3e89 - Revision history

OCA at 09:45, 21 February 2024

2024-02-21T09:45:47Z

←Older revision		Revision as of 09:45, 21 February 2024
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	<StructureSection load='3e89' size='340' side='right'caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3e89' size='340' side='right'caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_14579 Atcc 14579~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E89 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [https://pdbe.org/3e89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [https://www.ebi.ac.uk/pdbsum/3e89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e89 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [https://pdbe.org/3e89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [https://www.ebi.ac.uk/pdbsum/3e89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e89 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q81HW2_BACCR Q81HW2_BACCR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e89 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e89 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Here we present a detailed characterization of ion binding in the NaK pore using the high-resolution structures of NaK in complex with various cations. These structures reveal four ion binding sites with similar chemical environments but vastly different ion preference. The most nonselective of all is site 3, which is formed exclusively by backbone carbonyl oxygen atoms and resides deep within the selectivity filter. Additionally, four water molecules in combination with four backbone carbonyl oxygen atoms are seen to participate in K(+) and Rb(+) ion chelation, at both the external entrance and the vestibule of the NaK filter, confirming the channel's preference for an octahedral ligand configuration for K(+) and Rb(+) binding. In contrast, Na(+) binding in the NaK filter, particularly at site 4, utilizes a pyramidal ligand configuration that requires the participation of a water molecule in the cavity. Therefore, the ability of the NaK filter to bind both Na(+) and K(+) ions seemingly arises from the ions' ability to use the existing environment in unique ways, rather than from any structural rearrangements of the filter itself.
-
-	Structural analysis of ion selectivity in the NaK channel.,Alam A, Jiang Y Nat Struct Mol Biol. 2009 Jan;16(1):35-41. Epub 2008 Dec 21. PMID:19098915<ref>PMID:19098915</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3e89" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]		*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 14579~~]]	+	[[Category: Bacillus cereus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alam, A]]	+	[[Category: Alam A]]
-	[[Category: Jiang, Y]]	+	[[Category: Jiang Y]]
-	~~[[Category: 2-transmembrane helix channel]]~~	+
-	~~[[Category: Ionic channel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Non-selective cation channel]]~~	+
-	~~[[Category: Tetrameric cation channel family~~]]	+

OCA at 11:43, 16 February 2022

2022-02-16T11:43:12Z

←Older revision		Revision as of 11:43, 16 February 2022
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	<StructureSection load='3e89' size='340' side='right'caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3e89' size='340' side='right'caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3E89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E89 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [~~http~~://pdbe.org/3e89 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3e89 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3e89 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [https://pdbe.org/3e89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [https://www.ebi.ac.uk/pdbsum/3e89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e89 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:28, 31 July 2019

2019-07-31T07:28:09Z

←Older revision		Revision as of 07:28, 31 July 2019
Line 1:		Line 1:

	==Crystal Structure of the the open NaK channel-low Na+ complex==		==Crystal Structure of the the open NaK channel-low Na+ complex==
-	<StructureSection load='3e89' size='340' side='right' caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3e89' size='340' side='right'caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/3e89_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/3e89_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 3e89" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3e89" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 14579]]		[[Category: Atcc 14579]]
		+	[[Category: Large Structures]]
	[[Category: Alam, A]]		[[Category: Alam, A]]
	[[Category: Jiang, Y]]		[[Category: Jiang, Y]]

OCA at 09:05, 25 October 2017

2017-10-25T09:05:08Z

←Older revision		Revision as of 09:05, 25 October 2017
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 3e89" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3e89" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Potassium Channel\|Potassium Channel]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:55, 11 August 2016

2016-08-11T17:55:03Z

←Older revision		Revision as of 17:55, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the the open NaK channel-low Na+ complex==		==Crystal Structure of the the open NaK channel-low Na+ complex==
	<StructureSection load='3e89' size='340' side='right' caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3e89' size='340' side='right' caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_cereus Bacillus cereus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [http://www.ebi.ac.uk/pdbsum/3e89 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [http://pdbe.org/3e89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [http://www.ebi.ac.uk/pdbsum/3e89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e89 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e89 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3e89" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus cereus~~]]	+	[[Category: Atcc 14579]]
	[[Category: Alam, A]]		[[Category: Alam, A]]
	[[Category: Jiang, Y]]		[[Category: Jiang, Y]]

