3dne - Revision history

OCA at 07:00, 19 August 2020

2020-08-19T07:00:17Z

←Older revision		Revision as of 07:00, 19 August 2020
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	==cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24==		==cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24==
-	<StructureSection load='3dne' size='340' side='right' caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3dne' size='340' side='right'caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3DNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3DNE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LL1:3-PYRIDIN-4-YL-1H-INDAZOLE'>LL1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LL1:3-PYRIDIN-4-YL-1H-INDAZOLE'>LL1</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://pdbe.org/3dne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dne ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://pdbe.org/3dne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]	+	*[[CAMP-dependent protein kinase 3D structures\|CAMP-dependent protein kinase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
	[[Category: Schiffer, A]]		[[Category: Schiffer, A]]

OCA at 09:59, 14 November 2018

2018-11-14T09:59:53Z

←Older revision		Revision as of 09:59, 14 November 2018
Line 1:		Line 1:
		+
	==cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24==		==cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24==
	<StructureSection load='3dne' size='340' side='right' caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3dne' size='340' side='right' caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://pdbe.org/3dne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://pdbe.org/3dne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/3dne_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/3dne_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:07, 9 February 2016

2016-02-09T14:07:38Z

←Older revision		Revision as of 14:07, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3dne' size='340' side='right' caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3dne' size='340' side='right' caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3dne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3dne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DNE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LL1:3-PYRIDIN-4-YL-1H-INDAZOLE'>LL1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LL1:3-PYRIDIN-4-YL-1H-INDAZOLE'>LL1</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://pdbe.org/3dne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dne ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
	[[Category: Schiffer, A]]		[[Category: Schiffer, A]]

OCA at 07:17, 25 December 2014

2014-12-25T07:17:21Z

←Older revision		Revision as of 07:17, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAPCA_BOVIN KAPCA_BOVIN]] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). [[http://www.uniprot.org/uniprot/IPKA_RABIT IPKA_RABIT]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:22, 18 December 2014

2014-12-18T14:22:40Z

←Older revision		Revision as of 14:22, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3dne\| PDB=3dne \| SCENE= }}~~	+	==cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24==
-	===cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24===	+	<StructureSection load='3dne' size='340' side='right' caption='[[3dne]], [[Resolution\|resolution]] 2.00Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3dne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DNE FirstGlance]. <br>
-	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~KAPCA_BOVIN KAPCA_BOVIN~~]] ~~Phosphorylates~~ a ~~large number of substrates in the cytoplasm and~~ the ~~nucleus~~. ~~Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis~~. ~~Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5~~/~~RPT6, PJA2, RYR2, RORA, TRPC1 and VASP~~. ~~RORA is activated by phosphorylation~~. ~~Required for glucose~~-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-~~kappa~~-~~B (NFKB1 and NFKB2) and I~~-~~kappa~~-B-~~alpha (NFKBIA)~~, ~~but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP~~. ~~Prevents the antiproliferative and anti~~-~~invasive effects of alpha~~-~~difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+)~~, ~~leading to reduced amplitude and increased frequency of store overload~~-~~induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(~~2~~+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+)~~. ~~TRPC1 activation by phosphorylation promotes Ca(~~2~~+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers~~. ~~PSMC5~~/~~RPT6 activation by phosphorylation stimulates proteasome~~. ~~Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation~~. ~~NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding~~. ~~Involved in embryonic development by down~~-~~regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis~~. ~~Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation~~. ~~Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation~~. ~~May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity)~~. [[http://www.~~uniprot~~.org/~~uniprot~~/~~IPKA_RABIT IPKA_RABIT~~]~~] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity~~, ~~this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LL1:3-PYRIDIN-4-YL-1H-INDAZOLE'>LL1</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	==~~About this Structure~~==	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dnd\|3dnd]]</td></tr>
-	[[~~3dne~~]] ~~is a 2 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Bos_taurus Bos taurus~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~3DNE OCA~~].	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dne RCSB], [http://www.ebi.ac.uk/pdbsum/3dne PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/3dne_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]		*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:018767090</ref><references group="xtra"/>~~<~~references~~/>	+
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
-	[[Category: Schiffer, A.]]	+	[[Category: Schiffer, A]]
-	[[Category: Wendt, K U.]]	+	[[Category: Wendt, K U]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Camp]]		[[Category: Camp]]

OCA at 05:08, 10 October 2013

2013-10-10T05:08:52Z

←Older revision		Revision as of 05:08, 10 October 2013
Line 1:		Line 1:
-	[[Image:3dne.png\|left\|200px]]
-
	{{STRUCTURE_3dne\| PDB=3dne \| SCENE= }}		{{STRUCTURE_3dne\| PDB=3dne \| SCENE= }}
-
	===cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24===		===cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/KAPCA_BOVIN KAPCA_BOVIN]] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). [[http://www.uniprot.org/uniprot/IPKA_RABIT IPKA_RABIT]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:018767090</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018767090</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]

OCA: Protected "3dne" [edit=sysop:move=sysop]

2013-01-07T18:23:49Z

Protected "3dne" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:23, 7 January 2013

OCA at 18:23, 7 January 2013

2013-01-07T18:23:47Z

←Older revision		Revision as of 18:23, 7 January 2013
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-	{{Seed}}
	[[Image:3dne.png\|left\|200px]]		[[Image:3dne.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3dne", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3dne\| PDB=3dne \| SCENE= }}		{{STRUCTURE_3dne\| PDB=3dne \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~3DNE~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA].	+	[[3dne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA].
		+
		+	==See Also==
		+	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18767090~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018767090</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
	[[Category: Schiffer, A.]]		[[Category: Schiffer, A.]]
	[[Category: Wendt, K U.]]		[[Category: Wendt, K U.]]
-	[[Category: 3d-structure]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Camp]]		[[Category: Camp]]
-	[[Category: Cytoplasm]]
-	[[Category: Direct protein sequencing]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
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	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	[[Category: Transferase/transferase inhibitor complex]]	+	[[Category: Transferase-transferase inhibitor complex]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:52:11 2009''~~	+

OCA at 06:52, 1 July 2009

2009-07-01T06:52:12Z

←Older revision		Revision as of 06:52, 1 July 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3dne.~~jpg~~\|left\|200px]]	+	[[Image:3dne.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transferase/transferase inhibitor complex]]		[[Category: Transferase/transferase inhibitor complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 25~~ 09:14:30 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:52:11 2009''

OCA at 06:14, 25 June 2009

2009-06-25T06:14:32Z

←Older revision		Revision as of 06:14, 25 June 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3dne.jpg\|left\|200px]]

-	The ~~entry 3dne~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3dne", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3dne\| PDB=3dne \| SCENE= }}

-	~~Authors: Orts, J., Tuma, J., Reese, M., Grimm, S.K., Monecke, P., Bartoschek, S., Schiffer, A., Wendt, K.U., Griesinger, C., Carlomagno, T.~~	+	===cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24===

-	Description: cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Aug 6 12~~:28:~~25 2008~~''	+	==About this Structure==
		+	3DNE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DNE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18767090</ref><references group="xtra"/>
		+	[[Category: Bos taurus]]
		+	[[Category: CAMP-dependent protein kinase]]
		+	[[Category: Schiffer, A.]]
		+	[[Category: Wendt, K U.]]
		+	[[Category: 3d-structure]]
		+	[[Category: Atp-binding]]
		+	[[Category: Camp]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Direct protein sequencing]]
		+	[[Category: Kinase]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Myristate]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein kinase inhibitor]]
		+	[[Category: Serine/threonine-protein kinase]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase/transferase inhibitor complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 09:14:30 2009''