3e9s - Revision history

OCA at 11:44, 16 February 2022

2022-02-16T11:44:26Z

←Older revision		Revision as of 11:44, 16 February 2022
Line 1:		Line 1:

	==A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication==		==A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication==
-	<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3e9s' size='340' side='right'caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e9s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3E9S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E9S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TTT:5-AMINO-2-METHYL-N-[(1R)-1-NAPHTHALEN-1-YLETHYL]BENZAMIDE'>TTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TTT:5-AMINO-2-METHYL-N-[(1R)-1-NAPHTHALEN-1-YLETHYL]BENZAMIDE'>TTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fe8\|2fe8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fe8\|2fe8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [~~http~~://pdbe.org/3e9s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3e9s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [https://pdbe.org/3e9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [https://www.ebi.ac.uk/pdbsum/3e9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>	+	[[https://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e9s ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e9s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Cvhsa]]		[[Category: Cvhsa]]
		+	[[Category: Large Structures]]
	[[Category: Mesecar, A D]]		[[Category: Mesecar, A D]]
	[[Category: Pegan, S]]		[[Category: Pegan, S]]

OCA at 22:08, 2 December 2018

2018-12-02T22:08:21Z

←Older revision		Revision as of 22:08, 2 December 2018
Line 1:		Line 1:
		+
	==A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication==		==A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication==
	<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fe8\|2fe8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fe8\|2fe8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://pdbe.org/3e9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://pdbe.org/3e9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/3e9s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/3e9s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	[[Category: Ratia, K]]		[[Category: Ratia, K]]
	[[Category: Coronavirus]]		[[Category: Coronavirus]]
		+	[[Category: Cytoplasm]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 38:		Line 40:
	[[Category: Plpro]]		[[Category: Plpro]]
	[[Category: Protease]]		[[Category: Protease]]
		+	[[Category: Ribosomal frameshifting]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Sar]]		[[Category: Sar]]
Line 43:		Line 46:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Virus]]		[[Category: Virus]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 21:14, 9 February 2016

2016-02-09T21:14:12Z

←Older revision		Revision as of 21:14, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sars_coronavirus Sars coronavirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E9S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E9S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TTT:5-AMINO-2-METHYL-N-[(1R)-1-NAPHTHALEN-1-YLETHYL]BENZAMIDE'>TTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TTT:5-AMINO-2-METHYL-N-[(1R)-1-NAPHTHALEN-1-YLETHYL]BENZAMIDE'>TTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fe8\|2fe8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fe8\|2fe8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 ~~SARS coronavirus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://pdbe.org/3e9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e9s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sars coronavirus~~]]	+	[[Category: Cvhsa]]
	[[Category: Mesecar, A D]]		[[Category: Mesecar, A D]]
	[[Category: Pegan, S]]		[[Category: Pegan, S]]

OCA at 09:34, 25 December 2014

2014-12-25T09:34:43Z

←Older revision		Revision as of 09:34, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:32, 19 November 2014

2014-11-19T13:32:15Z

←Older revision		Revision as of 13:32, 19 November 2014
Line 1:		Line 1:
-	~~[[Image:3e9s.png\|left\|200px]]~~	+	==A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication==
-		+	<StructureSection load='3e9s' size='340' side='right' caption='[[3e9s]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{STRUCTURE_3e9s\| PDB=3e9s \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E9S FirstGlance]. <br>
-	===A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TTT:5-AMINO-2-METHYL-N-[(1R)-1-NAPHTHALEN-1-YLETHYL]BENZAMIDE'>TTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-	~~{{ABSTRACT_PUBMED_018852458}}~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fe8\|2fe8]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e9s RCSB], [http://www.ebi.ac.uk/pdbsum/3e9s PDBsum]</span></td></tr>
-	[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].	+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/3e9s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
-	[[Category: Mesecar, A D.]]	+	[[Category: Mesecar, A D]]
-	[[Category: Pegan, S.]]	+	[[Category: Pegan, S]]
-	[[Category: Ratia, K.]]	+	[[Category: Ratia, K]]
	[[Category: Coronavirus]]		[[Category: Coronavirus]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA: Protected "3e9s" [edit=sysop:move=sysop]