OCA at 07:56, 20 January 2015

2015-01-20T07:56:57Z

←Older revision		Revision as of 07:56, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [http://www.ebi.ac.uk/pdbsum/3e89 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [http://www.ebi.ac.uk/pdbsum/3e89 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
-	[[Category: Alam, A.]]	+	[[Category: Alam, A]]
-	[[Category: Jiang, Y.]]	+	[[Category: Jiang, Y]]
	[[Category: 2-transmembrane helix channel]]		[[Category: 2-transmembrane helix channel]]
	[[Category: Ionic channel]]		[[Category: Ionic channel]]

OCA at 10:59, 29 September 2014

2014-09-29T10:59:10Z

←Older revision		Revision as of 10:59, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3e89.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the the open NaK channel-low Na+ complex==
		+	<StructureSection load='3e89' size='340' side='right' caption='[[3e89]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E89 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e83\|3e83]], [[3e86\|3e86]], [[3e8b\|3e8b]], [[3e8f\|3e8f]], [[3e8g\|3e8g]], [[3e8h\|3e8h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e89 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e89 RCSB], [http://www.ebi.ac.uk/pdbsum/3e89 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/3e89_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we present a detailed characterization of ion binding in the NaK pore using the high-resolution structures of NaK in complex with various cations. These structures reveal four ion binding sites with similar chemical environments but vastly different ion preference. The most nonselective of all is site 3, which is formed exclusively by backbone carbonyl oxygen atoms and resides deep within the selectivity filter. Additionally, four water molecules in combination with four backbone carbonyl oxygen atoms are seen to participate in K(+) and Rb(+) ion chelation, at both the external entrance and the vestibule of the NaK filter, confirming the channel's preference for an octahedral ligand configuration for K(+) and Rb(+) binding. In contrast, Na(+) binding in the NaK filter, particularly at site 4, utilizes a pyramidal ligand configuration that requires the participation of a water molecule in the cavity. Therefore, the ability of the NaK filter to bind both Na(+) and K(+) ions seemingly arises from the ions' ability to use the existing environment in unique ways, rather than from any structural rearrangements of the filter itself.

-	~~{{STRUCTURE_3e89\| PDB=3e89 \| SCENE= }}~~	+	Structural analysis of ion selectivity in the NaK channel.,Alam A, Jiang Y Nat Struct Mol Biol. 2009 Jan;16(1):35-41. Epub 2008 Dec 21. PMID:19098915<ref>PMID:19098915</ref>

-	~~===Crystal Structure~~ of the ~~the open NaK channel-low Na+ complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19098915}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3e89]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_cereus Bacillus cereus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA].~~	+

	==See Also==		==See Also==
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019098915<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Alam, A.]]		[[Category: Alam, A.]]

OCA at 21:35, 20 October 2012

2012-10-20T21:35:33Z

←Older revision		Revision as of 21:35, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3e89]] is a 2 chain structure ~~of [[Potassium Channel]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA].	+	[[3e89]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E89 OCA].

	==See Also==		==See Also==

OCA at 13:41, 27 July 2012

2012-07-27T13:41:54Z

←Older revision		Revision as of 13:41, 27 July 2012
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	[[Image:3e89.png\|left\|200px]]		[[Image:3e89.png\|left\|200px]]

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	{{STRUCTURE_3e89\| PDB=3e89 \| SCENE= }}		{{STRUCTURE_3e89\| PDB=3e89 \| SCENE= }}

	===Crystal Structure of the the open NaK channel-low Na+ complex===		===Crystal Structure of the the open NaK channel-low Na+ complex===

-
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	==See Also==		==See Also==
-	*[[Potassium Channel]]	+	*[[Potassium Channel\|Potassium Channel]]

	==Reference==		==Reference==

OCA: Protected "3e89" [edit=sysop:move=sysop]

2011-11-16T10:09:23Z

Protected "3e89" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:09, 16 November 2011