~~ of ~~Dihydrodipicolinate synthase from Staphylococcus aureus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18671976}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3di0]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus_subsp~~.~~_aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA].~~	+

	==See Also==		==See Also==
-	*[[Dihydrodipicolinate ~~Synthase~~\|Dihydrodipicolinate ~~Synthase~~]]	+	*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018671976<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
	[[Category: Staphylococcus aureus subsp. aureus]]		[[Category: Staphylococcus aureus subsp. aureus]]
-	[[Category: Tavarekere, G S.]]	+	[[Category: Tavarekere, G S]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
-	[[Category: Dihydrodipicolinate synthase]]
	[[Category: Feeb-back inhibition]]		[[Category: Feeb-back inhibition]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA: Protected "3di0" [edit=sysop:move=sysop]

2012-10-20T08:42:05Z

Protected "3di0" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:42, 20 October 2012

OCA at 08:42, 20 October 2012

2012-10-20T08:42:03Z

←Older revision		Revision as of 08:42, 20 October 2012
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-	{{Seed}}
	[[Image:3di0.png\|left\|200px]]		[[Image:3di0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3di0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3di0\| PDB=3di0 \| SCENE= }}		{{STRUCTURE_3di0\| PDB=3di0 \| SCENE= }}

	===Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus===		===Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18671976}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18671976 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18671976}}		{{ABSTRACT_PUBMED_18671976}}

	==About this Structure==		==About this Structure==
-	~~3DI0~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp.~~_aureus_col~~ Staphylococcus aureus subsp. aureus ~~col~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA].	+	[[3di0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA].
		+
		+	==See Also==
		+	*[[Dihydrodipicolinate Synthase\|Dihydrodipicolinate Synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18671976~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018671976</ref><references group="xtra"/>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
-	[[Category: Staphylococcus aureus subsp. aureus ~~col~~]]	+	[[Category: Staphylococcus aureus subsp. aureus]]
	[[Category: Tavarekere, G S.]]		[[Category: Tavarekere, G S.]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
-	[[Category: Cytoplasm]]
	[[Category: Diaminopimelate biosynthesis]]		[[Category: Diaminopimelate biosynthesis]]
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
Line 36:		Line 26:
	[[Category: Ping-pong mechanism]]		[[Category: Ping-pong mechanism]]
	[[Category: Schiff base]]		[[Category: Schiff base]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:21:13 2009''

OCA at 16:21, 16 February 2009

2009-02-16T16:21:14Z

←Older revision		Revision as of 16:21, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3DI0 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_col Staphylococcus aureus subsp. aureus col]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA].	+	3DI0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_col Staphylococcus aureus subsp. aureus col]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA].

	==Reference==		==Reference==
-	~~Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase., Girish TS, Sharma E, Gopal B, FEBS Lett. 2008 Aug 20;582(19):2923-30. Epub 2008 Jul 29.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18671976 18671976]~~	+	<ref group="xtra">PMID:18671976</ref><references group="xtra"/>
	[[Category: Dihydrodipicolinate synthase]]		[[Category: Dihydrodipicolinate synthase]]
-	[[Category: Single protein]]
	[[Category: Staphylococcus aureus subsp. aureus col]]		[[Category: Staphylococcus aureus subsp. aureus col]]
	[[Category: Tavarekere, G S.]]		[[Category: Tavarekere, G S.]]
Line 38:		Line 37:
	[[Category: Schiff base]]		[[Category: Schiff base]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 17 13~~:10:13 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:21:13 2009''

OCA at 10:10, 17 September 2008

2008-09-17T10:10:14Z

←Older revision		Revision as of 10:10, 17 September 2008
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3di0.~~jpg~~\|left\|200px]]	+	[[Image:3di0.png\|left\|200px]]

	<!--		<!--
Line 38:		Line 38:
	[[Category: Schiff base]]		[[Category: Schiff base]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug~~ 13 14:13:54 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 13:10:13 2008''

OCA at 11:13, 13 August 2008

2008-08-13T11:13:55Z

←Older revision		Revision as of 11:13, 13 August 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3di0.jpg\|left\|200px]]

-	The ~~entry 3di0~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3di0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3di0\| PDB=3di0 \| SCENE= }}

-	~~Authors: Tavarekere, G.S., Sharma, E., Gopal, B.~~	+	===Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus===

-	Description: Crystal Structure of Dihydrodipicolinate synthase from Staphylococcus aureus

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 23 12~~:13:51 2008''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18671976}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18671976 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18671976}}
		+
		+	==About this Structure==
		+	3DI0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_col Staphylococcus aureus subsp. aureus col]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DI0 OCA].
		+
		+	==Reference==
		+	Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase., Girish TS, Sharma E, Gopal B, FEBS Lett. 2008 Aug 20;582(19):2923-30. Epub 2008 Jul 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18671976 18671976]
		+	[[Category: Dihydrodipicolinate synthase]]
		+	[[Category: Single protein]]
		+	[[Category: Staphylococcus aureus subsp. aureus col]]
		+	[[Category: Tavarekere, G S.]]
		+	[[Category: Amino-acid biosynthesis]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Diaminopimelate biosynthesis]]
		+	[[Category: Dihydrodipicolinate synthase]]
		+	[[Category: Feeb-back inhibition]]
		+	[[Category: Lyase]]
		+	[[Category: Lysine biosynthesis]]
		+	[[Category: Ping-pong mechanism]]
		+	[[Category: Schiff base]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 14:13:54 2008''