2013-01-09T09:00:13Z

Protected "3e9s" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:00, 9 January 2013

OCA at 09:00, 9 January 2013

2013-01-09T09:00:10Z

←Older revision		Revision as of 09:00, 9 January 2013
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-	{{Seed}}
	[[Image:3e9s.png\|left\|200px]]		[[Image:3e9s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3e9s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3e9s\| PDB=3e9s \| SCENE= }}		{{STRUCTURE_3e9s\| PDB=3e9s \| SCENE= }}

	===A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication===		===A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication===

		+	{{ABSTRACT_PUBMED_018852458}}

	==About this Structure==		==About this Structure==
-	~~3E9S~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].	+	[[3e9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
	[[Category: Mesecar, A D.]]		[[Category: Mesecar, A D.]]
Line 20:		Line 14:
	[[Category: Ratia, K.]]		[[Category: Ratia, K.]]
	[[Category: Coronavirus]]		[[Category: Coronavirus]]
-	[[Category: Cytoplasm]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 29:		Line 22:
	[[Category: Plpro]]		[[Category: Plpro]]
	[[Category: Protease]]		[[Category: Protease]]
-	[[Category: Ribosomal frameshifting]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Sar]]		[[Category: Sar]]
Line 35:		Line 27:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Virus]]		[[Category: Virus]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:48:00 2009''

OCA at 10:48, 17 February 2009

2009-02-17T10:48:02Z

←Older revision		Revision as of 10:48, 17 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3e9s.~~jpg~~\|left\|200px]]	+	[[Image:3e9s.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	3E9S is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].	+	3E9S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
-	[[Category: Single protein]]
	[[Category: Mesecar, A D.]]		[[Category: Mesecar, A D.]]
	[[Category: Pegan, S.]]		[[Category: Pegan, S.]]
Line 39:		Line 38:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 8 09~~:35:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:48:00 2009''

OCA at 07:35, 8 October 2008

2008-10-08T07:35:19Z

←Older revision		Revision as of 07:35, 8 October 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3e9s.jpg\|left\|200px]]

-	The ~~entry 3e9s~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3e9s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3e9s\| PDB=3e9s \| SCENE= }}

-	~~Authors: Mesecar,~~ A~~.D., Ratia, K., Pegan, S.~~	+	===A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication===

-	Description: A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 10 12~~:34:53 2008''	+	==About this Structure==
		+	3E9S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9S OCA].
		+	[[Category: Sars coronavirus]]
		+	[[Category: Single protein]]
		+	[[Category: Mesecar, A D.]]
		+	[[Category: Pegan, S.]]
		+	[[Category: Ratia, K.]]
		+	[[Category: Coronavirus]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane]]
		+	[[Category: Metal-binding]]
		+	[[Category: Nsp3]]
		+	[[Category: Papain]]
		+	[[Category: Papain-like]]
		+	[[Category: Plpro]]
		+	[[Category: Protease]]
		+	[[Category: Ribosomal frameshifting]]
		+	[[Category: Rna-binding]]
		+	[[Category: Sar]]
		+	[[Category: Thiol protease]]
		+	[[Category: Transmembrane]]
		+	[[Category: Virus]]
		+	[[Category: Zinc]]
		+	[[Category: Zinc-finger]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:35:17 2008''

OCA: New page: '''Unreleased structure''' The entry 3e9s is ON HOLD Authors: Mesecar, A.D., Ratia, K., Pegan, S. Description: A new class of papain-like protease/deubiquitinase inhibitors blocks SARS...

2008-09-10T09:34:53Z

New page: '''Unreleased structure''' The entry 3e9s is ON HOLD Authors: Mesecar, A.D., Ratia, K., Pegan, S. Description: A new class of papain-like protease/deubiquitinase inhibitors blocks SARS...

New page

'''Unreleased structure'''

The entry 3e9s is ON HOLD

Authors: Mesecar, A.D., Ratia, K., Pegan, S.

Description: A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 12:34:53 2008''