3dkn - Revision history

OCA at 09:41, 21 February 2024

2024-02-21T09:41:51Z

←Older revision		Revision as of 09:41, 21 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [https://pdbe.org/3dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [https://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [https://pdbe.org/3dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [https://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SECY_METJA SECY_METJA] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dkn ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dkn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	During cotranslational protein translocation, the ribosome associates with a membrane channel, formed by the Sec61 complex, and recruits the translocon-associated protein complex (TRAP). Here we report the structure of a ribosome-channel complex from mammalian endoplasmic reticulum in which the channel has been visualized at 11 A resolution. In this complex, single copies of Sec61 and TRAP associate with a nontranslating ribosome and this stoichiometry was verified by quantitative mass spectrometry. A bilayer-like density surrounds the channel and can be attributed to lipid and detergent. The crystal structure of an archaeal homolog of the Sec61 complex was then docked into the map. In this model, two cytoplasmic loops of Sec61 may interact with RNA helices H6, H7, and H50, while the central pore is located below the ribosome tunnel exit. Hence, this copy of Sec61 is positioned to capture and translocate the nascent chain. Finally, we show that mammalian and bacterial ribosome-channel complexes have similar architectures.
-
-	Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.,Menetret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW Structure. 2008 Jul;16(7):1126-37. PMID:18611385<ref>PMID:18611385</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3dkn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Preprotein translocase\|Preprotein translocase]]	+	*[[Preprotein translocase 3D structures\|Preprotein translocase 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Akey, C]]	+	[[Category: Akey C]]
-	[[Category: Menetret, J F]]	+	[[Category: Menetret J-F]]
-	~~[[Category: Co-translational translocation]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Protein transport-rna complex]]~~	+
-	~~[[Category: Ribosome-channel complex~~]]	+

OCA at 08:00, 9 February 2022

2022-02-09T08:00:54Z

←Older revision		Revision as of 08:00, 9 February 2022
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	<SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>		<SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [~~http~~://pdbe.org/3dkn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [https://pdbe.org/3dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [https://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:17, 10 April 2020

2020-04-10T17:17:22Z

←Older revision		Revision as of 17:17, 10 April 2020
Line 3:		Line 3:
	<SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>		<SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://pdbe.org/3dkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://pdbe.org/3dkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:06, 6 March 2020

2020-03-06T17:06:35Z

←Older revision		Revision as of 17:06, 6 March 2020
Line 1:		Line 1:

	==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum==		==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum==
-	<~~StructureSection~~ load='3dkn' size='340' side='right' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>	+	<SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
Line 31:		Line 31:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
		+	[[Category: Large Structures]]
	[[Category: Akey, C]]		[[Category: Akey, C]]
	[[Category: Menetret, J F]]		[[Category: Menetret, J F]]

OCA at 07:55, 18 July 2018

2018-07-18T07:55:14Z

←Older revision		Revision as of 07:55, 18 July 2018
Line 1:		Line 1:
		+
	==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum==		==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum==
	<StructureSection load='3dkn' size='340' side='right' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>		<StructureSection load='3dkn' size='340' side='right' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from ~~[http://en.wikipedia.org/wiki/Canfa Canfa] and~~ [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://pdbe.org/3dkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://pdbe.org/3dkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dkn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dkn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Canfa]]
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Akey, C]]		[[Category: Akey, C]]

OCA at 07:58, 10 February 2016

2016-02-10T07:58:02Z

←Older revision		Revision as of 07:58, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3dkn' size='340' side='right' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>		<StructureSection load='3dkn' size='340' side='right' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa] and [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://pdbe.org/3dkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dkn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3dkn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Canfa]]
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Akey, C]]		[[Category: Akey, C]]

OCA at 22:54, 3 January 2015

2015-01-03T22:54:44Z

←Older revision		Revision as of 22:54, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.,Menetret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW Structure. 2008 Jul;16(7):1126-37. PMID:18611385<ref>PMID:18611385</ref>		Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.,Menetret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW Structure. 2008 Jul;16(7):1126-37. PMID:18611385<ref>PMID:18611385</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Preprotein translocase\|Preprotein translocase]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
-	[[Category: Akey, C.]]	+	[[Category: Akey, C]]
-	[[Category: Menetret, J F.]]	+	[[Category: Menetret, J F]]
	[[Category: Co-translational translocation]]		[[Category: Co-translational translocation]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
	[[Category: Protein transport-rna complex]]		[[Category: Protein transport-rna complex]]
	[[Category: Ribosome-channel complex]]		[[Category: Ribosome-channel complex]]

OCA at 09:50, 21 May 2014

2014-05-21T09:50:23Z

←Older revision		Revision as of 09:50, 21 May 2014
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-	[[~~Image~~:3dkn.~~png\|left~~\|200px]]	+	==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum==
		+	<StructureSection load='3dkn' size='340' side='right' caption='[[3dkn]], [[Resolution\|resolution]] 8.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [http://www.ebi.ac.uk/pdbsum/3dkn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dkn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	During cotranslational protein translocation, the ribosome associates with a membrane channel, formed by the Sec61 complex, and recruits the translocon-associated protein complex (TRAP). Here we report the structure of a ribosome-channel complex from mammalian endoplasmic reticulum in which the channel has been visualized at 11 A resolution. In this complex, single copies of Sec61 and TRAP associate with a nontranslating ribosome and this stoichiometry was verified by quantitative mass spectrometry. A bilayer-like density surrounds the channel and can be attributed to lipid and detergent. The crystal structure of an archaeal homolog of the Sec61 complex was then docked into the map. In this model, two cytoplasmic loops of Sec61 may interact with RNA helices H6, H7, and H50, while the central pore is located below the ribosome tunnel exit. Hence, this copy of Sec61 is positioned to capture and translocate the nascent chain. Finally, we show that mammalian and bacterial ribosome-channel complexes have similar architectures.

-	~~<!--~~	+	Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.,Menetret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW Structure. 2008 Jul;16(7):1126-37. PMID:18611385<ref>PMID:18611385</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3dkn"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3dkn\| PDB=3dkn \| SCENE= }}~~	+

-	~~===Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_18611385}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 18611385 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_18611385}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3dkn]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018611385<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Akey, C.]]		[[Category: Akey, C.]]

OCA: Protected "3dkn" [edit=sysop:move=sysop]

2011-08-24T05:41:39Z

Protected "3dkn" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 24 August 2011

OCA at 05:41, 24 August 2011

2011-08-24T05:41:37Z

←Older revision		Revision as of 05:41, 24 August 2011
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-	{{Seed}}
	[[Image:3dkn.png\|left\|200px]]		[[Image:3dkn.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3DKN~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA].	+	[[3dkn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18611385~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018611385</ref><references group="xtra"/>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Akey, C.]]		[[Category: Akey, C.]]
	[[Category: Menetret, J F.]]		[[Category: Menetret, J F.]]
	[[Category: Co-translational translocation]]		[[Category: Co-translational translocation]]
-	[[Category: Cryo-electron microscopy]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
-	[[Category: Protein transport/rna complex]]	+	[[Category: Protein transport-rna complex]]
	[[Category: Ribosome-channel complex]]		[[Category: Ribosome-channel complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:40:45 2009''